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                <text>Characterization of the Immune Response of MERS-CoV Vaccine Candidates Derived from Two Different Vectors in Mice</text>
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                <text>Entao Li, Feihu Yan, Pei Huang, Hang Chi, Shengnan Xu, Guo-hua Li, Chuanyu Liu, Na Feng, Hualei Wang, Yongkun Zhao, Songtao Yang, Xianzhu Xia</text>
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                <text>Middle East respiratory syndrome (MERS) is an acute, high-mortality-rate, severe infectious disease caused by an emerging MERS coronavirus (MERS-CoV) that causes severe respiratory diseases. The continuous spread and great pandemic potential of MERS-CoV make it necessarily important to develop effective vaccines. We previously demonstrated that the application of Gram-positive enhancer matrix (GEM) particles as a bacterial vector displaying the MERS-CoV receptor-binding domain (RBD) is a very promising MERS vaccine candidate that is capable of producing potential neutralization antibodies. We have also used the rabies virus (RV) as a viral vector to design a recombinant vaccine by expressing the MERS-CoV S1 (spike) protein on the surface of the RV. In this study, we compared the immunological efficacy of the vaccine candidates in BALB/c mice in terms of the levels of humoral and cellular immune responses. The results show that the rabies virus vector-based vaccine can induce remarkably earlier antibody response and higher levels of cellular immunity than the GEM particles vector. However, the GEM particles vector-based vaccine candidate can induce remarkably higher antibody response, even at a very low dose of 1 &amp;#181;g. These results indicate that vaccines constructed using different vaccine vector platforms for the same pathogen have different rates and trends in humoral and cellular immune responses in the same animal model. This discovery not only provides more alternative vaccine development platforms for MERS-CoV vaccine development, but also provides a theoretical basis for our future selection of vaccine vector platforms for other specific pathogens.</text>
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                <text>MERS-CoV, recombinant rabies virus, bacterium-like particle, immune response</text>
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                <text>DOI: 10.3390/v12010125</text>
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                <text>Microbiology</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>The 2019 Novel Coronavirus (2019-nCoV): Novel Virus, Old Challenges</text>
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                <text>Raquel Duarte, Isabel Furtado, Luís Sousa, Carlos Filipe Afonso Carvalho</text>
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                <text>coronavirus, coronavirus infections, Disease Outbreaks</text>
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                <text>DOI: 10.20344/amp.13547</text>
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                <text>Acta Médica Portuguesa</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Chiroptera as a Potential Reservoir of Dangerous for Humans Viruses in the territory  of the Republic of Guinea. Part 1</text>
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                <text>A.M. Porshakov, Yu. V. Kononova, V. B. Loktev, M. I. Boiro</text>
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                <text>Chiroptera is one of the largest in numbers orders of mammals which can take on the role of natural host and vector of various viruses, bacteria, and pathogenic fungi. Over the period of 2007–2013, 248 new viruses pertaining to 24 families were detected in chiropterans. Lately, a range of novel infections that provoked severe diseases in humans were associated with bats-carriers. Presently they are viewed as a potential reservoir of Ebola, Marburg, and Hendra viruses, severe acute respiratory syndrome agents, as well as many other lethal diseases. Chiropterans started drawing particular attention after establishment of the fact that they are involved in circulation of ebolavirus Zaire and possibly participate in the formation of natural foci of this infection. Currently chiropterans are considered to be natural reservoirs of ebolavirus Zaire and some other filoviruses (Filoviridae). Accept from filoviruses, other significant for public healthcare viruses were isolated from chiropterans on the African continent – lyssaviruses (Rhabdoviridae, Lyssavirus), henipaviruses (Paramixoviridae, Henipavirus), and coronaviruses (Coronaviridae, Alphacoronavirus, Betacoronavirus) that can also circulate among chiropterans in West Africa. The data available from literature sources on dissemination of chiropterans in the territory of the African continent, their species diversity, peculiarities of ecology and behavior are analyzed in this paper. The information on the infections for which chiropterans can serve as potential reservoirs is also provided. Specifics of interaction between the population residing on African continent and bats of different species are described too. The review is devoted to the assessment of results of studies on population, ecological, and epidemiological factors contributing to maintenance of circulation of a number of dangerous for humans viruses (filoviruses, lyssaviruses, henipaviruses, and coronaviruses) among African chiropterans. The need for further investigation of the mentioned factors affecting chiropteran populations in the Republic of Guinea is substantiated.</text>
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                <text>2018</text>
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                <text>chiropterans, fruit bats, space telemetry, Ebolavirus Zaire, Republic of Guinea</text>
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                <text>DOI: 10.21055/0370-1069-2018-3-32-39</text>
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                <text>Проблемы особо опасных инфекций</text>
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                <text>Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”</text>
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                <text>Infectious and parasitic diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells</text>
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                <text>Shaoju Qian, Zi-tong Gao, Rui Cao, Kang Yang, Yijie Cui, Shaowen Li, Xianrong Meng, Qigai He, Zili Li</text>
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                <text>Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon viral stimulation, which significantly enhances mucosal immunity. We utilized TGEV as a model pathogen to explore the role of FcRn in resisting viral invasion in overall intestinal mucosal immunity. TGEV induced FcRn expression by activating NF-κB signaling in porcine small intestinal epithelial (IPEC-J2) cells, however, the underlying mechanisms are unclear. First, using small interfering RNAs, we found that TGEV up-regulated FcRn expression via TLR3, TLR9 and RIG-I. Moreover, TGEV induced IL-1β, IL-6, IL-8, TGF-β, and TNF-α production. TGF-β-stimulated IPEC-J2 cells highly up-regulated FcRn expression, while treatment with a JNK-specific inhibitor down-regulated the expression. TGEV nucleocapsid (N) protein also enhanced FcRn promoter activity via the NF-κB signaling pathway and its central region (aa 128–252) was essential for FcRn activation. Additionally, N protein-mediated FcRn up-regulation promotes IgG transcytosis. Thus, TGEV N protein and TGF-β up-regulated FcRn expression, further clarifying the molecular mechanism of up-regulation of FcRn expression by TGEV.</text>
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                <text>Transmissible gastroenteritis virus, Nucleocapsid protein, TGF-β, neonatal Fc receptor, toll-like receptor, NF-κB</text>
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                <text>DOI: 10.3389/fmicb.2019.03085</text>
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                <text>Frontiers in Microbiology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Microbiology</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <description>A name given to the resource</description>
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                <text>An Adaptive Hierarchical Detection Method for Ship Targets in High-Resolution SAR Images</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Yi Liang, Kun Sun, Yugui Zeng, Guo-Fei Li, Mengdao Xing</text>
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                <text>With the improvement of image resolution in synthetic aperture radars (SARs), sea clutter characteristics become more complex, which poses new challenges to traditional ship target detection missions. In this paper, to detect ship targets quickly and efficiently in a complex background, we propose an adaptive hierarchical detection method based on a coarse-to-fine mechanism. This method constructs a new visual attention mechanism to strengthen ship targets and obtain the candidate targets adaptively by the means dichotomy method. On this basis, the precise detection results of the targets are obtained using the speed block kernel density estimation method, which maintains constant false alarm characteristics. Compared with existing methods, the adaptive hierarchical detection method has simple, fast, and accurate characteristics. Experiments based on GF-III satellite and airborne SAR datasets are presented to demonstrate the effectiveness of the proposed method.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>ship detection, saliency method, superpixel segmentation, kernel density estimation, synthetic aperture radar</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="13039">
                <text>DOI: 10.3390/rs12020303</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Remote Sensing</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13041">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Science</text>
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            </elementTextContainer>
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            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13043">
                <text>EN</text>
              </elementText>
            </elementTextContainer>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="13044">
                <text>A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13045">
                <text>Ying-Hui Jin, Lin Cai, Zhen-Shun  Cheng, Hong Cheng, Tong Deng, Yi-Pin Fan, Cheng Fang, Di Huang, Luqi Huang, Qiao Huang, Yong HAN, Bo Hu, Fen Hu, Bing-Hui Li, Yi-Rong Li, Ke Liang, Li-Kai Lin, Lisha Luo, Jing Ma, Lin-Lu Ma, Zhi-Yong Peng, Yunbao Pan, Zhenyu Pan, Xuequn Ren, Hui-Min Sun, Ying Wang, Yunyun Wang, Hong Weng, Chao-Jie Wei, Dongfang Wei, Jian Xia, Yong Xiong, Hai-bo Xu, Xiaomei Yao, Tai-Sheng Ye, Yufeng Yuan, Xiaochun Zhang, Ying Wen Zhang, Yingao Zhang, Huamin Zhang, Yan Zhao, Ming-Juan Zhao, Hao Zi, Xian-Tao Zeng, Yongyan Wang, Xinghuan Wang, for the Zhongnan Hospital of Wuhan Unive Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter, China International Exchange and Promoti for Medical and Health Care (CPAM)</text>
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            <description>An account of the resource</description>
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                <text>10.11855/j.issn.0577-7402.2020.01.01</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="13047">
                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="13048">
                <text>DOI: </text>
              </elementText>
            </elementTextContainer>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="13049">
                <text>Medical Journal of Chinese People's Liberation Army</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13050">
                <text>Editorial Board of Medical Journal of Chinese People's Liberation Army</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="13051">
                <text>Medicine (General), Medicine</text>
              </elementText>
            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13052">
                <text>ZH</text>
              </elementText>
            </elementTextContainer>
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  <item itemId="1365" public="1" featured="0">
    <fileContainer>
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        <src>https://www.socictopen.socict.org/files/original/f50187c72b5c76c33d468754e7043b17.pdf</src>
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          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="13053">
                <text>The interpretation of Consensus on emergency surgery and infection prevention and control for severe trauma patients with 2019 novel corona virus pneumonia</text>
              </elementText>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13054">
                <text>Yang Li, Lian-yang ZHANG</text>
              </elementText>
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            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="13055">
                <text>A coronavirus disease 2019 (COVID-19) outbreak has occurred in Wuhan, Hubei province since Dec. 2019. As of Feb. 10, 2020, more than 40,000 cases had been confirmed, nearly 30,000 cases in Hubei alone, and no inflection point in epidemiology appeared. Severe trauma may still occur during the outbreak of the COVID-19. In order to protect the medical personnel involved in emergency treatment and ensuring the timeliness of treatment for trauma patients, The Trauma Surgery Branch of Chinese Medical Doctors' Association (CMDA) organized the drafting of the present expert consensus. This paper interprets the main views of the expert consensus, emphasizes that the safety of health care staff and patients are equally important, and that the treatment strategies and procedures for severe trauma need to be adjusted during the COVID-19 outbreak. The consensus also recommends the use of CT scan, which plays both the role of screening COVID-19 and accurate assessment of trauma, and strengthening the protection of medical staff. The consensus states that medical personnel can be exempted from isolation if they wear standard three-level protective equipment and are not accidentally exposed during the operation. This expert consensus is the first one to systematically review, summarize and analyze the progress of COVID-19 from a surgeon's perspective. It may be used as a reference for medical institutions at all levels to treat patients with severe trauma and perform other kinds of operations during the COVID-19 outbreak.  DOI: 10.11855/j.issn.0577-7402.2020.02.02</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="13056">
                <text>2020</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="13057">
                <text>DOI: </text>
              </elementText>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="13058">
                <text>Medical Journal of Chinese People's Liberation Army</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13059">
                <text>Editorial Board of Medical Journal of Chinese People's Liberation Army</text>
              </elementText>
            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="13060">
                <text>Medicine (General), Medicine</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13061">
                <text>ZH</text>
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  <item itemId="1366" public="1" featured="0">
    <fileContainer>
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        <src>https://www.socictopen.socict.org/files/original/12309c35b3dab1257704137c7a3c3829.pdf</src>
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          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                <elementText elementTextId="1">
                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
    <elementSetContainer>
      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13062">
                <text>Emerging Viruses without Borders: The Wuhan Coronavirus</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="13063">
                <text>Shan-Lu Liu, Linda Saif</text>
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          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="13064">
                <text>The recently emerged coronavirus in Wuhan, China has claimed at least six lives as of January 22 and infected hundreds if not thousands of individuals. The situation has drawn international attention, including from the virology community. We applaud the rapid release to the public of the genome sequence of the new virus by Chinese virologists, but we also believe that increased transparency on disease reporting and data sharing with international colleagues are crucial for curbing the spread of this newly emerging virus to other parts of the world.</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="13065">
                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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              <elementText elementTextId="13066">
                <text>n/a</text>
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              <elementText elementTextId="13067">
                <text>DOI: 10.3390/v12020130</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="13068">
                <text>Viruses</text>
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            </elementTextContainer>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="13069">
                <text>MDPI AG</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="13070">
                <text>Microbiology</text>
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            </elementTextContainer>
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            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="13071">
                <text>EN</text>
              </elementText>
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        <src>https://www.socictopen.socict.org/files/original/54fed5b3419954857a25c1aab4515361.pdf</src>
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          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="13072">
                <text>Novel Coronavirus Outbreak in Wuhan, China, 2020: Intense Surveillance Is Vital for Preventing Sustained Transmission in New Locations</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Robin N Thompson</text>
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            <description>An account of the resource</description>
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                <text>The outbreak of pneumonia originating in Wuhan, China, has generated 24,500 confirmed cases, including 492 deaths, as of 5 February 2020. The virus (2019-nCoV) has spread elsewhere in China and to 24 countries, including South Korea, Thailand, Japan and USA. Fortunately, there has only been limited human-to-human transmission outside of China. Here, we assess the risk of sustained transmission whenever the coronavirus arrives in other countries. Data describing the times from symptom onset to hospitalisation for 47 patients infected early in the current outbreak are used to generate an estimate for the probability that an imported case is followed by sustained human-to-human transmission. Under the assumptions that the imported case is representative of the patients in China, and that the 2019-nCoV is similarly transmissible to the SARS coronavirus, the probability that an imported case is followed by sustained human-to-human transmission is 0.41 (credible interval [0.27, 0.55]). However, if the mean time from symptom onset to hospitalisation can be halved by intense surveillance, then the probability that an imported case leads to sustained transmission is only 0.012 (credible interval [0, 0.099]). This emphasises the importance of current surveillance efforts in countries around the world, to ensure that the ongoing outbreak will not become a global pandemic.</text>
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                <text>2019ncov, Mathematical modelling, infectious disease epidemiology, major outbreak, forecasting, coronavirus, Wuhan, SARS</text>
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                <text>DOI: 10.3390/jcm9020498</text>
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        <src>https://www.socictopen.socict.org/files/original/a710d73cfac568f1d7bc96fa4337e971.pdf</src>
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                <text>Estimation of the Transmission Risk of the 2019-nCoV and Its Implication for Public Health Interventions</text>
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                <text>Biao Tang, Xia Wang, Qian Li, Nicola Luigi Bragazzi, Sanyi Tang, Yanni Xiao, Jianhong Wu</text>
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                <text>Since the emergence of the first cases in Wuhan, China, the novel coronavirus (2019-nCoV) infection has been quickly spreading out to other provinces and neighboring countries. Estimation of the basic reproduction number by means of mathematical modeling can be helpful for determining the potential and severity of an outbreak and providing critical information for identifying the type of disease interventions and intensity. A deterministic compartmental model was devised based on the clinical progression of the disease, epidemiological status of the individuals, and intervention measures. The estimations based on likelihood and model analysis show that the control reproduction number may be as high as 6.47 (95% CI 5.71&amp;#8722;7.23). Sensitivity analyses show that interventions, such as intensive contact tracing followed by quarantine and isolation, can effectively reduce the control reproduction number and transmission risk, with the effect of travel restriction adopted by Wuhan on 2019-nCoV infection in Beijing being almost equivalent to increasing quarantine by a 100 thousand baseline value. It is essential to assess how the expensive, resource-intensive measures implemented by the Chinese authorities can contribute to the prevention and control of the 2019-nCoV infection, and how long they should be maintained. Under the most restrictive measures, the outbreak is expected to peak within two weeks (since 23 January 2020) with a significant low peak value. With travel restriction (no imported exposed individuals to Beijing), the number of infected individuals in seven days will decrease by 91.14% in Beijing, compared with the scenario of no travel restriction.</text>
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                <text>DOI: 10.3390/jcm9020462</text>
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                <text>Journal of Clinical Medicine</text>
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                <text>MDPI AG</text>
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