1090 10 20655 https://www.socictopen.socict.org/files/original/e37020d3320fac9b86ba2056530c3362.pdf c91a96434c26372b5c6f7c9b2a52fc48 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The tech-novation pathway from pandemic to prosperity: a post Covid-19 roadmap for African economy Creator An entity primarily responsible for making the resource Ayodeji A. Aduloju, Temitayo A. Adedoyin Description An account of the resource While the post-colonial African economy remains the poorest performing economy globally, the outbreak of the Coronavirus pandemic has further gravely aggravated its precarious position in the world. This study reflects on the multiple impacts of Covid-19 on African economy and suggests a pathway for its revitalization in the post Covid-19 environment. Undoubtedly, the Covid-19 pandemic has brought the world to a temporary halt, with its attendant bruises mostly notable on the economies of almost all African countries. This paper empirically analyse the incapacitation of African states in providing some strategic responses to the economic wreckages caused by the pandemic. Using technological-determinism as a theoretical framework, this study suggests the technological-innovation pathway as a bridge between the pandemic-induced economic circumstances and prosperity for Africa. Sequentially, the five junctions on the pathway splits as pulling, recovery, innovations, growth, and sustainability (PRIGS), but, however, the kernel of the discussion revolves around the commodification of innovation (technology) for Africa’s economic growth and development. This study concludes, the five junctions on the PRIGS’ highway absorbs the current developmental challenges of African states and hence, recommends an alternative roadmap for Africa, in its long-term quest and vision for development Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, innovation, Technology, recovery, managerial control, pulling, development service industry, managerial risks Identifier An unambiguous reference to the resource within a given context 10.46224/ecoc.2020.3.1 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Management. Industrial management https://www.socictopen.socict.org/files/original/b5e29e1f50ad3620c729e04bf3fcf589.pdf 5bca1df8d3002e9811cfda890542a709 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Interventions and compliance Creator An entity primarily responsible for making the resource Girvin Liggans, Devin Dutilly, Komita Carrington-Liggans, Mary Cartagena, Charles Idjagboro, Laurie Williams, Glenda Lewis, Mia Russell, Veronica Moore, Robert Sudler Description An account of the resource Preventing the spread of infectious disease relies heavily upon the development and implementation of public health interventions. The requisite debate over the effectiveness of these interventions is accom­panied by discussions about which, if any, should be made mandatory. We contend that efforts to man­date interventions in the fight to prevent the spread of COVID-19 have clear similarities to the long­standing efforts to establish and promote retail food safety interventions. Specific similarities are that science is rarely the sole driver in deciding public health mandates and individuals’ responses to them, compliance is key but can be difficult to achieve, and the concurrent incorporation of two or more interventions is a barrier against poor compliance. As these factors have a direct effect on the success of public health mandates, understanding the role and relationships among them can aid government and public health officials in ongoing efforts to prevent foodborne illness and slow the spread of COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Pandemic, interventions, decision making, compliance, Retail Food Safety Identifier An unambiguous reference to the resource within a given context 10.5304/jafscd.2020.101.007 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture, Environmental sciences, Geography. Anthropology. Recreation, Technology, Social Sciences, Nutrition. Foods and food supply, Recreation. Leisure, Urban groups. The city. Urban sociology, Regional planning, Communities. Classes. Races, Human ecology. Anthropogeography, Home economics https://www.socictopen.socict.org/files/original/b73e3c929e5290c486a46b43527a7894.pdf b992e3fd11cbf23f556a0c1ba96e1e6c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 and Extracellular Vesicles: An Intriguing Interplay Creator An entity primarily responsible for making the resource Gabriella Pocsfalvi, Ramila Mammadova, Ana Paulina Ramos Juarez, Ramesh Bokka, Francesco Trepiccione, Giovambattista Capasso Description An account of the resource Background: The outbreak of severe acute respiratory syndrome β-coronavirus 2 (SARS-CoV-2) has the potential to become a long-lasting global health crisis. The number of people infected with the novel coronavirus has surpassed 22 million globally, resulting in over 700,000 deaths with more than 15 million people having recovered (https://covid19.who.int). Enormous efforts are underway for rapid vaccine and treatment developments. Amongst the many ways of tackling the novel coronavirus disease 2019 (COVID-19) pandemic, extracellular vesicles (EVs) are emerging. Summary: EVs are lipid bilayer-enclosed structures secreted from all types of cells, including those lining the respiratory tract. They have established roles in lung immunity and are involved in the pathogenesis of various lung diseases, including viral infection. In this review, we point out the roles and possible contribution of EVs in viral infections, as well as ongoing EV-based approaches for the treatment of COVID-19, including clinical trials. Key Messages: EVs share structural similarities to viruses and recent findings demonstrate that viruses exploit EVs for cellular exit and EVs exploit viral entry mechanisms for cargo delivery. Moreover, EV-virus interplay could be exploited for future antiviral drug and vaccine development. EV-based therapies, especially the mesenchymal stem cell-derived EVs, are being intensively studied for the treatment of COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, Extracellular vesicles, Pulmonary disease Identifier An unambiguous reference to the resource within a given context 10.1159/000511402 Source A related resource from which the described resource is derived Kidney & Blood Pressure Research Publisher An entity responsible for making the resource available Karger Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the circulatory (Cardiovascular) system, Dermatology, Diseases of the genitourinary system. Urology https://www.socictopen.socict.org/files/original/ed9930cc65e9a1b395fd177fa991df5b.pdf 02085295299433714455a6a88ec07455 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular Targets for Diagnostics and Therapeutics of Severe Acute Respiratory Syndrome (SARS-CoV) Creator An entity primarily responsible for making the resource Mavanur R. Suresh, Pravin K. Bhatnagar, Dipankar Das Description An account of the resource PURPOSE. The large number of deaths in a short period of time due to the spread of severe acute respiratory syndrome (SARS) infection led to the unparalleled collaborative efforts world wide to determine and characterize the new coronavirus (SARS-CoV). The full genome sequence was determined within weeks of the first outbreak by the Canadian group with international collaboration. As per the World Health Organization (WHO), the continual lack of a rapid laboratory test to aid the early diagnosis of suspected cases of SARS makes this area a priority for future research. To prevent deaths in the future, early diagnosis and therapy of this infectious disease is of paramount importance. METHODS. This review describes the specific molecular targets for diagnostics and therapeutics of viral infection. RESULTS. The three major diagnostic methods available for SARS includes viral RNA detection by reverse transcription polymerase chain reaction (RT-PCR), virus induced antibodies by immunofluorescence assay (IFA) or by enzyme linked immunosorbant assay (ELISA) of nucleocapsid protein (NP). The spike glycoprotein of SARS-CoV is the major inducer of neutralizing antibodies. The receptor binding domain (RBD) in the S1 region of the spike glycoprotein contains multiple conformational epitopes that induces highly potent neutralizing antibodies. The genetically engineered attenuated form of the virus or viral vector vaccine encoding for the SARS-CoV spike glycoprotein has been shown to elicit protective immunity in vaccinated animals. CONCLUSION. NP is the preferred target for routine detection of SARS-CoV infection by ELISA which is an economical method compared to other methods. The RBD of the spike glycoprotein is both a functional domain for cell receptor binding and also a major neutralizing determinant of SARS-CoV. The progress in evaluating a therapeutic or vaccine would depend on the availability of clinically relevant animal model. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Identifier An unambiguous reference to the resource within a given context 10.18433/J3J019 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology, Pharmacy and materia medica https://www.socictopen.socict.org/files/original/e7b784980877ce1738296a4b050b63c4.pdf 8130ea4876bbe4cfd3537a228a089d55 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Approaches for Covid-19 infection control in the workplaces Creator An entity primarily responsible for making the resource Ehsan Rafeemanesh, Farzaneh Rahimpour, Maryam Memarzadeh Description An account of the resource Introduction: Due to the spread of the new coronavirus around the world, workplaces are not safe against this disease. Different guidelines have been promoted by international organizations regarding high-risk jobs and the necessity of implementing health rules in the workplaces. According to the considerable number of incidence of this disease in our country, the aim of this review article is to evaluate the epidemiologic studies on prevention and control of new coronavirus in the workplaces. Method: In this study, with the aim of evaluating occupational risk factors for new coronavirus infection, different databases such as Scopus, PubMed, and Google Scholar from 2019 to 2020 and CDC, NIOSH, OSHA, and WHO instructions were evaluated. 