117 10 20655 https://www.socictopen.socict.org/files/original/414d19c86f7290b4cdc67688d2b35e80.pdf 6faa404445fe2d29de8e697a89c0f43a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A planarian nidovirus expands the limits of RNA genome size. Creator An entity primarily responsible for making the resource Amir Saberi, Anastasia A Gulyaeva, John L Brubacher, Phillip A Newmark, Alexander E Gorbalenya Description An account of the resource RNA viruses are the only known RNA-protein (RNP) entities capable of autonomous replication (albeit within a permissive host environment). A 33.5 kilobase (kb) nidovirus has been considered close to the upper size limit for such entities; conversely, the minimal cellular DNA genome is in the 100-300 kb range. This large difference presents a daunting gap for the transition from primordial RNP to contemporary DNA-RNP-based life. Whether or not RNA viruses represent transitional steps towards DNA-based life, studies of larger RNA viruses advance our understanding of the size constraints on RNP entities and the role of genome size in virus adaptation. For example, emergence of the largest previously known RNA genomes (20-34 kb in positive-stranded nidoviruses, including coronaviruses) is associated with the acquisition of a proofreading exoribonuclease (ExoN) encoded in the open reading frame 1b (ORF1b) in a monophyletic subset of nidoviruses. However, apparent constraints on the size of ORF1b, which encodes this and other key replicative enzymes, have been hypothesized to limit further expansion of these viral RNA genomes. Here, we characterize a novel nidovirus (planarian secretory cell nidovirus; PSCNV) whose disproportionately large ORF1b-like region including unannotated domains, and overall 41.1-kb genome, substantially extend the presumed limits on RNA genome size. This genome encodes a predicted 13,556-aa polyprotein in an unconventional single ORF, yet retains canonical nidoviral genome organization and expression, as well as key replicative domains. These domains may include functionally relevant substitutions rarely or never before observed in highly conserved sites of RdRp, NiRAN, ExoN and 3CLpro. Our evolutionary analysis suggests that PSCNV diverged early from multi-ORF nidoviruses, and acquired additional genes, including those typical of large DNA viruses or hosts, e.g. Ankyrin and Fibronectin type II, which might modulate virus-host interactions. PSCNV's greatly expanded genome, proteomic complexity, and unique features-impressive in themselves-attest to the likelihood of still-larger RNA genomes awaiting discovery. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1007314 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/32623397d1115488e34963b60cf0810c.pdf 444957d8cdf07d5164cc12c79aa1abb2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Obesity and COVID-19: Oro-Naso-Sensory Perception Creator An entity primarily responsible for making the resource Amira Sayed Khan, Aziz Hichami, Naim Akhtar Khan Description An account of the resource Through a recent upsurge of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, the clinical assessment of most of the coronavirus disease 19 (COVID-19) patients clearly presents a health condition with the loss of oro-naso-sensory (ONS) perception, responsible for the detection of flavor and savor. These changes include anosmia and dysgeusia. In some cases, these clinical manifestations appear even before the general flu-like symptoms, e.g., sore throat, thoracic oppression and fever. There is no direct report available on the loss of these chemical senses in obese COVID-19 patients. Interestingly, obesity has been shown to be associated with low ONS cues. These alterations in obese subjects are due to obesity-induced altered expression of olfacto-taste receptors. Besides, obesity may further aggravate the SARS-CoV-2 infection, as this pathology is associated with a high degree of inflammation/immunosuppression and reduced protection against viral infections. Hence, obesity represents a great risk factor for SARS-CoV-2 infection, as it may hide the viral-associated altered ONS symptoms, thus leading to a high mortality rate in these subjects. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, obesity, taste, Smell Identifier An unambiguous reference to the resource within a given context 10.3390/jcm9072158 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/9150ad8b82cb7b995ba08e2afe1b7217.pdf ed3d0683c30c9f33c96c05b0d1d6ab4a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen Creator An entity primarily responsible for making the resource Amira Mohammed Ali, Hiroshi Kunugi Description An account of the resource The global pandemic of sarcopenia, skeletal muscle loss and weakness, which prevails in up to 50% of older adults is increasing worldwide due to the expansion of aging populations. It is now striking young and midlife adults as well because of sedentary lifestyle and increased intake of unhealthy food (e.g., western diet). The lockdown measures and economic turndown associated with the current outbreak of Coronavirus Disease 2019 (COVID-19) are likely to increase the prevalence of sarcopenia by promoting sedentarism and unhealthy patterns of eating. Sarcopenia has multiple detrimental effects including falls, hospitalization, disability, and institutionalization. Although a few pharmacological agents (e.g., bimagrumab, sarconeos, and exercise mimetics) are being explored in different stages of trials, not a single drug has been approved for sarcopenia treatment. Hence, research has focused on testing the effect of nutraceuticals, such as bee products, as safe treatments to prevent and/or treat sarcopenia. Royal jelly, propolis, and bee pollen are common bee products that are rich in highly potent antioxidants such as flavonoids, phenols, and amino acids. These products, in order, stimulate larval development into queen bees, promote defenses of the bee hive against microbial and environmental threats, and increase royal jelly production by nurse bees. Thanks to their versatile pharmacological activities (e.g., anti-aging, anti-inflammatory, anticarcinogenic, antimicrobial, etc.), these products have been used to treat multiple chronic conditions that predispose to muscle wasting such as hypertension, diabetes mellitus, cardiovascular disorder, and cancer, to name a few. They were also used in some evolving studies to treat sarcopenia in laboratory animals and, to a limited degree, in humans. However, a collective understanding of the effect and mechanism of action of these products in skeletal muscle is not well-developed. Therefore, this review examines the literature for possible effects of royal jelly, bee pollen, and propolis on skeletal muscle in aged experimental models, muscle cell cultures, and humans. Collectively, data from reviewed studies denote varying levels of positive effects of bee products on muscle mass, strength, and function. The likely underlying mechanisms include amelioration of inflammation and oxidative damages, promotion of metabolic regulation, enhancement of satellite stem cell responsiveness, improvement of muscular blood supply, inhibition of catabolic genes, and promotion of peripheral neuronal regeneration. This review offers suggestions for other mechanisms to be explored and provides guidance for future trials investigating the effects of bee products among people with sarcopenia. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource sarcopenia, propolis, royal jelly, apitherapy, dietary interventions, bee pollen Identifier An unambiguous reference to the resource within a given context 10.3390/foods9101362 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chemical technology https://www.socictopen.socict.org/files/original/cf9e0665563a2b5634074943f5dfbe33.pdf 17730b35985687f9d1c381400546d264 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Human-Wildlife Conflicts in the Southern Yungas: What Role do Raptors Play for Local Settlers? Creator An entity primarily responsible for making the resource Amira Salom, María Eugenia Suárez, Cecilia Andrea Destefano, Joaquín Cereghetti, Félix Hernán Vargas, Juan Manuel Grande Description An account of the resource Wildlife persecution due to human-wildlife conflict has become a serious concern for biodiversity conservation, especially for many endangered species. In this context, conservation approaches need to consider the socio-ecological dimensions of each particular situation. The aim of this study was to evaluate the existence, extent and social characteristics of Human-Raptor Conflicts (HRC) in the Southern Yungas region in northwestern Argentina. We conducted 115 semi-structured interviews in 21 sites and analyzed attitudes and associations between sociodemographic variables and the existence of HRC. Forty percent of interviewees showed negative attitudes towards raptors, mainly with those species considered livestock predators rather than poultry predators. A total of 11 species were regarded as conflictive because of predation on domestic animals, of which Andean condors showed the highest conflict. The only socio-demographic factor affecting conflicts was livestock and poultry rearing, independently of age, gender and occupation of interviewees. The fact that only 8.7% of interviewees reported taking direct actions towards conflictive species indicates a relatively peaceful coexistence of people with raptors. Nevertheless, negative attitudes towards Andean condor together with their extreme susceptibility to any increase in non-natural mortality indicate the need of an integral conservation approach to tackle future threats for this species’ conservation in the area. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource <i>Vultur gryphus</i>, Andean Condor, Attitudes, Human-wildlife conflict, human-wildlife interactions, perceptions Identifier An unambiguous reference to the resource within a given context 10.3390/ani11051428 Source A related resource from which the described resource is derived Animals Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine, Zoology Relation A related resource <a href="https://www.mdpi.com/2076-2615/11/5/1428" target="_blank" rel="noreferrer noopener">https://www.mdpi.com/2076-2615/11/5/1428</a> https://www.socictopen.socict.org/files/original/150afc1bc62e2896b792d356b9c862e0.pdf e7500ac71384addb8ab5763d0ea2eac6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Asthma and COVID-19: In Defense of Evidence-Based SABA Creator An entity primarily responsible for making the resource Amirav I, Newhouse MT Description An account of the resource Israel Amirav,1 Michael T Newhouse2 1Pediatric Department, University of Alberta, Edmonton, AB T6G2C6, Canada; 2Firestone Institute for Respiratory Health, St. Joseph&rsquo;s Hospital, McMaster University, Hamilton, ON, CanadaCorrespondence: Israel AmiravDana-Dwek Children&rsquo;s Hospital, Tel Aviv, IsraelTel +1 972-55-6649359Email amirav@ualberta.caAbstract: There have recently been major objections to the use of short-acting beta-agonist (SABA) in episodic acute asthma culminating in a call for replacing SABA with combination of inhaled corticosteroids and long-acting beta-agonists despite little evidence supporting this point of view. It is regrettable to note that this attack on SABA occurs in the midst of an unprecedented demand for, and shortage of, SABA inhalers during the current COVID-19 pandemic, and the worldwide efforts to increase SABA supplies. In this commentary, we defend the well-established role of SABA and argue that the call for the phase out of SABA is inappropriate, since it is not solidly evidence based.Keywords: asthma, beta-agonists, COVID-19, inhalers Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Asthma, covid-19, inhalers, beta-agonists Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy https://www.socictopen.socict.org/files/original/1ec8849be26e3ec750750b39adf84051.pdf 3a89ef74b4bf685e2311f014744349d8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Design of Novel ETL Model to Analyse Corona Virus Data Creator An entity primarily responsible for making the resource Amit Dewangan, S.M. Ghosh, Akhilesh Shrivas Description An account of the resource INTRODUCTION:The corona disease was first recognized in 2019 in Wuhan, which is the capital of China’s Hubei-province,and from then it continued spreading and as a result declared as a pandemic by all nations. The COVID-19virus has different effects on people in various ways. It is a kind of respiratory disease. The confirmed casesare increasing day to day in India, which leads to complete lockdown throughout the nation.OBJECTIVE:The objective of this research is to design a novel Extract-Trandform and Load NETL model to analyse covid19 data in india.METHODS:The extraction of useful information from a large database is a well-connected research field of text mining.This paper is proposed a novel extract-transform-load ETL model to process the COVID-19 data of India toget the exact recovery data from the multiple data sources from different states of India. In this, a knowledgebased model that generate knowledge based on three different module split, validation, and join is discussed.RESULTS:The outcomes of the proposed NETL process are, output file which has the description of total positive cases,active cases, recovery cases, and death rate, based on different regions. The analysis of NETL is done basedon accuracy, failure count, and execution time. The proposed NETL process is more accurate and taking lesscompilation time with minimum failure count as compared with existing models.CONCLUSION:To analyze the coronavirus data in India, a novel ETL (NETL) model is proposed. In this model, a total of 9CSV files is processed as input files to get different results in different categories. This model is having threemodules namely splitting, verification, and join. The dataset is split into based on its coupling attributes andthen joined with a single value to produce the updated results as per the current dataset. The last stage of thisprocess is to join the data which is generated through splitting. The proposed NETL model is more accurateas compared with existing ETM models. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, covid-19, Pandemic, text mining, Data analytics, ETL Identifier An unambiguous reference to the resource within a given context 10.4108/eai.13-7-2018.165671 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Medical technology https://www.socictopen.socict.org/files/original/e9d132c338cca57331e687defaaea045.pdf 2819c9d464dde05f06d8d63e5477262e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Analytical Review of COVID-19 Outbreak in India During the Global Pandemic Creator An entity primarily responsible for making the resource Amit Ganatra, Parth Goel, Dweepna Garg Description An account of the resource COVID-19 is one of the very contagious diseases from the family Coronaviridae and spreading at afaster rate in the community. In December 2019, the first case of COVID-19 was reported in Wuhan,China. An epidemic outbreak of COVID-19 was seen in India from March 2020. Epidemiological dataof COVID-19 cases of the world and India have been analyzed in our study. We have utilized publiclyavailable two databases from data repository by Johns Hopkins CSSE and covid19india.org. COVID-19cases and case fatality rate (CFR) of the world have been summarized and compared with India fromJanuary 22, 2020 to April 15, 2020. Indian cases were analyzed among states of India and also comparedwith age and gender by performing statistical approaches such as central tendency, standard deviationand interquartile range. By April 15, 2020, Indian has reported 12,322 confirmed cases, 1,498 recoveredcases and 405 death cases of COVID-19. In spite of India being a diverse country with the secondhighest population, the deadly side of COVID-19 was comparatively far less as compared to the othercountries. India has taken preemptive measures at an early stage to prevent transmission of COVID-19outbreak and it is reviewed from our study by comparing India with other countries. Our study alsosummarizes that age also plays a vital role in the intervention of COVID-19 cases. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource India, coronavirus, statistical analysis, epidemic, Pandemic, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.27 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/5663a4c4dead516fe62657a25094f2b4.pdf 6a0ba4fc78f218468e589a864cf4c9a6 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Indian Economy Amid COVID-19 Lockdown: A Prespective Creator An entity primarily responsible for making the resource Amit Joshi, Puneet Kumar Gupta, Preeti Bhaskar Description An account of the resource COVID-19 virus has resulted in the lockdown of schools, offices, factories, temples, railway stations,and even the airspace. It is estimated that due to the lockdown, the Indian economy may faceprolonged adverse impact. The paper is an attempt to ascertain the impact of lockdown on the Indianeconomy and explore future perspective. The study has addressed important issues like consumptionexpenditure, demand & supply, unemployment rate, purchasing power, financial market, etc. Under thegiven circumstances, the lockdown will cost India around USD 120 bn. The manufacturing and servicesector has come to an abrupt stop and interrupted domestic supply chains. If this crisis continuous itwill indirectly affect all economic sectors. The study has given suggestions as a learning curve whichcan be used by different stakeholder to improve the economic situation of the country and minimizenegative effect of lockdown. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource crisis, coronavirus, economy, WHO, COVID-19, lockdown Identifier An unambiguous reference to the resource within a given context DOI: 10.22207/JPAM.14.SPL1.33 Source A related resource from which the described resource is derived Journal of Pure and Applied Microbiology Publisher An entity responsible for making the resource available Journal of Pure and Applied Microbiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/2cfcf3860158c6be92cd074d1f3997da.pdf 2236bb2be203c284373b70903bd9e46e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource CoronaVR: A Computational Resource and Analysis of Epitopes and Therapeutics for Severe Acute Respiratory Syndrome Coronavirus-2 Creator An entity primarily responsible for making the resource Amit Kumar Gupta, Md. Shoaib Khan, Shubham Choudhury, Adhip Mukhopadhyay, Adhip Mukhopadhyay, Sakshi, Sakshi, Amber Rastogi, Amber Rastogi, Anamika Thakur, Anamika Thakur, Pallawi Kumari, Manmeet Kaur, Shalu, Chanchal Saini, Vandna Sapehia, Barkha, Pradeep Kumar Patel, Kailash T. Bhamare, Manoj Kumar, Manoj Kumar Description An account of the resource In December 2019, the Chinese city of Wuhan was the center of origin of a pneumonia-like disease outbreak with an unknown causative pathogen. The CDC, China, managed to track the source of infection to a novel coronavirus (2019-nCoV; SARS-CoV-2) that shares approximately 79.6% of its genome with SARS-CoV. The World Health Organization (WHO) initially declared COVID-19 as a Public Health Emergency of International Concern (PHEIC) and later characterized it as a global pandemic on March 11, 2020. Due to the novel nature of this virus, there is an urgent need for vaccines and therapeutics to control the spread of SARS-CoV-2 and its associated disease, COVID-19. Global efforts are underway to circumvent its further spread and treat COVID-19 patients through experimental vaccine formulations and therapeutic interventions, respectively. In the absence of any effective therapeutics, we have devised h bioinformatics-based approaches to accelerate global efforts in the fight against SARS-CoV-2 and to assist researchers in the initial phase of vaccine and therapeutics development. In this study, we have performed comprehensive meta-analyses and developed an integrative resource, “CoronaVR” (http://bioinfo.imtech.res.in/manojk/coronavr/). Predominantly, we identified potential epitope-based vaccine candidates, siRNA-based therapeutic regimens, and diagnostic primers. The resource is categorized into the main sections “Genomes,” “Epitopes,” “Therapeutics,” and Primers.” The genome section harbors different components, viz, genomes, a genome browser, phylogenetic analysis, codon usage, glycosylation sites, and structural analysis. Under the umbrella of epitopes, sub-divisions, namely cross-protective epitopes, B-cell (linear/discontinuous), T-cell (CD4+/CD8+), CTL, and MHC binders, are presented. The therapeutics section has different sub-sections like siRNA, miRNAs, and sgRNAs. Further, experimentally confirmed and designed diagnostic primers are earmarked in the primers section. Our study provided a set of shortlisted B-cell and T-cell (CD4+ and CD8+) epitopes that can be experimentally tested for their incorporation in vaccine formulations. The list of selected primers can be used in testing kits to identify SARS-CoV-2, while the recommended siRNAs, sgRNAs, and miRNAs can be used in therapeutic regimens. We foresee that this resource will help in advancing the research against coronaviruses. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource 2019ncov, covid-19, SARS-CoV-2, therapeutics, epitopes, Primers Identifier An unambiguous reference to the resource within a given context 10.3389/fmicb.2020.01858 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/683ec0f8a693a82748a01346c0aa8c63.pdf e0e7d3cb7a0838bc5244e9a2f63f7d06 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Self-propagative replication of Aβ oligomers suggests potential transmissibility in Alzheimer disease. Creator An entity primarily responsible for making the resource Amit Kumar, Kayla M Pate, Melissa A. Moss, Dexter N. Dean, Vijayaraghavan Rangachari Description An account of the resource The aggregation of amyloid-β (Aβ) peptide and its deposition in parts of the brain form the central processes in the etiology of Alzheimer disease (AD). The low-molecular weight oligomers of Aβ aggregates (2 to 30 mers) are known to be the primary neurotoxic agents whose mechanisms of cellular toxicity and synaptic dysfunction have received substantial attention in the recent years. However, how these toxic agents proliferate and induce widespread amyloid deposition throughout the brain, and what mechanism is involved in the amplification and propagation of toxic oligomer species, are far from clear. Emerging evidence based on transgenic mice models indicates a transmissible nature of Aβ aggregates and implicates a prion-like mechanism of oligomer propagation, which manifests as the dissemination and proliferation of Aβ toxicity. Despite accumulating evidence in support of a transmissible nature of Aβ aggregates, a clear, molecular-level understanding of this intriguing mechanism is lacking. Recently, we reported the characterization of unique replicating oligomers of Aβ42 (12-24 mers) in vitro called Large Fatty Acid-derived Oligomers (LFAOs) (Kumar et al., 2012, J. Biol. Chem). In the current report, we establish that LFAOs possess physiological activity by activating NF-κB in human neuroblastoma cells, and determine the experimental parameters that control the efficiency of LFAO replication by self-propagation. These findings constitute the first detailed report on monomer - oligomer lateral propagation reactions that may constitute potential mechanism governing transmissibility among Aβ oligomers. These data support the previous reports on transmissible mechanisms observed in transgenic animal models. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0111492 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN