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                <text>Human rhinovirus infection in young African children with acute wheezing</text>
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                <text>Abstract Background Infections caused by human rhinoviruses (HRVs) are important triggers of wheezing in young children. Wheezy illness has increasingly been recognised as an important cause of morbidity in African children, but there is little information on the contribution of HRV to this. The aim of this study was to determine the role of HRV as a cause of acute wheezing in South African children. Methods Two hundred and twenty children presenting consecutively at a tertiary children's hospital with a wheezing illness from May 2004 to November 2005 were prospectively enrolled. A nasal swab was taken and reverse transcription PCR used to screen the samples for HRV. The presence of human metapneumovirus, human bocavirus and human coronavirus-NL63 was assessed in all samples using PCR-based assays. A general shell vial culture using a pool of monoclonal antibodies was used to detect other common respiratory viruses on 26% of samples. Phylogenetic analysis to determine circulating HRV species was performed on a portion of HRV-positive samples. Categorical characteristics were analysed using Fisher's Exact test. Results HRV was detected in 128 (58.2%) of children, most (72%) of whom were under 2 years of age. Presenting symptoms between the HRV-positive and negative groups were similar. Most illness was managed with ambulatory therapy, but 45 (35%) were hospitalized for treatment and 3 (2%) were admitted to intensive care. There were no in-hospital deaths. All 3 species of HRV were detected with HRV-C being the most common (52%) followed by HRV-A (37%) and HRV-B (11%). Infection with other respiratory viruses occurred in 20/128 (16%) of HRV-positive children and in 26/92 (28%) of HRV-negative samples. Conclusion HRV may be the commonest viral infection in young South African children with acute wheezing. Infection is associated with mild or moderate clinical disease.</text>
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                <text>Abstract Background Infections caused by human rhinoviruses (HRVs) are important triggers of wheezing in young children. Wheezy illness has increasingly been recognised as an important cause of morbidity in African children, but there is little information on the contribution of HRV to this. The aim of this study was to determine the role of HRV as a cause of acute wheezing in South African children. Methods Two hundred and twenty children presenting consecutively at a tertiary children's hospital with a wheezing illness from May 2004 to November 2005 were prospectively enrolled. A nasal swab was taken and reverse transcription PCR used to screen the samples for HRV. The presence of human metapneumovirus, human bocavirus and human coronavirus-NL63 was assessed in all samples using PCR-based assays. A general shell vial culture using a pool of monoclonal antibodies was used to detect other common respiratory viruses on 26% of samples. Phylogenetic analysis to determine circulating HRV species was performed on a portion of HRV-positive samples. Categorical characteristics were analysed using Fisher's Exact test. Results HRV was detected in 128 (58.2%) of children, most (72%) of whom were under 2 years of age. Presenting symptoms between the HRV-positive and negative groups were similar. Most illness was managed with ambulatory therapy, but 45 (35%) were hospitalized for treatment and 3 (2%) were admitted to intensive care. There were no in-hospital deaths. All 3 species of HRV were detected with HRV-C being the most common (52%) followed by HRV-A (37%) and HRV-B (11%). Infection with other respiratory viruses occurred in 20/128 (16%) of HRV-positive children and in 26/92 (28%) of HRV-negative samples. Conclusion HRV may be the commonest viral infection in young South African children with acute wheezing. Infection is associated with mild or moderate clinical disease.</text>
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                <text>Zohaib Khurshid, Faris Yahya Ibrahim Asiri, Hamed Al Wadaani</text>
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                <text>The breakthrough of novel coronavirus (2019-nCoV) in Wuhan, a city of China, has damaged the status of health and quality of life. In the sequel of this epidemic or contagious disease, the patient experiences fever, chest paint, chills, a rapid heartbeat, breathing difficulties, pneumonia, and kidney failure. It has been suggested that this disease can spread through human-to-human transmission or by super spreading. By the help of the non-invasive fluid &amp;#8220;saliva&amp;#8221;, it is easy to detect the virus. This can help with the comfort of the patient as well as healthcare personnel. Under this perspective, we discuss the epidemic situation of 2019-nCOV and its relationship with human saliva.</text>
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                <text>Coronavirus disease 2019 (COVID-19) is now a global public health threat with many medical, ethical, economic, and socialimpacts. COVID-19 has spread worldwide, to many Asian and Middle Eastern countries, the United Statesof America, and European countries. The current COVID-19 pandemic that has devastated Indonesia, has infected and killed more healthcare workers, in particular doctors and nurses, than any other outbreak in the history of this virus. People have basic needs that must be met for them to feel safe and secure. A history of the outbreak of the COVID-19 is brifley showed, before exploring the impact the virus had in Indonesia. During this exploration, some of the key issues arising from the experiences in Indonesia, in addressing the threat of COVID-19 will be reviewed. Drawing on the COVID-19 as the case study, we consider the ways in which the concept of human security expands understanding of its relationship to health. Further, weshow how major public health issues can evolve into security threats.The final section of the article will be an analysis of the lessons learned from COVID-19 and policy implications in addressing health and human security threats.</text>
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                <text>Frontiers in Immunology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Human T leukaemia Type 1 and COVID-19</text>
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                <text>Fabiola Martin, Abelardo Araújo</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>In the absence of clinical data on Human T leukaemia Type 1 and COVID-19 infection, we are providing guidance to clinicians who look after people living with HTLV-1.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>n/a</text>
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              <elementText elementTextId="33271">
                <text>DOI: 10.3390/pathogens9060438</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="33272">
                <text>Pathogens</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="33273">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="33274">
                <text>Medicine</text>
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            </elementTextContainer>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Human β-defensin 2 plays a regulatory role in innate antiviral immunity and is capable of potentiating the induction of antigen-specific immunity</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="19201">
                <text>Ju Kim, Yelin Yang, Sun-Hee Jang, Yong-Suk Jang</text>