18 articles and 5 instructions were selected for this review article. Results: Investigations revealed that most of occupations such as healthcare workers, waste workers, and public transportation staff are at increased risk of this disease. Conclusion: All members of the society including employers, employees and laborers should be completely ready to overcome the virus, even if the epidemic has not been spreading in that country or area. This point can be effective on the reduction of lost workdays, work absenteeism and prevent the spread of the virus in the community. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, control, workplaces, occupation Source A related resource from which the described resource is derived طب کار Publisher An entity responsible for making the resource available Shahid Sadoughi University of Medical Science Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Special situations and conditions https://www.socictopen.socict.org/files/original/964312a5e82facff3350ecc231a39c7e.pdf d3b9c26f9cbcc0c48a5a619eb484a2be Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SR/RS Motifs as Critical Determinants of Coronavirus Life Cycle Creator An entity primarily responsible for making the resource Eleni Nikolakaki, Thomas Giannakouros Description An account of the resource SR/RS domains are found in almost all eukaryotic genomes from C. elegans to human. These domains are thought to mediate interactions between proteins but also between proteins and RNA in complex networks associated with mRNA splicing, chromatin structure, transcription, cell cycle and cell structure. A precise and tight regulation of their function is achieved through phosphorylation of a number of serine residues within the SR/RS motifs by the Serine-Arginine protein kinases (SRPKs) that lead to delicate structural alterations. Given that coronavirus N proteins also contain SR/RS domains, we formulate the hypothesis that the viruses exploit the properties of these motifs to promote unpacking of viral RNA and virion assembly. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Coronaviruses, N protein, SR protein kinases, SR/RS motifs, capsid assembly/disassembly Identifier An unambiguous reference to the resource within a given context 10.3389/fmolb.2020.00219 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/823ce4a60b711fed83f60c5275e382e9.pdf a02d319c8e2f6100075e3b546b3aff71 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Clinical, laboratory and radiological characteristics and outcomes of novel coronavirus (SARS-CoV-2) infection in humans: A systematic review and series of meta-analyses Creator An entity primarily responsible for making the resource Israel Júnior Borges do Nascimento, Thilo Caspar von Groote, Dónal P. O’Mathúna, Hebatullah Mohamed Abdulazeem, Catherine Henderson, Umesh Jayarajah, Ishanka Weerasekara, Tina Poklepovic Pericic, Henning Edgar Gerald Klapproth, Livia Puljak, Nensi Cacic, Irena Zakarija-Grkovic, Silvana Mangeon Meirelles Guimarães, Alvaro Nagib Atallah, Nicola Luigi Bragazzi, Milena Soriano Marcolino, Ana Marusic, Ana Jeroncic, On behalf of the International Task Force Network of Coronavirus Disease 2019 (InterNetCOVID-19), Ehab Farag Description An account of the resource New evidence on the COVID-19 pandemic is being published daily. Ongoing high-quality assessment of this literature is therefore needed to enable clinical practice to be evidence-based. This review builds on a previous scoping review and aimed to identify associations between disease severity and various clinical, laboratory and radiological characteristics. We searched MEDLINE, CENTRAL, EMBASE, Scopus and LILACS for studies published between January 1, 2019 and March 22, 2020. Clinical studies including ≥10 patients with confirmed COVID-19 of any study design were eligible. Two investigators independently extracted data and assessed risk of bias. A quality effects model was used for the meta-analyses. Subgroup analysis and meta-regression identified sources of heterogeneity. For hospitalized patients, studies were ordered by overall disease severity of each population and this order was used as the modifier variable in meta-regression. Overall, 86 studies (n = 91,621) contributed data to the meta-analyses. Severe disease was strongly associated with fever, cough, dyspnea, pneumonia, any computed tomography findings, any ground glass opacity, lymphocytopenia, elevated C-reactive protein, elevated alanine aminotransferase, elevated aspartate aminotransferase, older age and male sex. These variables typically increased in prevalence by 30–73% from mild/early disease through to moderate/severe disease. Among hospitalized patients, 30–78% of heterogeneity was explained by severity of disease. Elevated white blood cell count was strongly associated with more severe disease among moderate/severe hospitalized patients. Elevated lymphocytes, low platelets, interleukin-6, erythrocyte sedimentation rate and D-dimers showed potential associations, while fatigue, gastrointestinal symptoms, consolidation and septal thickening showed non-linear association patterns. Headache and sore throat were associated with the presence of disease, but not with more severe disease. In COVID-19, more severe disease is strongly associated with several clinical, laboratory and radiological characteristics. Symptoms and other variables in early/mild disease appear non-specific and highly heterogeneous. Clinical Trial Registration: PROSPERO CRD42020170623. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine https://www.socictopen.socict.org/files/original/fa4e18cb0f4b060ed59d7509a40d39b3.pdf 808ae9521dca70dad658d2af698d1239 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource IMPACT OF COVID-19 PANDEMIC ON TOURISM: RECOVERY PROPOSAL FOR FUTURE TOURISM Creator An entity primarily responsible for making the resource Santus Kumar DEB, Shohel Md. NAFI Description An account of the resource The aim of the study was to examine the consequence of the COVID-19 pandemic on tourism. Qualitative analysis was adopted, whereas data were collected from secondary sources like journals, newspapers, statistical data obtained from international tourism organizations, and websites on COVID-19 incidences in tourism. Due to the outbreak, it had a severe adverse impact on tourism and employment. Airlines have canceled flights, and hotels are almost vacant; thus, supporting tourism agencies face substantial economic losses and employment cuts. This study develops a framework with a recovery plan for future tourism across a slogan: putting people first and travel tomorrow. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, Pandemic, Tourism, travel restriction, Future tourism Identifier An unambiguous reference to the resource within a given context 10.30892/gtg.334spl06-597 Source A related resource from which the described resource is derived Geo Journal of Tourism and Geosites Publisher An entity responsible for making the resource available Editura Universităţii din Oradea Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Geography. Anthropology. Recreation, Geography (General) https://www.socictopen.socict.org/files/original/3b78d227d6695a83cc7e416e37069b44.pdf f3fb13d43e533712033ff69b8fdc1ea9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study Creator An entity primarily responsible for making the resource Sai Chen, Hanting Liu, Tie Li, Rong Huang, Rong Gui, Junhua Zhang Description An account of the resource Background The novel coronavirus disease 2019 (COVID-19) is currently breaking out worldwide. COVID-19 patients may have different degrees of coagulopathy, but the mechanism is not yet clear. We aimed to analyse the relationship between coagulation dysfunction and liver damage in patients with COVID-19. Methods A retrospective analysis of 74 patients with COVID-19 admitted to the First People’s Hospital of Yueyang from 1 January to 30 March 2020 was carried out. According to the coagulation function, 27 cases entered the coagulopathy group and 47 cases entered the control group. A case control study was conducted to analyse the correlation between the occurrence of coagulation dysfunction and liver damage in COVID-19 patients. Results Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), markers of liver damage, were positively correlated with coagulopathy (p = 0.039, OR 2.960, 95% CI 1.055–8.304; and p = 0.028, OR 3.352, 95% CI 1.137–9.187). Alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GT), and total bilirubin (TBIL) were not statistically correlated with coagulopathy. According to the diagnosis and treatment plan, the included cases were classified into mild, moderate, severe, and critical. The results showed that the occurrence of coagulation dysfunction had no statistical correlation with the severity of COVID-19. Conclusion Coagulation dysfunction in patients with COVID-19 is closely related to liver damage. A longer course of the disease may cause a vicious circle of coagulopathy and liver damage. Clinicians need to closely monitor coagulation and liver function tests and to give prophylactic or supportive therapy when needed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, pneumonia, SARS-CoV-2, liver damage, blood coagulation dysfunction Identifier An unambiguous reference to the resource within a given context 10.1080/03009734.2020.1822960 Source A related resource from which the described resource is derived Upsala Journal of Medical Sciences Publisher An entity responsible for making the resource available Upsala Medical Society Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/c6f71845cb4727c231fbd47a7702036f.pdf 0fdb4829ad7174192e63806a1b40f7db Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Multi-System Inflammatory Syndrome in Children (MIS-C) Following SARS-CoV-2 Infection: Review of Clinical Presentation, Hypothetical Pathogenesis, and Proposed Management Creator An entity primarily responsible for making the resource Satyan Lakshminrusimha, Natasha A. Nakra, Dean A. Blumberg, Angel Herrera-Guerra Description An account of the resource Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, kawasaki disease, hemophagocytic lymphohistiocytosis, Multisystem inflammatory syndrome in children (MIS-C), toxic shock syndrome Identifier An unambiguous reference to the resource within a given context 10.3390/children7070069 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics