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                <text>Hydroxychloroquine in a G6PD-Deficient Patient with COVID-19 Complicated by Haemolytic Anaemia: Culprit or Innocent Bystander</text>
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                <text>Sammy Place, François Mastroianni, Vincent Colombie, Géraldine Claes, Axelle Gilles, Frédéric Vandergheynst</text>
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                <text>Hydroxychloroquine has been used worldwide as a first-line treatment for patients hospitalized with COVID-19. Little is known about COVID-19 and its effects on patients with congenital red blood cell disorders. We report a case of haemolytic anaemia in a 32-year-old patient and a fortuitous highlighting of G6PD deficiency. We reviewed the literature to assess the risk of hydroxychloroquine use in this context.</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Boris Revollo, Cristian Tebe, Judith Peñafiel, Ignacio Blanco, Nuria Perez-Alvarez, Ruth Lopez, Laura Rodriguez, Josep Ferrer, Pilar Ricart, Enrique Moret, Cristina Tural, Anna Carreres, Joan Matllo, Sebastià Videla, Bonaventura Clotet, Josep M Llibre</text>
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                <text>10.1093/jac/dkaa477</text>
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                <text>The Journal of antimicrobial chemotherapy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models</text>
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                <text>Kyle Rosenke, Michael A. Jarvis, Friederike Feldmann, Benjamin Schwarz, Atsushi Okumura, Jamie Lovaglio, Greg Saturday, Patrick W. Hanley, Kimberly Meade-White, Brandi N. Williamson, Frederick Hansen, Lizette Perez-Perez, Shanna Leventhal, Tsing-Lee Tang-Huau, Julie Callison, Elaine Haddock, Kaitlin A. Stromberg, Dana Scott, Graham Sewell, Catharine M. Bosio, David Hawman, Emmie de Wit, Heinz Feldmann</text>
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                <text>We remain largely without effective prophylactic/therapeutic interventions for COVID-19. Although many human COVID-19 clinical trials are ongoing, there remains a deficiency of supportive preclinical drug efficacy studies to help guide decisions. Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19 management, in 2 animal disease models. The standard human malaria HCQ prophylaxis (6.5 mg/kg given weekly) and treatment (6.5 mg/kg given daily) did not significantly benefit clinical outcome, nor did it reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory tract in the rhesus macaque disease model. Similarly, when used for prophylaxis or treatment, neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding) in the Syrian hamster disease model. Results from these 2 preclinical animal models may prove helpful in guiding clinical use of HCQ for prophylaxis/treatment of COVID-19.</text>
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                <text>2020</text>
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                <text>covid-19, therapeutics</text>
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                <text>Korean Society of Epidemiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus</text>
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                <text>Alexander KC Leung, Tara McMillan, Andrea Human, Joseph M Lam</text>
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                <text>Hydroxychloroquine (HCQ)-induced hyperpigmentation is uncommon but is increasingly recognized. To our knowledge, HCQ-induced hyperpigmentation has not been reported in the pediatric age group. Herein, we present the case of a 14-year-old girl with systemic lupus erythematosus, who developed hyperpigmentation on her shins and dorsum of the left foot, approximately 3 years after initiating treatment with HCQ. Physicians who treat children with HCQ for reasons such as rheumatologic disorders, dermatologic disorders and, more recently, coronavirus disease-19 should be aware of this less-known side effect of HCQ.</text>
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                <text>2020</text>
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                <text>covid-19, chloroquine, melanin, Rheumatologic disorders, dermatologic disorders</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Drugs in Context</text>
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                <text>BioExcel Publishing Ltd</text>
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                <text>Therapeutics. Pharmacology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Hydroxychloroquine: A Familiar Agent to Combat the Pandemic of COVID-19</text>
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                <text>Vasilios M. Polymeropoulos</text>
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                <text>chloroquine, hydroxychloroquine, SARS, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3389/fmed.2020.00192</text>
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                <text>Frontiers in Medicine</text>
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                <text>Frontiers Media S.A.</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Hydroxycinnamic Acids and Carotenoids of Dried Loquat Fruit cv. ‘Algar’ Affected by Freeze-, Convective-, Vacuum-Microwave- and Combined-Drying Methods</text>
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            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="146352">
                <text>Aneta Wojdyło, Adam Figiel, Krzysztof Lech, David  Bernardo López-Lluch, Marina Cano-Lamadrid, Francisca Hernández, Aleksandra Zimmer, Ángel  Antonio Carbonell-Barrachina</text>
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            <description>An account of the resource</description>
