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                  <text>Agricultura sostenible</text>
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                <text>Rupesh Kumar Singh, Lav Sharma, Nitin Bohra, Vishnu  D. Rajput, Francisco  Roberto Quiroz-Figueroa, Guilhermina Marques</text>
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                <text>Entomopathogenic bacteria and fungi are quite frequently found in soils and insect cadavers. The first step in utilizing these microbes as biopesticides is to isolate them, and several culture media and insect baiting procedures have been tested in this direction. In this work, the authors review the current techniques that have been developed so far, in the last five decades, and display brief protocols which can be adopted for the isolations of these entomopathogens. Among bacteria, this review focuses on Serratia spp. and bacteria from the class Bacilli. Among fungi, the review focuses those from the order Hypocreales, for example, genera Beauveria, Clonostachys, Lecanicillium, Metarhizium, and Purpureocillium. The authors chose these groups of entomopathogenic bacteria and fungi based on their importance in the microbial biopesticide market.</text>
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                <text>&lt;a href="https://www.mdpi.com/2076-2607/9/1/16" target="_blank" rel="noreferrer noopener"&gt;https://www.mdpi.com/2076-2607/9/1/16&lt;/a&gt;</text>
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                <text>Yusen Zhou, Yang Yang, Jingwei Huang, Shibo Jiang, Lanying Du</text>
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                <text>Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy.</text>
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                <text>DOI: 10.3390/v11010060</text>
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                <text>(1) Background: Viral respiratory infections cause life-threatening diseases in millions of people worldwide every year. Human coronavirus and several picornaviruses are responsible for worldwide epidemic outbreaks, thus representing a heavy burden to their hosts. In the absence of specific treatments for human viral infections, natural products offer an alternative in terms of innovative drug therapies. (2) Methods: We analyzed the antiviral properties of the leaves and stem bark of the mulberry tree (Morus spp.). We compared the antiviral activity of Morus spp. on enveloped and nonenveloped viral pathogens, such as human coronavirus (HCoV 229E) and different members of the Picornaviridae family—human poliovirus 1, human parechovirus 1 and 3, and human echovirus 11. The antiviral activity of 12 water and water–alcohol plant extracts of the leaves and stem bark of three different species of mulberry—Morus alba var. alba, Morus alba var. rosa, and Morus rubra—were evaluated. We also evaluated the antiviral activities of kuwanon G against HCoV-229E. (3) Results: Our results showed that several extracts reduced the viral titer and cytopathogenic effects (CPE). Leaves’ water-alcohol extracts exhibited maximum antiviral activity on human coronavirus, while stem bark and leaves’ water and water-alcohol extracts were the most effective on picornaviruses. (4) Conclusions: The analysis of the antiviral activities of Morus spp. offer promising applications in antiviral strategies.</text>
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                <text>(1) Background: Viral respiratory infections cause life-threatening diseases in millions of people worldwide every year. Human coronavirus and several picornaviruses are responsible for worldwide epidemic outbreaks, thus representing a heavy burden to their hosts. In the absence of specific treatments for human viral infections, natural products offer an alternative in terms of innovative drug therapies. (2) Methods: We analyzed the antiviral properties of the leaves and stem bark of the mulberry tree (Morus spp.). We compared the antiviral activity of Morus spp. on enveloped and nonenveloped viral pathogens, such as human coronavirus (HCoV 229E) and different members of the Picornaviridae family—human poliovirus 1, human parechovirus 1 and 3, and human echovirus 11. The antiviral activity of 12 water and water–alcohol plant extracts of the leaves and stem bark of three different species of mulberry—Morus alba var. alba, Morus alba var. rosa, and Morus rubra—were evaluated. We also evaluated the antiviral activities of kuwanon G against HCoV-229E. (3) Results: Our results showed that several extracts reduced the viral titer and cytopathogenic effects (CPE). Leaves’ water-alcohol extracts exhibited maximum antiviral activity on human coronavirus, while stem bark and leaves’ water and water-alcohol extracts were the most effective on picornaviruses. (4) Conclusions: The analysis of the antiviral activities of Morus spp. offer promising applications in antiviral strategies.</text>
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                <text>Aletta E Schutte</text>
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                <text>10.1111/jch.14211</text>
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                <text>Journal of clinical hypertension (Greenwich, Conn.)</text>
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                <text>Advancing Neuroanesthesia and Neurocritical Care during the COVID-19 Pandemic and Infodemic: Focus on Education, Innovation, and Collaboration</text>
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                <text>Deepak Sharma</text>
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                <text>DOI: 10.1055/s-0040-1713018</text>
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                <text>Journal of Neuroanaesthesiology and Critical Care</text>
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                <text>Anesthesiology</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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        <name>Dublin Core</name>
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          <element elementId="50">
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                <text>Advancing Through the Pandemic From the Perspective of Marine Graduate Researchers: Challenges, Solutions, and Opportunities</text>
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              <elementText elementTextId="38101">
                <text>Isa Elegbede, Gabriel Stefanelli-Silva, Juan C. F. Pardo, Debra Ramon, Luciana S. Lima, Silas C. Principe</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="38102">
                <text>The ongoing COVID-19 pandemic has brought about a new social and academic reality to researchers worldwide. The field of marine science, our own topic of interest, has also been impacted in multiple ways, from cancelation of laboratory and field activities to postponement of onboard research. As graduate researchers, we have a time-sensitive academic path, and our current situation may constrain our academic future. At the same time, the pandemic demands revised strategies to deal with the ongoing difficulties and tackle similar future situations. In this perspective, we have gathered information on the challenges, solutions and opportunities for graduate researchers in the field of marine science by (1) discussing the relevant short-, long-term challenges caused by the pandemic, (2) providing feasible immediate and near-future solutions, (3) compiling opportunities (courses, scientific events, academic positions), and (4) creating a shared social media account to make the available information on new opportunities more accessible. With this, we hope to add to the efforts to advance the academic career of marine graduates during this harsh period.</text>
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              <elementText elementTextId="38103">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="38104">
                <text>Career, opportunities, early career researchers, marine science and technology, coronavirus pandemic</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="38105">
                <text>DOI: 10.3389/fmars.2020.00528</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="38106">
                <text>Frontiers in Marine Science</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="38107">
                <text>Frontiers Media S.A.</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="38108">
                <text>Science, General. Including nature conservation, geographical distribution</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
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          <element elementId="50">
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                <text>Adverse and Benevolent Childhood Experiences Predict Mental Health During the COVID-19 Pandemic.</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="78031">
                <text>Jenalee R Doom, Deborah Seok, Angela J Narayan, Kathryn R Fox</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="78032">
                <text>Adverse childhood experiences (ACEs) are associated with poorer adult mental health, and benevolent childhood experiences (BCEs) are associated with better adult mental health. This study aims to test whether ACEs and BCEs predict adult mental health above and beyond current stress and social support during the COVID-19 pandemic. We analyzed data from undergraduate and graduate students (N = 502) at an urban private university in the Western United States. An online survey was conducted to assess ACEs and BCEs, current stress and social support, depressive and anxiety symptoms, perceived stress, and loneliness in May 2020. Higher levels of ACEs were associated with higher levels of depressive symptoms, β = 0.45, p = 0.002. Higher levels of BCEs were associated with lower depressive symptoms, β = -0.39, p = 0.03; lower perceived stress, β = -0.26, p = 0.002; and less loneliness, β = -0.12, p = 0.04. These associations held while controlling for current stress, social support, and socioeconomic status. Childhood experiences are associated with mental health during the COVID-19 pandemic. BCEs should be considered an important promotive factor, independent of ACEs, for psychological well-being during a global public health crisis. BCEs should be included along with ACEs in future research, assessment, and screening with distressed and vulnerable populations.</text>
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            <name>Date</name>
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              <elementText elementTextId="78033">
                <text>2021</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="78034">
                <text>mental health, covid-19, Adverse childhood experiences, Benevolent childhood experiences</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="78035">
                <text>10.1007/s42844-021-00038-6</text>
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            <name>Source</name>
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              <elementText elementTextId="78036">
                <text>Adversity and resilience science</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="12378">
                <text>Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015</text>
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          <element elementId="39">
            <name>Creator</name>
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              <elementText elementTextId="12379">
                <text>Yanru Du, Jiahe Lin, Jingzan Shen, Siqi Ding, Mengqian Ye, Li Wang, Yi Wang, Xin-Shi Wang, Niange Xia, Rong-Yuan Zheng, Hong Chen, Hui-qin Xu</text>
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            <description>An account of the resource</description>
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              <elementText elementTextId="12380">
                <text>Abstract Background This active, open observational study aimed to investigate adverse drug reactions (ADRs) associated with six commonly used antiepileptic drugs (AEDs) in southern Chinese outpatients with epilepsy from 2003 to 2015. Methods The Wenzhou Epilepsy Follow-Up Registry Database (WEFURD) was established by a single epilepsy center in China in January 2003 to record AED efficacy and the associated ADRs by registered outpatients diagnosed with epilepsy. We reviewed the data of outpatients who had only taken one or more of six commonly used AEDs, namely, carbamazepine (CBZ), valproate (VPA), lamotrigine (LTG), oxcarbazepine (OXC), topiramate (TPM) and levetiracetam (LEV), and were registered in the WEFURD between 2003 and 2015. We evaluated the ADRs caused by the single or combined use of the above six specific AEDs based on the WHO-UMC scale. The data of the ADRs were categorized by age, sex, number of AEDs related to ADRs, medications, seriousness of ADRs, causality levels of the WHO-UMC scale and system organ class (SOC). The unit of analysis was one ADR. Results A total of 3069 epilepsy outpatients (1807 outpatients with 5049 eligible ADRs and 1262 outpatients without ADRs) were included. The overall ADR rate was 58.88% (1807/3069). An average of 2.79 ADRs (5049/1807) occurred per patient with an ADR; 53.8% of the 5049 ADRs were recorded in females, and 50.4% were caused by monotherapy. Of the ADRs, 10.6% (537/5049) were severe adverse reactions (SARs), including 34 serious adverse effects (SAEs). The SAR rates caused by one, two and three or more AEDs were 9.9, 10.0 and 19.6%, respectively (p </text>
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                <text>2019</text>
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            <name>Subject</name>
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                <text>adverse drug reactions, Antiepileptic drug, Severe adverse reactions, China</text>
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                <text>DOI: 10.1186/s40360-019-0285-y</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="12384">
                <text>BMC Pharmacology and Toxicology</text>
              </elementText>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="12386">
                <text>Therapeutics. Pharmacology, Toxicology. Poisons</text>
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            <description>A language of the resource</description>
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                <text>EN</text>
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                  <text>Agricultura sostenible</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Advertencias del panel intergubernamental del cambio climático</text>
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                <text>Revista de Economía Institucional</text>
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                <text>Economic theory. Demography, Economic history and conditions</text>
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                <text>&lt;a href="https://revistas.uexternado.edu.co/index.php/ecoins/article/view/7646" target="_blank" rel="noreferrer noopener"&gt;https://revistas.uexternado.edu.co/index.php/ecoins/article/view/7646&lt;/a&gt;</text>
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