113 10 20655 https://www.socictopen.socict.org/files/original/be9f833c8a138b0ca88711f26623ba8b.pdf 570831f69abf94871ef3a513313e257d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism Creator An entity primarily responsible for making the resource Jin-long Cheng, Ye Zhao, Gang Xu, Keran Zhang, Wenfeng Jia, Yali Sun, Jing Zhao, Jia Xue, Yanxin Hu, Guozhong Zhang Description An account of the resource Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2′ site of QX genotype (QX-type) infectious bronchitis virus (IBV) spike protein (S) in a recombinant virus background results in higher pathogenicity, pronounced neural symptoms and neurotropism when compared with conditions in wild-type IBV (WT-IBV) infected chickens. In this study, we present evidence suggesting that recombinant IBV with a mutant S2′ site (furin-S2′ site) leads to higher mortality. Infection with mutant IBV induces severe encephalitis and breaks the blood−brain barrier. The results of a neutralization test and immunoprotection experiment show that an original serum and vaccine can still provide effective protection in vivo and in vitro. This is the first demonstration of IBV-induced neural symptoms in chickens with encephalitis and the furin-S2′ site as a determinant of neurotropism. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource coronavirus, infectious bronchitis virus, qx type, furin-s2′ site, encephalitis, neurotropism Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11100972 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/040b800a45fe0264c4cf397a17b39d0e.pdf 4dfc8462558779cb87c9a3f989d1ce42 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 R0: Magic number or conundrum? Creator An entity primarily responsible for making the resource Giulio Viceconte, Nicola Petrosillo Description An account of the resource There is an increasing concern about COVID-19 worldwide. This is a new emerging infectious disease caused by a novel coronavirus (SARS-CoV-2), which recently broke out from the Chinese city of Wuhan and has quickly spread in China, with sporadic cases in each continent [...]. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource COVID-19; SARS-CoV-2; reproductive number; transmission Identifier An unambiguous reference to the resource within a given context DOI: 10.4081/idr.2020.8516 Source A related resource from which the described resource is derived Infectious Disease Reports Publisher An entity responsible for making the resource available PAGEPress Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Other systems of medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/10ce1ca35b1ae29cbf08c80e0253058a.pdf 6b9291b241224f6fdd8d293f16fabdaa Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome Creator An entity primarily responsible for making the resource I-Yin Chen, Miyu Moriyama, Ming-Fu Chang, Takeshi Ichinohe Description An account of the resource Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins stimulate IL-1β secretion following activation of the NLRP3 inflammasome. However, the mechanism by which severe acute respiratory syndrome coronavirus (SARS-CoV) activates the NLRP3 inflammasome remains unknown. Here, we provide direct evidence that SARS-CoV 3a protein activates the NLRP3 inflammasome in lipopolysaccharide-primed macrophages. SARS-CoV 3a was sufficient to cause the NLRP3 inflammasome activation. The ion channel activity of the 3a protein was essential for 3a-mediated IL-1β secretion. While cells uninfected or infected with a lentivirus expressing a 3a protein defective in ion channel activity expressed NLRP3 uniformly throughout the cytoplasm, NLRP3 was redistributed to the perinuclear space in cells infected with a lentivirus expressing the 3a protein. K+ efflux and mitochondrial reactive oxygen species were important for SARS-CoV 3a-induced NLRP3 inflammasome activation. These results highlight the importance of viroporins, transmembrane pore-forming viral proteins, in virus-induced NLRP3 inflammasome activation. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource SARS-CoV, Viroporin, inflammasome, IL-1β, inflammation Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2019.00050 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/3575937055efde49a0eef61b774d7d77.pdf 51088a2c7eaf3ec8ec7fcff6cba9629c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human Antibody Creator An entity primarily responsible for making the resource Sang-il Kim, Sujeong Kim, Jin-Hee Kim, Soyoung Chang, Jung Min Shim, Jongwha Jin, Chungsu Lim, Songyi Baek, Ji-Young MIN, Wan Beom Park, Myoung-don Oh, Seungtaek Kim, Junho Chung Description An account of the resource Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe aggravating respiratory failure in infected patients, frequently resulting in mechanical ventilation. As limited therapeutic antibody is accumulated in lung tissue following systemic administration, inhalation is newly recognized as an alternative, possibly better, route of therapeutic antibody for pulmonary diseases. The nebulization process, however, generates diverse physiological stresses, and thus, the therapeutic antibody must be resistant to these stresses, remain stable, and form minimal aggregates. We first isolated a MERS-CoV neutralizing antibody that is reactive to the receptor-binding domain (RBD) of spike (S) glycoprotein. To increase stability, we introduced mutations into the complementarity-determining regions (CDRs) of the antibody. In the HCDRs (excluding HCDR3) in this clone, two hydrophobic residues were replaced with Glu, two residues were replaced with Asp, and four residues were replaced with positively charged amino acids. In LCDRs, only two Leu residues were replaced with Val. These modifications successfully generated a clone with significantly greater stability and equivalent reactivity and neutralizing activity following nebulization compared to the original clone. In summary, we generated a MERS-CoV neutralizing human antibody that is reactive to recombinant MERS-CoV S RBD protein for delivery via a pulmonary route by introducing stabilizing mutations into five CDRs. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS-CoV, Aerosol delivery, Nebulizer, neutralizing antibody, antibody engineering, Pulmonary disease, complementarity determining regions Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijms20205073 Source A related resource from which the described resource is derived International Journal of Molecular Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry Language A language of the resource EN https://www.socictopen.socict.org/files/original/667675837725ac5958a46e3325f5896e.pdf 7edc8b7143c8c9e4315abc660dc93c91 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain Creator An entity primarily responsible for making the resource Yusen Zhou, Yang Yang, Jingwei Huang, Shibo Jiang, Lanying Du Description An account of the resource Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource coronavirus, MERS-CoV, spike protein, receptor-binding domain, vaccines, therapeutics Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11010060 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/5d23d88a959fe883801e5c8fcdbbca41.pdf 090df127af4e2002c9fb21192b024038 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Identification of a Novel Betacoronavirus (Merbecovirus) in Amur Hedgehogs from China Creator An entity primarily responsible for making the resource Susanna K. P. Lau, Hayes K. H. Luk, Antonio C. P. Wong, Rachel Y.Y. Fan, Carol S. F. Lam, Kenneth S. M. Li, Syed Shakeel Ahmed, Franklin W. N. Chow, Jian-Piao Cai, Xun Zhu, Jasper F. W. Chan, Terrence C. K. Lau, Kai-Yuan Cao, Mengfeng Li, Patrick C. Y. Woo, Kwok-yung Yuen Description An account of the resource While dromedaries are the immediate animal source of Middle East Respiratory Syndrome (MERS) epidemic, viruses related to MERS coronavirus (MERS-CoV) have also been found in bats as well as hedgehogs. To elucidate the evolution of MERS-CoV-related viruses and their interspecies transmission pathway, samples were collected from different mammals in China. A novel coronavirus related to MERS-CoV, Erinaceus amurensis hedgehog coronavirus HKU31 (Ea-HedCoV HKU31), was identified from two Amur hedgehogs. Genome analysis supported that Ea-HedCoV HKU31 represents a novel species under Merbecovirus, being most closely related to Erinaceus CoV from European hedgehogs in Germany, with 79.6% genome sequence identity. Compared to other members of Merbecovirus, Ea-HedCoV HKU31 possessed unique non-structural proteins and putative cleavage sites at ORF1ab. Phylogenetic analysis showed that Ea-HedCoV HKU31 and BetaCoV Erinaceus/VMC/DEU/2012 were closely related to NeoCoV and BatCoV PREDICT from African bats in the spike region, suggesting that the latter bat viruses have arisen from recombination between CoVs from hedgehogs and bats. The predicted HKU31 receptor-binding domain (RBD) possessed only one out of 12 critical amino acid residues for binding to human dipeptidyl peptidase 4 (hDPP4), the MERS-CoV receptor. The structural modeling of the HKU31-RBD-hDPP4 binding interphase compared to that of MERS-CoV and Tylonycteris bat CoV HKU4 (Ty-BatCoV HKU4) suggested that HKU31-RBD is unlikely to bind to hDPP4. Our findings support that hedgehogs are an important reservoir of Merbecovirus, with evidence of recombination with viruses from bats. Further investigations in bats, hedgehogs and related animals are warranted to understand the evolution of MERS-CoV-related viruses. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Hedgehog, merbecovirus, coronavirus, Novel species, China Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v11110980 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/22827db6d0a0a021330c3e46d80984a1.pdf 9bfb3fddc2d106dcc787e5b800528ec8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Selective Recording of Tectonic Forcings in an Oligocene/Miocene Submarine Channel System: Insights From New Age Constraints and Sediment Volumes From the Austrian Northern Alpine Foreland Basin Creator An entity primarily responsible for making the resource Julian Hülscher, Gero Fischer, Patrick Grunert, Gerald Auer, Anne Bernhardt Description An account of the resource Detailed characterization of variations in sediment architecture, flux, and transport processes in peri-orogenic basins offers insights into external climatic or tectonic forcings. We tested how four well-known tectonic/erosional events in the Oligocene/Miocene Alpine source area are recorded in the sediment-accumulation rates (SARs) of the deep marine sink in the Northern Alpine Foreland Basin (NAFB): exhumation of the Lepontine Dome (starting at 30 Ma) and the Tauern Window (23-21 Ma), erosion of the Augenstein Formation (∼21 Ma), and the visco-elastic relaxation of the European Plate. The Upper Austrian NAFB offers a unique opportunity to investigate external forcings on sedimentary infill due to the large amount of data on the Alpine hinterland and foreland. Deep-marine sedimentation, forming the Puchkirchen Group and the basal Hall Formation, was controlled by a basin-axial submarine channel (3–5 km wide, >100 km length). Two basin-wide unconformities were recognized in seismic-reflection data: the Northern Slope Unconformity (NSU) and the Base Hall Unconformity (BHU). We combine biostratigraphic and chemostratigraphic analyses of 316 drill-cutting samples from three wells with a large 3D-seismic-reflection data set (3300 km2, >5 km depth) to determine age and duration of the unconformities and to calculate spatially averaged SARs for the submarine channel and its overbanks, separately. Deepening of the basin, recorded by the NSU, occurred between 28.1 and 26.9 Ma. The Puchkirchen Group (26.9–19.6 Ma) is characterized by constant SARs (within standard deviation) in the channel [432–623 (t/m2/Ma)] and on the overbanks [240–340 (t/m2/Ma)]. The visco-elastic relaxation of the European Plate results in low SARs on the overbanks [186 (t/m2/Ma)], a decrease in sediment grain size in channel deposits and a decrease in sea level at the BHU (19.6–19.0 Ma). In the upper Hall Formation (19.0–18.1 Ma), clinoforms prograding from the south filled up the basin [1497 (t/m2/Ma)] within 1 Myrs. We conclude that only two of the tectonic signals are recorded in this part of the deep-marine sink, erosion of Augenstein Formation and visco-elastic relaxation of the European Plate; the exhumation of the Tauern Window and Lepontine Dome remain unrecorded. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource foraminiferal analysis, calcareous nannoplankton analysis, chemostratigraphy, submarine channel, Molasse Basin, environmental signal propagation Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/feart.2019.00302 Source A related resource from which the described resource is derived Frontiers in Earth Science Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Language A language of the resource EN https://www.socictopen.socict.org/files/original/c70d6778de044892f063f11e1361f06a.pdf db53c42fc6260dfa58f72d05adff6553 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists Creator An entity primarily responsible for making the resource Daniela Catarzi, Flavia Varano, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta Description An account of the resource The amino-3,5-dicyanopyridine derivatives belong to an intriguing series of adenosine receptor (AR) ligands that has been developed by both academic researchers and industry. Indeed, the studies carried out to date underline the versatility of the dicyanopyridine scaffold to obtain AR ligands with not only a wide range of affinities but also with diverse degrees of efficacies at the different ARs. These observations prompted us to investigate on the structure–activity relationships (SARs) of this series leading to important previously reported results. The present SAR study has helped to confirm the 1H-imidazol-2-yl group at R2 position as an important feature for producing potent AR agonists. Moreover, the nature of the R1 substituent highly affects not only affinity/activity at the hA1 and hA2B ARs but also selectivity versus the other subtypes. Potent hA1 and hA2B AR ligands were developed, and among them, the 2-amino-6-[(1H-imidazol-2-ylmethyl)sulfanyl]-4-[4-(prop-2-en-1-yloxy)phenyl]pyridine-3,5-dicarbonitrile (3) is active in the low nanomolar range at these subtypes and shows a good trend of selectivity versus both the hA2A and hA3 ARs. This combined hA1/hA2B partial agonist activity leads to a synergistic effect on glucose homeostasis and could potentially be beneficial in treating diabetes and related complications. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource G protein-coupled receptors, adenosine a2b receptor ligands, adenosine a1 receptor ligands, aminopyridine-3, 5-dicarbonitriles, ligand-adenosine receptor modeling studies Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ph12040159 Source A related resource from which the described resource is derived Pharmaceuticals Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica Language A language of the resource EN https://www.socictopen.socict.org/files/original/3de75c93461f9cc4c634b549bfb1bfc1.pdf 03dd75cc90e552b1fcc0396d621b16a1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study Creator An entity primarily responsible for making the resource Muhammad Tahir ul Qamar, Saman Saleem, Usman Ali Ashfaq, Amna Bari, Farooq Anwar, Safar Alqahtani Description An account of the resource Abstract Background Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia and South Korea. This infectious single-stranded, positive (+) sense RNA virus enters the host by binding to dipeptidyl-peptide receptors. Since no vaccine is yet available for MERS-COV, rapid case identification, isolation, and infection prevention strategies must be used to combat the spreading of MERS-COV infection. Additionally, there is a desperate need for vaccines and antiviral strategies. Methods The present study used immuno-informatics and computational approaches to identify conserved B- and T cell epitopes for the MERS-COV spike (S) protein that may perform a significant role in eliciting the resistance response to MERS-COV infection. Results Many conserved cytotoxic T-lymphocyte epitopes and discontinuous and linear B-cell epitopes were predicted for the MERS-COV S protein, and their antigenicity and interactions with the human leukocyte antigen (HLA) B7 allele were estimated. Among B-cell epitopes, QLQMGFGITVQYGT displayed the highest antigenicity-score, and was immensely immunogenic. Among T-cell epitopes, MHC class-I peptide YKLQPLTFL and MHC class-II peptide YCILEPRSG were identified as highly antigenic. Furthermore, docking analyses revealed that the predicted peptides engaged in strong bonding with the HLA-B7 allele. Conclusion The present study identified several MERS-COV S protein epitopes that are conserved among various isolates from different countries. The putative antigenic epitopes may prove effective as novel vaccines for eradication and combating of MERS-COV infection. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource MERS-CoV, spike protein, T-and B-cell epitopes, Computational approaches, vaccine design Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12967-019-2116-8 Source A related resource from which the described resource is derived Journal of Translational Medicine Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/5cd2daa9c98d85c92e94164651dcd4e7.pdf d5171dd9376d89c220b12b152c1eed73 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Les concours de l’enseignement : s’y préparer et réfléchir aux passerelles didactiques entre géographie scolaire et géographie scientifique Creator An entity primarily responsible for making the resource Sophie Bresc-Litzler Description An account of the resource Cet article vise à établir une synthèse sur les exigences du nouveau concours de l’enseignement (CAPES) d’histoire-géographie ainsi que sur de nouvelles méthodes pour s’y préparer. Les attentes au concours ont évolué avec le temps ; il faut donc aussi bien en comprendre les fondamentaux que réfléchir à la méthode, aux connaissances et au suivi de l’actualité afin de construire des schématisations, une culture générale réactualisée et acquérir une bonne connaissance des programmes du secondaire, qui sont des plus-values aux épreuves du concours de l’enseignement. Nous aimerions ainsi proposer des analyses de documents, des schémas, et des débats d’actualité sur les questions de géographie au programme (Mers et océans, la France des marges). Il s’agit de comprendre parallèlement la démarche de travail et les attentes de la réflexion géographique en identifiant les passerelles didactiques entre la géographie scolaire et la géographie scientifique universitaire : cela passe ainsi par la maîtrise des travaux scientifiques des principaux auteurs des questions mais aussi des échelles, des acteurs et des enjeux afin de les transmettre à de jeunes publics. Ces prolégomènes cherchent donc à fournir aux étudiants une méthode de travail efficace pour acquérir certaines compétences essentielles, nécessaires à la préparation des concours et attendues aux épreuves pour enseigner une discipline scientifique. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Concours de l’enseignement, programme scolaire, didactique, étude de cas, schematisation, géographie scientifique universitaire Identifier An unambiguous reference to the resource within a given context DOI: 10.4000/echogeo.14814 Source A related resource from which the described resource is derived EchoGéo Publisher An entity responsible for making the resource available Pôle de Recherche pour l'Organisation et la diffusion de l'Information Géographique Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Geography (General) Language A language of the resource FR