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Backcalculating the Incidence of Infection with COVID-19 on the Diamond Princess
To understand the time-dependent risk of infection on a cruise ship, the Diamond Princess, I estimated the incidence of infection with novel coronavirus (COVID-19). The epidemic curve of a total of 199 confirmed cases was drawn, classifying…
Position: 8740 (27 views)
Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies
The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an imminent need to better understand this new virus and to develop ways to…
Position: 8740 (27 views)
Detecting differential transmissibilities that affect the size of self-limited outbreaks.
Our ability to respond appropriately to infectious diseases is enhanced by identifying differences in the potential for transmitting infection between individuals. Here, we identify epidemiological traits of self-limited infections (i.e. infections…
Position: 8052 (28 views)
The impact of prior information on estimates of disease transmissibility using Bayesian tools.
The basic reproductive number (R₀) and the distribution of the serial interval (SI) are often used to quantify transmission during an infectious disease outbreak. In this paper, we present estimates of R₀ and SI from the 2003 SARS outbreak in Hong…
Position: 12109 (23 views)
Indexing Arbitrary-Length k-Mers in Sequencing Reads.
We propose a lightweight data structure for indexing and querying collections of NGS reads data in main memory. The data structure supports the interface proposed in the pioneering work by Philippe et al. for counting and locating k-mers in…
Position: 9472 (26 views)
Laboratory investigation and phylogenetic analysis of an imported Middle East respiratory syndrome coronavirus case in Greece.
Rapid and reliable laboratory diagnosis of persons suspected of Middle East respiratory syndrome coronavirus (MERS-CoV) infection is important for timely implementation of infection control practices and disease management. In addition, monitoring…
Position: 8740 (27 views)
Clinical trials on drug repositioning for COVID-19 treatment
The World Health Organization (WHO) was informed on December 2019 about a coronavirus pneumonia outbreak in Wuhan, Hubei province (China). Subsequently, on March 12, 2020, 125,048 cases and 4,614 deaths were reported. Coronavirus is an enveloped RNA…
Position: 13083 (22 views)
Using the spike protein feature to predict infection risk and monitor the evolutionary dynamic of coronavirus
Abstract Background Coronavirus can cross the species barrier and infect humans with a severe respiratory syndrome. SARS-CoV-2 with potential origin of bat is still circulating in China. In this study, a prediction model is proposed to evaluate the…
Position: 16104 (19 views)
Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth.
We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist. To determine whether PEPCK-M had a causative role in modulating…
Position: 8740 (27 views)
Pre-Hispanic fishing practices in interfluvial Amazonia: Zooarchaeological evidence from managed landscapes on the Llanos de Mojos savanna.
Recent evidence suggests the existence of Pre-Hispanic fisheries in savanna areas of the Amazon basin. How these fisheries may have functioned is still poorly known. Although many studies have drawn attention to how Pre-Hispanic inhabitants of these…
Position: 5548 (33 views)