1102 10 20655 https://www.socictopen.socict.org/files/original/1bf276dadbcb53ad3ef3df5aa9e6e518.pdf fea6210f3ba46724de8022cdf0d501f6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Disparities in COVID-19 severities and casualties across ethnic groups around the globe and patterns of ACE2 and PIR variants. Creator An entity primarily responsible for making the resource Sabrina Samad Shoily, Tamim Ahsan, Kaniz Fatema, Abu Ashfaqur Sajib Description An account of the resource Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mediated Coronavirus disease-19 (COVID-19) has affected millions of individuals around all corners of the globe. Symptoms and severities of infection with this highly contagious virus vary among individuals and there is disparity in the number of COVID-19-related casualties across different ethnic groups. The primary receptor for SARS-CoV-2 entry into the host cells is angiotensin-converting enzyme 2 (ACE2). Certain variants of ACE2 are known to be associated with COVID-19 comorbidities such as hypertension, cardiovascular complications, diabetes, chronic lung disease, etc. In this study, we looked into the geographic distribution of disease-associated variants of ACE2 as well as closely located PIR gene to explore any possible correlation with the disparities in COVID-19 severities and casualties across ethnic groups. Frequencies of the ACE2 variants associated with COVID-19 comorbidities are higher in the European and the admixed American populations. These variants are also present with stronger pairwise linkage disequilibrium (LD) in the European and the admixed American populations. On the other hand, the variants with protective role are more prevalent in the East and the South Asian populations. Strong pairwise LD exists among the activity modifying (modifier) variants of the PIR and ACE2 genes only in the European super-population. Absence of these PIR variants in the South Asian population may contribute to the overall lower COVID-19 case fatality rates (CFR) despite the dense population in this region. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, ACE2, genetic variants, Haplotype, geographic distribution, Linkage disequilibrium, PIR Identifier An unambiguous reference to the resource within a given context 10.1016/j.meegid.2021.104888 Source A related resource from which the described resource is derived Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases https://www.socictopen.socict.org/files/original/70221c1c546ef6a601f482522afc1945.pdf e9f3fae7b9403794d20141f7da19c01b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reconstitution and functional characterization of SARS-CoV-2 proofreading complex. Creator An entity primarily responsible for making the resource Zhijun Ma, Yasin Pourfarjam, In-Kwon Kim Description An account of the resource The novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 or COVID-19) has led to a world-wild pandemic. The replication of SARS-CoV-2 RNA genome involves the core replication-transcription complex (RTC, nsp12-nsp7-nsp8) and the proofreading complex (nsp14-nsp10) that can correct mismatched base pairs during replication. Structures and functions of SARS-CoV-2 RTC have been actively studied, yet little is known about SARS-CoV-2 nsp14-nsp10. Here, we purified, reconstituted, and characterized the SARS-CoV-2 nsp14-nsp10 proofreading nuclease in vitro. We show that SARS-CoV-2 nsp14 is activated by nsp10, functioning as a potent RNase that can hydrolyze RNAs in the context of single- and double-stranded RNA and RNA/DNA hybrid duplex. SARS-CoV-2 nsp14-nsp10 shows a metal-dependent nuclease activity but has different metal selectivity from RTC. While RTC is activated by Ca2+, nsp14-nsp10 is completely inhibited. Importantly, the reconstituted SARS-CoV-2 nsp14-nsp10 efficiently removed the A:A mismatch at the 3'-end of the primer, enabling the stalled RTC to restart RNA replication. Our collective results confirm that SARS-CoV-2 nsp14-nsp10 functions as the RNA proofreading complex in SARS-CoV-2 replication and provide a useful foundation to understand the structure and function of SARS-CoV-2 RNA metabolism. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, SARS-CoV-2, proofreading, RNA replication, nsp14, nsp10 Identifier An unambiguous reference to the resource within a given context 10.1016/j.pep.2021.105894 Source A related resource from which the described resource is derived Protein expression and purification https://www.socictopen.socict.org/files/original/a86f199fcf0f3330d6359fc1f9013137.pdf fbe7b7e3aaff6c4dac7c9baa2c752f86 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hotels in contexts of uncertainty: Measuring organisational resilience. Creator An entity primarily responsible for making the resource Lucía Melián-Alzola, Margarita Fernández-Monroy, Marisa Hidalgo-Peñate Description An account of the resource The tourism industry faces multiple changes (economic crises, climate change, technology innovation…). Because of this vulnerability, as evidenced by the COVID-19 pandemic, the study of hotel resilience is a key issue for the survival and competitiveness of organisations and destinations. Therefore, this paper proposes a holistic model to measure organisational resilience. To that end, it aims to analyse the determinants of organisational resilience, i.e. predictors of resilience (strategy and change), and to assess how they contribute to hotel resilience and performance. Firstly, the hotel context in the Canary Islands is examined to identify the level of impact, frequency and predictability of each type of change. Secondly, scales development and validation were conducted. Finally, the proposed model is validated. Findings confirm that the strategy and change dimensions have a considerable effect on hotel resilience, which positively influences hotel performance. Discussion provides hotel managers with guidelines to improve organisational resilience and performance. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource performance, resilience, crisis, vulnerability, Tourism, Change, Hotel Identifier An unambiguous reference to the resource within a given context 10.1016/j.tmp.2020.100747 Source A related resource from which the described resource is derived Tourism management perspectives https://www.socictopen.socict.org/files/original/8505f7eff35c442a2cbc71c2388de348.pdf a26bd36835743b11c83d611fb367e1be Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Organizational aspects of care associated with mortality in critically ill COVID-19 patients. Creator An entity primarily responsible for making the resource Thomas Rimmelé, Léa Pascal, Stéphanie Polazzi, Antoine Duclos Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1007/s00134-020-06249-2 Source A related resource from which the described resource is derived Intensive care medicine https://www.socictopen.socict.org/files/original/06f089eab79da85c858b0a87060e8bf0.pdf 56b018aab30956b8b6a48ceb79201fe4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Early observations on the impact of a healthcare worker COVID-19 vaccination programme at a major UK tertiary centre. Creator An entity primarily responsible for making the resource Mark I Garvey, Martyn A C Wilkinson, Elisabeth Holden, Adrian Shields, Alastair Robertson, Alex Richter, Simon Ball Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Healthcare workers, covid-19, Vaccination, lateral flow Identifier An unambiguous reference to the resource within a given context 10.1016/j.jinf.2021.04.027 Source A related resource from which the described resource is derived The Journal of infection https://www.socictopen.socict.org/files/original/2d22e433d3829a3c185b49601e7b0a22.pdf 3e2db354825eb6b3d931c32b2f2b088d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reinforcement learning-based decision support system for COVID-19. Creator An entity primarily responsible for making the resource Regina Padmanabhan, Nader Meskin, Tamer Khattab, Mujahed Shraim, Mohammed Al-Hitmi Description An account of the resource Globally, informed decision on the most effective set of restrictions for the containment of COVID-19 has been the subject of intense debates. There is a significant need for a structured dynamic framework to model and evaluate different intervention scenarios and how they perform under different national characteristics and constraints. This work proposes a novel optimal decision support framework capable of incorporating different interventions to minimize the impact of widely spread respiratory infectious pandemics, including the recent COVID-19, by taking into account the pandemic's characteristics, the healthcare system parameters, and the socio-economic aspects of the community. The theoretical framework underpinning this work involves the use of a reinforcement learning-based agent to derive constrained optimal policies for tuning a closed-loop control model of the disease transmission dynamics. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Optimal control, reinforcement learning, Active intervention, Differential disease severity Identifier An unambiguous reference to the resource within a given context 10.1016/j.bspc.2021.102676 Source A related resource from which the described resource is derived Biomedical signal processing and control https://www.socictopen.socict.org/files/original/09f500e14911e5c719a9e8a74b16956a.pdf 9181ea2960606bef2a8cbf76c6d7385f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Changes in the clustering of unhealthy movement behaviors during the COVID-19 quarantine and the association with mental health indicators among Brazilian adults. Creator An entity primarily responsible for making the resource André O Werneck, Danilo R Silva, Deborah C Malta, Paulo R B Souza-Júnior, Luiz O Azevedo, Marilisa B A Barros, Célia L Szwarcwald Description An account of the resource Our aim was to analyze the prevalence of unhealthy movement behavior clusters before and during the COVID-19 pandemic, as well as to investigate whether changes in the number of unhealthy behaviors during the COVID-19 pandemic quarantine were associated with mental health indicators. Data of 38,353 Brazilian adults from a nationwide behavior research were used. For movement behaviors, participants reported the frequency and duration of physical activity and daily time on TV viewing and computer/tablet use before and during the pandemic period. Participants also reported the frequency of loneliness, sadness (feeling sad, crestfallen, or depressed), and anxiety feelings (feeling worried, anxious, or nervous) during the pandemic period. Sex, age group, highest academic achievement, working status during quarantine, country region, and time adhering to the quarantine were used as correlates. We used descriptive statistics and logistic regression models for the data analysis. The prevalence of all movement behavior clusters increased during the COVID-19 pandemic. The cluster of all three unhealthy movement behaviors increased from 4.6% (95% confidence interval [CI]: 3.9-5.4) to 26.2% (95% CI: 24.8-27.7). Younger adults, people with higher academic achievement, not working or working at home, and those with higher time in quarantine presented higher clustering. People that increased one and two or three unhealthy movement behaviors were, respectively, more likely to present loneliness (odds ratio [OR] = 1.41 [95% CI: 1.21-1.65] and OR = 1.71 [95% CI: 1.42-2.07]), sadness (OR = 1.25 [95% CI: 1.06-1.48] and OR = 1.73 [95% CI: 1.42-2.10]), and anxiety (OR = 1.34 [95% CI: 1.13-1.57] and OR = 1.78 [95% CI: 1.46-2.17]) during the COVID-19 quarantine. Clustering of unhealthy movement behaviors substantially increased and was associated with poorer mental health during the COVID-19 pandemic. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource exercise, sedentary lifestyle, Sedentary behavior, sitting Identifier An unambiguous reference to the resource within a given context 10.1093/tbm/ibaa095 Source A related resource from which the described resource is derived Translational behavioral medicine https://www.socictopen.socict.org/files/original/ca0038a9c49908e527439ea497fb8fc5.pdf 9b0c83c4befc94540dc9093b3540f5f2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Alveolar hemorrhage in the setting of COVID-19: Report of a successful vascular intervention and embolization. Creator An entity primarily responsible for making the resource Afshin Mohammadi, Behdad Boroofeh, Seyed Ali Mousavi-Aghdas, Mohammad Mirza-Aghazadeh-Attari Description An account of the resource The coronavirus disease 2019 (COVID-19) is characterized by viral pneumonia with mild to moderate symptoms. Emerging studies suggest that some patients may experience uncommon complications, such as thrombotic or hemorrhagic episodes. Here we present a 59-year-old male patient who had a hemorrhage episode from a branch of the pulmonary arteries and was treated by interventional embolization. Our case report demonstrates the importance of early diagnosis of hemorrhagic complications of COVID-19 and the possible benefits of early vascular intervention. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, radiology, vascular intervention Identifier An unambiguous reference to the resource within a given context 10.1016/j.radcr.2021.04.034 Source A related resource from which the described resource is derived Radiology case reports https://www.socictopen.socict.org/files/original/490ab04b1c6804e3669403719fa20c8e.pdf 4bcb2b5f2a50d1d3a7d731ddaded474e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Failure of Anticoagulation to Prevent Stroke in Context of Lupus-Associated Anti-Phospholipid Syndrome and Mild COVID-19. Creator An entity primarily responsible for making the resource Keith J Kincaid, Alexis N Simpkins Description An account of the resource Hypercoagulability and virally-mediated vascular inflammation have become well-recognized features of the SARS-CoV-2 virus infection, COVID-19. Of growing concern is the apparent ineffectiveness of therapeutic anticoagulation in preventing thromboembolic events among some at-risk patient subtypes with COVID-19. We present a 43-year-old female with a history of seropositive-antiphospholipid syndrome and systemic lupus erythematosus who developed an acute ischemic stroke in the setting of mild COVID-19 infection despite adherence to chronic systemic anticoagulation. The clinical significance of SARS-CoV-2-mediated endothelial cell dysfunction and its potential to cause macrovascular events in spite of full anticoagulation warrants further investigation and likely represents another disease-defining pathology of COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Anti coagulation, Ischemic Stroke, Hypercoagulable state, antiphospholipid Identifier An unambiguous reference to the resource within a given context 10.1016/j.jstrokecerebrovasdis.2021.105817 Source A related resource from which the described resource is derived Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association https://www.socictopen.socict.org/files/original/980e97633c96b90506595a1a5e2291a9.pdf 345d0ea1d7335552826a641f800a12f7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Is Early Traumatic Facial Nerve Surgery a Priority during the COVID-19 Pandemic? Creator An entity primarily responsible for making the resource Mohammad Faramarzi, Ali Faramarzi, Milad Hosseinialhashemi Description An account of the resource As otolaryngologists are exposed to high risk of coronavirus disease 2019 (COVID-19) infection, logic and evidence-based prioritization for surgeries is essential to reduce the risk of infection amongst healthcare workers. Several clinical guidelines and surgery prioritizing recommendations have been published during the COVID-19 pandemic. They recommended the surgery in the setting of immediate facial nerve paralysis within 72 hours after trauma, but none of the previous studies in the literature suggests that the optimal timing of operation should be less than 2 weeks from injury. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, Pandemic, facial nerve Identifier An unambiguous reference to the resource within a given context 10.1055/s-0041-1724089 Source A related resource from which the described resource is derived International Archives of Otorhinolaryngology Publisher An entity responsible for making the resource available Thieme Revinter Publicações Ltda. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Otorhinolaryngology