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Coronaviruses (CoVs) are enveloped, positive sense, single strand RNA viruses that cause respiratory, intestinal and neurological diseases in mammals and birds. Following replication, CoVs assemble on intracellular membranes including the endoplasmic…

Abstract Background The major structural protein of coronaviruses, the membrane (M) protein, can elicit the formation of protective antibodies, but little information is available about the M protein of porcine epidemic diarrhea virus (PEDV).…

The rapid discovery of novel viruses using next generation sequencing (NGS) technologies including DNA-Seq and RNA-Seq, has greatly expanded our understanding of viral diversity in recent years. The timely identification of novel viruses using NGS…

We have recently developed a high-density photolithographic, peptide array technology with a theoretical upper limit of 2 million different peptides per array of 2 cm(2). Here, we have used this to perform complete and exhaustive analyses of linear B…

Emerging infectious diseases (EIDs) are newly identified or known infectious diseases that have either expanded in geographic range or increased in infection prevalence over the previous two decades. During the last three decades, more than 30 EIDs…

Porcine epidemic diarrhea virus (PEDV), a member of Alphacoronavirus, has caused huge economic losses for the global pork industry recently. The spike (S) protein mediates PEDV entry into host cells. Herein, we investigated the interactions between…

Nucleocapsid (N) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a major pathological determinant in the host that may cause host cell apoptosis, upregulate the proinflammatory cytokine production, and block innate…

In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A…

Deforestation is a severe threat to diversity in the Ecuadorian Amazon Region (EAR). To mitigate deforestation, it is necessary to know the relevant stakeholders’ roles and interactions and deepen our knowledge of the local livelihoods, objectives,…

O objetivo do trabalho é identificar determinantes da inadimplência dos tomadores de financiamento do Programa Agroamigo Crescer Pecuária, no período de 2005 a 2017, atribuindo probabilidades a cada fator relacionado. Como metodologia, dentre as…