1073 10 20655 https://www.socictopen.socict.org/files/original/63980bb2b56717ac3b1803821e8c3519.pdf 4b11733b8e81184dab89c2c8c62c61c9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Structure and inhibition of the SARS coronavirus envelope protein ion channel. Creator An entity primarily responsible for making the resource Konstantin Pervushin, Edward Tan, Krupakar Parthasarathy, Xin Lin, Fengli Jiang, Dejie Yu, Ardcharaporn Vararattanavech, Tuck Wah Soong, Ding Xiang Liu, Jaume Torres Description An account of the resource The envelope (E) protein from coronaviruses is a small polypeptide that contains at least one alpha-helical transmembrane domain. Absence, or inactivation, of E protein results in attenuated viruses, due to alterations in either virion morphology or tropism. Apart from its morphogenetic properties, protein E has been reported to have membrane permeabilizing activity. Further, the drug hexamethylene amiloride (HMA), but not amiloride, inhibited in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication. We have previously shown for the coronavirus species responsible for severe acute respiratory syndrome (SARS-CoV) that the transmembrane domain of E protein (ETM) forms pentameric alpha-helical bundles that are likely responsible for the observed channel activity. Herein, using solution NMR in dodecylphosphatidylcholine micelles and energy minimization, we have obtained a model of this channel which features regular alpha-helices that form a pentameric left-handed parallel bundle. The drug HMA was found to bind inside the lumen of the channel, at both the C-terminal and the N-terminal openings, and, in contrast to amiloride, induced additional chemical shifts in ETM. Full length SARS-CoV E displayed channel activity when transiently expressed in human embryonic kidney 293 (HEK-293) cells in a whole-cell patch clamp set-up. This activity was significantly reduced by hexamethylene amiloride (HMA), but not by amiloride. The channel structure presented herein provides a possible rationale for inhibition, and a platform for future structure-based drug design of this potential pharmacological target. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1000511 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/48d35be53476ec775062a93248a41c57.pdf e87be76fa34af0d809e4d2e6cf7f3894 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource El fin de la frontera agrícola en Nicaragua y su impacto en el desarrollo nacional Creator An entity primarily responsible for making the resource Konstantinos Bairamis Description An account of the resource El fin de la frontera agrícola en Nicaragua significa el fin de la disponibilidad de tierra para aumentar la producción agropecuaria extensiva, la cual, desde 1950 hasta ahora, es la principal base de la economía Nicaragüense. El presente estudio tuvo como objetivo, describir el proceso de destrucción de los recursos naturales en la frontera agrícola y explicar el mecanismo social que condujo a esta situación. En el proceso de investigación, se revisó bibliografía desde 1950, se utilizaron datos cuantitativos de instituciones nacionales e internacionales en forma comparativa y se formaron variables cuantitativas y cualitativas para explicar el fenómeno y hacer predicciones científicas. Se presenta la tesis, que el agotamiento de tierra disponible, combinado con los graves efectos de cambio climático en la disponibilidad de agua, conduce a Nicaragua por primera vez en su historia, en un desequilibrio económico y un posible conflicto social grave. La propuesta para evitar la crisis, es la alianza entre productores, estratos de la comunidad epistémica y gobierno, que permita cambiar las políticas públicas del estado y establecer una agroindustria sostenible para una producción sostenible, en sustitución de la actual agroindustria de empresas carteles oligopsonicos Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Conflicto social, Producción sostenible, disponibilidad de tierra Source A related resource from which the described resource is derived La Calera Publisher An entity responsible for making the resource available Universidad Nacional Agraria Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Agriculture Relation A related resource <a href="https://lacalera.una.edu.ni/index.php/CALERA/article/view/257" target="_blank" rel="noreferrer noopener">https://lacalera.una.edu.ni/index.php/CALERA/article/view/257</a> https://www.socictopen.socict.org/files/original/dfe8d13f31fd3edcfb1efebdbecb07ad.pdf b83d6a6896ca256b6ccb60224f14aacb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource [Lactate dehydrogenase, COVID-19 and mortality]. Creator An entity primarily responsible for making the resource Konstantinos Bartziokas, Konstantinos Kostikas Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1016/j.medcli.2020.07.043 Source A related resource from which the described resource is derived Medicina clinica https://www.socictopen.socict.org/files/original/c6ea3e19616dee1c94ea150b8739c9ad.pdf da163a674b7e4ce750e7e0e7f24275b6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Modeling and Forecasting the COVID-19 Temporal Spread in Greece: An Exploratory Approach based on Complex Network Defined Splines Creator An entity primarily responsible for making the resource Konstantinos Demertzis, Dimitrios Tsiotas, Lykourgos Magafas Description An account of the resource Within the complex framework of anti-COVID-19 health management, where the criteria of diagnostic testing, the availability of public-health resources and services, and the applied anti-COVID-19 policies vary between countries, the reliability and accuracy in the modeling of temporal spread can prove to be effective in the worldwide fight against the disease. This paper applies an exploratory time-series analysis to the evolution of the disease in Greece, which currently suggests a success story of COVID-19 management. The proposed method builds on a recent conceptualization of detecting connective communities in a time-series and develops a novel spline regression model where the knot vector is determined by the community detection in the complex network. Overall, the study contributes to the COVID-19 research by proposing a free of disconnected past-data and reliable framework of forecasting, which can facilitate decision-making and management of the available health resources. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Outbreak, prediction, modeling, COVID-19 coronavirus pandemic, Regression splines, modularity optimization algorithm Identifier An unambiguous reference to the resource within a given context 10.3390/ijerph17134693 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/0b580b683813f827e2a5e9fd8cde3e26.pdf 9560657750ef5a350c87e20619cd7d58 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Activation of TRL-7 and Innate Immunity as an Efficient Method Against COVID-19 Pandemic: Imiquimod as a Potential Therapy Creator An entity primarily responsible for making the resource Konstantinos Farsalinos, Konstantinos Poulas, Charilaos Zanidis Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Innate Immunity, immune activation, SARS-CoV-2, COVID-19, Imiquimod (IMQ) Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2020.01373 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/aa988c365b53814efecc20df7af64dfa.pdf bf58ad66d1f9bddf5bee866cc95623c0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Anticoagulation therapy in COVID-19: Is there a dose-dependent benefit? Creator An entity primarily responsible for making the resource Konstantinos G Kyriakoulis, Anastasios Kollias, Nikolaos K Syrigos, George S Stergiou Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Anti coagulation, survival, Dose, thromboprophylaxis Identifier An unambiguous reference to the resource within a given context 10.1016/j.thromres.2020.12.013 Source A related resource from which the described resource is derived Thrombosis research https://www.socictopen.socict.org/files/original/b3a710c6a934cc32f0d50dc3cd1678ef.pdf 8d8a68adf9cd568a03f2e7b95a9caaee Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource When there is a pandemic there is no time to waste: should we have hydroxychloroquine in our armoury against COVID-19 infected patients? Creator An entity primarily responsible for making the resource Konstantinos Gourgoulianis, Dimitrios P. Bogdanos, Lazaros I. Sakkas, Epaminondas Zakynthinos, Zoi Daniil Description An account of the resource The current use of chloroquine and/or hydroxychloroquine, a drug currently used to treat autoimmune rheumatic diseases, in treating severe acute respiratory syndrome caused by coronavirus 2 (SARSCoV-2) or COVID-19-infected patients with pneumonia is a matter of intense consideration. We wish to enter the ongoing debate as to whether this well-known drug must be given to Greek COVID-19-infected patients, especially those with pneumonia. Our arguments are based on the existing data and the capacity of the Greek health system to afford potent anti-viral treatments, which are under immense investigation. We propose several suggestions related to treatment of COVID-19 pneumonia with chloroquine/hydroxychloroquine that we think must be taken into consideration to fit the evolving situation of the pandemic in Greece. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource chloroquine, hydroxychloroquine, Pandemic, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.31138/mjr.31.1.94 Source A related resource from which the described resource is derived Mediterranean Journal of Rheumatology Publisher An entity responsible for making the resource available PCO Convin S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the musculoskeletal system https://www.socictopen.socict.org/files/original/21a93333e0fa6dcbc5cac21ec7b8b1e9.pdf ae09d8f00bf994ee110fafbb26199e76 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Online education and best practices for the development of a distance education program Creator An entity primarily responsible for making the resource Koptelov Andrey, Turner Stephen Description An account of the resource This article discusses the benefits and challenges of online teaching and learning and details the process for creating a distance education program from the formation of a development team through the creation, implementation and evaluation of courses. It explores current networking technologies and pedagogical approaches that are combined to create a student experience that is satisfying for the current generation of students. The demand for online learning has rapidly increased over the years, especially with the recent COVID-19 situation around the world. Schools transitioned to online teaching and learning. Teachers adapted to the changes and with the help of technology, created collaborative and engaging online experiences. These experiences will be memorable for students. New skills were learned along the way such as organization, time management, communication, etc. These skills can help students and prepare them for their future. Many studies have focused on the topic of teaching and learning online. This study is aimed to target parents, students, and teachers who are looking into furthering or completing their education online. With the recent events in the world happening with COVID-19, children and teachers had to resort to continue their education online. Many families and teachers struggled with technology while others adapted to the situation quickly. To be prepared for any situation we must inform ourselves about how teaching and learning online happens and how to be successful. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource online learning, higher education, Technology, distance education Identifier An unambiguous reference to the resource within a given context 10.1051/shsconf/20219805009 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social Sciences https://www.socictopen.socict.org/files/original/65425ab3e99b4b2be48b14fb5634f8fd.pdf 7608ab1ec0e74bee1399437b03d8635d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Multisystem Inflammatory Syndrome in Children (MIS-C) associated with Kawasaki Disease in a three-year-old girl with SARS-CoV-2 infection Creator An entity primarily responsible for making the resource Koroush Yousefi, Salar Poorbarat, Amin Hoseinzadeh, Sajad Rahimi, Zohreh Abbasi Description An account of the resource Kawasaki Disease (KD) is an acute and restrictive vasculitis. Studies have noted a viral association with the occurrence of this syndrome. This article reports a child with several severe inflammatory syndrome symptoms associated with COVID-19 and KD. The patient, a three-year-old Iranian Kurdish girl without a history of internal diseases and with no history of drug and food allergies, was referred to Imam Hasan hospital three days after diarrhea, nausea, and pain in the inner part of the left thigh. Scattered rashes around the face, neck, and arms during fever were significant. Reverse transcription polymerase chain reaction (RT-PCR) was positive for COVID-19, but the lung high-resolution computed tomography (HRCT) did not show involvement, so the diagnosis of KD associated with viral infection was suggested. In further studies, Wright and 2ME tests, Widal, and purified protein derivative (PPD) tests were declared negative. After intravenous immunoglobulin (IVIG), the patient’s fever continued, but other symptoms improved. Since COVID-19 is a new disease and our understanding of its numerous symptoms is evolving, we recommend physicians to be vigilant about secondary inflammatory syndromes that induce KD; rapid treatment with IVIG and steroids may improve patients’ conditions. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, covid-19, kawasaki disease, vasculitis Identifier An unambiguous reference to the resource within a given context 10.7363/100110 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Pediatrics https://www.socictopen.socict.org/files/original/35569d4e4721f161f8bde276b4741511.pdf 0149cea6f7b0b1898765ab33d3988bb0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells Creator An entity primarily responsible for making the resource Korrakod Petsri, Masashi Yokoya, Sucharat Tungsukruthai, Thanyada Rungrotmongkol, Bodee Nutho, Chanida Vinayanuwattikun, Naoki Saito, Matsubara Takehiro, Ryo Sato, Pithi Chanvorachote Description An account of the resource Myeloid cell leukemia 1 (Mcl-1) and B-cell lymphoma 2 (Bcl-2) proteins are promising targets for cancer therapy. Here, we investigated the structure–activity relationships (SARs) and performed molecular docking analysis of renieramycin T (RT) and its analogues and identified the critical functional groups of Mcl-1 targeting. RT have a potent anti-cancer activity against several lung cancer cells and drug-resistant primary cancer cells. RT mediated apoptosis through Mcl-1 suppression and it also reduced the level of Bcl-2 in primary cells. For SAR study, five analogues of RT were synthesized and tested for their anti-cancer and Mcl-1- and Bcl-2-targeting effects. Only two of them (TM-(–)-18 and TM-(–)-4a) exerted anti-cancer activities with the loss of Mcl-1 and partly reduced Bcl-2, while the other analogues had no such effects. Specific cyanide and benzene ring parts of RT’s structure were identified to be critical for its Mcl-1-targeting activity. Computational molecular docking indicated that RT, TM-(–)-18, and TM-(–)-4a bound to Mcl-1 with high affinity, whereas TM-(–)-45, a compound with a benzene ring but no cyanide for comparison, showed the lowest binding affinity. As Mcl-1 helps cancer cells evading apoptosis, these data encourage further development of RT compounds as well as the design of novel drugs for treating Mcl-1-driven cancers. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Renieramycin T, structure–activity relationship, patient-derived primary lung cancer cells, lung cancer, apoptosis, Mcl-1 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/cancers12040875 Source A related resource from which the described resource is derived Cancers Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neoplasms. Tumors. Oncology. Including cancer and carcinogens Language A language of the resource EN