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                <text>Adaptive Time-Dependent Priors and Bayesian Inference to Evaluate SARS-CoV-2 Public Health Measures Validated on 31 Countries</text>
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                <text>Hugues Turbé, Hugues Turbé, Mina Bjelogrlic, Mina Bjelogrlic, Arnaud Robert, Arnaud Robert, Christophe Gaudet-Blavignac, Christophe Gaudet-Blavignac, Jean-Philippe Goldman, Jean-Philippe Goldman, Christian Lovis, Christian Lovis</text>
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                <text>With the rapid spread of the SARS-CoV-2 virus since the end of 2019, public health confinement measures to contain the propagation of the pandemic have been implemented. Our method to estimate the reproduction number using Bayesian inference with time-dependent priors enhances previous approaches by considering a dynamic prior continuously updated as restrictive measures and comportments within the society evolve. In addition, to allow direct comparison between reproduction number and introduction of public health measures in a specific country, the infection dates are inferred from daily confirmed cases and confirmed death. The evolution of this reproduction number in combination with the stringency index is analyzed on 31 European countries. We show that most countries required tough state interventions with a stringency index equal to 79.6 out of 100 to reduce their reproduction number below one and control the progression of the pandemic. In addition, we show a direct correlation between the time taken to introduce restrictive measures and the time required to contain the spread of the pandemic with a median time of 8 days. This analysis is validated by comparing the excess deaths and the time taken to implement restrictive measures. Our analysis reinforces the importance of having a fast response with a coherent and comprehensive set of confinement measures to control the pandemic. Only restrictions or combinations of those have shown to effectively control the pandemic.</text>
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                <text>epidemiology, infectious diseases, nonpharmaceutical interventions, Health sciences, reproductive number estimation, Bayesian inference (BI)</text>
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                <text>Addendum: A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology.</text>
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                <text>An Addendum to this paper has been published: https://doi.org/10.1038/s41564-021-00872-5.</text>
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                <text>Diverse studies have shown that a significant percentage of the Spanish university population suffers from different addictions. They are both a personal and public health problem if there is not a greater awareness of the risks involved and if the appropriate prevention measures are not taken, among them educational ones. In this context, a descriptive and explanatory cross-sectional study was conducted during the first half of June 2020, coinciding with the period of confinement that occurred in Spain during the first wave of the COVID-19 pandemic. Given that this is such an exceptional time, the main objective of this study was to obtain information especially on students’ substance consumption and possible addictions at this time. Knowing the specific situation of this problem in that specific situation may allow for comparative studies in the future. The sample was composed of 310 university students from 14 Spanish universities. The instrument used in the research was the ASSIST questionnaire, developed by the WHO for the detection of alcohol, tobacco, and substance consumption. As result, a moderate and high risk was observed mainly in the following substances: alcohol (36.2%), tobacco (33.2%), cannabis (22.9%), and sedatives (10.3%). Through the logistic regression of the set of drugs, it has been proven that, on the one hand, the addiction to cocaine and sedatives in the family environment and age, on the other hand, are the main predictive variables of drug consumption. The existence of polysubstance abuse was also determined. These data show the need for educational bodies and university institutions to promote awareness, sensitization, and health education programs to deal with this important problem, especially in extraordinary situations, such as the one referred to, which could increase this consumption.</text>
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                <text>Shadi Ziaie, Mohsen Nafar, Alireza Kashefi Zadeh, Shiva Samavat, Fariba Samadian, Ahmad Firouzan, Somayeh Fatemizadeh, Nooshin Dalili, Fatemeh Poorrezagholi</text>
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                <text>Abstract Objectives Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress pathways which all are important and pathologic components in the clinical course and outcome of patients infected with COVID-19. This study aims to assess the anti-inflammatory effects of colchicine in non-severe hospitalized COVID-19 patients. Trial design Prospective, randomized (1:1 ratio), double blind study with parallel group design. Participants Hospitalized patients with positive nasopharyngeal swab for COVID-19 infection (RT -PCR) and lung Computed tomography scan involvement compatible with COVID-19 pneumonia. The patients are not severely hypoxic, do not need intubation or invasive oxygenation. Exclusion criteria: known hypersensitivity to colchicine; known hepatic failure; estimated glomerular filtration rate (eGFR)450 msec. Participants will be recruited from inpatients at Labbafinejad Meidcal Center , Tehran, Iran. Intervention and comparator Eligible enrolled patients will be randomized into two groups. Group A will receive the antiretroviral Lopinavir/Ritonavir (Kaletra) while group B will receive Lopinavir/Ritonavir (Kaletra) + Colchicine 1.5 mg loading then 0.5 mg twice daily orally. All patients in both groups will receive the same amounts of essential minerals, vitamins as antioxidants, and antibiotics. Patients of both groups will be treated under optimal treatment based on the CDC and WHO guidelines and national consensus proposed in Iran including the same dosages of Lopinavir/Ritonavir, antibiotics, trace elements and antioxidants while only in group-B patients Colchicine will be added on top of this protocol. Main outcomes Primary: Time for clinical improvement and lung CT score changes 14 days after treatment. Secondary: 14 days after treatment – C-Reactive Protein test x Neutrophil to Lymphocyte Ratio , Interleukin-6, malondialdehyde (MDA) levels reduction – Percentage of patients who require supplemental Oxygen – Mean hospital stay length Randomisation Patients will be allocated to each group (ratio 1:1) by using an online randomization tool: http://www.graphpad.com/quickcalcs/index.cfm Blinding (masking) This will be a double-blind study in which participants and those assessing the final outcomes will be blinded to group assignment. Numbers to be randomised (sample size) Regarding the pandemic crisis and our center capacity to hospitalize confirmed COVID-19 patients, a total of 80 patients was found to be logical to be randomized into two groups of 40- patients. Trial Status Recruitment is ongoing. Recruitment began on 20/03/2020 and the date by which the recruitment is anticipated to be completed is 30/05/2020. Trial registration ClinicalTrials.gov Identifier: NCT04360980, registered 24/04/2020. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol.</text>
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                <text>2020</text>
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            </elementTextContainer>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>oxidative stress, inflammation, Randomised controlled trial, protocol, Colchicine, COVID-19</text>
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                <text>DOI: 10.1186/s13063-020-04455-3</text>
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                <text>Trials</text>
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                <text>BMC</text>
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                <text>Medicine (General)</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Adding Space to Disease Models: A Case Study with COVID-19 in Oregon, USA</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Nathan  H. Schumaker, Sydney  M. Watkins</text>
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                <text>We selected the COVID-19 outbreak in the state of Oregon, USA as a system for developing a general geographically nuanced epidemiological forecasting model that balances simplicity, realism, and accessibility. Using the life history simulator HexSim, we inserted a mathematical SIRD disease model into a spatially explicit framework, creating a distributed array of linked compartment models. Our spatial model introduced few additional parameters, but casting the SIRD equations into a geographic setting significantly altered the system’s emergent dynamics. Relative to the non-spatial model, our simple spatial model better replicated the record of observed infection rates in Oregon. We also observed that estimates of vaccination efficacy drawn from the non-spatial model tended to be higher than those obtained from models that incorporate geographic variation. Our spatially explicit SIRD simulations of COVID-19 in Oregon suggest that modest additions of spatial complexity can bring considerable realism to a traditional disease model.</text>
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                <text>2021</text>
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                <text>epidemiology, covid-19, SIRD-model, simulation model, spatially-explicit model, HexSim</text>
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                <text>10.3390/land10040438</text>
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                <text>Epidemiology and Health</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Agriculture</text>
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              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Adding Value to Goat Meat: Biochemical and Technological Characterization of Autochthonous Lactic Acid Bacteria to Achieve High-Quality Fermented Sausages</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="162808">
                <text>Miriam T. Nediani, Luis García, Lucila Saavedra, Sandra Martínez, Soledad López Alzogaray, Silvina Fadda</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="162809">
                <text>Quality and safety are important challenges in traditional fermented sausage technology. Consequently, the development of a tailored starter culture based on indigenous microbiota constitutes an interesting alternative. In the present study, spontaneously fermented goat meat sausages were created and analyzed using a physicochemical and microbiological approach. Thereafter 170 lactic acid bacteria (LAB) strains were isolated and preliminary characterized by phenotypic assays. The hygienic and technological properties, and growth and fermentative potential of isolates using a goat-meat-based culture medium were evaluated. All strains proved to have bioprotective features due to their acidogenic metabolism. Almost all grew optimally in meat environments. LAB isolates presented proteolytic activity against meat proteins and enriched amino acid contents of the goat-meat-based model. The most efficient strains were four different Lactobacillus sakei isolates, as identified by genotyping and RAPD analysis. L. sakei strains are proposed as optimal candidates to improve the production of fermented goat meat sausages, creating a new added-value fermented product.</text>
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                <text>2017</text>
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                <text>Food quality, fermented sausages, food safety, goat meat, lactic acid bacteria, meat fermentation, starter cultures</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="162812">
                <text>10.3390/microorganisms5020026</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Microorganisms</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="162814">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Biology (General)</text>
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            <description>A related resource</description>
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                <text>&lt;a href="http://www.mdpi.com/2076-2607/5/2/26" target="_blank" rel="noreferrer noopener"&gt;http://www.mdpi.com/2076-2607/5/2/26&lt;/a&gt;</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Addition of Corticosteroids to Immunoglobulins Is Associated With Recovery of Cardiac Function in Multi-Inflammatory Syndrome in Children.</text>
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                <text>Zahra Belhadjer, Johanne Auriau, Mathilde Méot, Mehdi Oualha, Sylvain Renolleau, Lucile Houyel, Damien Bonnet</text>
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                <text>severe acute respiratory syndrome coronavirus 2, Heart failure, immunoglobulins, intravenous, pediatric multisystem inflammatory disease, COVID-19 related</text>
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                <text>10.1161/CIRCULATIONAHA.120.050147</text>
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                <text>Circulation</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Addressing Challenges in Obtaining Emergency Medicine Away Rotations and Standardized Letters of Evaluation Due to COVID-19 Pandemic</text>
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                <text>Michael Pasirstein, Douglas Franzen, Xiao Chi Zhang, Liza Smith, Emily Hillman, Ronnie Ren, Alexis Pelletier-Bui, Linda Katirji, Mark Olaf, Jazmyn Shaw</text>
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                <text>DOI: 10.5811/westjem.2020.3.47444</text>
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                <text>Western Journal of Emergency Medicine</text>
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                <text>eScholarship Publishing, University of California</text>
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                <text>Medicine, Medical emergencies. Critical care. Intensive care. First aid</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Addressing power asymmetries in global health: Imperatives in the wake of the COVID-19 pandemic.</text>
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                <text>Madhukar Pai, Seye Abimbola, Sumegha Asthana, Cristian Montenegro, Renzo R Guinto, Desmond Tanko Jumbam, Lance Louskieter, Kenneth Munge Kabubei, Shehnaz Munshi, Kui Muraya, Fredros Okumu, Senjuti Saha, Deepika Saluja</text>
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                <text>Seye Abimbola and co-authors argue for a transformation in global health research and practice in the post-COVID-19 world.</text>
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                <text>10.1371/journal.pmed.1003604</text>
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                <text>PLoS Medicine</text>
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