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                <text>The effect of different drying techniques (freeze, convective, vacuum-microwave and combined drying) on the drying kinetics, the phytochemical compounds and sensory characteristics in loquat cultivar ‘Algar’ was studied. The convective drying resulted in the highest amount of total hydroxycinnamic acids (5077 mg/kg wet weight (ww)), with 3-caffeoyl quinic acid and 5-caffeoyl quinic acid being the greatest carotenoids. The highest values of total carotenoids were obtained by the freeze-drying technique (2601 mg/kg ww), followed by all convective treatments and vacuum-microwave at 360 W. The highest carotenoid was β-carotene. The ABTS+• (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (Ferric Ion Reducing Antioxidant Power) values ranged from 2.04 up to 3.27 mmol Trolox/100 g ww, and from 1.89 up to 2.29 mmol Trolox/100 g ww, respectively. As expected, the color difference of freeze-dried samples was the lowest (7.06), similar to combined drying conditions (9.63), whilst the highest value was found after convective drying (37.0). All treatments were sensory acceptable (no off-flavors). However, still, further research is needed to fully optimize these studied drying treatments because the freeze-dried sample still had higher carotenoid content and better instrumental color parameters. Although recently the impact of microwave drying has been studied, this is the first work comparing phytochemical composition of loquat fruit under the different drying methods mentioned above.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="146355">
                <text>&lt;i&gt;Eriobotrya japonica Lindl&lt;/i&gt;, Vacuum microwave, antioxidant capacity, bioactive compounds, convective</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="146356">
                <text>10.3390/molecules25163643</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="146357">
                <text>Molecules</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="146358">
                <text>MDPI AG</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="146359">
                <text>Organic chemistry</text>
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            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="146360">
                <text>&lt;a href="https://www.mdpi.com/1420-3049/25/16/3643" target="_blank" rel="noreferrer noopener"&gt;https://www.mdpi.com/1420-3049/25/16/3643&lt;/a&gt;</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="85260">
                <text>Hyperbaric Oxygen Therapy in Patients with COVID-19</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="85261">
                <text>S. S. Petrikov, A. K. Evseev, O. A. Levina, A. K. Shabanov, V. V. Kulabukhov, N. Yu. Kutrovskaya, N. V. Borovkova, Е. V. Klychnikova, I. V. Goroncharovskaya, E. V. Tazina, K. А. Popugaev, D. A. Kosolapov, D. S. Slobodeniuk</text>
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            <description>An account of the resource</description>
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                <text>The aim of the study is to evaluate the efficacy of hyperbaric oxygen therapy and its effect on oxidative stress and apoptosis in patients with new coronavirus infection COVID-19.Materials and methods. 90 patients diagnosed with new coronavirus infection caused by SARS-CoV-2 virus were examined. Hyperbaric oxygen therapy sessions were conducted in 57 patients (38 in severe condition (CT 3-4), 19 in moderate condition (CT 1-2)). The procedures were performed in 1.4-1.6 ATA mode for 40 minutes, 247 sessions in total were performed. The effect of hyperbaric oxygenation was assessed by measuring the level of oxygen saturation, the severity of oxidative stress and apoptosis of blood lymphocytes.Results. In all examined patients with new coronavirus infection caused by SARS-CoV-2, positive changes such as dyspnea reduction and improvement of general well-being were registered after hyperbaric oxygen therapy sessions. The level of oxygen saturation after the end of the hyperbaric oxygen therapy course was 95.0±1.6% (before the course — 91.3±5.9%), which allowed to return almost all patients to spontaneous respiration without the need for further oxygenation therapy. Hyperbaric oxygen therapy did not reduce the total antioxidant activity, however, it was associated with a decrease in the blood malone dialdehyde from 4.34±0.52 pmol/l to 3.98±0.48 pmol/l and a decrease in open circuit potential of platinum electrode from -22.78±24.58 mV to -37.69±17.4 mV. Besides, the positive effect of hyperbaric oxygen therapy was manifested in normalization of blood cell apoptosis.Conclusion. Hyperbaric oxygen therapy in patients with new coronavirus infection caused by the SARS-CoV-2 virus is an effective treatment method with multiple effects resulting in improvement of subjective indicators of the patients' condition, increase of hemoglobin oxygen saturation, decrease of lipid peroxidation intensity, activation of antioxidant system, restoration of pro- and antioxidant balance and apoptosis normalization.</text>
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                <text>2021</text>
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                <text>covid-19, apoptosis, Oxidative stress, Respiratory Support, hyperbaric oxygen therapy</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.15360/1813-9779-2020-6-4-18</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="85266">
                <text>Obŝaâ Reanimatologiâ</text>
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            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="85267">
                <text>Russian Academy of Medical Sciences</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="85268">
                <text>Medical emergencies. Critical care. Intensive care. First aid</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Hypercytokinemia and Pathogen&amp;ndash;Host Interaction in COVID-19</text>
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              <elementText elementTextId="38173">
                <text>Badawi A</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="38174">
                <text>Alaa Badawi1,2 1Public Health Risk Sciences Division, Public Health Agency of Canada, Toronto, ON, Canada; 2Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCorrespondence: Alaa BadawiPublic Health Risk Sciences Division, Public Health Agency of Canada, 180 Queen Street West, Toronto, ON M5V 3L7, CanadaEmail alaa.badawi@canada.caAbstract: Severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) is a novel coronavirus identified as the cause of coronavirus disease-2019 (COVID-19) that began in Wuhan, China in late 2019 and spread now in 210 countries and territories around the world. Many people are asymptomatic or with mild symptoms. However, in some cases (usually the elderly and those with comorbidities) the disease may progress to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction that can lead to death. Such wide interindividual differences in response to SARS-CoV-2 infection may relate to several pathogen- and host-related factors. These include the different levels of the ubiquitously present human angiotensin I converting enzyme 2 (ACE2) receptors gene expression and its variant alleles, the different binding affinities of ACE2 to the virus spike (S) protein given its L- and S-subtypes and the subsequent extent of innate immunity-related hypercytokinemia. The extensive synthesis of cytokines and chemokines in coronavirus diseases was suggested as a major factor in exacerbating lung damage and other fatal complications. The polymorphisms in genes coding for pro-inflammatory cytokines and chemokines have been associated with mediating the response and susceptibility to a wide range of infections and their severe outcomes. Understanding the nature of pathogen&amp;ndash;host interaction in COVID-19 symptomatology together with the role of hypercytokinemia in disease severity may permit developing new avenues of approach for prevention and treatment and can delineate public health measures to control the spread of the disease.Keywords: SARS-CoV, MERS-CoV, SARS-CoV-2, COVID-19, hypercytokinemia</text>
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                <text>Pandemic, MERS-CoV, SARS-CoV, SARS-CoV-2, COVID-19</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Journal of Inflammation Research</text>
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              <elementText elementTextId="38179">
                <text>Dove Medical Press</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Pathology</text>
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                <text>Hypercytokinemia and Pathogen&amp;ndash;Host Interaction in COVID-19</text>
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              <elementText elementTextId="62156">
                <text>Badawi A</text>
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            <description>An account of the resource</description>
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                <text>Alaa Badawi1,2 1Public Health Risk Sciences Division, Public Health Agency of Canada, Toronto, ON, Canada; 2Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaCorrespondence: Alaa BadawiPublic Health Risk Sciences Division, Public Health Agency of Canada, 180 Queen Street West, Toronto, ON M5V 3L7, CanadaEmail alaa.badawi@canada.caAbstract: Severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) is a novel coronavirus identified as the cause of coronavirus disease-2019 (COVID-19) that began in Wuhan, China in late 2019 and spread now in 210 countries and territories around the world. Many people are asymptomatic or with mild symptoms. However, in some cases (usually the elderly and those with comorbidities) the disease may progress to pneumonia, acute respiratory distress syndrome and multi-organ dysfunction that can lead to death. Such wide interindividual differences in response to SARS-CoV-2 infection may relate to several pathogen- and host-related factors. These include the different levels of the ubiquitously present human angiotensin I converting enzyme 2 (ACE2) receptors gene expression and its variant alleles, the different binding affinities of ACE2 to the virus spike (S) protein given its L- and S-subtypes and the subsequent extent of innate immunity-related hypercytokinemia. The extensive synthesis of cytokines and chemokines in coronavirus diseases was suggested as a major factor in exacerbating lung damage and other fatal complications. The polymorphisms in genes coding for pro-inflammatory cytokines and chemokines have been associated with mediating the response and susceptibility to a wide range of infections and their severe outcomes. Understanding the nature of pathogen&amp;ndash;host interaction in COVID-19 symptomatology together with the role of hypercytokinemia in disease severity may permit developing new avenues of approach for prevention and treatment and can delineate public health measures to control the spread of the disease.Keywords: SARS-CoV, MERS-CoV, SARS-CoV-2, COVID-19, hypercytokinemia</text>
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                <text>Biotemas</text>
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              <elementText elementTextId="62161">
                <text>Universidade Federal de Santa Catarina</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="64600">
                <text>Hyperinflammation and Fibrosis in Severe COVID-19 Patients: Galectin-3, a Target Molecule to Consider</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="64601">
                <text>Juan Garcia-Revilla, Tomas Deierborg, Jose Luis Venero, Antonio Boza-Serrano, Antonio Boza-Serrano</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="64602">
                <text>COVID-19 disease have become so far the most important sanitary crisis in the XXI century. In light of the events, any clinical resource should be considered to alleviate this crisis. Severe COVID-19 cases present a so-called cytokine storm as the most life-threatening symptom accompanied by lung fibrosis. Galectin-3 has been widely described as regulator of both processes. Hereby, we present compelling evidences on the potential role of galectin-3 in COVID-19 in the regulation of the inflammatory response, fibrosis and infection progression. Moreover, we provide a strong rationale of the utility of measuring plasma galectin-3 as a prognosis biomarker for COVID-19 patients and propose that inhibition of galectin-3 represents a feasible and promising new therapeutical approach.</text>
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            <name>Date</name>
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              <elementText elementTextId="64603">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="64604">
                <text>covid-19, biomarker, cytokine storm, fibrosis, galectin-3</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
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              <elementText elementTextId="64605">
                <text>10.3389/fimmu.2020.02069</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="64606">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="64607">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="64608">
                <text>Immunologic diseases. Allergy</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