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            </elementTextContainer>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Abstract Background Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested their modulatory activity in immune induction. Given that most subunit vaccines require an adjuvant to achieve effective immune induction through the activation of innate immunity, AMPs are plausible candidate molecules for stimulating not only innate immune but also adaptive immune responses. Results In this study, we investigated the ability of human β-defensin (HBD) 2 to promote antiviral immunity in vitro and in vivo using a receptor-binding domain (RBD) of Middle East respiratory syndrome-coronavirus (MERS-CoV) spike protein (S RBD) as a model antigen (Ag). When HBD 2-conjugated S RBD was used to treat THP-1 human monocytic cells, the expression levels of antiviral (IFN-β, IFN-γ, MxA, PKR, and RNaseL) and primary immune-inducing (NOD2, TNF-α, IL-1β, and IL-6) molecules were enhanced compared to those expressed after treatment with S RBD only. The expression of chemokines capable of recruiting leukocytes, including monocytes/macrophages, natural killer cells, granulocytes, T cells, and dendritic cells, was also increased following HBD 2-conjugated S RBD treatment. More important, immunization of mice with HBD 2-conjugated S RBD enhanced the immunogenicity of the S RBD and elicited a higher S RBD-specific neutralizing antibody response than S RBD alone. Conclusions We conclude that HBD 2 activates the primary antiviral innate immune response and may also mediate the induction of an effective adaptive immune response against a conjugated Ag.</text>
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            <name>Date</name>
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                <text>2018</text>
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                <text>adjuvant, antigen, Antibody, human β-defensin, MERS-CoV</text>
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            <name>Identifier</name>
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                <text>DOI: 10.1186/s12985-018-1035-2</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="19206">
                <text>Virology Journal</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>BMC</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="19208">
                <text>Infectious and parasitic diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <name>Language</name>
            <description>A language of the resource</description>
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                <text>EN</text>
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            <element elementId="50">
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              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Human-Wildlife Conflicts in the Southern Yungas: What Role do Raptors Play for Local Settlers?</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Amira Salom, María  Eugenia Suárez, Cecilia  Andrea Destefano, Joaquín Cereghetti, Félix  Hernán Vargas, Juan  Manuel Grande</text>
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            <description>An account of the resource</description>
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                <text>Wildlife persecution due to human-wildlife conflict has become a serious concern for biodiversity conservation, especially for many endangered species. In this context, conservation approaches need to consider the socio-ecological dimensions of each particular situation. The aim of this study was to evaluate the existence, extent and social characteristics of Human-Raptor Conflicts (HRC) in the Southern Yungas region in northwestern Argentina. We conducted 115 semi-structured interviews in 21 sites and analyzed attitudes and associations between sociodemographic variables and the existence of HRC. Forty percent of interviewees showed negative attitudes towards raptors, mainly with those species considered livestock predators rather than poultry predators. A total of 11 species were regarded as conflictive because of predation on domestic animals, of which Andean condors showed the highest conflict. The only socio-demographic factor affecting conflicts was livestock and poultry rearing, independently of age, gender and occupation of interviewees. The fact that only 8.7% of interviewees reported taking direct actions towards conflictive species indicates a relatively peaceful coexistence of people with raptors. Nevertheless, negative attitudes towards Andean condor together with their extreme susceptibility to any increase in non-natural mortality indicate the need of an integral conservation approach to tackle future threats for this species’ conservation in the area.</text>
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                <text>2021</text>
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                <text>&lt;i&gt;Vultur gryphus&lt;/i&gt;, Andean Condor, Attitudes, Human-wildlife conflict, human-wildlife interactions, perceptions</text>
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                <text>10.3390/ani11051428</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Animals</text>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Veterinary medicine, Zoology</text>
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            <description>A related resource</description>
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                <text>&lt;a href="https://www.mdpi.com/2076-2615/11/5/1428" target="_blank" rel="noreferrer noopener"&gt;https://www.mdpi.com/2076-2615/11/5/1428&lt;/a&gt;</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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        <name>Dublin Core</name>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Human–Bat Interactions in Rural West Africa</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="28094">
                <text>Sung Sup Park, Yaw Adu-Sarkodie, Michael Owusu, Augustina Annan, Samuel Oppong, Evans Ewald Nkrumah, Ebenezer Kofi Badu, Priscilla Anti, Olivia Agbenyega, Marco Tschapka</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Because some bats host viruses with zoonotic potential, we investigated human–bat interactions in rural Ghana during 2011–2012. Nearly half (46.6%) of respondents regularly visited bat caves; 37.4% had been bitten, scratched, or exposed to bat urine; and 45.6% ate bat meat. Human–bat interactions in rural Ghana are frequent and diverse.</text>
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            <name>Date</name>
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                <text>2015</text>
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            <name>Subject</name>
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                <text>Ebola, bats, severe acute respiratory syndrome, SARS, MERS, virus reservoir</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.3201/eid2108.142015</text>
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            <name>Source</name>
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              <elementText elementTextId="28099">
                <text>Emerging Infectious Diseases</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Centers for Disease Control and Prevention</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="28101">
                <text>Infectious and parasitic diseases, Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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  </item>
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