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Comparative clinical and economic evaluation of two alternative antiviral therapy regimens for influenza patients
In the Russian Federation, the number of new cases of influenzaand SARS each year reaches 30 million people, and the annual total economic damage is estimated at 40 billion rubles, accounting for about 80% of the damage from all infectious…
Position: 9471 (26 views)
Streaming histogram sketching for rapid microbiome analytics
Abstract Background The growth in publically available microbiome data in recent years has yielded an invaluable resource for genomic research, allowing for the design of new studies, augmentation of novel datasets and reanalysis of published works.…
Position: 9471 (26 views)
Mining statistically-solid k-mers for accurate NGS error correction
Abstract Background NGS data contains many machine-induced errors. The most advanced methods for the error correction heavily depend on the selection of solid k-mers. A solid k-mer is a k-mer frequently occurring in NGS reads. The other k-mers are…
Position: 13079 (22 views)
Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial
Abstract The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard…
Position: 16102 (19 views)
The architecture of cell differentiation in choanoflagellates and sponge choanocytes.
Although collar cells are conserved across animals and their closest relatives, the choanoflagellates, little is known about their ancestry, their subcellular architecture, or how they differentiate. The choanoflagellate Salpingoeca rosetta expresses…
Position: 12107 (23 views)
Effectiveness of zinc supplementation on diarrhea and average daily gain in pre-weaned dairy calves: A double-blind, block-randomized, placebo-controlled clinical trial.
The objective of this clinical trial was to evaluate the effectiveness of zinc supplementation on diarrhea and average daily weight gain (ADG) in pre-weaned dairy calves. A total of 1,482 healthy Holstein heifer and bull calves from a large…
Position: 14099 (21 views)
Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host.
Bats of different species play a major role in the emergence and transmission of highly pathogenic viruses including Ebola virus, SARS-like coronavirus and the henipaviruses. These viruses require proteolytic activation of surface envelope…
Position: 12107 (23 views)
Adenovirus and herpesvirus diversity in free-ranging great apes in the Sangha region of the Republic Of Congo.
Infectious diseases have caused die-offs in both free-ranging gorillas and chimpanzees. Understanding pathogen diversity and disease ecology is therefore critical for conserving these endangered animals. To determine viral diversity in free-ranging,…
Position: 13079 (22 views)
Evaluation of the Association between Air Pollutants and Number of Cases with Severe Acute Respiratory Syndrome Recorded at Emergency Medical Centers in Tehran, Iran in 2013
Introduction and purpose: Air pollution is an important risk factor for theenvironment and public health, associated with increased severity of respiratorydiseases. This study aimed to evaluate the association between various air pollutantsand number…
Position: 3666 (40 views)