1077 10 20655 https://www.socictopen.socict.org/files/original/ed380aaafc39e8777f3aa727bcc5a326.pdf 83964fcc0ee6cbfa19fa8a9657bcd870 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In situ immune-mediated pulmonary artery thrombosis and Covid-19 pneumonitis. Creator An entity primarily responsible for making the resource Jason Kho, Adam Ioannou, Koenraad Van den Abbeele, Amit K J Mandal, Constantinos G Missouris Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1016/j.thromres.2020.11.006 Source A related resource from which the described resource is derived Thrombosis research https://www.socictopen.socict.org/files/original/a7ef6a6b78c89d7a18724375b1699e46.pdf 44e1dcccc396e939a57366befbea9a85 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In Situ Tagged nsp15 Reveals Interactions with Coronavirus Replication/Transcription Complex-Associated Proteins Creator An entity primarily responsible for making the resource Jeremiah Athmer, Anthony R. Fehr, Matthew Grunewald, Everett Clinton Smith, Mark R. Denison, Stanley Perlman, Peter Palese Description An account of the resource Coronavirus (CoV) replication and transcription are carried out in close proximity to restructured endoplasmic reticulum (ER) membranes in replication/transcription complexes (RTC). Many of the CoV nonstructural proteins (nsps) are required for RTC function; however, not all of their functions are known. nsp15 contains an endoribonuclease domain that is conserved in the CoV family. While the enzymatic activity and crystal structure of nsp15 are well defined, its role in replication remains elusive. nsp15 localizes to sites of RNA replication, but whether it acts independently or requires additional interactions for its function remains unknown. To begin to address these questions, we created an in situ tagged form of nsp15 using the prototypic CoV, mouse hepatitis virus (MHV). In MHV, nsp15 contains the genomic RNA packaging signal (P/S), a 95-bp RNA stem-loop structure that is not required for viral replication or nsp15 function. Utilizing this knowledge, we constructed an internal hemagglutinin (HA) tag that replaced the P/S. We found that nsp15-HA was localized to discrete perinuclear puncta and strongly colocalized with nsp8 and nsp12, both well-defined members of the RTC, but not the membrane (M) protein, involved in virus assembly. Finally, we found that nsp15 interacted with RTC-associated proteins nsp8 and nsp12 during infection, and this interaction was RNA independent. From this, we conclude that nsp15 localizes and interacts with CoV proteins in the RTC, suggesting it plays a direct or indirect role in virus replication. Furthermore, the use of in situ epitope tags could be used to determine novel nsp-nsp interactions in coronaviruses. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Identifier An unambiguous reference to the resource within a given context DOI: 10.1128/mBio.02320-16 Source A related resource from which the described resource is derived mBio Publisher An entity responsible for making the resource available American Society for Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/8ffa4e09919d06de65df8e68dbbfdea1.pdf fc00dafa273c92e8d698912e52e9e10e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In the Age of COVID: Genomic Changes Over the Lifespan Help Explain Severe SARS-CoV-2 Disease. Creator An entity primarily responsible for making the resource Brandon J Beddingfield, Gregory J Bix Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, cardiovascular, Age, Endothelial cells Identifier An unambiguous reference to the resource within a given context 10.1016/j.jacbts.2020.10.004 Source A related resource from which the described resource is derived JACC. Basic to translational science https://www.socictopen.socict.org/files/original/55a67b96e144d1bcf2cb538b6f22f8de.pdf fe34fe5712f83b6f04215682eb0130f3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In the coronavirus disease-19 era, is the care of noncoronavirus disease-19 patients being compromised? Creator An entity primarily responsible for making the resource Abdullah Mobeireek, Hana Alzamil Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.4103/atm.ATM_176_20 Source A related resource from which the described resource is derived Annals of Thoracic Medicine Publisher An entity responsible for making the resource available Wolters Kluwer Medknow Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the circulatory (Cardiovascular) system, Diseases of the respiratory system https://www.socictopen.socict.org/files/original/ffcfe5fe3a00161e2bd143747fe0e78b.pdf d1a2a0af0b9e72ed7a90519bdf331a80 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In the Footsteps of Food Left by Our Ancestors: “Sowing the Past, Cultivating the Present in Harmony with Mother Earth” Tras las huellas alimentarias de nuestros ancestros “Sembrando el pasado y cultivando el presente en armonía con la Madre Tierra” Creator An entity primarily responsible for making the resource 0scar Leiva Morales, Rigoberto Díaz Leiva Description An account of the resource Indigenous peoples have experienced food shortages in recent years. The rapid destruction of natural resources, lack of incentives for producers, globalization and free tradeagreements havec caused an uprooting from the land in the native mind. Moreover, it has been difficult to establish an adequate relationship between traditional farming practices and technical advice to put the community economy on the right track with new ways to strengthen the knowledge inherited from our grandparents on the cultivation and consumption of agricultural products, in harmony with nature. This reality, which affects the Boruca indigenous region, has led to economic, social and cultural problems, coupled with an evident threat: loss of food sovereignty.Recibido 25 de mayo de 2012 • Corregido 07 de febrero de 2013 • Aceptado 13 de marzo de 2013Los pueblos indígenas han enfrentado problemas alimentarios en los últimos años. La rápida destrucción de los recursos naturales, la carencia de incentivos para los productores, la globalización y los tratados de libre comercio han creado, en el pensamiento indígena, un desarraigo a la tierra. Además, ha sido difícil establecer una adecuada interrelación entre las prácticas agrícolas tradicionales y la asesoría técnica, para encauzar la economía de la comunidad con nuevas alternativas que fortalezcan los conocimientos que dejaron nuestros abuelos en cuanto al cultivo y consumo de productos agrícolas, en armonía con la naturaleza. Esta realidad, presente también en Boruca, ha traído como consecuencia, problemas económicos, sociales y culturales, aunados a una amenaza cuyos indicios ya se atisban: la pérdida de soberanía alimentaria. Date A point or period of time associated with an event in the lifecycle of the resource 2013 Subject The topic of the resource Comunidad indígena Boruca, Costa Rica, Reconversión productiva, Revista Electrónica Educare, Soberanía alimentaria, alimentos autóctonos Source A related resource from which the described resource is derived Revista Electronic@ Educare Publisher An entity responsible for making the resource available Universidad Nacional, Costa Rica Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Special aspects of education, Education Relation A related resource <a href="http://www.revistas.una.ac.cr/index.php/EDUCARE/article/view/5021" target="_blank" rel="noreferrer noopener">http://www.revistas.una.ac.cr/index.php/EDUCARE/article/view/5021</a> https://www.socictopen.socict.org/files/original/075eebe84f442ab609abaf7848a5826b.pdf c2ae8ae083d1788e53961bc67459ad4c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In This Issue Creator An entity primarily responsible for making the resource David Briggs Description An account of the resource This issue of the journal commences with an editorial that provides some discussion about the current approaches to Covid and the tensions that exists in that context..... Editorial SettingsCovid-19: A strife of interests for us all and what problem are we attempting to solve? Research Articles Gender Equity in Australian Health Leadership Research Articles Assessing Quality of Healthcare Delivery When Making Choices: National Survey on Health Consumers’ Decision Making Practices Research Articles The Case for a Reciprocal Health Care Agreement between Australia and South Korea Commentary COVID-19 and Working Within Health Care Systems: the future is flexible Review Articles Review of Public Private Partnership in the Health Care in Hong Kong Viewpoint Article Hong Kong’s Growing Need for Palliative Care Services and the Role of the Nursing Profession Commentary Vietnam’s Healthcare System Decentralization: how well does it respond to global health crises such as covid-19 pandemic? Research Articles Publicly Financed Health Insurance Schemes and Horizontal Inequity in Inpatient Service Use in India Research Articles Distress and Quality of Life among Type II Diabetic Patients: Role of physical activity Viewpoint Article Achievements and Challenges of Iran Health System after Islamic Revolution: Structural reforms at the second step Research Articles Strategic Analysis of Community Participation in Primary Health Care in Iran and Presentation of Promotion Strategies Using Internal and External Environment Assessment Techniques Research Articles Utilization of Healthcare Services & Healthcare Expenditure Patterns in the Rural Households of Nepal Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.24083/apjhm.v16i1.695 Source A related resource from which the described resource is derived Asia Pacific Journal of Health Management Publisher An entity responsible for making the resource available ACHSM Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Medicine (General) https://www.socictopen.socict.org/files/original/fbc99a7416513c02eafedd0a6576b1d3.pdf 9d60a9df6c146dbf4cbdb8bee0a78046 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In Vitro Antimicrobial Activity of Cinnabarin on <i>Xanthomonas campestris</i> Isolated from Bean Crops of Puebla, Mexico Creator An entity primarily responsible for making the resource Omar Romero-Arenas, Antonio Rivera, Ana P. Jara y Rivera, Ma. Angeles Valencia de Ita, Conrado Parraguirre Lezama, Nemesio Villa-Ruano Description An account of the resource Phaseolus vulgaris is the most legume cultivated in the world; in Mexico, it is considered the second most important crop after corn. The aim of this research was to determine the characteristics of Xanthomonas campestris strain “Xcf1-APJR” isolated from the leaves of bean crops, and determine the antimicrobial activity of cinnabarin on this strain. Bacterial cultures were obtained from leaves with necrotic leaf spot symptoms of bean plant variety “Flor de Mayo M38” in Puebla, Mexico. The antimicrobial activity of cinnabarin was tested at 7, 14 and 21 days on X. campestris pv. campestris. The Xcf1-APJR strain showed 100% identity with X. campestris pv. campestris as a causal agent of necrotic leaf spot. Treatment with a potato dextrose medium with a dehydrated sugar cane (PDA+C) showed a higher orange pigmentation than the other treatments after 7, 14 and 21 days of incubation and a higher concentration of cinnabarin (54.33 InU/g) with in vitro antimicrobial activity against X. campestris pv. campestris. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource bacterial blight, inhibition, legume crops, mycelial growth, necrotic foliar spot Identifier An unambiguous reference to the resource within a given context 10.3390/app11125391 Source A related resource from which the described resource is derived Applied Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Engineering (General). Civil engineering (General), Technology, Biology (General), Chemistry, Physics Relation A related resource <a href="https://www.mdpi.com/2076-3417/11/12/5391" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/2076-3417/11/12/5391</a> https://www.socictopen.socict.org/files/original/bef6e339cc4f0c0a4db9b31a4b15150d.pdf ebc40dfa106889f90e40f6ec21c62623 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In Vitro Antiviral Activity of Circular Triple Helix Forming Oligonucleotide RNA towards Feline Infectious Peritonitis Virus Replication Creator An entity primarily responsible for making the resource Oi Kuan Choong, Parvaneh Mehrbod, Bimo Ario Tejo, Abdul Rahman Omar Description An account of the resource Feline Infectious Peritonitis (FIP) is a severe fatal immune-augmented disease in cat population. It is caused by FIP virus (FIPV), a virulent mutant strain of Feline Enteric Coronavirus (FECV). Current treatments and prophylactics are not effective. The in vitro antiviral properties of five circular Triple-Helix Forming Oligonucleotide (TFO) RNAs (TFO1 to TFO5), which target the different regions of virulent feline coronavirus (FCoV) strain FIPV WSU 79-1146 genome, were tested in FIPV-infected Crandell-Rees Feline Kidney (CRFK) cells. RT-qPCR results showed that the circular TFO RNAs, except TFO2, inhibit FIPV replication, where the viral genome copy numbers decreased significantly by 5-fold log10 from 1014 in the virus-inoculated cells to 109 in the circular TFO RNAs-transfected cells. Furthermore, the binding of the circular TFO RNA with the targeted viral genome segment was also confirmed using electrophoretic mobility shift assay. The strength of binding kinetics between the TFO RNAs and their target regions was demonstrated by NanoITC assay. In conclusion, the circular TFOs have the potential to be further developed as antiviral agents against FIPV infection. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Identifier An unambiguous reference to the resource within a given context DOI: 10.1155/2014/654712 Source A related resource from which the described resource is derived BioMed Research International Publisher An entity responsible for making the resource available Hindawi Limited Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/be75f6db1099ee3424f7154570f2c850.pdf 780ea7397c205bd6c20f99c79e99f51a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In Vitro Diagnostic Assays for COVID-19: Recent Advances and Emerging Trends Creator An entity primarily responsible for making the resource Sandeep Kumar Vashist Description An account of the resource There have been tremendous advances in in vitro diagnostic (IVD) assays for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main IVD assays used for COVID-19 employ real-time reverse transcriptase polymerase chain reaction (RT-PCR) that takes a few hours. But the assay duration has been shortened to 45 min by Cepheid. Of interest is the point-of-care (POC) molecular assay by Abbott that decreased the assay duration to just 5 min. Most molecular tests have been approved by the United States Food and Drug Administration (FDA) under emergency use authorization (EUA) and are Conformité Européenne (CE) marked. A wide range of serology immunoassays (IAs) have also been developed that complement the molecular assays for the diagnosis of COVID-19. The most prominent IAs are automated chemiluminescent IA (CLIA), manual ELISA, and rapid lateral flow IA (LFIA), which detect the immunoglobulin M (IgM) and immunoglobulin G (IgG) produced in persons in response to SARS-CoV-2 infection. The ongoing research efforts and advances in complementary technologies will pave the way to new POC IVD assays in the coming months. However, the performance of IVD assays needs to be critically evaluated before they are employed for the clinical diagnosis of COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource SARS-CoV-2, COVID-19, diagnostics, real-time reverse transcriptase polymerase chain (RT-PCR), lateral flow immunoassay (LFIA), immuno-assays Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/diagnostics10040202 Source A related resource from which the described resource is derived Diagnostics Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/2b0e8d17f5d5fcb72eb09fde8adacbbb.pdf 40230c408d96c0feaf154dcd9132867b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In vitro inhibition of transmissible gastroenteritis coronavirus replication in swine testicular cells by short hairpin RNAs targeting the ORF 7 gene Creator An entity primarily responsible for making the resource He Lei, Zhang Yan-ming, Dong Ling-juan, Cheng Min, Wang Jing, Tang Qing-hai, Wang Gang Description An account of the resource Abstract Background Transmissible gastroenteritis (TGE) is a highly contagious viral disease of swine, characterized by severe vomiting, diarrhea, and high mortality. Currently, the vaccines for it are only partially effective and no specific drug is available for treatment of TGE virus (TGEV) infection. RNA interference has been confirmed as a new approach for controlling viral infections. In this study, the inhibitory effect of short hairpin RNAs (shRNAs) targeting the ORF 7 gene of TGEV on virus replication was examined. Results Four theoretically effective sequences of TGEV ORF 7 gene were designed and selected for construction of shRNA expression plasmids. In the reporter assays, three of four shRNA expression plasmids were able to inhibit significantly the expression of ORF 7 gene and replication of TGEV, as shown by real-time quantitative RT-PCR analysis of viral ORF 7 and N genes and detection of virus titers (TCID50/ml). Stable swine testicular (ST) cells expressing the shRNAs were established. Observation of the cytopathic effect and apoptosis, as well as a cell proliferation assay demonstrated that the three shRNAs were capable of protecting ST cells against TGEV destruction, with high specificity and efficiency. Conclusions Our results indicated that plasmid-transcribed shRNAs targeting the ORF 7 gene in the TGEV genome effectively inhibited expression of the viral target gene and viral replication in vitro. These findings provide evidence that the shRNAs have potential therapeutic application for treatment of TGE. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Transmissible gastroenteritis virus, RNA interference, short-hairpin RNA, ORF 7 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1743-422X-9-176 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN