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                <text>Rajesh Bhatia, Devendra Mourya, Pranab Chatterjee, Swarup Sarkar, Anup Agarwal, Nazia Nagi, Rima Rakeshkumar Sahay</text>
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                <text>Preparedness for the ongoing coronavirus disease 2019 (COVID-19) and its spread in India calls for setting up of adequately equipped and dedicated health facilities to manage sick patients while protecting healthcare workers and the environment. In the wake of other emerging dangerous pathogens in recent times, such as Ebola, Nipah and Zika, it is important that such facilities are kept ready during the inter-epidemic period for training of health professionals and for managing cases of multi-drug resistant and difficult-to-treat pathogens. While endemic potential of such critically ill patients is not yet known, the health system should have surge capacity for such critical care units and preferably each tertiary government hospital should have at least one such facility. This article describes elements of design of such unit (e.g., space, infection control, waste disposal, safety of healthcare workers, partners to be involved in design and plan) which can be adapted to the context of either a new construction or makeshift construction on top of an existing structure. In view of a potential epidemic of COVID-19, specific requirements to handle it are also given.</text>
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                <text>biocontainment - biosafety - coronavirus - designated health facility - infection prevention and control</text>
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                <text>DOI: 10.4103/ijmr.IJMR_518_20</text>
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                <text>Indian Journal of Medical Research</text>
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                <text>Wolters Kluwer Medknow Publications</text>
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                <text>The endangered physician-scientist and COVID-19.</text>
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                <text>Rajesh C Rao, Brian J Dlouhy, Brian C Capell, Oluwaseun Akeju</text>
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                <text>The COVID-19 pandemic has affected almost every stakeholder in healthcare, including the vulnerable population of clinician investigators known as physician-scientists. In this commentary, Rao et al. highlight the underappreciated challenges and opportunities, and present solutions, for physician-scientists vis-à-vis the uniquely disruptive event of the pandemic.</text>
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                <text>10.1016/j.xcrm.2021.100190</text>
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                <text>Cell reports. Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Corona health-care warriors in India: knowledge, attitude, and practices during COVID-19 outbreak</text>
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                <text>Rajesh Kumar, Vanya Singh, Aroop Mohanty, Yogesh Bahurupi, Puneet Kumar Gupta</text>
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                <text>BACKGROUND: COVID-19 has become a global health emergency after its first case in Wuhan city, China. An increasing number of cases and deaths are challenging the health-care system globally. This study aims to assess knowledge, attitude, and practice toward COVID-19 disease among health personnel in rapid outbreak in India. MATERIALS AND METHODS: A cross-sectional survey was conducted using Google Forms through Google platform on-line. A total of 713 health personal allied health-care staff, working in different public and private health-care facilities, was conducted in the mid of April 2020. A structured knowledge, attitude, and practice questionnaire used to assess health personnel's knowledge, attitude, and practice toward COVID-19. All instruments were validated and pretested before use. Chi-square test, followed by binary logistic and multivariate regression, was applied to determine factors associated with knowledge scores. RESULTS: Seven hundred and thirteen health personnel participated, and 703 (98.6%) participants responded were analyzed for final results. 95.9% of the health personnel were aware about route of transmission and clinical symptoms (95.3%) of COVID-19. 63.7% believed that virus outbreak would be controlled globally and followed standard precautions (81.8%), including wearing the mask. Further, majority (98.3%) of the participants avoided social contact by not going to crowded places and not calling people to their homes (82.2%) during the advisory of the government. In binary logistic regression analyses, the adequate knowledge score found significantly associated with MBBS/bachelor's degree (odds ratio [OR]: 2.309, confidence interval [CI]: 1.232–4.324, P &lt; 0.009) and master's degree (OR: 2.944, CI: 1.485–5.835, P &lt; 0.002), working with government health-care facility (OR: 3.662, CI: 1.624–8.285, P &lt; 0.002), and holding a post of a physician (OR: 7.735, CI: 2.210–27.091, P &lt; 0.001) during outbreak. CONCLUSIONS: The level of education is associated with adequate knowledge scores among the health personnel. Type of health-care facility and post held in a health-care facility are significant predictors of adequacy of knowledge.</text>
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                <text>coronavirus, Health Personnel, covid-19, Knowledge, practice, attitude</text>
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                <text>10.4103/jehp.jehp_524_20</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Public aspects of medicine, Special aspects of education</text>
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                <text>Rajesh Naidu Janapala, Jigar Patel, Omar Belfaqeeh, Abdulla Alhashmi, Ali Pourmand</text>
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                <text>International Journal of Infectious Diseases</text>
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                <text>Identifying Research Trends and Gaps in the Context of COVID-19</text>
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                <text>Rajib Shaw, Hongyue Zhang</text>
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                <text>The COVID-19 pandemic has affected the world in different ways. Not only are people’s lives and livelihoods affected, but the virus has also affected people’s lifestyles. In the research sector, there have been significant changes, and new research is coming very strongly in the related fields of virology and epidemiology. Similar trends were observed after the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) episodes of 2003 and 2012, respectively. Analyzing 20 years of published scientific papers, this article points out the highlights of coronavirus-related research. Significant progress is observed in the past research related to virology, epidemiology, infectious diseases among others. However, in research linked to public health, its governance, technology, and risk communication there seem to be gap areas. Although the World Health Organization (WHO) global research road map has identified social science-related research as a priority area, more focus needs to be given in the upcoming days for multi, cross and trans-disciplinary research related to public health and disaster risk reduction.</text>
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                <text>mitigation, public health preparedness, Social Science Research, COVID-19, coronavirus research trends, public health and disaster risk reduction</text>
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                <text>DOI: 10.3390/ijerph17103370</text>
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                <text>International Journal of Environmental Research and Public Health</text>
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                <text>Medicine</text>
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                <text>Short-term impacts of air pollutants in three megacities of India during COVID-19 lockdown.</text>
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                <text>Rajiv Ganguly, Divyansh Sharma, Prashant Kumar</text>
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                <text>Lockdown was imposed by the Indian government in the month of March 2020 as an early precaution to the COVID-19 pandemic which obstructed the socio-economic growth globally. The main aim of this study was to analyse the impact of lockdown (imposed in March and continued in April 2020) on the existing air quality in three megacities of India (Delhi, Mumbai and Kolkata) by assessing the trends of PM10 and NO2 concentrations. A comparison of the percentage reduction in concentrations of lockdown period with respect to same period in year 2019 and pre-lockdown period (February 14-March 24) was made. It was observed from the study that an overall decrease of pollutant concentrations was in the ranges of 30-60% and 52-80% of PM10 and NO2, respectively, in the three cities during lockdown in comparison with previous year and pre-lockdown period. The overall decrease in concentrations of pollutants at urban sites was greater than the background sites. Highest decline in concentrations of PM10 were observed in Kolkata city, followed by Mumbai and Delhi, while decline in NO2 was highest in Mumbai. Results also highlighted that capital city Delhi had the worst air quality amongst three cities, with particulate matter (PM10) being the dominant pollutant. Although COVID-19 has significantly affected the human life considering the mortality and morbidity, lockdowns imposed to control the pandemic had significantly improved the air quality in the selected study locations, although for the short amount of period.</text>
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                <text>10.1007/s10668-021-01434-9</text>
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                <text>Environment, development and sustainability</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>Potential of Flavonoid-Inspired Phytomedicines against COVID-19</text>
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                <text>Rajiv Kumar, Wilfred Ngwa, Ngeh Toyang, Henry Lowe, Daryl Thompson, William Lyerly, Roscoe Moore, Terry-Elinor Reid</text>
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            <description>An account of the resource</description>
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                <text>Flavonoids are widely used as phytomedicines. Here, we report on flavonoid phytomedicines with potential for development into prophylactics or therapeutics against coronavirus disease 2019 (COVID-19). These flavonoid-based phytomedicines include: caflanone, Equivir, hesperetin, myricetin, and Linebacker. Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19. Meanwhile, in vitro studies show potential of caflanone to inhibit virus entry factors including, ABL-2, cathepsin L, cytokines (IL-1β, IL-6, IL-8, Mip-1α, TNF-α), and PI4Kiiiβ as well as AXL-2, which facilitates mother-to-fetus transmission of coronavirus. The potential for the use of smart drug delivery technologies like nanoparticle drones loaded with these phytomedicines to overcome bioavailability limitations and improve therapeutic efficacy are discussed.</text>
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                <text>2020</text>
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                <text>phytomedicine, SARS-CoV-2, COVID-19, smart nanoparticles, flavonoids and their derivatives</text>
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                <text>DOI: 10.3390/molecules25112707</text>
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                <text>Molecules</text>
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                <text>MDPI AG</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Organic chemistry</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>A preliminary study on contact tracing &amp; transmission chain in a cluster of 17 cases of severe acute respiratory syndrome coronavirus 2 infection in Basti, Uttar Pradesh, India</text>
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                <text>Rajni Kant, Kamran Zaman, Prem Shankar, Rajaram Yadav</text>
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                <text>Background &amp; objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread rapidly, causing unprecedented case fatalities across the world. The first laboratory-confirmed case of COVID-19 and also the first death associated with the disease in the eastern part of Uttar Pradesh (UP) was reported from Basti on March 31, 2020. The present study describes a cluster of 17 cases including one death of confirmed COVID-19 in Basti, UP, India. Methods: A 25 year old male from Basti, UP, India, who died of respiratory failure was diagnosed post-mortem as SARS-CoV-2 positive. Contact tracing carried out by the district administration found 16 cases positive among tested contacts. A detailed retrospective investigation in the form of one-to-one interview was carried out with 16 recovered individuals to understand the transmission dynamics and clinical characteristics. Results: The findings showed that the cluster transmission occurred at three levels: first was direct contact with the index case which resulted in two secondary cases. Second, at a household level where four of the seven susceptible contacts got infected, and the third was an event (funeral) where 50 individuals participated and this resulted in seven SARS-CoV-2-infected individuals in whom infection could be directly linked to a funeral gathering. The index case had associated comorbidities and succumbed to death. Most of the cases were asymptomatic except two individuals, who developed mild symptoms. The mean duration of quarantine facility was 21.6±7.3 days, and the average time taken for the first negative test after testing positive to COVID-19 was 12±4.1 days. Interpretation &amp; conclusions: The funeral acted as a super-spreader event for the transmission of infection among family members, relatives and others. Active contact tracing and confirmation of infection among the contacts led to the isolation of 16 SARS-CoV-2 positive cases and hence the limited spread of the disease. Asymptomatic carriers and super-spreader events are among the major challenges in the control and prevention of SARS-CoV-2 transmission. Early testing, quarantine and social distancing may play key role in breaking the chain of transmission.</text>
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                <text>2020</text>
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                <text>cluster - covid-19 - india - sars-cov-2 - transmission - uttar pradesh</text>
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            <name>Identifier</name>
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                <text>10.4103/ijmr.IJMR_2914_20</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Biotemas</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="39478">
                <text>Universidade Federal de Santa Catarina</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="39479">
                <text>Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
