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                  <text>Dominio científico: Coronavirus</text>
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                <text>Neurologic Emergencies during the Coronavirus Disease 2019 Pandemic.</text>
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                <text>Julie G Shulman, Thomas Ford, Anna M Cervantes-Arslanian</text>
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                <text>Although minor neurologic complications of coronavirus disease 2019 are common, life-threatening neurologic emergencies are rare. Acute ischemic stroke, intracerebral hemorrhage, venous sinus thrombosis, seizures, and posterior reversible encephalopathy syndrome have been described. Hospitals have seen significant changes in the volume of patients presenting with neurologic emergencies. We review what has thus far been published about the intersection of coronavirus disease 2019 and neurologic emergencies with particular attention to cerebrovascular disease and seizure. Considerations in managing the acute presentations of these conditions in the context of the pandemic can serve as a model for management of other neurologic emergencies.</text>
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                <text>2021</text>
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                <text>covid-19, thrombolysis, seizure, Cerebrovascular disease, Neurologic emergencies</text>
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                <text>10.1016/j.ncl.2021.02.007</text>
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                <text>Neurologic clinics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Severe Respiratory Illness Outbreak Associated with Human Coronavirus NL63 in a Long-Term Care Facility</text>
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                <text>Julie Hand, Erica Billig Rose, Andrea Salinas, Xiaoyan Lu, Senthil Kumar K. Sakthivel, Eileen Schneider, John T. Watson</text>
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            <description>An account of the resource</description>
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                <text>We describe an outbreak of severe respiratory illness associated with human coronavirus NL63 in a long-term care facility in Louisiana in November 2017. Six of 20 case-patients were hospitalized with pneumonia, and 3 of 20 died. Clinicians should consider human coronavirus NL63 for patients in similar settings with respiratory disease.</text>
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                <text>2018</text>
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                <text>Outbreak, coronavirus, long-term care facility, Respiratory Infections, Louisiana, USA</text>
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                <text>DOI: 10.3201/eid2410.180862</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="83802">
                <text>Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients</text>
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                <text>Julie Helms, Hamid Merdji, Raphaël Clere-Jehl, Ferhat Meziani, Stéphane Kremer, Malika Schenck, François Severac, Antoine Studer, Mirjana Radosavljevic, Christine Kummerlen, Alexandra Monnier, Clotilde Boulay, Samira Fafi-Kremer, Vincent Castelain, Mickaël Ohana, Mathieu Anheim, Francis Schneider</text>
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                <text>Abstract Background Neurotropism of SARS-CoV-2 and its neurological manifestations have now been confirmed. We aimed at describing delirium and neurological symptoms of COVID-19 in ICU patients. Methods We conducted a bicentric cohort study in two French ICUs of Strasbourg University Hospital. All the 150 patients referred for acute respiratory distress syndrome due to SARS-CoV-2 between March 3 and May 5, 2020, were included at their admission. Ten patients (6.7%) were excluded because they remained under neuromuscular blockers during their entire ICU stay. Neurological examination, including CAM-ICU, and cerebrospinal fluid analysis, electroencephalography, and magnetic resonance imaging (MRI) were performed in some of the patients with delirium and/or abnormal neurological examination. The primary endpoint was to describe the incidence of delirium and/or abnormal neurological examination. The secondary endpoints were to describe the characteristics of delirium, to compare the duration of invasive mechanical ventilation and ICU length of stay in patients with and without delirium and/or abnormal neurological symptoms. Results The 140 patients were aged in median of 62 [IQR 52; 70] years old, with a median SAPSII of 49 [IQR 37; 64] points. Neurological examination was normal in 22 patients (15.7%). One hundred eighteen patients (84.3%) developed a delirium with a combination of acute attention, awareness, and cognition disturbances. Eighty-eight patients (69.3%) presented an unexpected state of agitation despite high infusion rates of sedative treatments and neuroleptics, and 89 (63.6%) patients had corticospinal tract signs. Brain MRI performed in 28 patients demonstrated enhancement of subarachnoid spaces in 17/28 patients (60.7%), intraparenchymal, predominantly white matter abnormalities in 8 patients, and perfusion abnormalities in 17/26 patients (65.4%). The 42 electroencephalograms mostly revealed unspecific abnormalities or diffuse, especially bifrontal, slow activity. Cerebrospinal fluid examination revealed inflammatory disturbances in 18/28 patients, including oligoclonal bands with mirror pattern and elevated IL-6. The CSF RT-PCR SARS-CoV-2 was positive in one patient. The delirium/neurological symptoms in COVID-19 patients were responsible for longer mechanical ventilation compared to the patients without delirium/neurological symptoms. Delirium/neurological symptoms could be secondary to systemic inflammatory reaction to SARS-CoV-2. Conclusions and relevance Delirium/neurological symptoms in COVID-19 patients are a major issue in ICUs, especially in the context of insufficient human and material resources. Trial registration NA.</text>
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                <text>2020</text>
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                <text>ICU, covid-19, Delirium, encephalopathy, MRI</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="83807">
                <text>10.1186/s13054-020-03200-1</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Immunological Subpopulations Within Critically Ill COVID-19 Patients.</text>
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              <elementText elementTextId="74485">
                <text>Julie Kay Wilson, Manu Shankar-Hari</text>
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                <text>2021</text>
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                <text>10.1016/j.chest.2021.01.023</text>
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                <text>Chest</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Pensar la paz… solo cuando tenga la tierra</text>
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                <text>Julie Mena Ortega</text>
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                <text>En este texto se exponen algunos de los hechos históricos más relevantes en el proceso de introducción de la agroindustria del monocultivo de palma de aceite en el municipio de Tumaco, Nariño. Este, desde sus inicios, estuvo relacionado con hechos violentos de desplazamiento forzado, amenazas y persecuciones a campesinos que se negaban a vender sus tierras, lo cual llevó a que, finalmente, estas personas se convirtieran en jornaleros que dejaron de producir sus propios alimentos para comprarlos, hasta que la plaga que secó la palma los dejó en el limbo. Razón por la cual la premisa que motiva este análisis es que no es posible pensar el posconflicto en el marco de las actuales negociaciones de paz entre la guerrilla y el Gobierno nacional en La Habana mientras la tierra de campesinos, afrodescendientes e indígenas siga en prenda en nombre del desarrollo.  Palabra Clave: Palma aceitera, Monocultivo, Agroindustria, Afrodescendientes, Soberanía alimentaria, Desplazamiento forzado, Tierra, Territorio colectivo     THINK PEACE... ONLY WHEN YOU HAVE THE EARTH  In this paper some of the most relevant historical facts are exposed in the process of entering the agribusiness monoculture oil palm in the municipality of Tumaco, Nariño, which since its inception was related to violent acts of forced displacement, threats and persecution of peasants who refused to sell their land, who finally became laborers stopped producing their own food to buy, until the plague that wiped the palm left them in limbo. Why the premise that motivates this analysis is that it is not possible to think about the post-conflict within the framework of the ongoing peace negotiations between the guerrillas and the national government in Havana, while the land of peasants, Afro-descendants and indigenous people continue to be in pledge in the name of development.  Key Words: Palm oil, Monoculture, Agribusiness, African descent, Food sovereignty, Forced displacement, Land, Collective territory</text>
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                <text>Indian fruit bats, flying fox Pteropus medius was identified as an asymptomatic natural host of recently emerged Nipah virus, which is known to induce a severe infectious disease in humans. The absence of P. medius genome sequence presents an important obstacle for further studies of virus–host interactions and better understanding of mechanisms of zoonotic viral emergence. Generation of the high-quality genome sequence is often linked to a considerable effort associated to elevated costs. Although secondary scaffolding methods have reduced sequencing expenses, they imply the development of new tools for the integration of different data sources to achieve more reliable sequencing results. We initially sequenced the P. medius genome using the combination of Illumina paired-end and Nanopore sequencing, with a depth of 57.4x and 6.1x, respectively. Then, we introduced the novel scaff2link software to integrate multiple sources of information for secondary scaffolding, allowing to remove the association with discordant information among two sources. Different quality metrics were next produced to validate the benefits from secondary scaffolding. The P. medius genome, assembled by this method, has a length of 1,985 Mb and consists of 33,613 contigs and 16,113 scaffolds with an NG50 of 19 Mb. At least 22.5% of the assembled sequences is covered by interspersed repeats already described in other species and 19,823 coding genes are annotated. Phylogenetic analysis demonstrated the clustering of P. medius genome with two other Pteropus bat species, P. alecto and P. vampyrus, for which genome sequences are currently available. SARS-CoV entry receptor ACE2 sequence of P. medius was 82.7% identical with ACE2 of Rhinolophus sinicus bats, thought to be the natural host of SARS-CoV. Altogether, our results confirm that a lower depth of sequencing is enough to obtain a valuable genome sequence, using secondary scaffolding approaches and demonstrate the benefits of the scaff2link application. The genome sequence is now available to the scientific community to (i) proceed with further genomic analysis of P. medius, (ii) to characterize the underlying mechanism allowing Nipah virus maintenance and perpetuation in its bat host, and (iii) to monitor their evolutionary pathways toward a better understanding of bats’ ability to control viral infections.</text>
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                <text>bats, Nipah virus, Pteropus medius, Pteropus giganteus, hybrid genome assembly, secondary scaffolding</text>
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                <text>Julien Pottecher, Hervé Bouaziz, Jean-Yves Lefrant, Romain Pirracchio, Dan Benhamou, Bertrand Dureuil, Emmanuel Samain, Olivier Joannes-Boyau</text>
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                <text>Anaesthesia, critical care &amp; pain medicine</text>
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                <text>Bulletin de l'Institut Français d'Études Andines</text>
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                <text>Social sciences (General), Latin America. Spanish America</text>
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                <text>Julien Sarkis, Pierre Sarkis</text>
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            <name>Date</name>
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            <name>Identifier</name>
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                <text>10.1080/2090598X.2020.1788285</text>
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                <text>Arab journal of urology</text>
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