1079 10 20655 https://www.socictopen.socict.org/files/original/a65d8f4f45402a42aac4efda9b0574e0.pdf f7cee52a8414f498a24433137ad35e82 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource How to rapidly design and operationalise PPE donning and doffing areas for a COVID-19 care facility: quality improvement initiative Creator An entity primarily responsible for making the resource LaxmiTej Wundavalli, Sheetal Singh, Angel Rajan Singh, Sidhartha Satpathy Description An account of the resource Introduction Effective implementation of standard precautions specific to COVID-19 is a challenge for hospitals within the existing constraints of time and resources.Aim To rapidly design and operationalise personal protective equipment (PPE) donning and doffing areas required for a COVID-19 care facility.Methods Literature review was done to identify all issues pertaining to donning and doffing in terms of Donabedian’s structure, process and outcome. Training on donning and doffing was given to hospital staff. Donning and doffing mock drills were held. 5S was used as a tool to set up donning and doffing areas. Instances of donning and doffing were observed for protocol deviations and errors. Plan–do–study–act cycles were conducted every alternate day for 4 weeks. The initiative was reported using Standards for QUality Improvement Reporting Excellence (SQUIRE) guidelines.Results Best practices in donning and doffing were described. Our study recommends a minimum area of 16 m2 each for donning and doffing rooms. Verbally assisted doffing was found most useful than visual prompts.Discussion Challenges included sustaining the structure and process of donning and doffing, varied supplies of PPE which altered sequencing of donning and/or doffing, and training non-healthcare workers such as plumbers, electricians and drivers who were required during emergencies in the facility.Conclusion Our study used evidence-based literature and quality improvement (QI) tools to design and operationalise donning and doffing areas with focus on people, task and environment. Our QI will enable healthcare facilities to rapidly prototype donning and doffing areas in a systematic way. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1136/bmjoq-2020-001022 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/5c46340e365b31579e3e2d235ea8a7f1.pdf 1d0ca520ab42043faf3b8964723b9133 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Animal coronaviruses and coronavirus disease 2019: Lesson for One Health approach Creator An entity primarily responsible for making the resource Uddab Poudel, Deepak Subedi, Saurav Pantha, Santosh Dhakal Description An account of the resource Coronaviruses are a group of enveloped, single-stranded, positive-sense RNA viruses which are broadly classified into Alpha, Beta, Gamma, and Delta coronaviruses genera based on the viral genome. Coronavirus was not thought to be a significant problem in humans until the outbreak of Severe Acute Respiratory Syndrome (SARS) in 2002 but infection in animals including pigs, cats, dogs and poultry has been problematic for long. The outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019 in Wuhan, China drew special attention towards this virus once again. The intermediate host of this novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is yet to be determined, but it has a very close genomic relationship with the bat coronavirus (BatCoV), RaTG13 strain, and the pangolin coronaviruses. As veterinary medicine has long term experience dealing with coronaviruses, this could be helpful in better understanding to detect the origin of SARS-CoV-2 and drive human medicine towards the development of vaccines and antiviral drugs through the collaborative and transdisciplinary approach of One Health. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource One health, covid-19, SARS-CoV-2, animal coronaviruses Identifier An unambiguous reference to the resource within a given context http://dx.doi.org/10.4314/ovj.v10i3.1 Source A related resource from which the described resource is derived Open Veterinary Journal Publisher An entity responsible for making the resource available Tripoli University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Zoology https://www.socictopen.socict.org/files/original/f5c3408404827d2769b706c5d64dfafd.pdf 70b0aa07793eeeaaec14f927babe36ed Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource An ecological study of socioeconomic predictors in detection of COVID-19 cases across neighborhoods in New York City Creator An entity primarily responsible for making the resource Richard S. Whittle, Ana Diaz-Artiles Description An account of the resource Abstract Background New York City was the first major urban center of the COVID-19 pandemic in the USA. Cases are clustered in the city, with certain neighborhoods experiencing more cases than others. We investigate whether potential socioeconomic factors can explain between-neighborhood variation in the COVID-19 test positivity rate. Methods Data were collected from 177 Zip Code Tabulation Areas (ZCTA) in New York City (99.9% of the population). We fit multiple Bayesian Besag-York-Mollié (BYM) mixed models using positive COVID-19 tests as the outcome, a set of 11 representative demographic, economic, and health-care associated ZCTA-level parameters as potential predictors, and the total number of COVID-19 tests as the exposure. The BYM model includes both spatial and nonspatial random effects to account for clustering and overdispersion. Results Multiple regression approaches indicated a consistent, statistically significant association between detected COVID-19 cases and dependent children (under 18 years old), population density, median household income, and race. In the final model, we found that an increase of only 5% in young population is associated with a 2.3% increase in COVID-19 positivity rate (95% confidence interval (CI) 0.4 to 4.2%, p=0.021). An increase of 10,000 people per km2 is associated with a 2.4% (95% CI 0.6 to 4.2%, p=0.011) increase in positivity rate. A decrease of $10,000 median household income is associated with a 1.6% (95% CI 0.7 to 2.4%, p Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, population density, Socio-economic factors, positivity rate, Besag-York-Mollié model, Youth dependency Identifier An unambiguous reference to the resource within a given context 10.1186/s12916-020-01731-6 Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/1bc6cd75840b7b17fdd0da7268eb08b5.pdf 401d7af17430a0eea15d64db3caba151 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Directly Acting Antivirals for COVID-19: Where Do We Stand? Creator An entity primarily responsible for making the resource Siew L. Teoh, Yi H. Lim, Nai M. Lai, Nai M. Lai, Nai M. Lai, Shaun W. H. Lee, Shaun W. H. Lee, Shaun W. H. Lee Description An account of the resource The outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China in December 2019 has now become a pandemic with no approved therapeutic agent. At the moment, the genomic structure, characteristics, and pathogenic mechanisms of SARS-CoV-2 have been reported. Based upon this information, several drugs including the directly acting antivirals have been proposed to treat people with coronavirus disease 2019 (COVID-19). This rapid review aims to describe the directly acting antivirals that have been examined for use in the management of COVID-19. Searches were conducted in three electronic databases, supplemented with a search on arXiv, bioRxiv, medRxiv, ChinaXiv, ClinicalTrials.gov, and Chinese Clinical Trial Registry for studies examining the use of antivirals in COVID-19 to identify for case reports, case series, observational studies, and randomized controlled studies describing the use of antivirals in COVID-19. Data were extracted independently and presented narratively. A total of 98 studies were included, comprising of 38 published studies and 60 registered clinical trials. These drugs include the broad spectrum antivirals such as umifenovir, protease inhibitors such as lopinavir/ritonavir as well as the RNA-dependent RNA polymerase inhibitors, remdesivir, and favipiravir. Other drugs that have been used include the nucleosidase inhibitors and polymerase acidic endonuclease inhibitors which are currently approved for prevention of influenza infections. While some of the drugs appear promising in small case series and reports, more clinical trials currently in progress are required to provide higher quality evidence. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Pandemic, systematic review, antivirals, Rapid review Identifier An unambiguous reference to the resource within a given context 10.3389/fmicb.2020.01857 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/979818e85839765b0a0e0015d0e1bb1f.pdf 222fb2a8adbc9b4cbf0c304dd7bf09fe Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Factors Affecting COVID-19 Outcomes in Cancer Patients: A First Report From Guy's Cancer Center in London Creator An entity primarily responsible for making the resource Beth Russell, Charlotte Moss, Sophie Papa, Sophie Papa, Sheeba Irshad, Sheeba Irshad, Paul Ross, James Spicer, James Spicer, Shahram Kordasti, Shahram Kordasti, Danielle Crawley, Danielle Crawley, Harriet Wylie, Fidelma Cahill, Anna Haire, Kamarul Zaki, Fareen Rahman, Ailsa Sita-Lumsden, Debra Josephs, Debra Josephs, Deborah Enting, Deborah Enting, Mary Lei, Sharmistha Ghosh, Claire Harrison, Claire Harrison, Angela Swampillai, Elinor Sawyer, Elinor Sawyer, Andrea D'Souza, Simon Gomberg, Paul Fields, David Wrench, Kavita Raj, Mary Gleeson, Kate Bailey, Richard Dillon, Richard Dillon, Matthew Streetly, Anne Rigg, Richard Sullivan, Saoirse Dolly, Mieke Van Hemelrijck, Mieke Van Hemelrijck Description An account of the resource Background: There is insufficient evidence to support clinical decision-making for cancer patients diagnosed with COVID-19 due to the lack of large studies.Methods: We used data from a single large UK Cancer Center to assess the demographic/clinical characteristics of 156 cancer patients with a confirmed COVID-19 diagnosis between 29 February and 12 May 2020. Logistic/Cox proportional hazards models were used to identify which demographic and/or clinical characteristics were associated with COVID-19 severity/death.Results: 128 (82%) presented with mild/moderate COVID-19 and 28 (18%) with a severe case of the disease. An initial cancer diagnosis >24 months before COVID-19 [OR: 1.74 (95% CI: 0.71–4.26)], presenting with fever [6.21 (1.76–21.99)], dyspnea [2.60 (1.00–6.76)], gastro-intestinal symptoms [7.38 (2.71–20.16)], or higher levels of C-reactive protein [9.43 (0.73–121.12)] were linked with greater COVID-19 severity. During a median follow-up of 37 days, 34 patients had died of COVID-19 (22%). Being of Asian ethnicity [3.73 (1.28–10.91)], receiving palliative treatment [5.74 (1.15–28.79)], having an initial cancer diagnosis >24 months before [2.14 (1.04–4.44)], dyspnea [4.94 (1.99–12.25)], and increased CRP levels [10.35 (1.05–52.21)] were positively associated with COVID-19 death. An inverse association was observed with increased levels of albumin [0.04 (0.01–0.04)].Conclusions: A longer-established diagnosis of cancer was associated with increased severity of infection as well as COVID-19 death, possibly reflecting the effects a more advanced malignant disease has on this infection. Asian ethnicity and palliative treatment were also associated with COVID-19 death in cancer patients. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource cancer, covid-19, SARS-CoV-2, Outcomes, directed acyclic graph Identifier An unambiguous reference to the resource within a given context 10.3389/fonc.2020.01279 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Neoplasms. Tumors. Oncology. Including cancer and carcinogens https://www.socictopen.socict.org/files/original/d498057f29ae23794ee68773a44083a5.pdf f48aa948701b45066dd304d43db6dbf5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Message from the Human Placenta: Structural and Immunomodulatory Defense against SARS-CoV-2 Creator An entity primarily responsible for making the resource Nina-Naomi Kreis, Andreas Ritter, Frank Louwen, Juping Yuan Description An account of the resource The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global public health crisis. Viral infections may predispose pregnant women to a higher rate of pregnancy complications, including preterm births, miscarriage, and stillbirth. Despite reports of neonatal COVID-19, definitive proof of vertical transmission is still lacking. In this review, we summarize studies regarding the potential evidence for transplacental transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterize the expression of its receptors and proteases, describe the placental pathology and analyze virus-host interactions at the maternal-fetal interface. We focus on the syncytium, the barrier between mother and fetus, and describe in detail its physical and structural defense against viral infections. We further discuss the potential molecular mechanisms, whereby the placenta serves as a defense front against pathogens by regulating the interferon type III signaling, microRNA-triggered autophagy and the nuclear factor-κB pathway. Based on these data, we conclude that vertical transmission may occur but rare, ascribed to the potent physical barrier, the fine-regulated placental immune defense and modulation strategies. Particularly, immunomodulatory mechanisms employed by the placenta may mitigate violent immune response, maybe soften cytokine storm tightly associated with severely ill COVID-19 patients, possibly minimizing cell and tissue damages, and potentially reducing SARS-CoV-2 transmission. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, Vertical transmission, miRNA, placenta, immune defense Identifier An unambiguous reference to the resource within a given context 10.3390/cells9081777 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/7aeaa5a5fc08061e2ecb1286bf29d350.pdf ecfe5959c8990e0228fdfd9fd501fce6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Türkçe Eğitiminde Dijital Yetkinlik Kavramının Farklı Değişkenler Açısından İncelenmesi Creator An entity primarily responsible for making the resource Hulusi GEÇGEL, Fatih KANA, Duygu EREN Description An account of the resource Dünyada ve Türkiye’de devam eden COVİD 19 salgını süresince araştıran, düşünen, üreten bireyin yanı sıra dijital yetkinliğe sahip bireylerin önemi ortaya çıkmıştır. Özellikle öğrencilerin okula gidememesi ve derslerin uzaktan yapılması süresince, teknolojik donanım eksikliği, içerik eksikliği ve bireylerin dijital yetkinlik eksikliği ön plana çıkmıştır. Bu çalışmanın amacı ortaokul öğrencilerinin dijital yetkinlik becerileriyle ilgili öğretmen görüşlerini belirlemektir. Bu amaç doğrultusunda araştırmada nitel araştırma yöntemlerinden durum çalışması deseni kullanılmıştır. Araştırmanın çalışma grubunu Türkiye’nin batısında yer alan bir devlet ortaokulunda görev yapan öğretmenler oluşturmaktadır. Araştırmanın veri analizinde içerik analizi yöntemi kullanılmıştır. Araştırmada veri toplama aracı olarak yarı yapılandırılmış görüşme formu kullanılmıştır. Okullarda FATİH projesinden dolayı etkileşimli tahtaların yeteri kadar bulunduğu ama bilgisayarların ihtiyacı karşılayacak düzeyde ve dijital çağa uygun olmadığı görülmüştür. Öğrencilerin proje merkezli değil de sınav merkezli yetiştiği, bu yüzden teknolojik araçlara yönelmede problem yaşandığı görülmüştür. Dünyayı etkisine alan COVİD 19 salgını sürecinde öğretmen ve öğrencilerin dijital yetkinlikler açısından yetiştirilmesi gerektiği görülmüştür. Bu araştırmada dijital yetkinlik açısından öğretmenlerin, öğrencilerin, programların ve kitapların yeniden değerlendirilmesi gerektiği sonucuna ulaşılmıştır. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, EBA, Fatih projesi, dijital yetkinlik, dijital öğrenme Identifier An unambiguous reference to the resource within a given context 10.16916/aded.742352 Source A related resource from which the described resource is derived Ana Dili Eğitimi Dergisi Publisher An entity responsible for making the resource available Mehmet KURUDAYIOĞLU Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Education https://www.socictopen.socict.org/files/original/a5079857e7c84e82e7f6a803f2652d67.pdf e9fecd4727a11d6fc727f7fff16dd6ea Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource How Did Chinese Government Implement Unconventional Measures Against COVID-19 Pneumonia Creator An entity primarily responsible for making the resource Yu X, Li N Description An account of the resource Xiang Yu,1 Na Li2,3 1School of Public Affairs, Fujian Jiangxia University, Fuzhou, Fujian Province, People’s Republic of China; 2School of Law, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of China; 3Research Academy of Belt and Road, Ningbo University, Ningbo, Zhejiang Province, People’s Republic of ChinaCorrespondence: Na LiNingbo University, 818st Fenghua Road Jiangbei, Ningbo 315211, People’s Republic of ChinaEmail nali321@126.comAbstract: In recent years, respiratory infectious diseases had continued to attack China, the recent outbreak of COVID-19 pneumonia had attracted worldwide attention. Through studying the literature, interpreting official documents, analyzing medical and social management data, we summarized and compared some powerful measures taken by the Chinese government, such as declaring emergency state, blocking down the epidemic center, prohibiting crowd gathering activities, forcing residents to wear masks, and mobilizing medical staff and products. We found that these unconventional measures, on the one hand, controlled the spread of the epidemic in China, and on the other hand, exposed some of China’s shortcomings in biosafety, food safety, public health input, and emergency system construction. This paper also recommends that other countries should take strict isolation measures as early as possible when fighting COVID-19 epidemics, and also mobilize citizens to strengthen self-protection.Keywords: COVID-19, anti-epidemic, risk, legality Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, anti-epidemic, risk；legality Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/fe17598daeaf6c42c7f520d17b447377.pdf fec047588dd778e6970c3d514b30e56d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Impact of Comorbidities on SARS-CoV-2 Viral Entry-Related Genes Creator An entity primarily responsible for making the resource Prabhatchandra Dube, Deepak Malhotra, David J. Kennedy, Steven T. Haller, Joshua D. Breidenbach, Subhanwita Ghosh, Belal N. Abdullah, Nikolai N. Modyanov, Lance D. Dworkin Description An account of the resource Viral entry mechanisms for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are an important aspect of virulence. Proposed mechanisms involve host cell membrane-bound angiotensin-converting enzyme 2 (ACE2), type II transmembrane serine proteases (TTSPs), such as transmembrane serine protease isoform 2 (TMPRSS2), lysosomal endopeptidase Cathepsin L (CTSL), subtilisin-like proprotein peptidase furin (FURIN), and even potentially membrane bound heparan sulfate proteoglycans. The distribution and expression of many of these genes across cell types representing multiple organ systems in healthy individuals has recently been demonstrated. However, comorbidities such as diabetes and cardiovascular disease are highly prevalent in patients with Coronavirus Disease 2019 (COVID-19) and are associated with worse outcomes. Whether these conditions contribute directly to SARS-CoV-2 virulence remains unclear. Here, we show that the expression levels of ACE2, TMPRSS2 and other viral entry-related genes, as well as potential downstream effector genes such as bradykinin receptors, are modulated in the target organs of select disease states. In tissues, such as the heart, which normally express ACE2 but minimal TMPRSS2, we found that TMPRSS2 as well as other TTSPs are elevated in individuals with comorbidities compared to healthy individuals. Additionally, we found the increased expression of viral entry-related genes in the settings of hypertension, cancer, or smoking across target organ systems. Our results demonstrate that common comorbidities may contribute directly to SARS-CoV-2 virulence and we suggest new therapeutic targets to improve outcomes in vulnerable patient populations. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, comorbidities, renin-angiotensin-aldosterone system, Bradykinin, tropism Identifier An unambiguous reference to the resource within a given context 10.3390/jpm10040146 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/db8d44241750d62af26b34b1a9dae467.pdf 37fe7f7737b48dc1f635e4acae6b44e3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Interaction of Hydroxychloroquine with Pharmacokinetically Important Drug Transporters Creator An entity primarily responsible for making the resource Johanna Weiss, Walter E. Haefeli, Gzona Bajraktari-Sylejmani Description An account of the resource (1) Background: Hydroxychloroquine is used to treat malaria and autoimmune diseases, and its potential use against COVID-19 is currently under investigation. Thus far, information on interactions of hydroxychloroquine with drug transporters mediating drug-drug interactions is limited. We assessed the inhibition of important efflux (P-glycoprotein (P-gp), breast cancer resistance protein (BCRP)) and uptake transporters (organic anion transporting polypeptide (OATP)-1B1, OATP1B3, OATP2B1) by hydroxychloroquine, tested its P-gp and BCRP substrate characteristics, and evaluated the induction of pharmacokinetically relevant genes regulated by the nuclear pregnane X (PXR) (CYP3A4, ABCB1) and aryl hydrocarbon receptor (AhR) (CYP1A1, CYP1A2). (2) Methods: Transporter inhibition was evaluated in transporter over-expressing cell lines using fluorescent probe substrates. P-gp and BCRP substrate characteristics were assessed by comparing growth inhibition of over-expressing and parental cell lines. Possible mRNA induction was analysed in LS180 cells by quantitative real-time PCR. (3) Results: Hydroxychloroquine did not inhibit BCRP or the OATPs tested but inhibited P-gp at concentrations exceeding 10 µM. P-gp overexpressing cells were 5.2-fold more resistant to hydroxychloroquine than control cells stressing its substrate characteristics. Hydroxychloroquine did not induce genes regulated by PXR or AhR. (4) Conclusions: This is the first evidence that hydroxychloroquine’s interaction potential with drug transporters is low, albeit bioavailability of simultaneously orally administered P-gp substrates might be increased by hydroxychloroquine. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Hydroxychloroquine, inhibition, P-glycoprotein, induction, drug-drug interaction, drug transporters Identifier An unambiguous reference to the resource within a given context 10.3390/pharmaceutics12100919 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica