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                <text>Praveer Rai</text>
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                <text>Corona viruses are a group of medium-sized positive-sense single-stranded RNA viruses with crown-like structure due to projections noted over the surface of the virus. The infection has been declared as a pandemic by the world health organization (WHO) in March 2020. Health care professionals in endoscopy are at high risk of infection by novel corona virus disease 2019 (COVID-19) from inhalation of droplets, conjunctival contact, feces, and touch contamination. Upper gastrointestinal (GI) endoscopy is considered to be a high-risk aerosol-generating procedures (AGPs) and the live virus has been found in patient stool. Flexible endoscopes when contaminated have been considered as the vector for transmission of infections. Infections related to the side viewing endoscopes and endoscopic ultrasound scopes are more frequent than upper GI scope and colonoscopes. Stratifying patients needing endoscopy and deferral of elective procedures will help to decrease the virus spread. Planning and revision of workflows is necessary for safety of patient and staff and to successfully provide infection prevention and control measures, for this a “three zones and two passages” concept should be followed. Manual cleaning followed by high-level disinfection (HLD), effectively eliminates nearly all microorganisms from endoscopes during reprocessing. Transmission of viral infections during endoscopy is quite rare and, it is usually the result of noncompliance from the essential steps of reprocessing. Reuse of any disposable GI endoscopic device is strongly discouraged. Environmental decontamination is essential to reduce the risk of fomite transmission. Noncritical environmental surfaces frequently touched by hands (e.g., bedside tables and bed rails) and endoscopy furniture and floor should be considered heavily contaminated in patients with intermediate or high risk of COVID-19 and should be thoroughly disinfected at the end of each procedure. If available, negative pressure rooms are preferred for endoscopy, as has been advised by Centers for Disease Control and Prevention (CDC). Staff involved in reprocessing and the cleaning of endoscopy rooms should utilize personal protective equipment (PPE) including N95 mask. Reprocessing staff should undergo necessary training and ongoing annual assessment of competency.</text>
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                <text>DOI: 10.1055/s-0040-1712238</text>
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                <text>Journal of Digestive Endoscopy</text>
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                <text>Diseases of the digestive system. Gastroenterology</text>
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                <text>Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions</text>
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                <text>Preetam Ghosh, Dhanasekhar Reddy, Ranjith Kumavath, Debmalya Barh, Vasco Azevedo</text>
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                <text>Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent reports have suggested that CGs also possess anticancer and antiviral activities. The primary mechanism of action of these anticancer agents is by suppressing the Na+/k+-ATPase by decreasing the intracellular K+ and increasing the Na+ and Ca2+. Additionally, CGs were known to act as inhibitors of IL8 production, DNA topoisomerase I and II, anoikis prevention and suppression of several target genes responsible for the inhibition of cancer cell proliferation. Moreover, CGs were reported to be effective against several DNA and RNA viral species such as influenza, human cytomegalovirus, herpes simplex virus, coronavirus, tick-borne encephalitis (TBE) virus and Ebola virus. CGs were reported to suppress the HIV-1 gene expression, viral protein translation and alters viral pre-mRNA splicing to inhibit the viral replication. To date, four CGs (Anvirzel, UNBS1450, PBI05204 and digoxin) were in clinical trials for their anticancer activity. This review encapsulates the current knowledge about CGs as anticancer and antiviral drugs in isolation and in combination with some other drugs to enhance their efficiency. Further studies of this class of biomolecules are necessary to determine their possible inhibitory role in cancer and viral diseases.</text>
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                <text>antiviral, autophagy, cardiac glycosides, Signaling pathway, Anticancer, viral protein translation</text>
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                <text>10.3390/molecules25163596</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Organic chemistry</text>
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                <text>Preetam Ghosh, Khalid J. Alzahrani, Debmalya Barh, Bruno   Silva Andrade, Sérgio Siqueira, Wagner  Rodrigues de Assis Soares, Fernanda de Souza Rangel, Naiane  Oliveira Santos, Andria   dos Santos Freitas, Priscila Ribeiro da Silveira, Sandeep Tiwari, Aristóteles Góes-Neto, Vasco Azevedo</text>
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                <text>The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study post-COVID (i.e., short-term) and long-COVID (i.e., long-term) effects, specifically as local and systemic pathophysiological outcomes of other coronavirus-related diseases (such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS)) were well-cataloged. We conducted a comprehensive review of adverse post-COVID health outcomes and potential long-COVID effects. We observed that such adverse outcomes were not localized. Rather, they affected different human systems, including: (i) immune system (e.g., Guillain–Barré syndrome, rheumatoid arthritis, pediatric inflammatory multisystem syndromes such as Kawasaki disease), (ii) hematological system (vascular hemostasis, blood coagulation), (iii) pulmonary system (respiratory failure, pulmonary thromboembolism, pulmonary embolism, pneumonia, pulmonary vascular damage, pulmonary fibrosis), (iv) cardiovascular system (myocardial hypertrophy, coronary artery atherosclerosis, focal myocardial fibrosis, acute myocardial infarction, cardiac hypertrophy), (v) gastrointestinal, hepatic, and renal systems (diarrhea, nausea/vomiting, abdominal pain, anorexia, acid reflux, gastrointestinal hemorrhage, lack of appetite/constipation), (vi) skeletomuscular system (immune-mediated skin diseases, psoriasis, lupus), (vii) nervous system (loss of taste/smell/hearing, headaches, spasms, convulsions, confusion, visual impairment, nerve pain, dizziness, impaired consciousness, nausea/vomiting, hemiplegia, ataxia, stroke, cerebral hemorrhage), (viii) mental health (stress, depression and anxiety). We additionally hypothesized mechanisms of action by investigating possible molecular mechanisms associated with these disease outcomes/symptoms. Overall, the COVID-19 pathology is still characterized by cytokine storm that results to endothelial inflammation, microvascular thrombosis, and multiple organ failures.</text>
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                <text>Have you ever felt stuck? Or rather unmotivated and unsatisfied at your work? Maybe you do not feel like being a doctor anymore, but the fear of what will you do after; scares you more. Or maybe, you do wish to continue your medical practices but feel rather tired and let down at most times. In either scenario, you are not alone. Several healthcare workers feel underappreciated and suffer from lack of enthusiasm for work, feelings of cynicism towards life and low sense of personal accomplishment, in short, they feel “Burnt out”.  Burnout is on the rise in medical fraternity. Established professionals, residents in training, to young medical school trainees beginning their careers in medicine, none can escape from the brunt of burnout. Long working hours and increasing burden of bureaucratic tasks make the medical profession a tedious one. Continued exposure to human suffering and death introduces cynicism towards life and its purpose. Constant need to be compassionate to patients and their family members require immense mental and emotional fortitude. However, with an increase in violence against the medical fraternity,[5] a typical doctor begins to question the sanctity of the profession and feels unappreciated.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Healthcare workers, covid-19, Burnout</text>
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                <text>10.22502/jlmc.v8i1.380</text>
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                <text>Journal of Lumbini Medical College</text>
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            <name>Publisher</name>
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                <text>Lumbini Medical College</text>
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                <text>Medicine (General)</text>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Analyses of spike protein from first deposited sequences of SARS-CoV2 from West Bengal, India [version 1; peer review: 2 approved, 1 approved with reservations]</text>
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                <text>Prem Prakash Tripathi, Upasana Ray, Feroza Begum, Debica Mukherjee, Sandeepan Das, Arup Kumar Banerjee, Dluya Thagriki</text>
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                <text>India has recently started sequencing SARS-CoV2 genome from clinical isolates. Currently only few sequences are available from three states in India. Kerala was the first state to deposit complete sequence from two isolates followed by one from Gujarat. On April 27, 2020, the first five sequences from the state of West Bengal (Eastern India) were deposited on GISAID, a global initiative for sharing avian flu data. In this study, we have analysed the spike protein sequences from all five isolates and also compared their similarities or differences with other sequences reported in India and with isolates of Wuhan origin. We report one unique mutation at position 723 and another at 1124 in the S2 domain of spike protein of the isolates from West Bengal only.  There was one mutation downstream of the receptor binding domain at position 614 in S1 domain which was common with the sequence from Gujarat (a state of western India).  Mutation in the S2 domain showed changes in the secondary structure of the spike protein at region of the mutation. We also studied molecular dynamics using normal mode analyses and found that this mutation decreases the flexibility of S2 domain.  Since both S1 and S2 are important in receptor binding followed by entry in the host cells, such mutations may define the affinity or avidity of receptor binding.</text>
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                <text>DOI: 10.12688/f1000research.23805.1</text>
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            <description>A related resource from which the described resource is derived</description>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>F1000 Research Ltd</text>
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                <text>Biology (General), Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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          <element elementId="50">
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            <description>A name given to the resource</description>
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                <text>Health System Response to COVID-19 Epidemic in India</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Prema Ramachandran, Krishnamurthy Kalaivani</text>
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                <text>The coronavirus disease 2019 (COVID-19) epidemic, detected first in China in December 2019, is now rapidly spreading across the world. India responded by drawing up National Containment Plan for COVID-19 that envisaged screening of people for COVID-19 for early detection of infection, providing community, primary health care-centered management for those with mild infection, tertiary care for those with severe infection, and health education to the population to reduce person-to-person transmission of infection. To minimize the spread of infection from other countries, all travelers were screened and quarantined; in the third week of March, India imposed ban on all international travel. To prevent person-to-person spread, congregation of people for commercial, educational, entertainment, sports, religious, and other social activities was banned. To minimize intracity, interstate, and urban rural spread, India imposed nationwide lockdown on 25th March 2020. The lockdown flattened the epidemic curve and provided needed time for the country to reorganize the health system, so that it can provide needed care for the increasing number of COVID-19 patients at all levels of health care. National guidelines for screening of people for severe acute respiratory syndrome-coronavirus-2 infection, quarantine, and home isolation and care of infected people were drawn up and implemented. Health education on methods by which person-to-person transmission of infection can be minimized has been provided using all media of communication. Global comparison shows that currently India has low infection rates, low fatality rates per 1,00,000, and high recovery rates. There are ongoing research studies to document the course and outcome of COVID-19 in India. Clinical trials of potential drugs for treatment of severe infections and vaccines for preventing infection in the high-risk groups are underway. A COVID-19 disease surveillance program is underway to track the infection rates and bring appropriate midcourse corrections in interventions. In the coming months, the people and health system will not only have to evolve a sustainable strategy to provide needed care for COVID-19 cases but also ensure that all other health care programs are implemented and patients with other illnesses get optimal care too.</text>
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                <text>2020</text>
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                <text>health education, home care, national guidelines, health system response, Hospital-based care, COVID-19 epidemic</text>
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                <text>DOI: 10.1055/s-0040-1713347</text>
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                <text>Annals of the National Academy of Medical Sciences (India)</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>National Academy of Medical Sciences</text>
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                <text>General Works</text>
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                  <text>Coronavirus</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Impact of COVID-19 on Cardio-obstetric Risk Indicators: Future Directions</text>
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                <text>Prerna Goyal, Shibba Takkar Chhabra</text>
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                <text>Cardiovascular illness is one the foremost causes of death in females. The goal of preventive medicine is to identify and target high-risk females belonging to the younger age group in order to prevent future onset of cardiovascular pathologies. Certain obstetric complications like idiopathic preterm birth, preeclampsia (PE), gestational diabetes and abruptio placentae mark their presence in the checklist of risk indicators for cardiovascular diseases (CVD) among the female population. Previous severe acute respiratory syndrome-1 (SARS-1) infections recorded a significant impact on maternal and fetal outcomes. In this article, we aim to focus on the incidence of cardiovascular risk indicators with the incessant novel Coronavirus disease-19 (COVID-19) pandemic in pregnant women and to provide recommendations for venous thromboembolism (VTE) prophylaxis in infected females. As the disease is novel and gradually unfolding to clinicians globally, the data and the publications are also evolving. Studies on COVID-19 in pregnancy has shown an increase in the number of preterm births, and PE with some reports on vertical transmission, but no significant increase in miscarriage, still births and teratogenicity. Preterm births appear more likely to be iatrogenic rather than idiopathic, owing to severity of infection or maternal/fetal safety. Causal association of virus with PE needs further analysis by large population studies, as both have common overlapping clinical and laboratory parameters. Direct placental involvement by virus leading on to PE or infection itself simulating PE needs further explication. Assessment of placental function, histopathological examination, and measurement of antiangiogenic factors are some of the suggested measures to differentiate further. Peripartum cardiomyopathy in COVID-19 positive pregnant females has not yet been actively explored, particularly in cases of clinical deterioration. Practical utilization of handheld point-of-care echocardiography machines stand in need for diagnosing myocardial dysfunction in this pandemic. COVID-19 infection and pregnancy together may impart a greater thromboembolism risk due to their inherent hypercoagulable states. All pregnant females with COVID-19 infection are candidates for VTE prophylaxis, both antepartum and postpartum depending on the severity of illness.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Pregnancy, cardiovascular, thromboembolism, Preeclampsia, preterm birth</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>10.1055/s-0040-1716815</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Epidemiology and Health</text>
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              <elementText elementTextId="81432">
                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Surgery</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Corona-test of the Real Economy and Financial and Economic Imperatives to Overcome the Effects of the COVID-19 Pandemic</text>
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                <text>Prianyshnykova Marharyta V., Hudenko Oleksandr D.</text>
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                <text>The article aims at highlighting the financial and economic imperatives and semantics of the practical ways for overcoming the negative effects of the COVID-19 pandemic by country, and finding capabilities for their implementation in Ukraine, taking into account the corona test results of the real economy expressed in the national measures of sustainable and comprehensive development, traditionally taken as a whole. The state of institutional and sectoral units of the real sector of economy during the COVID-19 global pandemic has been analyzed. The key factors of the negative impact on economic sustainability have been systematized based on the criterial invariance of the quantitative and qualitative indices of the production, logistics, labor availability (saving) and bankruptcy parameters. The research results in suggesting two types of measures to overcome the pandemic effects: the first one is at the enterprise level, and the second one is at the state level. The first group should include the companies’ strategy decomposition, e.g. reducing costs, restructuring activities, diversifying production to meet the domestic market needs, supporting employees’ mobility and engagement in remote work (online operation). The second group should include deferring tax payments, providing assistance (support) to enterprises and employees, state guarantees on loans, interest-free loans, one-time financial help, one-time grants for certain sectors, which are among the most sensitive ones to the COVID-19 pandemic effects. A critical analysis of the best practices in overcoming the pandemic effects in such countries as France, the USA, Germany, Great Britain, Italy, Turkey, Japan, China, South Korea and others has been carried out. Possible ways of their application in Ukraine have been offered.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>coronavirus, Pandemic, losses, Interest-free loan, tax breaks, cash aid, repayment holiday</text>
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            <name>Identifier</name>
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                <text>10.32983/2222-0712-2020-3-18-24</text>
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                <text>Biotemas</text>
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            <name>Publisher</name>
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                <text>Universidade Federal de Santa Catarina</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Economics as a science, Finance</text>
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        <src>https://www.socictopen.socict.org/files/original/ce0a11be0bc4f75743a35ea019c929db.pdf</src>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Agricultura sostenible</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Agricultura sostenible</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Notas sobre la familia Taccaceae (Liliidae) y su presencia en Colombia</text>
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            <name>Creator</name>
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                <text>Prieto C. Adriana, Fernández Alonso José Luis, Liesner Ronald L.</text>
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            <description>An account of the resource</description>
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                <text>The Taccaceae (Liliidae) are known in Colombia only from an old and obscure collection of Tacca parkeri Seem. Two new localities from the department of Guainía are here reported. This variable species is widely distributed in the Guayana region and the Amazonian lowlands. Some comments about morphological variability, flowering time and distribution of this species are also included.Se documenta la presencia de la familia Taccaceae (Liliidae) en Colombia, conocida solo por un impreciso registro de Tacca parkeri Seem., con la adición de dos nuevas localidades provenientes del departamento del Guainía. La especie, muy variable, se encuentra ampliamente distribuida en la región Guayana y en zonas bajas de la cuenca amazónica. Se adiciona información sobre variabilidad morfológica, período de floración y distribución de esta especie.</text>
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            <name>Date</name>
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                <text>2000</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Corología, Neotrópico, Tacca, Taccaceae, distribución, ecología</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="176684">
                <text>Caldasia</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Universidad Nacional de Colombia</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="176686">
                <text>Science, Botany, Zoology</text>
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          </element>
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            <name>Relation</name>
            <description>A related resource</description>
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                <text>&lt;a href="http://www.revistas.unal.edu.co/index.php/cal/article/view/17583" target="_blank" rel="noreferrer noopener"&gt;http://www.revistas.unal.edu.co/index.php/cal/article/view/17583&lt;/a&gt;</text>
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