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The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism
Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2′ site of QX genotype (QX-type)…
Position: 11139 (24 views)
COVID-19 R0: Magic number or conundrum?
There is an increasing concern about COVID-19 worldwide. This is a new emerging infectious disease caused by a novel coronavirus (SARS-CoV-2), which recently broke out from the Chinese city of Wuhan and has quickly spread in China, with sporadic…
Position: 14067 (21 views)
Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome
Nod-like receptor family, pyrin domain-containing 3 (NLRP3) regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18. We previously showed that influenza virus M2 or encephalomyocarditis virus (EMCV) 2B proteins…
Position: 8010 (28 views)
Generation of a Nebulizable CDR-Modified MERS-CoV Neutralizing Human Antibody
Middle East respiratory syndrome coronavirus (MERS-CoV) induces severe aggravating respiratory failure in infected patients, frequently resulting in mechanical ventilation. As limited therapeutic antibody is accumulated in lung tissue following…
Position: 11139 (24 views)
Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and…
Position: 8706 (27 views)
Identification of a Novel Betacoronavirus (<i>Merbecovirus</i>) in Amur Hedgehogs from China
While dromedaries are the immediate animal source of Middle East Respiratory Syndrome (MERS) epidemic, viruses related to MERS coronavirus (MERS-CoV) have also been found in bats as well as hedgehogs. To elucidate the evolution of MERS-CoV-related…
Position: 5882 (32 views)
Selective Recording of Tectonic Forcings in an Oligocene/Miocene Submarine Channel System: Insights From New Age Constraints and Sediment Volumes From the Austrian Northern Alpine Foreland Basin
Detailed characterization of variations in sediment architecture, flux, and transport processes in peri-orogenic basins offers insights into external climatic or tectonic forcings. We tested how four well-known tectonic/erosional events in the…
Position: 2601 (46 views)
Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors. Ranging from Pan Ligands to Combined A1/A2B Partial Agonists
The amino-3,5-dicyanopyridine derivatives belong to an intriguing series of adenosine receptor (AR) ligands that has been developed by both academic researchers and industry. Indeed, the studies carried out to date underline the versatility of the…
Position: 8706 (27 views)
Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study
Abstract Background Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the main cause of lung and kidney infections in developing countries such as Saudi Arabia and South Korea. This infectious single-stranded, positive (+) sense RNA virus…
Position: 13036 (22 views)
Les concours de l’enseignement : s’y préparer et réfléchir aux passerelles didactiques entre géographie scolaire et géographie scientifique
Cet article vise à établir une synthèse sur les exigences du nouveau concours de l’enseignement (CAPES) d’histoire-géographie ainsi que sur de nouvelles méthodes pour s’y préparer. Les attentes au concours ont évolué avec le temps ; il faut donc…
Position: 13036 (22 views)