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                <text>Francesco Nappi</text>
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                <text>The Annals of thoracic surgery</text>
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                <text>Incidence and Persistence of Viral Shedding in COVID-19 Post-acute Patients With Negativized Pharyngeal Swab: A Systematic Review</text>
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                <text>Giovanni Morone, Angela Palomba, Marco Iosa, Teodorico Caporaso, Domenico De Angelis, Vincenzo Venturiero, Anna Savo, Paola Coiro, Dario Carbone, Francesca Gimigliano, Giovanni Iolascon, Stefano Paolucci</text>
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                <text>After the global spread of a severe acute respiratory syndrome caused by a coronavirus (SARS-CoV-2), factors that influence viral diffusion have gained great attention. Human-to-human transmission mainly occurs through droplets, but viral RNA clearance in different biological fluids in coronavirus disease 2019 (COVID-19) remains unclear. We aimed to correlate the presence and the relevant temporal patterns of SARS-CoV-2 viral RNA in biological specimens (stool, urine, blood, and tears) of the transmission with clinical/epidemiological features in patients with COVID-19. We focused on the time window between the positivity of reverse transcriptase-polymerase chain reaction (RT-PCR) tests from different specimens. We used the Mantel–Cox log rank test to verify the differences in terms of viral shedding duration, while we employed the Mann–Whitney U-test for subgroup analysis. This review protocol was registered with PROSPERO number: CRD42020183629. We identified 147 studies; we included 55 (1,348 patients) for epidemiological analysis, of which we included 37 (364 patients) for statistical analysis. The most frequently used specimens other than respiratory tract swabs were stool samples (or anal/rectal swabs), with a positivity rate of 48.8%, followed by urine samples, with a positivity rate of 16.4%; blood samples showed a positivity rate of 17.5%. We found that fecal positivity duration (median 19 days) was significantly (p &amp;lt; 0.001) longer than respiratory tract positivity (median 14 days). Limited data are available about the other specimens. In conclusion, medical and social communities must pay close attention to negativization criteria for COVID-19, because patients could have longer alternative viral shedding.</text>
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                <text>10.3389/fmed.2020.00562</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Incidence of bacterial and fungal bloodstream infections in COVID-19 patients in intensive care: An alarming collateral effect"."</text>
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                <text>Nicola Petrosillo, Alessandro Capone, Emanuela Caraffa, Luisa Marchioni, Nardi Tetaj, Marina Selleri, Antonino Di Caro, Maria Adriana Cataldo</text>
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                <text>10.1016/j.jgar.2020.10.004</text>
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                <text>Journal of global antimicrobial resistance</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Incidence of COVID-19 in random trauma patients at DHQ Teaching Hospital, Rawalpindi, measures to prevent its spread among patients and health care workers</text>
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                <text>Tariq Nawaz, Bilal Mehmood, Muhammad Waqas Ayub, Irfan Malik, Umar Qaisar</text>
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                <text>Background: The objective of the study was to see the incidence of COVID-19 positive, in random trauma patients received in the emergency of abdomen or chest may be penetrating or blunt.  Materials and Methods: This study was conducted in the Accident and Emergency department of District Head Quarter Hospital, Rawalpindi. All trauma patients of abdomen or chest either penetrating or blunt admitted from 1-3-20 to 10-6-20 were included, irrespective of age, gender, comorbidities, and COVID-19 status at the time of admission to hospital. Also to see steps of preventive measures taken in the emergency department, operation theatres, and inwards.  Results: Total number of trauma patients received in the emergency department of District Headquarter Hospital Rawalpindi during this period was 163. Total male patients: 116. Total female patients:47. Penetrating injuries (firearm or stab wounds): 93. Blunt injuries: 70. All the penetrating injuries were operated as an emergency. Among blunt injuries, 51 were operated 19 were treated conservatively. Preoperatively none of the patients’ COVID-19 test was performed because none of them showed any symptoms likely of COVID-19 such as chest infection, flue, malaise, or fever. After the second postoperative day, 12 of the patients developed respiratory distress and their COVID-19 test was sent. Out of 12 patients, 7 turned out to be COVID-19 positive. Other on the second or third postoperative day 7 patients had fever without chest symptoms and underwent COVID-19 testing. 3 turned out to be COVID-19 positive. So a total of 11 patients were found to be positive for COVID-19. The percentage became 6.7% which is quite high.  Conclusion: From this study, its clear in acute trauma patients where you can’t go for the COVID-19 test even then we have to operate may be positive. So every trauma patient should have suspected COVID-19 positive and preventive measures should be taken starting from the emergency department till operation theatres.</text>
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                <text>2020</text>
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                <text>covid-19, Trauma Patients, Preventive measures in emergency, operation theaters and ward</text>
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                <text>10.37939/jrmc.v24iSupp-1.1437</text>
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                <text>Journal of Rawalpindi Medical College</text>
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                <text>Rawalpindi Medical University</text>
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                <text>Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Incidence of respiratory viruses in a pediatric population: molecular and epidemiological aspects</text>
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                <text>Anna Di Taranto, Rosella De Nittis, Mariantonietta Di Stefano, Giuseppina Faleo, Maria Rosaria Lipsi, Valeria Delli Carri, Mariangela Pugliese, Teresa Colapietra, Rosaria Agriesti, Raffaele Antonetti</text>
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                <text>Introduction: Respiratory infections are not well defined and the etiology is often unknown. Material and method: four hundred fortynine subjectrs were enrolled in the study; in all patientes there was a suspect of inflammatory diseases of the respiratory tract. At admission, a nasopharyngeal swab was made. A multiplex PCR was performed after extraction and reverse transcription of viral RNA. The amplified fragments were revealed by using an electrophoresis separation. Results: Two hundred and four patients (45.4%) were hospitalized for infection of the upper respiratory tract, 141 (31.4%) for lower respiratory infection and the remaining (23%) for other symptoms. One hundred fiftyseven (35%) patients were positive for human influenza A (H1N1 subtype) and 184 for other respiratory viruses,of which 59 (32%) gave a positive for respiratory syncytial virus, 42 (23%) for rhinovirus, 31 (17%) for parainfluenza virus, 12 (6.5%) for coronavirus, 28 (15%) for adenovirus and 6 (3%) for influenza B (3%) and 6 (3%) for metapneumovirus. The M1 gene sequence of influenza A H1N1 strains from 12 patients had a high identity with that of the reference virus. Conclusion: Furthermore H1N1 and RSV were the main causative agents of acute respiratory infection. A molecular approach provides an accurate and rapid aetiological diagnosis of viral respiratory infections. The molecolar features in the M1 gene suggested that the H1N1 influenza strains circulating in Apulia region had a conserved genetic make up.</text>
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                <text>2012</text>
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                <text>Respiratory viruses, Human Influenza A, H1N1</text>
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                <text>DOI: 10.4081/mm.2012.2300</text>
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                <text>Microbiologia Medica</text>
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                <text>Microbiology</text>
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                <text>EN, IT</text>
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                <text>Ofelia Baniandrés-Rodríguez, Jaime Vilar-Alejo, Raquel Rivera, José Manuel Carrascosa, Esteban Daudén, Enrique Herrera-Acosta, Antonio Sahuquillo-Torralba, Fran J Gómez-García, Lula María Nieto-Benito, Pablo de la Cueva, José Luis López-Estebaranz, Isabel Belinchón, Marta Ferrán Farrés, Mercè Alsina, Lourdes Rodríguez Fernández-Freire, Gregorio Carretero, Carmen García-Donoso, Ferrán Ballescá, Mar Llamas-Velasco, Enrique Herrera-Ceballos, Rafael Botella-Estrada, Diana Patricia Ruiz-Genao, Josep Riera-Monroig, Miguel Ángel Descalzo Gallego, Ignacio García-Doval</text>
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                <text>10.1016/j.jaad.2020.10.046</text>
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              <elementText elementTextId="66674">
                <text>Journal of the American Academy of Dermatology</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Incidence of Sino-Nasal Symptoms in COVID-19 Patients.</text>
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              <elementText elementTextId="64301">
                <text>M Meenakshi, K Deepak Raj, R Nandhini</text>
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                <text>Corona virus disease was first reported in December 2019 in Wuhan, China and is spreading across the world in an alarming fashion. To contain the spread, it is very important to identify the subtle/not readily apparent symptoms of COVID-19 at the earliest. The aim of the study is to determine the incidence duration progress of sino-nasal symptoms in COV 2 positive patients using SNAQ scoring. Patients who tested positive for SARS-COV 2 by RT-PCR and admitted in our hospital under category A (n = 382) were included in the study. A detailed history was collected from all the patients and sino-nasal assessment questionnaire (SNAQ) was provided to the patient with complaints of sinonasal symptoms and they were asked to fill the forms on day 3, 7 and 14. To identify the characteristics of sinonasal symptoms in COVID-19 patients with a history of smoking, smoking history was also collected in detail and patients were classified based on Brinkman's index into mild, moderate and severe smokers. In this study, the incidence of sinonasal symptoms was 24%. Average SNAQ scoring on day 3 was 30.09 and on day 7 was 12.9 and day 14 is 3.8. There was a decline in score on day 7 compared to day 3 indicating symptoms decrease by day7. Average SNAQ scoring in non-smokers and mild and moderate smokers was 20.18, 34.11, 57.5 respectively. The SNAQ scoring in smokers was more than that of non-smokers and was also persistent for a longer duration compared to non-smokers. Sino-nasal symptoms catch our eye because it is an important route for transmission. Viral shedding from sinonasal tract may be an important source for transmission. History and degree of smoking should also be considered while dividing COVID-19 patients into categories.</text>
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                <text>2021</text>
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                <text>Incidence, SARS-CoV-2, COVID‐19, smoker, Paranasal sinus, SNAQ, Sinonasal assessment questionnaire</text>
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                <text>10.1007/s12070-021-02569-x</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="64306">
                <text>Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: A prospective cohort study.</text>
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              <elementText elementTextId="69212">
                <text>Jiazhen Zheng, Rui Zhou, Fengjuan Chen, Guofang Tang, Keyi Wu, Furong Li, Huamin Liu, Jianyun Lu, Jiyuan Zhou, Ziying Yang, Yuxin Yuan, Chunliang Lei, Xianbo Wu</text>
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            <description>An account of the resource</description>
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                <text>The phenomenon of COVID-19 patients tested positive for SARS-CoV-2 after discharge (redetectable as positive, RP) emerged globally. The data of incidence rate and risk factors for RP event and the clinical features of RP patients may provide recommendations for virus containment and cases management for COVID-19. We prospectively collected and analyzed the epidemiological, clinical and virological data from 285 adult patients with COVID-19 and acquired their definite clinical outcome (getting PCR positive or not during post-discharge surveillance). By March 10, 27 (9.5%) discharged patients had tested positive for SARS-CoV-2 in their nasopharyngeal swab after a median duration of 7·0 days (IQR 5·0-8·0). Compared to first admission, RP patients generally had milder clinical symptoms, lower viral load, shorter length of stay and improved pulmonary conditions at readmission (p0.05). A prolonged duration of viral shedding (&gt;10 days) during the first hospitalization [adjusted odds ratio [aOR]: 5.82, 95% confidence interval [CI]: 2.50-13.57 for N gene; aOR: 9.64, 95% CI: 3.91-23.73 for ORF gene] and higher Ct value (ORF) in the third week of the first hospitalization (aOR: 0.69; 95% CI: 0.50-0.95) were associated with RP events. In conclusion, RP events occurred in nearly 10% of COVID-19 patients shortly after the negative tests, were not associated with worsening symptoms and unlikely reflect reinfection. Patients' lack of efficiency in virus clearance was a risk factor for RP result. It is noteworthy that elder RP patients (≥ 60 years old) were more susceptible to clinical symptoms at readmission.</text>
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                <text>2020</text>
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              <elementText elementTextId="69215">
                <text>10.1371/journal.pntd.0008648</text>
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              <elementText elementTextId="69216">
                <text>PLoS Neglected Tropical Diseases</text>
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                <text>Public Library of Science (PLoS)</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="69218">
                <text>Public aspects of medicine, Arctic medicine. Tropical medicine</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S8.</text>
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                <text>Sònia Jiménez, Òscar Miró, Pere Llorens, Francisco J Martín-Sánchez, Guillermo Burillo-Putze, Pascual Piñera, Alfonso Martín, Aitor Alquézar, Eric J García-Lamberechts, Javier Jacob, María L L Grima, Javier Millán, Francisca Molina, Patricia B Albero, Carlos Cardozo, Josep M Mòdol, Alfons Aguirre, Ruth Gaya, María Adroher, Lluís Llauger, Juan J L Díaz, Nayra C González, Paula L Aragües, Ana P Gómez, Juan G Del Castillo</text>
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                <text>A higher incidence of venous thromboembolism [both pulmonary embolism and deep vein thrombosis (DVT)] in patients with coronavirus disease 2019 (COVID-19) has been described. But little is known about the true frequency of DVT in patients who attend emergency department (ED) and are diagnosed with COVID-19. We investigated the incidence, risk factors, clinical characteristics and outcomes of DVT in patients with COVID-19 attending the ED before hospitalization. We retrospectively reviewed all COVID patients diagnosed with DVT in 62 Spanish EDs (20% of Spanish EDs, case group) during the first 2 months of the COVID-19 outbreak. We compared DVT-COVID-19 patients with COVID-19 without DVT patients (control group). Relative frequencies of DVT were estimated in COVID and non-COVID patients visiting the ED and annual standardized incidences were estimated for both populations. Sixty-three patient characteristics and four outcomes were compared between cases and controls. We identified 112 DVT in 74 814 patients with COVID-19 attending the ED [1.50‰; 95% confidence interval (CI), 1.23-1.80‰]. This relative frequency was similar than that observed in non-COVID patients [2109/1 388 879; 1.52‰; 95% CI, 1.45-1.69‰; odds ratio (OR) = 0.98 [0.82-1.19]. Standardized incidence of DVT was higher in COVID patients (98,38 versus 42,93/100,000/year; OR, 2.20; 95% CI, 2.03-2.38). In COVID patients, the clinical characteristics associated with a higher risk of presenting DVT were older age and having a history of venous thromboembolism, recent surgery/immobilization and hypertension; chest pain and desaturation at ED arrival and some analytical disturbances were also more frequently seen, d-dimer &gt;5000 ng/mL being the strongest. After adjustment for age and sex, hospitalization, ICU admission and prolonged hospitalization were more frequent in cases than controls, whereas mortality was similar (OR, 1.37; 95% CI, 0.77-2.45). DVT was an unusual form of COVID presentation in COVID patients but was associated with a worse prognosis.</text>
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                <text>2021</text>
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                <text>10.1097/MEJ.0000000000000783</text>
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              <elementText elementTextId="59501">
                <text>European journal of emergency medicine : official journal of the European Society for Emergency Medicine</text>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="88122">
                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>INCIDÊNCIA DA MOSCA-DAS-FRUTAS, Anastrepha fraterculus (DIPTERA: TEPHRITIDAE), EM CULTIVARES DE AMEIXA CONDUZIDAS SOB SISTEMA ORGÂNICO</text>
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              <elementText elementTextId="210347">
                <text>Paulo Antônio de Souza Gonçalves, João Favorito  Debarba, Cláudio Keske</text>
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            <description>An account of the resource</description>
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                <text>O objetivo deste trabalho foi avaliar os danos causados por mosca-das-frutas, Anastrepha fraterculus, em cultivares de ameixa no sistema orgânico. O trabalho de campo foi realizado em Ituporanga, SC, durante três safras consecutivas. As cultivares de ameixa avaliadas foram: Irati, Centenária, Rosa Mineira, Januária, Pluma 7, Reubenel, Carazinho e Santa Rosa Polirosa. Todas as cultivares apresentaram alta perda de frutos devido ao ataque da mosca-das-frutas. Entretanto na cultivar Irati, cuja colheita ocorre até meados de dezembro, o nível de danos causados pela mosca foi menor. Os resultados sugerem ser necessário desenvolver-se outras estratégias de manejo do inseto além da triagem de cultivares.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="210349">
                <text>2014</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="210350">
                <text>Agricultura orgânica, agroecologia, inseto</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="210351">
                <text>Revista de Ciências Agroveterinárias</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="210352">
                <text>Universidade do Estado de Santa Catarina</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="210353">
                <text>Agriculture (General), Agriculture, Veterinary medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="210354">
                <text>&lt;a href="https://www.revistas.udesc.br/index.php/agroveterinaria/article/view/5408" target="_blank" rel="noreferrer noopener"&gt;https://www.revistas.udesc.br/index.php/agroveterinaria/article/view/5408&lt;/a&gt;</text>
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