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Host–Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model
The respiratory Influenza A Viruses (IAVs) and emerging zoonotic viruses such as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) pose a significant threat to human health. To accelerate our understanding of the host–pathogen response to…
Position: 3490 (41 views)
Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods
The unprecedent situation generated by the COVID-19 global emergency has prompted us to actively work to fight against this pandemic by searching for repurposable agents among FDA approved drugs to shed light into immediate opportunities for the…
Position: 20540 (11 views)
Host-cell recognition through GRP78 is enhanced in the new UK variant of SARS-CoV-2, in silico.
Position: 6386 (31 views)
Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach
Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health Organization, and the identification of effective therapeutic strategy is a need of…
Position: 15171 (20 views)
Host tissue and glycan binding specificities of avian viral attachment proteins using novel avian tissue microarrays.
The initial interaction between viral attachment proteins and the host cell is a critical determinant for the susceptibility of a host for a particular virus. To increase our understanding of avian pathogens and the susceptibility of poultry species,…
Position: 8759 (27 views)
Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan
Position: 5952 (32 views)
Host or pathogen-related factors in COVID-19 severity? - Authors' reply.
Position: 3887 (39 views)
Host Factors Affecting Generation of Immunity Against Porcine Epidemic Diarrhea Virus in Pregnant and Lactating Swine and Passive Protection of Neonates
Porcine epidemic diarrhea virus (PEDV) is a highly virulent re-emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly…
Position: 10277 (25 views)
Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation.
Genetic perturbation screens using RNA interference (RNAi) have been conducted successfully to identify host factors that are essential for the life cycle of bacteria or viruses. So far, most published studies identified host factors primarily for…
Position: 2502 (47 views)
Host Diversity and Origin of Zoonoses: The Ancient and the New
Bacterial, viral, and parasitic zoonotic diseases are transmitted to humans from a wide variety of animal species that act as reservoir hosts for the causative organisms. Zoonoses contribute an estimated 75% of new or reemerging infectious diseases…
Position: 1063 (61 views)