1093 10 20655 https://www.socictopen.socict.org/files/original/db19888800c8e34f072f7f3aa39fe8ac.pdf 0131f00bc456c100d5c9c2ac50f1c116 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infants hospitalized for Bordetella pertussis infection commonly have respiratory viral coinfections Creator An entity primarily responsible for making the resource A. Frassanito, R. Nenna, A. Nicolai, A. Pierangeli, A.E. Tozzi, P. Stefanelli, R. Carsetti, C. Concato, I. Schiavoni, F. Midulla, the Pertussis study group Description An account of the resource Abstract Background Whether viral coinfections cause more severe disease than Bordetella pertussis (B. pertussis) alone remains unclear. We compared clinical disease severity and sought clinical and demographic differences between infants with B. pertussis infection alone and those with respiratory viral coinfections. We also analyzed how respiratory infections were distributed during the 2 years study. Methods We enrolled 53 infants with pertussis younger than 180 days (median age 58 days, range 17–109 days, 64.1% boys), hospitalized in the Pediatric Departments at “Sapienza” University Rome and Bambino Gesù Children’s Hospital from August 2012 to November 2014. We tested in naso-pharyngeal washings B. pertussis and 14 respiratory viruses with real-time reverse-transcriptase-polymerase chain reaction. Clinical data were obtained from hospital records and demographic characteristics collected using a structured questionnaire. Results 28/53 infants had B. pertussis alone and 25 viral coinfection: 10 human rhinovirus (9 alone and 1 in coinfection with parainfluenza virus), 3 human coronavirus, 2 respiratory syncytial virus. No differences were observed in clinical disease severity between infants with B. pertussis infection alone and those with coinfections. Infants with B. pertussis alone were younger than infants with coinfections, and less often breastfeed at admission. Conclusions In this descriptive study, no associations between clinical severity and pertussis with or without co-infections were found. Trial registration Policlinico Umberto I: protocol 213/14, 3085/13.02.2014, retrospectively registered. Bambino Gesù Children’s Hospital: protocol n. RF-2010-2317709. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Pertussis, respiratory virus, Severity, Child Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12879-017-2567-6 Source A related resource from which the described resource is derived BMC Infectious Diseases Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/04d9d4d68375ff4e1482afd62c6fdc37.pdf d6d7653a2835e6ea82283c6759c58e9c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infección in vitro de cepas de Beauveria spp. sobre Globodera rostochiensis Wollenweber (1923) Creator An entity primarily responsible for making the resource Melchor Cepeda Siller, Fabiola Garrido Cruz, Efraín Castro Narro, Sergio Rene Sánchez Peña, Miriam Desireé Davila Medina Description An account of the resource El nematodo dorado Globodera rostochiensis es uno de los principales problemas en el cultivo de la papa (Solanum tuberosum L.), sus quistes pueden permanecer viables en el suelo hasta por treinta años. Para su control se utilizan nematicidas químicos, sin embargo, los bioplaguicidas son una alternativa eficaz en el control de plagas agrícolas. Se aislaron y evaluaron cuatro cepas del hongo Beauveria spp. a concentracio-nes de 1 × 104, 1 × 105, 1 × 106 sobre quistes de G. rostochiensis. La infección se registró a las 72 h con todas las concentraciones, de todas las cepas, sin embargo, la RH4 fue la única que infectó al nematodo en el estadio de huevo en todas las concentraciones. A las 96 horas se observó infección en las diferentes cepas, excepto la U9 que infectó hasta las 120 h. Comprobando con esto que Beauveria spp. puede ser utilizado para el control de G. rostochiensis Date A point or period of time associated with an event in the lifecycle of the resource 2018 Identifier An unambiguous reference to the resource within a given context 10.15174/au.2018.1714 Source A related resource from which the described resource is derived Acta Universitaria Publisher An entity responsible for making the resource available Universidad de Guanajuato Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Social Sciences, Science (General) Relation A related resource <a href="https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1714/pdf" target="_blank" rel="noreferrer noopener">https://www.actauniversitaria.ugto.mx/index.php/acta/article/view/1714/pdf</a> https://www.socictopen.socict.org/files/original/9638d1b0fb2fe26b84a8aabb266554d3.pdf be855cd943c9efc4bbd8bd9980e80a79 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infección por Angiostrongylus cantonensis (Nematoda: Metastrongylidae) en Rattus rattus (Rodentia: Muridae) en una localidad de La Habana, Cuba Creator An entity primarily responsible for making the resource Ariamys Companioni, Jennys Peraza, Zulema Menendez, Aileen Gonzalez, Ledy Xiomara Lopez, Ana Elisa Rodriguez, Jorge Demetrio Cantillo, Fidel Angel Nuñez Description An account of the resource Introducción: La meningoencefalitis eosinofílica producida por Angiostrongylus cantonensis (Chen, 1935), es una zoonosis emergente presente en Cuba. En el país existen escasos estudios de prevalencia de infección en los hospederos definitivos, que puedan determinar sitios de riesgo para el establecimiento de medidas efectivas en la prevención de la enfermedad.Objetivo: Determinar la prevalencia de infección por A. cantonensis en una población natural de R. rattus, su relación con la estructura poblacional y la época del año en una finca que pertenece al Programa de la Agricultura Urbana y Suburbana de Cuba.Material y Métodos: Se realizó un estudio descriptivo en el municipio La Lisa, La Habana. Se hicieron capturas de roedores mensuales durante los períodos lluvioso y poco lluvioso. Se examinaron las arterias pulmonares de los roedores capturados en búsqueda de parásitos adultos. El índice parasitológico de prevalencia fue calculado y comparadas las frecuencias entre los períodos del año y la edad ecológica.Resultados: Se capturaron 63 roedores identificados como Rattus rattus, de ellos 46,03% estuvo infectado con A. cantonensis, con un incremento de la infección en los individuos adultos (59,46%) y en el período lluvioso (55,88%).Conclusiones: Se demuestra por primera vez en Cuba la infección de A. cantonensis en R. rattus. La presencia de individuos adultos, la alta abundancia de roedores y la temporada lluviosa son los factores que incidieron en una mayor infección de A. cantonensis, y que aumentan la probabilidad de transmisión a los hospederos intermediarios y, por ende, el riesgo de transmisión al humano. Palabras claves: Angiostrongylus cantonensis, Rattus, Roedores, huertos urbanos, período lluvioso. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Angiostrongylus cantonensis, Rattus, Roedores, huertos urbanos, período lluvioso Source A related resource from which the described resource is derived Revista Habanera de Ciencias Médicas Publisher An entity responsible for making the resource available Universidad de Ciencias Médicas de La Habana Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Medicine (General) Relation A related resource <a href="http://www.revhabanera.sld.cu/index.php/rhab/article/view/2454" target="_blank" rel="noreferrer noopener">http://www.revhabanera.sld.cu/index.php/rhab/article/view/2454</a> https://www.socictopen.socict.org/files/original/cd4b0a2731daa544f88cbcce03cd81bc.pdf e2ef6398fce3321450f53cccdc1600c3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource INFECCIONES ZOONÓTICAS CAUSADAS POR LEVADURAS DEL GÉNERO Malassezia: UNA REVISIÓN Creator An entity primarily responsible for making the resource Juan C Galvis Marín, Fernando Borda Rojas Description An account of the resource Las zoonosis son enfermedades que se transmiten de forma natural entre los animales vertebrados y el hombre. Existe un gran número de enfermedades bacterianas, virales y parasitarias, que son transmitidas de los animales a los humanos, mientras que pocas micosis son consideradas, actualmente, como zoonosis. Las micosis zoonóticas son más frecuentes en individuos inmunocomprometidos, incluyendo pacientes hospitalizados, en los cuales, Malassezia pachydermatis, una levadura zoofílica, aparece como un microorganismo importante, en la etiología de micosis nosocomiales. En esta revisión, se mencionan las publicaciones que han reportado la presencia de M pachydermatis en humanos, a través del tiempo, con especial énfasis, en infecciones sistémicas en población de riesgo, a partir de caninos y personal de la salud, colonizados por esta levadura. Asimismo, se recopilan estudios en los que se han aislado en animales, especies antropofílicas del género Malassezia, para contribuir al conocimiento de la ecología y posible mecanismo de transmisión zoonótica, de este microorganismo. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Humanos, animales, infecciones, micosis, transmisión Source A related resource from which the described resource is derived Revista U.D.C.A Actualidad & Divulgación Científica Publisher An entity responsible for making the resource available Universidad de Ciencias Aplicadas y Ambientales Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture (General), Biology (General), Medicine (General) Relation A related resource <a href="http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-42262016000200015&amp;lng=en&amp;tlng=en" target="_blank" rel="noreferrer noopener">http://www.scielo.org.co/scielo.php?script=sci_arttext&amp;pid=S0123-42262016000200015&amp;lng=en&amp;tlng=en</a> https://www.socictopen.socict.org/files/original/a3697fc4eb3f0cbee65d536c87d74e69.pdf 0db64463d07f9c1d3476a1cec53d5e65 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infected hip prosthesis in patient with suspected Covid-19 infection Creator An entity primarily responsible for making the resource A. Cosentino, G. Odorizzi, W. Berger Description An account of the resource Abstract Background Infections following arthroplasty are one of the major risks during this type of surgery. Moreover, the outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus Disease 2), has developed into an unprecedented pandemic, posing enormous pressure on health-care providers around the world. Case presentation Four and half years after right hip arthroplasty, the patient came back to our attention with pain at the same hip. The instrumental examinations showed signs of cup detachment. After carefully analyzing the case, we decided to perform a sterile aspiration of the hip in the operating room under C-arm fluoroscopy. Microbiological examinations showed positivity for E. coli. The patient underwent surgery by which the prosthesis was removed and a spacer was implanted. A therapy with Cefotaxim 2 g three times a day for 6 weeks was then set, and then a total arthroplasty was performed. During this period, the COVID-19 pandemic occurred and therefore the patient received nasal-throat swabbing two times, and both yielded negative results. However, 1 week after the final surgery, his respiratory conditions deteriorated and chest X-ray and CT scan showed images of ground-glass opacification patterns (GGO). Due to the clinical symptoms and the characteristic images of the instrumental examinations, the patient was transferred to an observation ward. Thereafter, two more swab tests gave negative results. The patient was then transferred to the ward for patients with typical symptoms of COVID-19 but with negative swab tests for 2 weeks and was subsequently discharged home. Conclusion The purpose of this case report was to point out the correct treatment of a PJI after the outbreak of COVID-19. Despite the ongoing COVID-19 pandemic, the guidelines in the case of periprosthetic hip infection further confirmed the correct management of the patient. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19 pandemic, prosthetic joint infection, Hip Infection Identifier An unambiguous reference to the resource within a given context 10.1186/s42836-020-00058-0 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Orthopedic surgery https://www.socictopen.socict.org/files/original/e16129281653dfdc81539d12d399bdca.pdf bce391415674e739f767d5d2533a7fb4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infection Control and SARS Transmission among Healthcare Workers, Taiwan Creator An entity primarily responsible for making the resource Yee-Chun Chen, Pei-Jer Chen, Shan-Chwen Chang, Chiang-Lian Kao, Shiou-Hwa Wang, Lihua Wang, Pan-Chyr Yang Description An account of the resource This study found infrequent transmission of severe acute respiratory syndrome (SARS) coronavirus to healthcare workers involved in the care of the first five case-patients in Taiwan, despite a substantial number of unprotected exposures. Nonetheless, given that SARS has been highly transmissible on some occasions, we still recommend strict precautions. Date A point or period of time associated with an event in the lifecycle of the resource 2004 Subject The topic of the resource infection control measures, serologic assays, SARS-CoV, Taiwan Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid1005.030777 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/4294f73a96eb96b27f5baffd59c6a33a.pdf 1faad6c21e757cd3c4825ada06e99ee7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infection control management of patients with suspected highly infectious diseases in emergency departments: data from a survey in 41 facilities in 14 European countries Creator An entity primarily responsible for making the resource Fusco Francesco M, Schilling Stefan, De Iaco Giuseppina, Brodt Hans-Reinhard, Brouqui Philippe, Maltezou Helena C, Bannister Barbara, Gottschalk René, Thomson Gail, Puro Vincenzo, Ippolito Giuseppe Description An account of the resource Abstract Background In Emergency and Medical Admission Departments (EDs and MADs), prompt recognition and appropriate infection control management of patients with Highly Infectious Diseases (HIDs, e.g. Viral Hemorrhagic Fevers and SARS) are fundamental for avoiding nosocomial outbreaks. Methods The EuroNHID (European Network for Highly Infectious Diseases) project collected data from 41 EDs and MADs in 14 European countries, located in the same facility as a national/regional referral centre for HIDs, using specifically developed checklists, during on-site visits from February to November 2009. Results Isolation rooms were available in 34 facilities (82,9%): these rooms had anteroom in 19, dedicated entrance in 15, negative pressure in 17, and HEPA filtration of exhausting air in 12. Only 6 centres (14,6%) had isolation rooms with all characteristics. Personnel trained for the recognition of HIDs was available in 24 facilities; management protocols for HIDs were available in 35. Conclusions Preparedness level for the safe and appropriate management of HIDs is partially adequate in the surveyed EDs and MADs. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2334-12-27 Source A related resource from which the described resource is derived BMC Infectious Diseases Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/9dd51fd6d2ba2e3588f5bbcf486d9369.pdf d8deb7aafc62f2f21056259f431fb97d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infection Control Practices in Endoscopy Room in COVID-19 Era Creator An entity primarily responsible for making the resource Piramanayagam Paramasivan Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1055/s-0040-1712599 Source A related resource from which the described resource is derived Journal of Digestive Endoscopy Publisher An entity responsible for making the resource available Thieme Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Diseases of the digestive system. Gastroenterology https://www.socictopen.socict.org/files/original/7cbc2e73a1348ac825e2dff82092b093.pdf 2995e3f1e3c955b3575771ea5ee36654 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infection with different strains of SARS-COV-2 in patients with COVID-19 Creator An entity primarily responsible for making the resource Hashim Hayder O., Mohammed Mudher K., Mousa Mazin J., Abdulameer Hadeer H., Alhassnawi Alaa T.S., Hassan Safa A., Al-Shuhaib Mohammed Baqur S. Description An account of the resource The biological diversity of SARS-CoV-2 was assessed by investigating the genetic variations of the spike glycoprotein of patients with COVID-19 in Iraq. Sequencing identified fifteen novel nucleic acid variations with a variety of distributions within the investigated samples. The electropherograms of all identified variations showed obvious co-infections with two different viral strains per sample. Most samples exhibited three nonsense single nucleotide polymorphism (SNPs), p.301Cdel, p.380Ydel and p.436del, which yielded three truncated spike glycoproteins, respectively. Network and phylogenetic analyses indicated that all viral infections were derived from multiple viral origins. Results inferred from the specific clade-based tree showed that some viral strains were derived from European G-clade sequences. Our data demonstrated the absence of single-strain infection among all investigated samples in the studied area, which entails a higher risk of SARS-CoV-2 in this country. The identified high frequency of truncated spike proteins suggests that defective SARS-CoV-2 depend on helper strains possessing intact spikes during infection. Alternatively, another putative ACE2-independent route of viral infection is suggested. To the best of our knowledge, this is the first report to describe co-infection with multiple strains of SARS-CoV-2 in patients with COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, spike glycoprotein, SARS-CoV-2, Co-infection, stop mutations Identifier An unambiguous reference to the resource within a given context 10.2298/ABS201024051H Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/ed81586f479549c5b571c85dd6e79aaa.pdf d6c9ab2bb897284ae5ff9fa381a3feab Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Infection with MERS-CoV causes lethal pneumonia in the common marmoset. Creator An entity primarily responsible for making the resource Jiang ZHU, Tingting Liu, Heinz Feldmann, Darryl Falzarano, Emmie de Wit, Friederike Feldmann, Elaine Haddock, Dana P. Scott, Neeltje van Doremalen, Vincent J. Munster, Atsushi Okumura, Michael G. Katze, Angela L. Rasmussen, Rachel LaCasse, Jason S. McLellan, Matthew J Thomas, Xinxia Peng, Lee Nagy Description An account of the resource The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction between the MERS-CoV spike glycoprotein and its receptor dipeptidyl peptidase 4 predicted comparable interaction energies in common marmosets and humans. The suitability of the marmoset as a MERS-CoV model was tested by inoculation via combined intratracheal, intranasal, oral and ocular routes. Most of the marmosets developed a progressive severe pneumonia leading to euthanasia of some animals. Extensive lesions were evident in the lungs of all animals necropsied at different time points post inoculation. Some animals were also viremic; high viral loads were detected in the lungs of all infected animals, and total RNAseq demonstrated the induction of immune and inflammatory pathways. This is the first description of a severe, partially lethal, disease model of MERS-CoV, and as such will have a major impact on the ability to assess the efficacy of vaccines and treatment strategies as well as allowing more detailed pathogenesis studies. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1004250 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy