111 10 20655 https://www.socictopen.socict.org/files/original/ba70ebc1c530e8c9dc8463e494733dca.pdf 6209fb014411300dec8218558e6dca66 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Conservation implications of primate trade in China over 18 years based on web news reports of confiscations Creator An entity primarily responsible for making the resource Qingyong Ni, Yu Wang, Ariana Weldon, Meng Xie, Huailiang Xu, Yongfang Yao, Mingwang Zhang, Ying Li, Yan LI, Bo Zeng, K.A.I. Nekaris Description An account of the resource Primate species have been increasingly threatened by legal and illegal trade in China, mainly for biomedical research or as pets and traditional medicine, yet most reports on trade from China regard international trade. To assess a proxy for amount of national primate trades, we quantified the number of reports of native primate species featuring in unique web news reports from 2000 to 2017, including accuracy of their identification, location where they were confiscated or rescued, and their condition upon rescue. To measure temporal trends across these categories, the time span was divided into three sections: 2000–2005, 2006–2011 and 2012–2017. A total of 735 individuals of 14 species were reported in 372 news reports, mostly rhesus macaques (n = 165, 22.5%, Macaca mulatta) and two species of slow lorises (n = 487, 66.3%, Nycticebus spp.). During the same period, live individuals of rhesus macaques were recorded 206 times (70,949 individuals) in the Convention on International Trade in Endangered Species of Wild Fauna and Flora Trade Database, whereas slow lorises were only recorded four times (nine individuals), indicating that the species originated illegally from China or were illegally imported into China. Due to their rescued locations in residential areas (n = 211, 56.7%), most primates appeared to be housed privately as pets. A higher proportion of ‘market’ rescues during 2006–2011 (χ2 = 8.485, df = 2, p = 0.014), could be partly attributed to an intensive management on wildlife markets since the outbreak of severe acute respiratory syndrome (SARS) in 2003. More than half (68.3%, 502 individuals) of the primate individuals were unhealthy, injured or dead when rescued. Thus, identification and welfare training and capacity-building should be provided to husbandry and veterinary professionals, as well as education to the public through awareness initiatives. The increase in presence of some species, especially slow lorises, with a declining population in restricted areas, also suggests the urgent need for public awareness about the illegal nature of keeping these taxa as pets. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource rescuing, welfare, recognition, mass media, spatial variation Identifier An unambiguous reference to the resource within a given context DOI: 10.7717/peerj.6069 Source A related resource from which the described resource is derived PeerJ Publisher An entity responsible for making the resource available PeerJ Inc. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/2eea90019470e64a75ddf604520006a3.pdf 6e71746edfa0428e45d42f2342e2450d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using peptide block entropy Creator An entity primarily responsible for making the resource Lars Rønn Olsen, Guanglan eZhang, Derin B Keskin, Ellis L Reinherz, Vladimir eBrusic Description An account of the resource Broad coverage of the pathogen population is particularly important when designing CD8+ T-cell epitope vaccines against viral pathogens. Traditional approaches to assembling broadly covering sets of peptides are commonly based on assembling highly conserved epitopes. Peptide block entropy analysis is a novel approach to assembling sets of broadly covering antigens. Since T-cell epitopes are recognized as peptides rather than individual residues, this method is based on calculating the information content of blocks of peptides from a multiple sequence alignment of homologous proteins rather than individual residues. The block entropy analysis provides broad coverage by variant inclusion, since high frequency may not be the sole determinant of the immunogenic potential of a predicted MHC class I binder. We applied block entropy analysis method to the proteomes of the four serotypes of dengue virus and found 1,551 blocks of 9-mer peptides, which covered all available sequences with five or fewer unique peptides. In contrast, the benchmark study by Khan et al. (2008), resulted in 165 9-mers being determined as conserved. Many of the blocks are located consecutively in the proteins, so connecting these blocks resulted in 78 conserved regions which can be covered with 457 subunit peptides. Of the 1551 blocks of 9-mer peptides, 110 blocks consisted of peptides all predicted to bind to MHC with similar affinity and the same HLA restriction. In total, we identified a pool of 333 peptides as T-cell epitope candidates. This set could form the basis for a broadly neutralizing dengue virus vaccine. The peptide block entropy analysis approach significantly increases the number of conserved peptide regions in comparison to traditional conservation analysis of individual residues. We determined 457 subunit peptides with the capacity to encompass the diversity of all sequenced DENV strains. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource immunoinformatics, antigenic diversity, Epitope-based vaccines, polyvalent vaccines, reverse vaccinology, vaccine informatics Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fimmu.2011.00069 Source A related resource from which the described resource is derived Frontiers in Immunology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/f85480dd96636fd7bd27c4a4ece37f29.pdf 1aa8bd3c9a7474192a7bd433798a0a9c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Some epidemiological features of BCoVs infection in Al-Qadisiyah Province by using real time-qPCR technique Creator An entity primarily responsible for making the resource Khetam Qaid Mayee Description An account of the resource This study was carried out to evaluate some epidemiological features of Bovine Coronavirus infection by using one-step real-time fluorogenic quantitative reverse transcription polymerase chain reaction (RT-qPCR) assay based on SYBR Green I dye in detection. Coronaviruses detected by the same nucleocapsid (N) gene primers under 98% similarity with HECV-4408 (human enteric Coronavirus) in children according to NCBI with product size 124bp. 285 fecal samples have been examined by routine methods against pathogenic bacteria in the intestines (E.coli, Salmonella Spp.) and Cryptosporidium parvum, the samples positive for the parasite submitted to molecular testing because they may be mixed with coronavirus infections. 100 samples were screened for the presence of BCoVs antigens by using an immunochromatographic rapid test as a field fast test. Where 44% of samples showed positivity to BCoVs, out of 50 samples submitted to quantitative reverse transcription (RT-qPCR) assay. Out of 50 – 31 samples had been positive. We found that distribution of BCoVs was significantly higher in rural areas 33.3%-87.5% as compare to cities 71.4%-75%, the infection in males reach to75% vas 53.5% in females, high infection rate 62.9% in < 1- 4 months age as compared with > 1 month age 62.9%. The results of infection rate showed high percentage during February 77.7% while the percentage on (January, December, March, and April) was (66.6%, 66.1%, 54.5%, and 50%) respectively. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Al-Qadisiyah Journal of Veterinary Medicine Sciences Publisher An entity responsible for making the resource available College of Veterinary Medicine Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/4786d8a094746fbfa1afc1e117bea9fa.pdf a3d9fe630e7e41adbae672cfcfd7f883 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Natural Bis-Benzylisoquinoline Alkaloids-Tetrandrine, Fangchinoline, and Cepharanthine, Inhibit Human Coronavirus OC43 Infection of MRC-5 Human Lung Cells Creator An entity primarily responsible for making the resource Dong Eon Kim, Jung Sun Min, Min Seong Jang, Jun Young Lee, Young Sup Shin, Jong Hwan Song, Hyoung Rae Kim, Seungtaek Kim, Young-Hee Jin, Sunoh Kwon Description An account of the resource Stephania tetrandra and other related species of Menispermaceae are the major sources of the bis-benzylisoquinoline alkaloids tetrandrine (TET), fangchinoline (FAN), and cepharanthine (CEP). Although the pharmacological properties of these compounds include anticancer and anti-inflammatory activities, the antiviral effects of these compounds against human coronavirus (HCoV) remain unclear. Hence, the aims of the current study were to assess the antiviral activities of TET, FAN, and CEP and to elucidate the underlying mechanisms in HCoV-OC43-infected MRC-5 human lung cells. These compounds significantly inhibited virus-induced cell death at the early stage of virus infection. TET, FAN, and CEP treatment dramatically suppressed the replication of HCoV-OC43 as well as inhibited viral S and N protein expression. The virus-induced host response was reduced by compound treatment as compared with the vehicle control. Taken together, these findings demonstrate that TET, FAN, and CEP are potential natural antiviral agents for the prevention and treatment of HCoV-OC43 infection. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource bis-benzylisoquinoline alkaloids, Tetrandrine, fangchinoline, cepharanthine, human coronavirus strain oc43, mrc-5 human lung cell, antiviral effect Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/biom9110696 Source A related resource from which the described resource is derived Biomolecules Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/94fb8cc0ad4046cd05b9f444d6894b64.pdf 5b80c6ff89e0d3d3837a8bb5d3ce91f1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Host Determinants of MERS-CoV Transmission and Pathogenesis Creator An entity primarily responsible for making the resource W. Widagdo, Syriam Sooksawasdi Na Ayudhya, Gadissa B. Hundie, Bart L. Haagmans Description An account of the resource Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen that causes respiratory infection in humans, ranging from asymptomatic to severe pneumonia. In dromedary camels, the virus only causes a mild infection but it spreads efficiently between animals. Differences in the behavior of the virus observed between individuals, as well as between humans and dromedary camels, highlight the role of host factors in MERS-CoV pathogenesis and transmission. One of these host factors, the MERS-CoV receptor dipeptidyl peptidase-4 (DPP4), may be a critical determinant because it is variably expressed in MERS-CoV-susceptible species as well as in humans. This could partially explain inter- and intraspecies differences in the tropism, pathogenesis, and transmissibility of MERS-CoV. In this review, we explore the role of DPP4 and other host factors in MERS-CoV transmission and pathogenesis&mdash;such as sialic acids, host proteases, and interferons. Further characterization of these host determinants may potentially offer novel insights to develop intervention strategies to tackle ongoing outbreaks. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS-CoV, Transmission, pathogenesis, host factors, DPP4 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11030280 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/03785ad71ccafebbf243db47e98f88c5.pdf a6a5742435032b61a5c66ce5fd924510 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource PEDV and PDCoV Pathogenesis: The Interplay Between Host Innate Immune Responses and Porcine Enteric Coronaviruses Creator An entity primarily responsible for making the resource Surapong Koonpaew, Samaporn Teeravechyan, Phanramphoei Namprachan Frantz, Thanathom Chailangkarn, Anan Jongkaewwattana Description An account of the resource Enteropathogenic porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV), members of the coronavirus family, account for the majority of lethal watery diarrhea in neonatal pigs in the past decade. These two viruses pose significant economic and public health burdens, even as both continue to emerge and reemerge worldwide. The ability to evade, circumvent or subvert the host’s first line of defense, namely the innate immune system, is the key determinant for pathogen virulence, survival, and the establishment of successful infection. Unfortunately, we have only started to unravel the underlying viral mechanisms used to manipulate host innate immune responses. In this review, we gather current knowledge concerning the interplay between these viruses and components of host innate immunity, focusing on type I interferon induction and signaling in particular, and the mechanisms by which virus-encoded gene products antagonize and subvert host innate immune responses. Finally, we provide some perspectives on the advantages gained from a better understanding of host-pathogen interactions. This includes their implications for the future development of PEDV and PDCoV vaccines and how we can further our knowledge of the molecular mechanisms underlying virus pathogenesis, virulence, and host coevolution. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource PEDV, PDCoV, innate antiviral response, interferon induction and signaling, innate immune antagonism Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fvets.2019.00034 Source A related resource from which the described resource is derived Frontiers in Veterinary Science Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/0081d6e6f999d2ae766c4e863d08add8.pdf 572f0af197a6d1d2e42bb498e2afe35e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Intestinal lesions in pigs affected with postweaning multisystemic wasting syndrome Lesões entéricas em suínos afetados por síndrome multissistêmica do definhamento dos suínos Creator An entity primarily responsible for making the resource Priscila Zlotowski, André M.R. Corrêa, David E.S.N. Barcellos, Cláudio E.F. Cruz, William Asanome, Aline Fernandes Barry, Amauri Alcindo Alfieri, David Driemeier Description An account of the resource Samples of mesenteric lymph nodes and intestines from 79 unthrifty 3- to 5-month-old postweaning pigs, confirmed as naturally affected with postweaning multisystemic wasting syndrome (PMWS), were studied. Pigs originated from 12 farms in southern Brazil and were selected on the basis of clinical signs and/or gross lesions suggestive of enteric disorder. Lymphohistiocytic infiltrates of varying intensity were associated with anti-porcine circovirus type 2 (anti-PCV2) immunostaining (IS) in samples of intestines and mesenteric lymph nodes from all pigs. Although most findings were similar to those described in PCV2-associated enteritis, anti-PCV2 IS in association with depletion of the goblet cell mucin stores (24 pigs), diffuse ileal villous atrophy and fusion (18 pigs), and dilatation of the lymphatic vessels (11 pigs) combined or not with lymphangitis were also observed. PCV2 antigen was immunohistochemically demonstrated in the cytoplasm and nuclei from intralesional epithelial cells, histiocytes, and endothelial-like cells in intestinal tissues. Together these findings imply an association with PCV2. The presence of co-infections by Lawsonia intracellularis, Brachyspira spp., Mycobacterium spp., Salmonella spp., rotavirus, parvovirus, coronavirus and enteric calicivirus with PCV2 in the intestinal lesions was investigated.Amostras de linfonodos mesentéricos e intestinos de 79 leitões desmamados refugos, entre 3 e 5 meses de idade e confirmados como naturalmente afetados pela síndrome multissistêmica do definhamento foram estudadas. Os suínos eram oriundos de 12 criações no sul do país e foram selecionados em função dos sinais clínicos e/ou lesões macroscópicas sugestivos de doença entérica. Infiltrados linfoistiocíticos de intensidades variáveis foram associados com marcação positiva anti-circovirus suíno tipo 2 (anti-PCV2) em amostras de intestinos e linfonodos mesentéricos de todos os 79 animais. Embora a maioria dos achados fossem semelhantes aos descritos em enterite associada com PCV2, marcação imuno-histoquímica anti-PCV2 foi associada com depleção de células caliciformes (24 suínos), atrofia e fusão de vilosidades do íleo (18 suínos) e dilatação de vasos linfáticos (11 suínos) combinada ou não com linfangite. Antígenos de PCV2 foram demonstrados por imuno-histoquímica no citoplasma e núcleo de células epiteliais intralesionais, histiócitos e células tipo endotelial em tecidos intestinais. Em conjunto, esses resultados sugerem que as lesões estavam associadas com PCV2. A presença de co-infecções por Lawsonia intracellularis, Brachyspira spp., Mycobacterium spp., Salmonella spp., rotavírus, parvovírus, coronavírus e calicivírus entérico com PCV2 nas lesões intestinais foi investigada. Date A point or period of time associated with an event in the lifecycle of the resource 2008 Subject The topic of the resource circovirus, Coinfecções, lesões entéricas, PCV2, SMDS, co-infections, enteric lesions, PMWS Identifier An unambiguous reference to the resource within a given context DOI: 10.1590/S0100-736X2008000600009 Source A related resource from which the described resource is derived Pesquisa Veterinária Brasileira Publisher An entity responsible for making the resource available Colégio Brasileiro de Patologia Animal (CBPA) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN, PT https://www.socictopen.socict.org/files/original/49c145a410a088f3d9221dbda7326562.pdf 05a2d08f9ac27a6a2dc69161377db875 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource EFFICIENCY OF MODERN NON-MEDICATION REHABILITATION METHODS OF PRESCHOOL CHILDREN OFTEN SUFFERING FROM SEVERE ACUTE RESPIRATORY SYNDROME Creator An entity primarily responsible for making the resource Vavilova V. P., Nechaeva I. A., Vavilov A. M., Tsarkova S. A., Tyulyukin V. A. Description An account of the resource Aim: To assess the comparative effectiveness of modern non-medication rehabilitation arrangements (transcranialelectric stimulation, quantum therapy, speleoclimatotherapy) in 5-7 year-olds, often suffering from SARS (SevereAcute Respiratory Syndrome) for both individual rehabilitation and rehabilitation with the mother.Material and methods. 445 children (280 children rehabilitated individually, 120 children rehabilitated together with their mothers, 45 children made up the control group) were examined using clinical, immunological and functional diagnosis.Results: In non-medication rehabilitation the rates of local immunity of upper respiratory tract mucosa (lysozym,secretory immunoglobulin) and phagocytizing activity of neutrophils definitely increased. Positive dynamics ofchildren’s and their mothers’ emotional state has been recorded (anxiety level reduction). Comparative effectiveness of individual and joint rehabilitation of a child and a mother has been assessed.Conclusion: In joint rehabilitation of a mother and a child morbidity level decreased by 2,1 times, whereas in individual rehabilitation this ratio decreased by 1,5 times (р Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource chronically ill children, non-medication rehabilitation, Morbidity Identifier An unambiguous reference to the resource within a given context DOI: 10.25298/2221-8785-2019-17-3-308-313 Source A related resource from which the described resource is derived Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta Publisher An entity responsible for making the resource available Grodno State Medical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource BE, EN, RU https://www.socictopen.socict.org/files/original/0a273f861b806780ef1bfde2765f2c76.pdf c490f9b6de0f0589cc0ee609d1936ac4 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Severe Immune Thrombocytopenia Complicated by Intracerebral Haemorrhage Associated with Coronavirus Infection: A Case Report and Literature Review Creator An entity primarily responsible for making the resource Mohamed Magdi, Ali Rahil Description An account of the resource Immune thrombocytopenic purpura (ITP) is an autoimmune disorder that causes isolated thrombocytopenia. Many viruses have been identified as triggering the autoimmune process, including HIV, MCV, EBV, parvovirus, rubella and measles. However, ITP in association with coronavirus infection has not previously been reported. We describe the case of a healthy man who presented with severe ITP complicated by intracranial haemorrhage following upper respiratory tract infection. An infection screen revealed coronavirus infection. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Idiopathic thrombocytopenia, Intracranial bleeding, coronavirus Identifier An unambiguous reference to the resource within a given context DOI: 10.12890/2019_001155 Source A related resource from which the described resource is derived European Journal of Case Reports in Internal Medicine Publisher An entity responsible for making the resource available SMC MEDIA SRL Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/8858e1bd032548f6c2fda5aa28a69df8.pdf 6de9db30abba195ade2e3dbc81bf4dd9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Shared Common Ancestry of Rodent Alphacoronaviruses Sampled Globally Creator An entity primarily responsible for making the resource Theocharis Tsoleridis, Joseph G. Chappell, Okechukwu Onianwa, Denise A. Marston, Anthony R. Fooks, Elodie Monchatre-Leroy, Gérald Umhang, Marcel A. Müller, Jan F. Drexler, Christian Drosten, Rachael E. Tarlinton, Charles P. McClure, Edward C. Holmes, Jonathan K. Ball Description An account of the resource The recent discovery of novel alphacoronaviruses (alpha-CoVs) in European and Asian rodents revealed that rodent coronaviruses (CoVs) sampled worldwide formed a discrete phylogenetic group within this genus. To determine the evolutionary history of rodent CoVs in more detail, particularly the relative frequencies of virus-host co-divergence and cross-species transmission, we recovered longer fragments of CoV genomes from previously discovered European rodent alpha-CoVs using a combination of PCR and high-throughput sequencing. Accordingly, the full genome sequence was retrieved from the UK rat coronavirus, along with partial genome sequences from the UK field vole and Poland-resident bank vole CoVs, and a short conserved ORF1b fragment from the French rabbit CoV. Genome and phylogenetic analysis showed that despite their diverse geographic origins, all rodent alpha-CoVs formed a single monophyletic group and shared similar features, such as the same gene constellations, a recombinant beta-CoV spike gene, and similar core transcriptional regulatory sequences (TRS). These data suggest that all rodent alpha CoVs sampled so far originate from a single common ancestor, and that there has likely been a long-term association between alpha CoVs and rodents. Despite this likely antiquity, the phylogenetic pattern of the alpha-CoVs was also suggestive of relatively frequent host-jumping among the different rodent species. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource coronavirus, alphacoronavirus, Rodents, ancestry, recombination, evolution Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11020125 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN