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                  <text>Dominio científico: Coronavirus</text>
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                <text>2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies</text>
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                <text>Jun She, Jinjun Jiang, Ling Ye, Lijuan Hu, Chunxue BAI, Yuanlin Song</text>
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                <text>Abstract An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, person-to-person transmission in family homes or hospitals, and intercity spread of 2019-nCoV occurred. At least 40,261 cases confirmed, 23,589 cases suspected, 909 cases death and 3444 cases cured in China and worldwide 24 countries confirmed 383 cases being diagnosed, 1 case death in February 10th, 2020. At present, the mortality of 2019-nCoV in China is 2.3%, compared with 9.6% of SARS and 34.4% of MERS reported by WHO. It seems the new virus is not as fatal as many people thought. Chinese authorities improved surveillance network, made the laboratory be able to recognize the outbreak within a few weeks and announced the virus genome that provide efficient epidemiological control. More comprehensive information is required to understand 2019-nCoV feature, the epidemiology of origin and spreading, and the clinical phenomina. According to the current status, blocking transmission, isolation, protection, and alternative medication are the urgent management strategies against 2019-nCoV.</text>
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                <text>2020</text>
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                <text>2019ncov, Transmission, isolation, Respiratory and eye protection, Hand Hygiene</text>
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                <text>DOI: 10.1186/s40169-020-00271-z</text>
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                <text>Clinical and Translational Medicine</text>
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                <text>Internal medicine</text>
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                <text>Public health lessons from crisis-related travel: The COVID-19 pandemic.</text>
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                <text>Jun Wen, Zhaohui Su</text>
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                <text>10.1016/j.jiph.2020.12.003</text>
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                <text>Journal of infection and public health</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Forecast Possible Risk for COVID-19 Epidemic Dissemination Under Current Control Strategies in Japan</text>
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                <text>Jun Yang, Binxiang Dai, Zhongxiang Chen</text>
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                <text>COVID-19 has globally spread to over 4 million people and the epidemic situation in Japan is very serious. The purpose of this research was to assess the risk of COVID-19 epidemic dissemination in Japan by estimating the current state of epidemic dissemination and providing some epidemic prevention and control recommendations. Firstly, the period from 6 January to 31 March 2020 was divided into four stages and the relevant parameters were estimated according to the imported cases in Japan. The basic reproduction number of the current stage is 1.954 (95% confidence interval (CI) 1.851–2.025), which means COVID-19 will spread quickly, and the self-healing rate of Japanese is about 0.495 (95% CI 0.437–0.506), with small variations in the four stages. Secondly, the results were applied to the actual reported cases from 1 to 5 April 2020, verifying the reliability of the estimated data using the accumulated reported cases located within the 95% confidence interval and the relative error of forecast data of five days being less than     2 . 5 %    . Thirdly, considering the medical resources in Japan, the times the epidemic beds and ventilators become fully occupied are predicted as 5 and 15 May 2020, respectively. Keeping with the current situation, the final death toll in Japan may reach into the millions. Finally, based on experience with COVID-19 prevention and control in China, robust measures such as nationwide shutdown, store closures, citizens isolating themselves at home, and increasing PCR testing would quickly and effectively prevent COVID-19 spread.</text>
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                <text>Basic reproduction number, COVID-19, SEIHR epidemic model</text>
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                <text>DOI: 10.3390/ijerph17113872</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Advice on Standardized Diagnosis and Treatment for Spinal Diseases during the Coronavirus Disease 2019 Pandemic</text>
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              <elementText elementTextId="2275">
                <text>Jun Zou, Hao YU, Dawei Song, Junjie Niu, Huilin Yang</text>
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            <description>An account of the resource</description>
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                <text>Coronavirus disease 2019 (COVID-19) outbreak started in December 2019 that caused difficulties for clinical work. Practical work experience in our spinal outpatient and emergency department during the COVID-19 pandemic is summarized in this article, with combined evidence-based medical evidence to explore a standardized process of diagnosis and treatment for spinal diseases. Outpatient reservation, continuous screening, triage, and isolation, first consultation accountability system, pandemic reporting system, and online revisit were strictly followed. We hope that our experience in prevention and control of COVID-19 can help spine surgeons globally in stopping the spread of COVID-19. Spine surgeons should collaborate with infection control specialists to avoid cross-infection in hospitals and optimize treatment.</text>
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                <text>COVID-19, infection control, Spinal Diseases, disease management</text>
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                <text>DOI: 10.31616/asj.2020.0122</text>
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                <text>Asian Spine Journal</text>
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                <text>Korean Spine Society</text>
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                <text>EN</text>
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              <name>Title</name>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>The prediction for development of COVID-19 in global major epidemic areas through empirical trends in China by utilizing state transition matrix model</text>
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                <text>Jun-Hua Zheng, Zhong Zheng, Ke Wu, Zhixian Yao, Xinyi Zheng, Jian Chen</text>
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                <text>Abstract Background Since pneumonia caused by coronavirus disease 2019 (COVID-19) broke out in Wuhan, Hubei province, China, tremendous infected cases has risen all over the world attributed to its high transmissibility. We aimed to mathematically forecast the inflection point (IFP) of new cases in South Korea, Italy, and Iran, utilizing the transcendental model from China. Methods Data from reports released by the National Health Commission of the People’s Republic of China (Dec 31, 2019 to Mar 5, 2020) and the World Health Organization (Jan 20, 2020 to Mar 5, 2020) were extracted as the training set and the data from Mar 6 to 9 as the validation set. New close contacts, newly confirmed cases, cumulative confirmed cases, non-severe cases, severe cases, critical cases, cured cases, and death were collected and analyzed. We analyzed the data above through the State Transition Matrix model. Results The optimistic scenario (non-Hubei model, daily increment rate of − 3.87%), the cautiously optimistic scenario (Hubei model, daily increment rate of − 2.20%), and the relatively pessimistic scenario (adjustment, daily increment rate of − 1.50%) were inferred and modeling from data in China. The IFP of time in South Korea would be Mar 6 to 12, Italy Mar 10 to 24, and Iran Mar 10 to 24. The numbers of cumulative confirmed patients will reach approximately 20 k in South Korea, 209 k in Italy, and 226 k in Iran under fitting scenarios, respectively. However, with the adoption of different diagnosis criteria, the variation of new cases could impose various influences in the predictive model. If that happens, the IFP of increment will be earlier than predicted above. Conclusion The end of the pandemic is still inapproachable, and the number of confirmed cases is still escalating. With the augment of data, the world epidemic trend could be further predicted, and it is imperative to consummate the assignment of global medical resources to curb the development of COVID-19.</text>
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            <name>Date</name>
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                <text>2020</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="65158">
                <text>novel coronavirus pneumonia, Coronavirus disease 2019, prediction, inflection point, The state transition matrix model</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="65159">
                <text>10.1186/s12879-020-05417-5</text>
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              <elementText elementTextId="65160">
                <text>Epidemiology and Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="65161">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="65162">
                <text>Infectious and parasitic diseases</text>
              </elementText>
            </elementTextContainer>
          </element>
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  <item itemId="2296" public="1" featured="0">
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="22068">
                <text>Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) in adults-a case report and literature review</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="22069">
                <text>Jun-liang Yuan, Shuna Yang, Shuang-kun Wang, Wei Qin, Lei YANG, Wen-li Hu</text>
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          <element elementId="41">
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            <description>An account of the resource</description>
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                <text>Abstract Background Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinico-radiological entity characterized by the magnetic resonance imaging (MRI) finding of a reversible lesion in the corpus callosum, sometimes involved the symmetrical white matters. Many cases of child-onset MERS with various causes have been reported. However, adult-onset MERS is relatively rare. The clinical characteristics and pathophysiologiccal mechanisms of adult-onset MERS are not well understood. We reviewed the literature on adult-onset MERS in order to describe the characteristics of MERS in adults and to provide experiences for clinician. Methods We reported a case of adult-onset MERS with acute urinary retension and performed literature search from PubMed and web of science databases to identify other adult-onset MERS reports from Januarary 2004 to March 2016. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed on selection process. And then we summarized the clinico-radiological features of adult-onset MERS. Results Twenty-nine adult-onset MERS cases were reviewed from available literature including the case we have. 86.2% of the cases (25/29) were reported in Asia, especially in Japan. Ages varied between 18 and 59 years old with a 12:17 female-to-male ratio. The major cause was infection by virus or bacteria. Fever and headache were the most common clinical manifestation, and acute urinary retention was observed in 6 patients. All patients recovered completely within a month. Conclusion Adult-onset MERS is an entity with a broad clinico-radiological spectrum because of the various diseases and conditions. There are similar characteristics between MERS in adults and children, also some differences.</text>
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              <elementText elementTextId="22071">
                <text>2017</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="22072">
                <text>Mild encephalitis/encephalopathy with reversible splenial lesion, Adult-onset MERS, encephalitis, encephalopathy, Corpus Callosum, Reversible plenial lesion</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="22073">
                <text>DOI: 10.1186/s12883-017-0875-5</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="22074">
                <text>BMC Neurology</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="22075">
                <text>BMC</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="22076">
                <text>Neurology. Diseases of the nervous system</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
          </elementContainer>
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      </elementSetContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
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              <elementText elementTextId="72295">
                <text>Corrigendum to Transmission onset distribution of COVID-19" [Int. J. Infect. Dis. 99(October) (2020) 403-407]."</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="72296">
                <text>June Young Chun, Gyuseung Baek, Yongdai Kim</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="72297">
                <text>2021</text>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="72298">
                <text>10.1016/j.ijid.2020.11.186</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="72299">
                <text>International Journal of Infectious Diseases</text>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="72300">
                <text>Elsevier</text>
              </elementText>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="184477">
                <text>Impactos del cambio climático frente al cambio del uso del suelo en el reciente régimen de inundaciones del río Lijiang, Sur de China</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="184478">
                <text>Junfeng Dai, Saeed Rad, Jingxuan Xu, Sytharith Pen, Lei Gan, Xiaobing Chen, ChenWenjiong Yu, Shuaipu Zhang</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="184479">
                <text>El cambio climático causado por el hombre, sincronizado con el rápido desarrollo en el sur de China, ha inducido varios desafíos ambientales críticos en dicha región. Este trabajo compara los impulsores de los cambios del flujo hidrológico y la recurrencia de inundaciones en la cuenca del río Lijiang. Se llevaron a cabo análisis estadísticos de los cambios climáticos y de uso/cobertura de la tierra (LULCC) utilizando imágenes satelitales, los modelos SWAT y HEC-HMS, pruebas de tendencia de Mann-Kendall y Minitab. Los mapas de uso del suelo se utilizaron para observar la conversión del suelo de la cuenca hidrográfica durante el desarrollo previo/posterior a través de GIS. Aunque se detectó un aumento de hasta el 76 % en las áreas urbanizadas, sólo el 0.6 % de LULCC se notó en toda la cuenca y había causado un cambio de 0.1 % en el número de curva (CN) en toda la cuenca. Los resultados del modelo HEC-HMS revelaron cambios insignificantes de hidrogramas con y sin LULCC. Los datos hidrometeorológicos diarios se analizaron cuantitativamente durante 1967-2016, para determinar el régimen de fluctuaciones y el reconocimiento de patrones. Se encontró un patrón de lluvia más desigual en las últimas décadas vinculado con una escorrentía excesiva. La temperatura media y la humedad relativa han aumentado continuamente en 0.96 °C y disminuido en un 3 %, respectivamente, durante los últimos 50 años. Nuestro estudio sugiere que la causa principal de las recientes tendencias al alza del volumen de escorrentía se atribuye a los cambios en el patrón de precipitación como respuesta al calentamiento global en lugar de LULCC. El resultado está respaldado por un aumento en la frecuencia del evento de lluvia de intensidad extrema. Los resultados respaldaron la necesidad de un desarrollo sostenible para adaptarse a la nueva situación.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="184480">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="184481">
                <text>Cambio climático, HEC-HMS, Mann-Kendall, Minitab, SWAT, cambiodeusodelatierra, cuenca del río lijiang</text>
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            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="184482">
                <text>10.24850/j-tyca-2021-03-07</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="184483">
                <text>Tecnología y ciencias del agua</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="184484">
                <text>Instituto Mexicano de Tecnología del Agua</text>
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            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="184485">
                <text>Hydraulic engineering, Water supply for domestic and industrial purposes</text>
              </elementText>
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          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="184486">
                <text>&lt;a href="http://revistatyca.org.mx/index.php/tyca/article/view/2465" target="_blank" rel="noreferrer noopener"&gt;http://revistatyca.org.mx/index.php/tyca/article/view/2465&lt;/a&gt;</text>
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  <item itemId="6404" public="1" featured="0">
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          <name>Dublin Core</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="56866">
                <text>Data mining of coronavirus: SARS-CoV-2, SARS-CoV and MERS-CoV</text>
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            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="56867">
                <text>Jung Eun Huh, Seunghee Han, Taeseon Yoon</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="56868">
                <text>Abstract Objective In this study we compare the amino acid and codon sequence of SARS-CoV-2, SARS-CoV and MERS-CoV using different statistics programs to understand their characteristics. Specifically, we are interested in how differences in the amino acid and codon sequence can lead to different incubation periods and outbreak periods. Our initial question was to compare SARS-CoV-2 to different viruses in the coronavirus family using BLAST program of NCBI and machine learning algorithms. Results The result of experiments using BLAST, Apriori and Decision Tree has shown that SARS-CoV-2 had high similarity with SARS-CoV while having comparably low similarity with MERS-CoV. We decided to compare the codons of SARS-CoV-2 and MERS-CoV to see the difference. Though the viruses are very alike according to BLAST and Apriori experiments, SVM proved that they can be effectively classified using non-linear kernels. Decision Tree experiment proved several remarkable properties of SARS-CoV-2 amino acid sequence that cannot be found in MERS-CoV amino acid sequence. The consequential purpose of this paper is to minimize the damage on humanity from SARS-CoV-2. Hence, further studies can be focused on the comparison of SARS-CoV-2 virus with other viruses that also can be transmitted during latent periods.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="56869">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="56870">
                <text>MERS-CoV, SARS-CoV, coronavirus, SARS-CoV-2, BLAST, Apriori</text>
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          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="56871">
                <text>10.1186/s13104-021-05561-4</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="56872">
                <text>Epidemiology and Health</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="56873">
                <text>Korean Society of Epidemiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="56874">
                <text>Biology (General), Medicine, Science (General)</text>
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                <text>Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis</text>
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                <text>Jung Sook Yeom, Chung Mo Koo, Ji Sook Park, Ji Hyun Seo, Eun-Sil Park, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn</text>
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                <text>We report the case of a 12-year-old girl who had mild encephalopathy with a reversible splenial lesion (MERS) associated with acutepyelonephritis caused by Escherichia coli. The patient was admitted with a high fever, and she was diagnosed with acute pyelonephritis based on pyuria and the results of urine culture, which detected cefotaxime-sensitive E. coli. Although intravenous cefotaxime and tobramycin were administered, her fever persisted and her C-reactive protein level increased to 307 mg/L. On day 3 of admission, she demonstrated abnormal neuropsychiatric symptoms, such as delirium, ataxia, and word salad. Magnetic resonance imaging (MRI) of the brain performed on day 4 showed marked hyperintensities in the bilateral corpus callosum and deep white matter on diffusion-weighted images, with corresponding diffusion restriction on apparent diffusion coefficient mapping. No abnormalities or pathogens were detected in the cerebrospinal fluid; however, lipopolysaccharides (LPS, endotoxin) were detected in plasma (41.6 pg/mL), associated with acute neurological deterioration. Her clinical condition gradually improved, and no neurological abnormalities were observed on day 6. Follow-up brain MRI performed 2 weeks later showed near-disappearance of the previously noted hyperintense lesions. In this patient, we first proved endotoxemia in a setting of MERS. The release of LPS following antibiotic administration might be related to the development of MERS in this patient. The possibility of MERS should be considered in patients who present with acute pyelonephritis and demonstrate delirious behavior.</text>
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                <text>encephalopathy, Corpus Callosum, White Matter, Pyelonephritis</text>
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                <text>DOI: 10.3345/kjp.2018.61.2.64</text>
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                <text>Korean Journal of Pediatrics</text>
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                <text>EN</text>
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