115 10 20655 https://www.socictopen.socict.org/files/original/b8b260db7971d1430bd2f882f3c83140.pdf fb5ccdd5b019cfd4d984f96a416df509 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Quadruple 9-mer-based protein binding microarray with DsRed fusion protein Creator An entity primarily responsible for making the resource Park Hyang-Mi, Kim Yul-Ho, Pahk Yoon-Mok, Lee Tae-Ho, Kim Min-Jeong, Choi Yang, Nahm Baek, Kim Yeon-Ki Description An account of the resource Abstract Background The interaction between a transcription factor and DNA motif (cis-acting element) is an important regulatory step in gene regulation. Comprehensive genome-wide methods have been developed to characterize protein-DNA interactions. Recently, the universal protein binding microarray (PBM) was introduced to determine if a DNA motif interacts with proteins in a genome-wide manner. Results We facilitated the PBM technology using a DsRed fluorescent protein and a concatenated sequence of oligonucleotides. The PBM was designed in such a way that target probes were synthesized as quadruples of all possible 9-mer combinations, permitting unequivocal interpretation of the cis-acting elements. The complimentary DNA strands of the features were synthesized with a primer and DNA polymerase on microarray slides. Proteins were labeled via N-terminal fusion with DsRed fluorescent protein, which circumvents the need for a multi-step incubation. The PBM presented herein confirmed the well-known DNA binding sequences of Cbf1 and CBF1/DREB1B, and it was also applied to elucidate the unidentified cis-acting element of the OsNAC6 rice transcription factor. Conclusion Our method demonstrated PBM can be conveniently performed by adopting: (1) quadruple 9-mers may increase protein-DNA binding interactions in the microarray, and (2) a one-step incubation shortens the wash and hybridization steps. This technology will facilitate greater understanding of genome-wide interactions between proteins and DNA. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2199-10-91 Source A related resource from which the described resource is derived BMC Molecular Biology Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Genetics, Cytology Language A language of the resource EN https://www.socictopen.socict.org/files/original/9cd91169012de2bf167485d0ed02838a.pdf e22e1a54ca21143ba74e23b5fa195f07 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections Creator An entity primarily responsible for making the resource Hugh D. Mitchell, Amie J Eisfeld, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Ji Wen, Jason E. McDermott, Lisa E Gralinski, Amy C. Sims, Mai Q. Le, Ralph S. Baric, Yoshihiro Kawaoka, Katrina M. Waters Description An account of the resource Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection and effective management of highly pathogenic influenza virus disease. We applied a network-based modeling approach to identify critical functions related to influenza virus pathogenicity using large transcriptomic and proteomic datasets from mice infected with six influenza virus strains or mutants. Our analysis revealed two pathogenicity-related gene expression clusters; these results were corroborated by matching proteomics data. We also identified parallel downstream processes that were altered during influenza pathogenesis. We found that network bottlenecks (nodes that bridge different network regions) were highly enriched in pathogenicity-related genes, while network hubs (highly connected network nodes) were significantly depleted in these genes. We confirmed that this trend persisted in a distinct virus: Severe Acute Respiratory Syndrome Coronavirus (SARS). The role of epidermal growth factor receptor (EGFR) in influenza pathogenesis, one of the bottleneck regulators with corroborating signals across transcript and protein expression data, was tested and validated in additional mouse infection experiments. We demonstrate that EGFR is important during influenza infection, but the role it plays changes for lethal versus non-lethal infections. Our results show that by using association networks, bottleneck genes that lack hub characteristics can be used to predict a gene’s involvement in influenza virus pathogenicity. We also demonstrate the utility of employing multiple network approaches for analyzing host response data from viral infections. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Systems Biology, network topology, influenza, SARS-CoV, Data integration Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fcell.2019.00200 Source A related resource from which the described resource is derived Frontiers in Cell and Developmental Biology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/f78d917eb4cb671da430f84530730295.pdf dafd1f8e5b8a71fa049a41790d52d81e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Identifications of conserved 7-mers in 3'-UTRs and microRNAs in <it>Drosophila</it> Creator An entity primarily responsible for making the resource Zhang Xuegong, Fu Hu, Gu Jin, Li Yanda Description An account of the resource Abstract Background MicroRNAs (miRNAs) are a class of endogenous regulatory small RNAs which play an important role in posttranscriptional regulations by targeting mRNAs for cleavage or translational repression. The base-pairing between the 5'-end of miRNA and the target mRNA 3'-UTRs is essential for the miRNA:mRNA recognition. Recent studies show that many seed matches in 3'-UTRs, which are fully complementary to miRNA 5'-ends, are highly conserved. Based on these features, a two-stage strategy can be implemented to achieve the de novo identification of miRNAs by requiring the complete base-pairing between the 5'-end of miRNA candidates and the potential seed matches in 3'-UTRs. Results We presented a new method, which combined multiple pairwise conservation information, to identify the frequently-occurred and conserved 7-mers in 3'-UTRs. A pairwise conservation score (PCS) was introduced to describe the conservation of all 7-mers in 3'-UTRs between any two Drosophila species. Using PCSs computed from 6 pairs of flies, we developed a support vector machine (SVM) classifier ensemble, named Cons-SVM and identified 689 conserved 7-mers including 63 seed matches covering 32 out of 38 known miRNA families in the reference dataset. In the second stage, we searched for 90 nt conserved stem-loop regions containing the complementary sequences to the identified 7-mers and used the previously published miRNA prediction software to analyze these stem-loops. We predicted 47 miRNA candidates in the genome-wide screen. Conclusion Cons-SVM takes advantage of the independent evolutionary information from the 6 pairs of flies and shows high sensitivity in identifying seed matches in 3'-UTRs. Combining the multiple pairwise conservation information by the machine learning approach, we finally identified 47 miRNA candidates in D. melanogaster. Date A point or period of time associated with an event in the lifecycle of the resource 2007 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2105-8-432 Source A related resource from which the described resource is derived BMC Bioinformatics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Computer applications to medicine. Medical informatics Language A language of the resource EN https://www.socictopen.socict.org/files/original/90767cad81e9a8f39a254629f4e9e4b5.pdf 86e1874b4f27d526f64d6c2e9a91ddfa Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource De la recommandation de 2002 au Livre Vert de 2006 : quelle stratégie européenne pour la gestion intégrée des zones côtières (GIZC) Creator An entity primarily responsible for making the resource Mahfoud Ghézali Description An account of the resource Le colloque « De la recommandation de 2002 au Livre Vert de 2006 : quelle stratégie européenne, pour la GIZC ? » avait pour ambition de rendre compte d’une double réalité différenciée et en construction. Il s’agit pour la Commission d’une part de promouvoir auprès des Etats à littoral de l’U.E. l’élaboration d’une approche stratégique nationale d’aménagement et de GIZC, selon l’échéance programmée de 2006 et de soumettre à évaluation les rapports nationaux notifiés par les Etats à la Commission. D’autre part de lancer un vaste débat auprès de toutes les parties prenantes de l’U.E. sur la construction d’une politique maritime intégrée européenne (PMI). Il apparaît tout d’abord que la stratégie de GIZC et la PMI sont étroitement liées entre elles, notamment autour de l’appel à une méthode d’approche commune, la GIZC appliquée à des échelles différenciées ; celles de la zone côtière et celle des espaces marins, la PMI étant par ailleurs enracinée dans le programme de Lisbonne pour la promotion de l’emploi et la stimulation de la croissance. On note d’emblée que la GIZC apparaît nettement à travers les textes fondamentaux pertinents comme une source d’inspiration méthodologique pour une approche globale et intégrée de la PMI aussi bien du point de vue des caractéristiques de la GIZC sur les espaces de référence que de l’équilibre vertueux exigé pour l’approche de la durabilité à la fois éco-systémique, économique et sociale, voire culturelle. A la dimension des mers et océans, une autre exigence se manifeste nettement, celle de renouveler l’appareil conceptuel et instrumental de la GIZC pour tenir compte des nouvelles échelles d’analyse entraînant le déplacement vers la mer du centre de gravité de la GIZC et du profil nouveau de la gouvernance. La conséquence logique de ce préalable important apparaît dans les caractéristiques des concepts utilisés, c’est-à-dire le territoire de la GIZC, la gouvernance, la planification participative, la répartition des compétences. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource coastal zone, environment, ENVIRONNEMENT, Governance, integrated coastal management, Integrated management Identifier An unambiguous reference to the resource within a given context DOI: 10.4000/vertigo.8327 Source A related resource from which the described resource is derived VertigO Publisher An entity responsible for making the resource available Éditions en environnement VertigO Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences Language A language of the resource FR https://www.socictopen.socict.org/files/original/117b7c7947b96ddb94ecf83d92e97153.pdf 09e4bab77eb30a9578a89a7b2ebd9c5b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource La gestion intégrée côtière et marine : nouvelles perspectives Creator An entity primarily responsible for making the resource Christophe Lefebvre Description An account of the resource Au niveau global et régional, la gestion intégrée côtière et marine en tant que processus itératif partant de l’évaluation scientifique vers l’aménagement intégré des côtes en passant par de nouveaux modes de gouvernance, doit être aussi reconnue comme un enjeu stratégique de développement durable de la partie marine des zones côtières. Il est impératif à cet égard qu’elle puisse se développer dans de nouveaux protocoles aux conventions régionales sur les mers où elle a toute sa place. Le comité opérationnel du Grenelle de la mer a d’ailleurs proposé au gouvernement de passer de la Gestion Intégrée des Zones Côtières à la Gestion Intégrée de la Mer et du Littoral, aux niveaux national et par façade maritime en s’appuyant notamment sur les mesures visant à élaborer la « stratégie nationale de la mer et du littoral », et à la déclinaison de cette stratégie par façade. En ce qui concerne les intentions, la France vient de faire un grand pas en avant vers la mer, ce territoire vingt fois plus grand que sa partie terrestre, au rang de la deuxième superficie maritime nationale au monde. Au regard des enjeux de développement durable, la France se doit de réussir la stratégie nationale de la mer et du littoral et d’établir les bases d’une planification spatiale marine indispensable aux acteurs de l’environnement et de l’économie, littoral et maritime. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource Coastal management, environment, Integrated management, integrated management of coastal areas Identifier An unambiguous reference to the resource within a given context DOI: 10.4000/vertigo.10985 Source A related resource from which the described resource is derived VertigO Publisher An entity responsible for making the resource available Éditions en environnement VertigO Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences Language A language of the resource FR https://www.socictopen.socict.org/files/original/9e1bab1be0b5db74ca6197c3ad113895.pdf f9e20e66bbd5e7f9cbbc236bd0e83eb9 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune system Creator An entity primarily responsible for making the resource Ya-nan WANG, Aoying Sun, Yu Sun, Sijia Zhang, Tian Xia, Tiantian GUO, Zhenye Hao, Li Sun, Yanping Jiang, Xinyuan Qiao, Wen Cui, Lijie Tang, Yigang Xu, Yijing Li, Li Wang Description An account of the resource Abstract Background Transmissible gastroenteritis virus (TGEV), a member of the family Coronaviridae, causes lethal watery diarrhea in piglets. Previous studies have revealed that the coronaviruses develop various strategies to evade the host innate immunity through the inhibition of nuclear factor kappa B (NF-κB) signaling pathway. However, the ability of TGEV to inhibit the host innate immune response by modulating the NF-κB signaling pathway is not clear. Methods In this study, a dual luciferase reporter assay was used to confirm the inhibition of NF-κB by TGEV infection and to identify the major viral proteins involved in the inhibition of NF-κB signaling. Real-time quantitative PCR was used to quantify the mRNA expression of inflammatory factors. The deubiquitination of Nsp3 domains and its effect on IκBα and p65 were analyzed by western blotting. The ubiquitination level of IκBα was analyzed by immunoprecipitation. Results In ST and IPEC-J2 cells, TGEV exhibited a dose-dependent inhibition of NF-κB activity. Individual TGEV protein screening revealed the high potential of non-structural protein 3 (Nsp3) to inhibit NF-κB signaling, and leading to the downregulation of the NF-κB-induced cytokine production. We demonstrated that the inhibitory effect of Nsp3 was mainly mediated through the suppression of IκBα degradation as well as the inhibition of p65 phosphorylation and nuclear translocation. Furthermore, the amino acid residues at positions 590–1,215 in Nsp3 were demonstrated to inhibit the degradation of IκBα by inhibiting the IκBα ubiquitination. Conclusion TGEV infection can inhibit the activation of the NF-κB signaling pathway, which is mainly mediated by Nsp3 through the canonical pathway. The amino acid residues at positions 590–1,215 in Nsp3 compose the critical domain that mediates NF-κB inhibition. We speculate that this inhibitory effect is likely to be related to the structure of PLP2 with deubiquitinating enzyme activity of the amino acid residues at positions 590–1,215 in Nsp3. Our study provides a better understanding of the TGEV-mediated innate immune modulation and lays the basis for studies on the pathogenesis of coronavirus. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource TGEV, nsP3, NF-κB, Ubiquitination, PLP Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12985-019-1206-9 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/473519f5ce1ef681238704463d51572f.pdf 7f0811ef72fa1e43cad2f2db24579890 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The causes and consequences of changes in virulence following pathogen host shifts. Creator An entity primarily responsible for making the resource Ben Longdon, Jarrod D Hadfield, Jonathan P Day, Sophia C L Smith, John E McGonigle, Rodrigo Cogni, Chuan Cao, Francis M. Jiggins Description An account of the resource Emerging infectious diseases are often the result of a host shift, where the pathogen originates from a different host species. Virulence--the harm a pathogen does to its host-can be extremely high following a host shift (for example Ebola, HIV, and SARs), while other host shifts may go undetected as they cause few symptoms in the new host. Here we examine how virulence varies across host species by carrying out a large cross infection experiment using 48 species of Drosophilidae and an RNA virus. Host shifts resulted in dramatic variation in virulence, with benign infections in some species and rapid death in others. The change in virulence was highly predictable from the host phylogeny, with hosts clustering together in distinct clades displaying high or low virulence. High levels of virulence are associated with high viral loads, and this may determine the transmission rate of the virus. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1004728 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/323901ed4e2a74f743fedf27323b3f21.pdf 50187142c95a84b933624ba331cf67a6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Porcine Deltacoronavirus Infection and Transmission in Poultry, United States Creator An entity primarily responsible for making the resource Patricia A. Boley, Moyasar A. Alhamo, Geoffrey Lossie, Kush Kumar Yadav, Marcia Vasquez-Lee, Linda J. Saif, Scott P Kenney Description An account of the resource Coronaviruses cause respiratory and gastrointestinal diseases in diverse host species. Deltacoronaviruses (DCoVs) have been identified in various songbird species and in leopard cats in China. In 2009, porcine deltacoronavirus (PDCoV) was detected in fecal samples from pigs in Asia, but its etiologic role was not identified until 2014, when it caused major diarrhea outbreaks in swine in the United States. Studies have shown that PDCoV uses a conserved region of the aminopeptidase N protein to infect cell lines derived from multiple species, including humans, pigs, and chickens. Because PDCoV is a potential zoonotic pathogen, investigations of its prevalence in humans and its contribution to human disease continue. We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource porcine deltacoronavirus, swine disease, interspecies transmission, Chickens, Turkeys, poultry Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid2602.190346 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/5beb25c99275a2672a0a657891548447.pdf 0f2819c4310863baa766ca11cd51d1d8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Hox gene expression during development of the phoronid Phoronopsis harmeri Creator An entity primarily responsible for making the resource Ludwik Gąsiorowski, Andreas Hejnol Description An account of the resource Abstract Background Phoronida is a small group of marine worm-like suspension feeders, which together with brachiopods and bryozoans form the clade Lophophorata. Although their development is well studied on the morphological level, data regarding gene expression during this process are scarce and restricted to the analysis of relatively few transcription factors. Here, we present a description of the expression patterns of Hox genes during the embryonic and larval development of the phoronid Phoronopsis harmeri. Results We identified sequences of eight Hox genes in the transcriptome of Ph. harmeri and determined their expression pattern during embryonic and larval development using whole mount in situ hybridization. We found that none of the Hox genes is expressed during embryonic development. Instead their expression is initiated in the later developmental stages, when the larval body is already formed. In the investigated initial larval stages the Hox genes are expressed in the non-collinear manner in the posterior body of the larvae: in the telotroch and the structures that represent rudiments of the adult worm. Additionally, we found that certain head-specific transcription factors are expressed in the oral hood, apical organ, preoral coelom, digestive system and developing larval tentacles, anterior to the Hox-expressing territories. Conclusions The lack of Hox gene expression during early development of Ph. harmeri indicates that the larval body develops without positional information from the Hox patterning system. Such phenomenon might be a consequence of the evolutionary intercalation of the larval form into an ancestral life cycle of phoronids. The observed Hox gene expression can also be a consequence of the actinotrocha representing a “head larva”, which is composed of the most anterior body region that is devoid of Hox gene expression. Such interpretation is further supported by the expression of head-specific transcription factors. This implies that the Hox patterning system is used for the positional information of the trunk rudiments and is, therefore, delayed to the later larval stages. We propose that a new body form was intercalated to the phoronid life cycle by precocious development of the anterior structures or by delayed development of the trunk rudiment in the ancestral phoronid larva. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Lophophorata, Spiralia, biphasic life cycle, intercalation, life history evolution, body plan Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13227-020-0148-z Source A related resource from which the described resource is derived EvoDevo Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Evolution Language A language of the resource EN https://www.socictopen.socict.org/files/original/358bee33378760771c2c875f67a99017.pdf 0708aae73463f14793ba8185d3ff8cf5 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Bythocythere solisdeus n. sp. and Cytheropteron eleonorae n. sp. (Crustacea, Ostracoda) from the Early Pleistocene Bathyal Sediments of Cape Milazzo (NE, Sicily) Creator An entity primarily responsible for making the resource Francesco Sciuto Description An account of the resource Two new fossil species of Ostracoda belonging to the genus Bythocythere Sars, 1866, Bythocythere solisdeus n. sp. and to the genus Cytheropteron Sars, 1866, Cytheropteron eleonorae n. sp. are described. The specimens come from the upper silty sand layers of the Globorotalia truncatulinoides excelsa Zone (“Sicilian” stage), cropping out in “Cala S. Antonino” along the western side of the Cape Milazzo Peninsula (NE Sicily). Both species belong to a typical Bathyal ostracod association characterized by very low temperatures. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Marine ostracods, new species, Early pleistocene, bathyal, Sicily Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/geosciences2030147 Source A related resource from which the described resource is derived Geosciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Geology Language A language of the resource EN