135 10 20655 https://www.socictopen.socict.org/files/original/2db8d69acbeb5139e08ecfd010dfd38e.pdf dfe44538c519366db7435bfb30c6f79e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights Creator An entity primarily responsible for making the resource Hiroshi Nishiura, Tetsuro Kobayashi, Yichi Yang, Katsuma Hayashi, Takeshi Miyama, Ryo Kinoshita, Natalie M. Linton, Sung-Mok Jung, Baoyin Yuan, Ayako Suzuki, Andrei R. Akhmetzhanov Description An account of the resource From 29 to 31 January 2020, a total of 565 Japanese citizens were evacuated from Wuhan, China on three chartered flights. All passengers were screened upon arrival in Japan for symptoms consistent with novel coronavirus (2019-nCoV) infection and tested for presence of the virus. Assuming that the mean detection window of the virus can be informed by the mean serial interval (estimated at 7.5 days), the ascertainment rate of infection was estimated at 9.2% (95% confidence interval: 5.0, 20.0). This indicates that the incidence of infection in Wuhan can be estimated at 20,767 infected individuals, including those with asymptomatic and mildly symptomatic infections. The infection fatality risk (IFR)&#8212;the actual risk of death among all infected individuals&#8212;is therefore 0.3% to 0.6%, which may be comparable to Asian influenza pandemic of 1957&#8722;1958. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Epidemiology, Ascertainment, diagnosis, travel, Importation, Statistical inference Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jcm9020419 Source A related resource from which the described resource is derived Journal of Clinical Medicine Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/f89bb5ef9cab2bd849993835a73385ca.pdf ed597eec07f7303ac7438366ef342ce7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Unique <i>k</i>-mers as Strain-Specific Barcodes for Phylogenetic Analysis and Natural Microbiome Profiling Creator An entity primarily responsible for making the resource Valery V. Panyukov, Sergey S. Kiselev, Olga N Ozoline Description An account of the resource The need for a comparative analysis of natural metagenomes stimulated the development of new methods for their taxonomic profiling. Alignment-free approaches based on the search for marker k-mers turned out to be capable of identifying not only species, but also strains of microorganisms with known genomes. Here, we evaluated the ability of genus-specific k-mers to distinguish eight phylogroups of Escherichia coli (A, B1, C, E, D, F, G, B2) and assessed the presence of their unique 22-mers in clinical samples from microbiomes of four healthy people and four patients with Crohn&#8217;s disease. We found that a phylogenetic tree inferred from the pairwise distance matrix for unique 18-mers and 22-mers of 124 genomes was fully consistent with the topology of the tree, obtained with concatenated aligned sequences of orthologous genes. Therefore, we propose strain-specific &#8220;barcodes&#8221; for rapid phylotyping. Using unique 22-mers for taxonomic analysis, we detected microbes of all groups in human microbiomes; however, their presence in the five samples was significantly different. Pointing to the intraspecies heterogeneity of E. coli in the natural microflora, this also indicates the feasibility of further studies of the role of this heterogeneity in maintaining population homeostasis. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource bacterial genomes, genome barcodes, <i>k</i>-mers, Alignment-free algorithms, Phylogenetic trees, metagenomes, Taxonomic profiling, Phylotyping, Human microbiome Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/ijms21030944 Source A related resource from which the described resource is derived International Journal of Molecular Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Chemistry Language A language of the resource EN https://www.socictopen.socict.org/files/original/29f30abd39c509c9c5b18f6adc572058.pdf cff9519fd992dd2c6b516b954acfae9a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In Vivo Antiviral Effects of U18666A Against Type I Feline Infectious Peritonitis Virus Creator An entity primarily responsible for making the resource Tomoyoshi Doki, Tomoyo Tarusawa, Tsutomu Hohdatsu, Tomomi Takano Description An account of the resource Background: The cationic amphiphilic drug U18666A inhibits the proliferation of type I FIPV in vitro. In this study, we evaluated the in vivo antiviral effects of U18666A by administering it to SPF cats challenged with type I FIPV. Methods: Ten SPF cats were randomly assigned to two experimental groups. FIPV KU-2 were inoculated intraperitoneally to cats. The control group was administered PBS, and the U18666A-treated group was administered U18666A subcutaneously at 2.5 mg/kg on day 0, and 1.25 mg/kg on days 2 and 4 after viral inoculation. Results: Two of the five control cats administered PBS alone developed FIP. Four of the five cats administered U18666A developed no signs of FIP. One cat that temporarily developed fever, had no other clinical symptoms, and no gross lesion was noted on an autopsy after the end of the experiment. The FIPV gene was detected intermittently in feces and saliva regardless of the development of FIP or administration of U18666A. Conclusions: When U18666A was administered to cats experimentally infected with type I FIPV, the development of FIP might be suppressed compared with the control group. However, the number of animals with FIP is too low to establish anti-viral effect of U18666A in cats. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Feline coronavirus, feline infectious peritonitis, U18666A, cationic amphiphilic drug, antiviral agent Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/pathogens9010067 Source A related resource from which the described resource is derived Pathogens Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/c163a2770758386a17f568e2ed32beae.pdf c2588a27ac9ac996b328ee35387633e8 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Barcode identification for single cell genomics Creator An entity primarily responsible for making the resource Akshay Tambe, Lior Pachter Description An account of the resource Abstract Background Single-cell sequencing experiments use short DNA barcode ‘tags’ to identify reads that originate from the same cell. In order to recover single-cell information from such experiments, reads must be grouped based on their barcode tag, a crucial processing step that precedes other computations. However, this step can be difficult due to high rates of mismatch and deletion errors that can afflict barcodes. Results Here we present an approach to identify and error-correct barcodes by traversing the de Bruijn graph of circularized barcode k-mers. Our approach is based on the observation that circularizing a barcode sequence can yield error-free k-mers even when the size of k is large relative to the length of the barcode sequence, a regime which is typical single-cell barcoding applications. This allows for assignment of reads to consensus fingerprints constructed from k-mers. Conclusion We show that for single-cell RNA-Seq circularization improves the recovery of accurate single-cell transcriptome estimates, especially when there are a high number of errors per read. This approach is robust to the type of error (mismatch, insertion, deletion), as well as to the relative abundances of the cells. Sircel, a software package that implements this approach is described and publically available. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource single cell, Barcodes, barcode identification, de Bruijn Graph, Circularization, k-mer counting Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12859-019-2612-0 Source A related resource from which the described resource is derived BMC Bioinformatics Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Computer applications to medicine. Medical informatics Language A language of the resource EN https://www.socictopen.socict.org/files/original/b54cdca01b632b887f83c6c7833b5e7c.pdf c5a3df4ec8600d2260b525c0a70ee619 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus. Creator An entity primarily responsible for making the resource Liu Cao, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo, Xiaolong Guo, Yongjia Tong, Xiao-Lu Zhao, Chunmei Li, Yu Chen, Deyin Guo Description An account of the resource Interferon-inducible p200 family protein IFI204 was reported to be involved in DNA sensing, and subsequently induces the production of type I interferons and proinflammatory mediators. However, its function in the regulation of antiviral innate immune signaling pathway remains unclear. Here we reported a novel role of IFI204 that specifically inhibits the IRF7-mediated type I interferons response during viral infection. IFI204 and other p200 family proteins are highly expressed in mouse hepatitis coronavirus-infected bone marrow-derived dendritic cells. The abundant IFI204 could significantly interact with IRF7 in nucleus by its HIN domain and prevent the binding of IRF7 with its corresponding promoter. Moreover, other p200 family proteins that possess HIN domain could also inhibit the IRF7-mediated type I interferons. These results reveal that, besides the positive regulation function in type I interferon response at the early stage of DNA virus infection, the interferon-inducible p200 family proteins such as IFI204 could also negatively regulate the IRF7-mediated type I interferon response after RNA virus infection to avoid unnecessary host damage from hyper-inflammatory responses. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.ppat.1008079 Source A related resource from which the described resource is derived PLoS Pathogens Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Immunologic diseases. Allergy Language A language of the resource EN https://www.socictopen.socict.org/files/original/e7ce2d95cc0e34b00af4d50b966e30e2.pdf 9272c6ac216bfcf20ef94550097c5f2f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource EPIDEMIOLOGICAL ASSESSMENT OF THE INCIDENCE OF ACUTE RESPIRATORY VIRAL INFECTION IN CHILDREN'S MULTIDISCIPLINARY HOSPITAL Creator An entity primarily responsible for making the resource L. V. Poslova, O. V. Kovalishena, A. V. Sergeeva, D. V. Kvashnina Description An account of the resource The results of the evaluation of the incidence of acute respiratory viral infection (ARVI) in a large children's multidisciplinary hospital are presented.It was established that the epidemic process of ARVI in the conditions of a children's versatile hospital was characterized by high intensity, the prevalence of infections associated with the provision of medical care, and different intensity in the departments, due to the contingent of patients, the features of the treatment and diagnostic process, the intensity of infection drifts. The risk factors for ARVI were high rates of infection drift, overconsolidation of departments, untimely isolation of patients, as well as inefficient ventilation.The introduction of targeted epidemiological surveillance for ARVI in hospital conditions made it possible to quickly assess the epidemiological situation in a multidisciplinary hospital in general and separately for each department for timely and adequate implementation of preventive and anti-epidemic measures. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource hais (healthcare-associated infections), acute respiratory viral infections (arvi), children's population, Respiratory Syncytial Virus, Metapneumovirus, parainfluenza virus, coronavirus, Rhinovirus, adenovirus, bocavirus Identifier An unambiguous reference to the resource within a given context DOI: 10.22627/2072-8107-2018-17-2-21-28 Source A related resource from which the described resource is derived Detskie Infekcii (Moskva) Publisher An entity responsible for making the resource available LLC Diagnostics and Vaccines"" Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics Language A language of the resource RU https://www.socictopen.socict.org/files/original/626b32ca972cd7195aa2be3ec301325b.pdf 71ed4b3ff5d850d3755b0b4a30f8093d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource METAPNEUMOVIRUS AND BOKAVIRUS RESPIRATORY INFECTIONS IN THE STRUCTURE OF SARS IN CHILDREN Creator An entity primarily responsible for making the resource F. S. Harlamov, O.V. Kladova, V. F. Uchaykin, S. G. Cheshik, R. V. Vartanyan, K. P. Yablonskaya Description An account of the resource The article provides an overview of the literature data about new pneumotropic viruses - metapneumovirus and bokavirus: taxonomy, structural features, pathogenesis, laboratory diagnosis, clinical symptoms of the diseases they cause and complications. The high incidence and bokavirus metapnevmovirus structure of SARS infections in preschool children, the authors have shown the example carried out at the Department of Infectious Diseases in Children Medical University (now RNIMU named after N.I. Pirogov) and on the basis of clinical Institute of Virology, multicenter, randomized, blind, placebo-controlled study on the therapeutic efficacy and safety of interferon inducer Kagocel in 120 children aged 2 to 6 years. The findings to point out on significant reduction in the rate of relief of basic clinical manifestations of SARS, regardless of etiology, in children taking Kagocel in compare with a group of children who took a placebo. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource influenza, metapnevmovirus, bokavirus, adenovirus, rs-infections Identifier An unambiguous reference to the resource within a given context DOI: 10.22627/2072-8107-2015-14-2-5-11 Source A related resource from which the described resource is derived Detskie Infekcii (Moskva) Publisher An entity responsible for making the resource available LLC Diagnostics and Vaccines"" Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics Language A language of the resource RU https://www.socictopen.socict.org/files/original/53914ccad1d2575a757949810edcab3f.pdf d8be12f34c4ae5f42724101ec3392d08 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource MEASLES IN INFANTS Creator An entity primarily responsible for making the resource V.N. Timchenko, T. M. Chernova, O. V. Bulina, E.B. Pavlova, A. N. Nazarova, O. A. Leonicheva, E.V. Timofeeva Description An account of the resource A clinical observation and treatment of 36 children between the ages of 5 months up to 3 years old with measles. In 34 persons. (94.4%) diagnosed with typical moderate forms, from 2 people (5.6%) — atypical (mitigirovannaya) a mild form of the disease. All children are vaccinated against measles. Typical measles char-acterized by moderate forms of cyclical flow with the change of the classical period and the presence of characteristic clinical syndromes. Pathognomonic symptom found: spots Belsky — Filatov — Koplik (67.7%), stages a rash (100%), stages of pigmentation (100%). Causal therapy was VIFERON®. Revealed the rapid disappearance of intoxication and normalization of body temperature, the early decline in the severity and duration of catarrhal syndrome, reducing the severity and frequency of complications, no stratification of SARS. Date A point or period of time associated with an event in the lifecycle of the resource 2015 Subject The topic of the resource Measles, young children, clinic, modern therapy, viferon® Identifier An unambiguous reference to the resource within a given context DOI: 10.22627/2072-8107-2015-14-2-52-58 Source A related resource from which the described resource is derived Detskie Infekcii (Moskva) Publisher An entity responsible for making the resource available LLC Diagnostics and Vaccines"" Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pediatrics Language A language of the resource RU https://www.socictopen.socict.org/files/original/a17b62c3cedcc0b7925e1d42661c0619.pdf 2ee124626a7eeb84a7df865e985b369f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation. Creator An entity primarily responsible for making the resource Simon Dirmeier, Christopher Dächert, Martijn van Hemert, Ali Taş, Natacha S. Ogando, Frank van Kuppeveld, Ralf Bartenschlager, Lars Kaderali, Marco Binder, Niko Beerenwinkel Description An account of the resource Genetic perturbation screens using RNA interference (RNAi) have been conducted successfully to identify host factors that are essential for the life cycle of bacteria or viruses. So far, most published studies identified host factors primarily for single pathogens. Furthermore, often only a small subset of genes, e.g., genes encoding kinases, have been targeted. Identification of host factors on a pan-pathogen level, i.e., genes that are crucial for the replication of a diverse group of pathogens has received relatively little attention, despite the fact that such common host factors would be highly relevant, for instance, for devising broad-spectrum anti-pathogenic drugs. Here, we present a novel two-stage procedure for the identification of host factors involved in the replication of different viruses using a combination of random effects models and Markov random walks on a functional interaction network. We first infer candidate genes by jointly analyzing multiple perturbations screens while at the same time adjusting for high variance inherent in these screens. Subsequently the inferred estimates are spread across a network of functional interactions thereby allowing for the analysis of missing genes in the biological studies, smoothing the effect sizes of previously found host factors, and considering a priori pathway information defined over edges of the network. We applied the procedure to RNAi screening data of four different positive-sense single-stranded RNA viruses, Hepatitis C virus, Chikungunya virus, Dengue virus and Severe acute respiratory syndrome coronavirus, and detected novel host factors, including UBC, PLCG1, and DYRK1B, which are predicted to significantly impact the replication cycles of these viruses. We validated the detected host factors experimentally using pharmacological inhibition and an additional siRNA screen and found that some of the predicted host factors indeed influence the replication of these pathogens. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pcbi.1007587 Source A related resource from which the described resource is derived PLoS Computational Biology Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/4484cb1a6d84c44963601a4cf3e9011a.pdf 7da890bb128866c74a0953159386ae05 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak Creator An entity primarily responsible for making the resource Shi Zhao, Salihu S. Musa, Qianying Lin, Jinjun Ran, Guangpu Yang, Weiming Wang, Yijun Lou, Lin Yang, Daozhou Gao, Daihai He, Maggie H. Wang Description An account of the resource Background: In December 2019, an outbreak of respiratory illness caused by a novel coronavirus (2019-nCoV) emerged in Wuhan, China and has swiftly spread to other parts of China and a number of foreign countries. The 2019-nCoV cases might have been under-reported roughly from 1 to 15 January 2020, and thus we estimated the number of unreported cases and the basic reproduction number, R0, of 2019-nCoV. Methods: We modelled the epidemic curve of 2019-nCoV cases, in mainland China from 1 December 2019 to 24 January 2020 through the exponential growth. The number of unreported cases was determined by the maximum likelihood estimation. We used the serial intervals (SI) of infection caused by two other well-known coronaviruses (CoV), Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) CoVs, as approximations of the unknown SI for 2019-nCoV to estimate R0. Results: We confirmed that the initial growth phase followed an exponential growth pattern. The under-reporting was likely to have resulted in 469 (95% CI: 403&#8722;540) unreported cases from 1 to 15 January 2020. The reporting rate after 17 January 2020 was likely to have increased 21-fold (95% CI: 18&#8722;25) in comparison to the situation from 1 to 17 January 2020 on average. We estimated the R0 of 2019-nCoV at 2.56 (95% CI: 2.49&#8722;2.63). Conclusion: The under-reporting was likely to have occurred during the first half of January 2020 and should be considered in future investigation. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource novel coronavirus, Outbreak, Modelling, underreporting, Reproduction number, China Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jcm9020388 Source A related resource from which the described resource is derived Journal of Clinical Medicine Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN