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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Hyponatremia in Infectious Diseases—A Literature Review</text>
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                <text>Anna L. Królicka, Adrianna Kruczkowska, Magdalena Krajewska, Mariusz A. Kusztal</text>
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                <text>Hyponatremia is one of the most common water–electrolyte imbalances in the human organism. A serum sodium concentration threshold of less than 135 mmol/L is diagnostic for hyponatremia. The disorder is usually secondary to various diseases, including infections. Our review aims to summarize the diagnostic value and impact of hyponatremia on the prognosis, length of the hospitalization, and mortality among patients with active infection. The scientific literature regarding hyponatremia was reviewed using PubMed, ClinicalKey, and Web of Science databases. Studies published between 2011 and 2020 were screened and eligible studies were selected according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement and specific inclusion criteria. The most common infections that were associated with hyponatremia were viral and bacterial infections, including COVID-19 (coronavirus disease 2019). The etiology varied according to the infection site, setting and patient cohort it concerned. In several studies, hyponatremia was associated with prolonged hospitalization, worse outcomes, and higher mortality rates. Hyponatremia can also play a diagnostic role in differentiating pathogens that cause a certain infection type, as it was observed in community-acquired pneumonia. Although many mechanisms leading to hyponatremia have already been described, it is impossible with any certainty to ascribe the etiology of hyponatremia to any of them.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>infectious diseases, infections, hyponatremia, Syndrome of inappropriate antidiuretic hormone secretion</text>
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            <name>Identifier</name>
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                <text>10.3390/ijerph17155320</text>
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                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19.</text>
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                <text>Xiyuan Bai, Joseph Hippensteel, Alida Leavitt, James P Maloney, David Beckham, Cindy Garcia, Qing Li, Brian M Freed, Diane Ordway, Robert A Sandhaus, Edward D Chan</text>
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                <text>No definitive treatment for COVID-19 exists although promising results have been reported with remdesivir and glucocorticoids. Short of a truly effective preventive or curative vaccine against SARS-CoV-2, it is becoming increasingly clear that multiple pathophysiologic processes seen with COVID-19 as well as SARS-CoV-2 itself should be targeted. Because alpha-1-antitrypsin (AAT) embraces a panoply of biologic activities that may antagonize several pathophysiologic mechanisms induced by SARS-CoV-2, we hypothesize that this naturally occurring molecule is a promising agent to ameliorate COVID-19. We posit at least seven different mechanisms by which AAT may alleviate COVID-19. First, AAT is a serine protease inhibitor (SERPIN) shown to inhibit TMPRSS-2, the host serine protease that cleaves the spike protein of SARS-CoV-2, a necessary preparatory step for the virus to bind its cell surface receptor ACE2 to gain intracellular entry. Second, AAT has anti-viral activity against other RNA viruses HIV and influenza as well as induces autophagy, a known host effector mechanism against MERS-CoV, a related coronavirus that causes the Middle East Respiratory Syndrome. Third, AAT has potent anti-inflammatory properties, in part through inhibiting both nuclear factor-kappa B (NFκB) activation and ADAM17 (also known as tumor necrosis factor-alpha converting enzyme), and thus may dampen the hyper-inflammatory response of COVID-19. Fourth, AAT inhibits neutrophil elastase, a serine protease that helps recruit potentially injurious neutrophils and implicated in acute lung injury. AAT inhibition of ADAM17 also prevents shedding of ACE2 and hence may preserve ACE2 inhibition of bradykinin, reducing the ability of bradykinin to cause a capillary leak in COVID-19. Fifth, AAT inhibits thrombin, and venous thromboembolism and in situ microthrombi and macrothrombi are increasingly implicated in COVID-19. Sixth, AAT inhibition of elastase can antagonize the formation of neutrophil extracellular traps (NETs), a complex extracellular structure comprised of neutrophil-derived DNA, histones, and proteases, and implicated in the immunothrombosis of COVID-19; indeed, AAT has been shown to change the shape and adherence of non-COVID-19-related NETs. Seventh, AAT inhibition of endothelial cell apoptosis may limit the endothelial injury linked to severe COVID-19-associated acute lung injury, multi-organ dysfunction, and pre-eclampsia-like syndrome seen in gravid women. Furthermore, because both NETs formation and the presence of anti-phospholipid antibodies are increased in both COVID-19 and non-COVID pre-eclampsia, it suggests a similar vascular pathogenesis in both disorders. As a final point, AAT has an excellent safety profile when administered to patients with AAT deficiency and is dosed intravenously once weekly but also comes in an inhaled preparation. Thus, AAT is an appealing drug candidate to treat COVID-19 and should be studied.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2021</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>SARS-CoV-2, Nets, serine protease, anti-inflammation, serpin, Anti-thrombosis</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="71028">
                <text>10.1016/j.mehy.2020.110394</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Medical hypotheses</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="18942">
                <text>Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="18943">
                <text>Donald J. Noble, Shawn Hochman</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text>Control of respiration provides a powerful voluntary portal to entrain and modulate central autonomic networks. Slowing and deepening breathing as a relaxation technique has shown promise in a variety of cardiorespiratory and stress-related disorders, but few studies have investigated the physiological mechanisms conferring its benefits. Recent evidence suggests that breathing at a frequency near 0.1 Hz (6 breaths per minute) promotes behavioral relaxation and baroreflex resonance effects that maximize heart rate variability. Breathing around this frequency appears to elicit resonant and coherent features in neuro-mechanical interactions that optimize physiological function. Here we explore the neurophysiology of slow, deep breathing and propose that coincident features of respiratory and baroreceptor afferent activity cycling at 0.1 Hz entrain central autonomic networks. An important role is assigned to the preferential recruitment of slowly-adapting pulmonary afferents (SARs) during prolonged inhalations. These afferents project to discrete areas in the brainstem within the nucleus of the solitary tract (NTS) and initiate inhibitory actions on downstream targets. Conversely, deep exhalations terminate SAR activity and activate arterial baroreceptors via increases in blood pressure to stimulate, through NTS projections, parasympathetic outflow to the heart. Reciprocal SAR and baroreceptor afferent-evoked actions combine to enhance sympathetic activity during inhalation and parasympathetic activity during exhalation, respectively. This leads to pronounced heart rate variability in phase with the respiratory cycle (respiratory sinus arrhythmia) and improved ventilation-perfusion matching. NTS relay neurons project extensively to areas of the central autonomic network to encode important features of the breathing pattern that may modulate anxiety, arousal, and attention. In our model, pronounced respiratory rhythms during slow, deep breathing also support expression of slow cortical rhythms to induce a functional state of alert relaxation, and, via nasal respiration-based actions on olfactory signaling, recruit hippocampal pathways to boost memory consolidation. Collectively, we assert that the neurophysiological processes recruited during slow, deep breathing enhance the cognitive and behavioral therapeutic outcomes obtained through various mind-body practices. Future studies are required to better understand the physio-behavioral processes involved, including in animal models that control for confounding factors such as expectancy biases.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="18945">
                <text>2019</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="18946">
                <text>slow, Deep breathing, relaxation, Neurophysiological mechanisms, slowly-adapting pulmonary afferents, slow brain rhythms</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="18947">
                <text>DOI: 10.3389/fphys.2019.01176</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="18948">
                <text>Frontiers in Physiology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="18949">
                <text>Frontiers Media S.A.</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Physiology</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <description>A name given to the resource</description>
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              <elementText elementTextId="53313">
                <text>Hypothesis: What is the Best We Can Do with Hydroxychloroquine for COVID-19?</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="53314">
                <text>Wang S, Mulier S, Jonscher C, Ye S, Chen L, Feng Y, Li Y, Ni Y</text>
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            <description>An account of the resource</description>
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                <text>Shuncong Wang,1,* Stefaan Mulier,1,2,* Charles Jonscher,3 Sheng Ye,4 Lei Chen,1 Yuanbo Feng,1 Yue Li,5 Yicheng Ni1 1Campus Gasthuisberg, Group of Biomedical Sciences, KU, Leuven, Belgium; 2Department of Surgery, Delta Hospital, Brussels, Belgium; 3Institute for Health Metrics &amp;amp; Evaluation, University of Washington, Seattle, WA, USA; 4Primary Care NJ, Englewood, NJ, USA; 5Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, People&amp;rsquo;s Republic of China*These authors contributed equally to this workCorrespondence: Yicheng NiDepartment of Radiology, University Hospital, Herestraat 49, Leuven B3000, BelgiumTel +32-16-32 27 52Fax + 32-16-34 37 65Email yicheng.ni@kuleuven.beAbstract: There are widespread anecdotal reports of seemingly successful treatment among the early (three to seven days from symptoms) stage coronavirus disease 2019 (COVID-19) patients with the drug hydroxychloroquine (HCQ), and randomized placebo-controlled trials of HCQ in outpatient settings are underway. In this note, we (1) report observational evidence and present scientific reasoning as to why early treatment with HCQ may succeed while treatment later in the disease progression is likely to fail and (2) hypothesize a public health regime under which HCQ may be used to mitigate the impact of the current pandemic.Keywords: COVID-19, pandemic, early treatment, hydroxychloroquine, lockdown</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>covid-19, Pandemic, Hydroxychloroquine, lockdown, Early treatment</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Universidade Federal de Santa Catarina</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Infectious and parasitic diseases</text>
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                <text>Anthony Uchenna Emeribe, Abdurrahman Elfulaty Ahmad, Idris Nasir Abdullahi</text>
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                <text>To the Editor, The world is currently battling with and trying to survive yet another pandemic that threatens human health security. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease 19 (COVID-19) is one of the three most virulent coronaviruses (CoVs). Based on available clinical details, geriatric group of over 65 years of age and persons with chronic comorbidities such as type-2 diabetes mellitus, chronic obstructive pulmonary disease, cardiovascular diseases and immunodeficiencies tend to rapidly develop multi-organ failure, severe COVID-19 and ultimately, death...</text>
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                <text>immunopathology, HIV co-infection, SARS-CoV-2, COVID-19</text>
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                <text>Italian Journal of Medicine</text>
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                <text>Osama Abou-Arab, Guillaume Haye, Christophe Beyls, Pierre Huette, Pierre-Alexandre Roger, Mathieu Guilbart, Michaël Bernasinski, Patricia Besserve, Faouzi Trojette, Hervé Dupont, Vincent Jounieaux, Yazine Mahjoub</text>
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                <text>2021</text>
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                <text>10.1007/s12630-020-01844-9</text>
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                <text>Canadian journal of anaesthesia = Journal canadien d'anesthesie</text>
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                  <text>Agricultura sostenible</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>I - Florística e fitossociologia de campo natural sobre banco de carvão e áreas mineradas, Rio Grande do Sul, Brasil Floristics and phytosociology of a natural grassland on a coal bank and mining areas, Rio Grande do Sul, Brazil</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Jairo José Zocche, Maria Luiza Porto</text>
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            <description>An account of the resource</description>
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                <text>Realizaram-se na Mina Recreio, município de Butiá, RS, estudos florísticos e fitossociológicos em uma área de campo natural sobre banco de carvão e em áreas mineradas a céu aberto e revegetadas naturalmente. Na área de campo natural detectaram-se duas unidades de vegetação principais, denominadas de unidades diferenciais A (AXONOPUS - ANDROPOGON) e B (AXONOPUS - PIPTOCHAETIUM), ambas com suas respectivas subunidades de espécies possivelmente associadas. A variação espacial gradual verificada na área de campo natural configura-se principalmente pelo conjunto de condições associadas à declividade e profundidade do lençol freático. Nas áreas mineradas II e III verificou-se que as unidades de vegetação não se tinham delineado muito claramente e apresentavam características de vegetação pioneira. Na área II evidenciou-se uma possível unidade de vegetação PIPTOCHAETIUM AXONOPUSPURPUSII e na área III, PIPTOCHAETIUM - CYNODON. Verificou-se maior similaridade florística entre a área de campo natural e a área II, do que entre a III e o campo natural. As espécies presentes nas áreas mineradas apresentam certo grau de pioneirismo e tolerância em relação ao conjunto de condições extremas que enfrentam, devendo, portanto, ser as primeiras a ser testadas em trabalhos de recomposição de áreas mineradas.Studies were conducted at Mina Recreio, Butiá, RS, on floristic and phytosociological aspects in a natural grassland area laying on a coal bank and in surface coal mining areas which had beem naturally reclaimed. Two main vegetation units denominated differential units a (AXONOPUS - ANDROPOGON) and B (AXONOPUS - PIPTOCHAETIUM), both of them with their respective sub-units of possibly associated species, were detected in the natural grassland area. The gradual spatial variation, detected in the natural grassland area, is mainly characterized by the set of conditions associated with land declivity and water table depth. In both surface coal mining areas II and III the vegetation units were not clearly defined, but were characterized as primary areas. The vegetation unit PIPTOCHAETIUM - AXONOPUS PURPUSII was detected in area II and a vegetation unit PIPTOCHAETIUM - CYNODON in area III. A greater floristic similarity was verified between area II and natural grassland than between area III and natural grassland. The species detected in mining areas present certain degree of pioneerism and tolerance in relation to the set of extreme conditions which they faced, and should, therefore, be the first to be tested on mining area recomposition.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>1992</text>
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            </elementTextContainer>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="218196">
                <text>Ecología vegetal, Mineração, mining, plant ecology, revegetation, revegetação, secondary succession, sucessão secundária</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="218197">
                <text>10.1590/S0102-33061992000200004</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="218198">
                <text>Acta Botânica Brasílica</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="218199">
                <text>Sociedade Botânica do Brasil</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Botany</text>
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            <name>Relation</name>
            <description>A related resource</description>
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                <text>&lt;a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;amp;pid=S0102-33061992000200004" target="_blank" rel="noreferrer noopener"&gt;http://www.scielo.br/scielo.php?script=sci_arttext&amp;amp;pid=S0102-33061992000200004&lt;/a&gt;</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>I “Protocolli per la ripresa delle celebrazioni delle confessioni diverse dalla cattolica”: una nuova stagione nella politica ecclesiastica italiana</text>
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                <text>Maria Luisa Lo Giacco</text>
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                <text>SOMMARIO: 1. Premessa - 2. La cronaca: come sono nati i protocolli - 3. Un metodo laico.  The Protocols for the resumption of religious ceremonies": the first signal of a new season in the Italian ecclesiastical politics  ABSTRACT: In Italy the religions have signed with the Government some protocols for the resumption of religious ceremonies after the lockdown for the Covid-19 emergency. Those protocols are an important step in the way of an effective protection of religious freedom in a pluralistic society. The protocols inaugurate a new season in the relationships between the religions and the state in Italy."</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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                <text>DOI: </text>
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              <elementText elementTextId="37664">
                <text>Stato, Chiese e Pluralismo Confessionale</text>
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            <name>Publisher</name>
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              <elementText elementTextId="37665">
                <text>Università degli Studi di Milano</text>
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                <text>Law</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>I Congreso Internacional de Conservación para la Industria Agroalimentaria CINCIA 2016 – Parte 1</text>
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                <text>Cincia 2016 - Parte 1</text>
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                <text>INVESTIGACIÓN CON UN PROPÓSITO La agroindustria en Colombia nació a raíz de la necesidad de generar valor agregado a la producción agropecuaria, sin embargo solo aquellos sectores productivos que consolidaron agremiaciones fuertes y bien organizadas tales como en los sectores cafetero, lácteo, cárnico, cerealista y azucarero, lograron dar el paso de la producción primaria a la industrialización y comercialización, con márgenes de rentabilidad aceptables, que contribuyeron a fortalecer la agroindustria del país.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2016</text>
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                <text>Vitae</text>
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                <text>Universidad de Antioquia</text>
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