1057 10 20655 https://www.socictopen.socict.org/files/original/76b8453213bc167acb4393436ac34184.pdf fca9e090b0f3bb54d4853d29922897f8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reverse Logistics Network Design for Effective Management of Medical Waste in Epidemic Outbreaks: Insights from the Coronavirus Disease 2019 (COVID-19) Outbreak in Wuhan (China) Creator An entity primarily responsible for making the resource Hao Yu, Xu Sun, Wei Deng Solvang, Xu Zhao Description An account of the resource The outbreak of an epidemic disease may pose significant treats to human beings and may further lead to a global crisis. In order to control the spread of an epidemic, the effective management of rapidly increased medical waste through establishing a temporary reverse logistics system is of vital importance. However, no research has been conducted with the focus on the design of an epidemic reverse logistics network for dealing with medical waste during epidemic outbreaks, which, if improperly treated, may accelerate disease spread and pose a significant risk for both medical staffs and patients. Therefore, this paper proposes a novel multi-objective multi-period mixed integer program for reverse logistics network design in epidemic outbreaks, which aims at determining the best locations of temporary facilities and the transportation strategies for effective management of the exponentially increased medical waste within a very short period. The application of the model is illustrated with a case study based on the outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Even though the uncertainty of the future COVID-19 spread tendency is very high at the time of this research, several general policy recommendations can still be obtained based on computational experiments and quantitative analyses. Among other insights, the results suggest installing temporary incinerators may be an effective solution for managing the tremendous increase of medical waste during the COVID-19 outbreak in Wuhan, but the location selection of these temporary incinerators is of significant importance. Due to the limitation on available data and knowledge at present stage, more real-world information are needed to assess the effectiveness of the current solution. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Medical Waste, Epidemic outbreak, Network design, reverse logistics, operations research, epidemic logistics Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph17051770 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/9df837995b7df5a7f769f0a65d059ec4.pdf e63dc389566ae23436af59a43a15af92 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Passata è la tempesta …”. A land use planning vision for the Italian Mezzogiorno in the post pandemic" Creator An entity primarily responsible for making the resource Paolo La Greca, Francesco Martinico, Fausto Carmelo Nigrelli Description An account of the resource The Covid-19 pandemic event can activate a comprehensive reflection on the change of development models, overcoming the current unsustainable ones. Present events in Italy are mainly affecting Northern Regions but also the Southern ones will suffer from economic consequences, related to the pandemic. This is particularly relevant for the marginal areas of the Italian Mezzogiorno. The article highlights issues that are deemed relevant for including inner areas of Italian Southern regions into the process of economic recovery after the pandemic, in order to avoid the deepening of the long lasting North South imbalance, in the light of the growing depopulation of this part of the Country. The focus is on the role of Health Services, Education, Built up Environment and Transports, systems considered as key elements for promoting a well-balanced use of existing territorial assets. The real challenge is to reverse this terrible threat into an opportunity, introducing effective changes into the way we waste our limited planetary resources, especially the territorial ones. In this direction, Southern regions can play a fundamental role for increasing the resilience of the entire nation. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource regional development, regional planning, Italian Mezzogiorno Identifier An unambiguous reference to the resource within a given context 10.6092/1970-9870/6853 Source A related resource from which the described resource is derived TeMA: Journal of Land Use, Mobility and Environment Publisher An entity responsible for making the resource available Università di Napoli Federico II Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Transportation engineering, Urbanization. City and country https://www.socictopen.socict.org/files/original/e7983ce1cd21864be7e6bce2f3df848d.pdf 618db8bbd5b9189adf8606eef48a2af3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Post Pandemic City: Challenges and Opportunities for a Non-Motorized Urban Environment. An Overview of Italian Cases Creator An entity primarily responsible for making the resource Luca Barbarossa Description An account of the resource COVID-19 has forced city governments to reconsider the relationship between mobility, urban space and health in order to ensure physical distancing while meeting the travel needs of inhabitants. Therefore, cities around the world are already involved in the transformation of mobility through new models of sustainable transport. The World Health Organization (WHO) guidelines on mobility during the COVID outbreak are mostly directed at creating more spaces for cyclists and pedestrians, especially in densely populated urban areas, thus avoiding the overloading of public transport and the use of private cars. Through the analysis of the programs set up by the 10 main Italian metropolitan cities, chosen as a case study, this research evaluates the response implemented by local governments in order to transform urban environments in one of the world’s most pandemic-affected countries in detail. Starting from the current mobility model, this paper focuses on local government policies concerning post-COVID sustainable mobility to understand policies, approaches and measures in depth, as well as the effectiveness of the ongoing actions in shaping future urban mobility. From the research, an almost homogeneous awareness among policy makers and planners emerges concerning the need to rethink urban spaces and mobility, to make up for lost time and to start a green revolution that is aimed at quickly decarbonizing urban transport and enhancing cycling and walking through the city. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Green Deal, cycling, Public spaces, Sustainable Urban Mobility, active mobility, post-pandemic city Identifier An unambiguous reference to the resource within a given context 10.3390/su12177172 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental effects of industries and plants, Renewable energy sources, Environmental sciences https://www.socictopen.socict.org/files/original/a9d5c696753869f2ede6dccb4caf1fd1.pdf 0a3c66376f8b2e3f2c550edd4629b511 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Absence of association between angiotensin converting enzyme polymorphism and development of adult respiratory distress syndrome in patients with severe acute respiratory syndrome: a case control study Creator An entity primarily responsible for making the resource Chiu Rossa WK, Chim Stephen SC, Wu Alan KL, Chung Grace TY, Hui David SC, Tang Nelson LS, Chan KC Allen, Lee Nelson, Choi KW, Sung YM, Chan Paul KS, Tong YK, Lai ST, Yu WC, Tsang Owen, Lo YM Dennis Description An account of the resource Abstract Background It has been postulated that genetic predisposition may influence the susceptibility to SARS-coronavirus infection and disease outcomes. A recent study has suggested that the deletion allele (D allele) of the angiotensin converting enzyme (ACE) gene is associated with hypoxemia in SARS patients. Moreover, the ACE D allele has been shown to be more prevalent in patients suffering from adult respiratory distress syndrome (ARDS) in a previous study. Thus, we have investigated the association between ACE insertion/deletion (I/D) polymorphism and the progression to ARDS or requirement of intensive care in SARS patients. Method One hundred and forty genetically unrelated Chinese SARS patients and 326 healthy volunteers were recruited. The ACE I/D genotypes were determined by polymerase chain reaction and agarose gel electrophoresis. Results There is no significant difference in the genotypic distributions and the allelic frequencies of the ACE I/D polymorphism between the SARS patients and the healthy control subjects. Moreover, there is also no evidence that ACE I/D polymorphism is associated with the progression to ARDS or the requirement of intensive care in the SARS patients. In multivariate logistic analysis, age is the only factor associated with the development of ARDS while age and male sex are independent factors associated with the requirement of intensive care. Conclusion The ACE I/D polymorphism is not directly related to increased susceptibility to SARS-coronavirus infection and is not associated with poor outcomes after SARS-coronavirus infection. Date A point or period of time associated with an event in the lifecycle of the resource 2005 Identifier An unambiguous reference to the resource within a given context 10.1186/1471-2334-5-26 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases https://www.socictopen.socict.org/files/original/ccd979d7ccd36a8e4a13b603681ff59c.pdf a69d0301de0aaf7fb5e36eb3d95f2837 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Safety Recommendations and Medical Liability in Ocular Surgery during the COVID-19 Pandemic: An Unsolved Dilemma Creator An entity primarily responsible for making the resource Pietro Emanuele Napoli, Matteo Nioi, Ernesto d’Aloja, Maurizio Fossarello Description An account of the resource Ocular surgery is one of the most performed medical procedures in the world. Its limitation or suspension, recursively extended over time, could be associated with a significant increase in the number of blind people worldwide. Indeed, cataract causes more than half of all cases of visual impairment in those countries with limited availability of means for performing eye operations (e.g., Africa or India). In this scenario, the pandemic of coronavirus disease 2019 (COVID-19) quickly resulted in the suspension or sharp reduction of various ophthalmic activities considered non-urgent, including lens replacement surgery or some intraocular injections. Despite the imperative need to continuously practice eye operations to avoid the abovementioned problems, there are currently little-shared and vague recommendations among the various countries on safety in operating rooms (for health care workers and patients) and poor legal protection for surgeons (potentially transmitting the COVID-19 infectious agent). Herein, we individuated and discussed some critical points in safety recommendations and medical liability. A paradigm shift for ocular surgery during the COVID-19 era is now mandatory. While telemedicine has been able to solve some problems in clinical ophthalmology, the lack of adequate health and legal protection for surgeons and patients may result in an excessive reduction in the volume of surgical interventions during a pandemic era and the immediately following period, thus determining inability to ensure health care to all patients. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, recommendations, covid-19, SARS-CoV-2, ocular surgery, Eye surgery Identifier An unambiguous reference to the resource within a given context 10.3390/jcm9051403 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/adcf2a0d66a9cea19706ad7353712b9a.pdf 130f1c17a527810fe34cd36dfac2e322 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Changes in Provision of Psychotherapy in the Early Weeks of the COVID-19 Lockdown in Austria Creator An entity primarily responsible for making the resource Thomas Probst, Christoph Pieh, Peter Stippl Description An account of the resource Reducing personal contacts is a central measure against the spreading of the novel coronavirus disease (COVID-19). This troubles mental health, but also mental health care as treatments usually take place in personal contact and switching to remote treatments might be necessary in times of COVID-19. The present study investigated the question how the provision of psychotherapy changed in the early weeks of the COVID-19 lockdown in Austria and whether there were differences between the four therapeutic orientations eligible in Austria (psychodynamic, humanistic, systemic, behavioral). Psychotherapists (N = 1547) completed an online survey. They entered their number of patients treated on average per week (in personal contact, via telephone, via Internet) in the early weeks of the COVID-19 lockdown in Austria as well as (retrospectively) in the months before. The number of patients treated on average per week in personal contact decreased (on average 81%; p Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Public health, covid-19, psychotherapy Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph17113815 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/609c2a452334a54f6d83d368206387cf.pdf b55ae608389b75ce8fba86512a9126d8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Effectiveness of Self-Sufficiency Policy: International Price Transmissions in Beef Markets Creator An entity primarily responsible for making the resource Jin Guo, Tetsuji Tanaka Description An account of the resource International beef markets have shocked regional markets in importing countries due to unexpected events such as the COVID-19 epidemic, bovine spongiform encephalopathy (BSE) and high prices for grain feed. After the global food price spikes in 2008, many national governments aimed to improve food self-sufficiency to secure food supply. However, the efficacy of food self-sufficiency policy, particularly that of meat products, is not fully understood. This paper investigates the causal nexus and estimates the degree of volatility transmissions between global and regional beef prices in 10 beef-importing nations for the period January 2006 to December 2013. Furthermore, we empirically analyze how beef self-sufficiency rates affect the correlations between global and local beef markets using a panel analysis. Our primary findings are: (1) Unidirectional causality from global to local markets was found for Georgia, the UK and the United States. Meanwhile, Japan is a large beef importer, and its price causally influences global prices; (2) We found that the interconnectivity between world and regional markets is relatively weak. Regional markets can absorb external shocks in the meat sector better than wheat because meat production is more flexible than grain production, which is heavily dependent on climatic conditions and (3) Empirical results provide strong indications that high self-sufficiency is useful in isolating local markets from global markets. The results obtained from our analysis are extremely useful for policymakers of national governments who desire to insulate domestic from international beef markets in an emergent situation. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource food self-sufficiency, causal nexus, global beef price, beef-importing country, price volatility transmission Identifier An unambiguous reference to the resource within a given context 10.3390/su12156073 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental effects of industries and plants, Renewable energy sources, Environmental sciences https://www.socictopen.socict.org/files/original/58c4f5889a2e71cdf39d3d5c902aeef4.pdf 9888f59668824279a2d1e904857836cb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Managing Soils for Recovering from the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Rainer Horn, Alfred E. Hartemink, Rattan Lal, Eric C. Brevik, Lorna Dawson, Damien Field, Bruno Glaser, Ryusuke Hatano, Bruce Lascelles, Curtis Monger, Thomas Scholten, Bal Ram Singh, Heide Spiegel, Fabio Terribile, Angelo Basile, Yakun Zhang, Takashi Kosaki, Laura Bertha Reyes Sánchez Description An account of the resource The COVID-19 pandemic has disrupted the global food supply chain and exacerbated the problem of food and nutritional insecurity. Here we outline soil strategies to strengthen local food production systems, enhance their resilience, and create a circular economy focused on soil restoration through carbon sequestration, on-farm cycling of nutrients, minimizing environmental pollution, and contamination of food. Smart web-based geospatial decision support systems (S-DSSs) for land use planning and management is a useful tool for sustainable development. Forensic soil science can also contribute to cold case investigations, both in providing intelligence and evidence in court and in ascertaining the provenance and safety of food products. Soil can be used for the safe disposal of medical waste, but increased understanding is needed on the transfer of virus through pedosphere processes. Strengthening communication between soil scientists and policy makers and improving distance learning techniques are critical for the post-COVID restoration. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19 pandemic, food security, circular economy, urban agriculture, soil management, soil carbon sequestration Identifier An unambiguous reference to the resource within a given context 10.3390/soilsystems4030046 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chemistry, Physical geography https://www.socictopen.socict.org/files/original/71124ba75636390adf0aaaff06580e02.pdf a14d0d6ea86ea49868dbd082f25f9863 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Potentially therapeutic agents against SARS-CoV-2: rapid review of the evidence Creator An entity primarily responsible for making the resource Guido Bendezu-Quispe, Milton José Max Rodríguez-Zúñiga, Yuani Miriam Roman, Laura Melissa Mori-Llontop, Verónica Peralta, Fabián Fiestas Description An account of the resource The Instituto de Evaluación de Tecnologías en Salud e Investigación (IETSI) of the Seguro Social de Salud (EsSalud) has completed seven brief reports by means of rapid reviews of evidence regarding the potentially effective therapies against SARS-CoV-2 in order to provide current and relevant information for decision makers, clinicians, researchers and the academic community in Peru. The therapeutic agents evaluated were chloroquine/hydroxychloroquine, lopinavir/ritonavir, tocilizumab, oseltamivir, interferon, atazanavir and anti SARS-CoV-2 serum. Evidence identification included the review of PubMed and Cochrane Library electronic databases. Additionally, manual search was carried out on websites from groups dedicated to research and education on health, as well as in the main specialized societies or institutions, such as, the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC). Furthermore, in order to reduce publication bias, the websites: www.clinicaltrials.gov and http://apps.who.int/trialsearch were searched to identify in-progress or unpublished clinical trials. Finally, a “snowball” strategy was performed by reviewing the reference lists of the systematic reviews, primary studies and selected narrative reviews to identify relevant information. The latest review (March 27, 2020) showed that there is no evidence to recommend any medication for patients´ treatment with COVID-19. More evidence, preferably high-quality randomized clinical trials, is needed for decision-making against SARS-CoV-2. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, covid-19, Peru, Evaluación de la Tecnología Biomédica, síndrome respiratorio agudo grave 2, tratamiento farmacológico covid-19 Identifier An unambiguous reference to the resource within a given context 10.17843/rpmesp.2020.372.5409 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medicine (General) https://www.socictopen.socict.org/files/original/95b07b8d99e596ebadbcd81786ec6052.pdf a2edc54c65e053aa9b31416fdb0f8756 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Identification of a Membrane Binding Peptide in the Envelope Protein of MHV Coronavirus Creator An entity primarily responsible for making the resource Ian M. Jones, Entedar A. J. Alsaadi, Benjamin W. Neuman Description An account of the resource Coronaviruses (CoVs) are enveloped, positive sense, single strand RNA viruses that cause respiratory, intestinal and neurological diseases in mammals and birds. Following replication, CoVs assemble on intracellular membranes including the endoplasmic reticulum Golgi intermediate compartment (ERGIC) where the envelope protein (E) functions in virus assembly and release. In consequence, E potentially contains membrane-modifying peptides. To search for such peptides, the E coding sequence of Mouse Hepatitis Virus (MHV) was inspected for its amino acid conservation, proximity to the membrane and/or predicted amphipathic helices. Peptides identified in silico were synthesized and tested for membrane-modifying activity in the presence of giant unilamellar vesicles (GUVs) consisting of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), sphingomyelin and cholesterol. To confirm the presence of membrane binding peptides identified in the context of a full-length E protein, the wild type and a number of mutants in the putative membrane binding peptide were expressed in Lenti-X-293T mammalian and insect cells, and the distribution of E antigen within the expressing cell was assessed. Our data identify a role for the post-transmembrane region of MHV E in membrane binding. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, peptide, membrane, envelope, E protein, GUV Identifier An unambiguous reference to the resource within a given context 10.3390/v12091054 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology