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                <text>Florence Jaguga, Sarah Kanana Kiburi</text>
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                <text>The lancet. Psychiatry</text>
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                <text>Reducing the Fatality Rate of COVID-19 by Applying Clinical Insights From Immuno-Oncology and Lung Transplantation</text>
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                <text>Fatih M. Uckun</text>
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                <text>There is an urgent need to identify effective strategies that can stop or reverse the inflammatory process that causes acute lung injury, ARDS, and multi-organ failure in COVID-19. Adaptive clinical trials with parallel enrollment to different arms each evaluating a rationally designed combination modality could provide the foundation for the accelerated identification of effective and safe multi-modality treatment algorithms for COVID-19 pneumonia. This article summarizes the insights and lessons learned from clinical immune-oncology trials as well as lung transplantation that are informing the clinical development of promising new strategies aimed at reducing the fatality rate in COVID-19.</text>
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                <text>2020</text>
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                <text>Acute lung injury, acute respiratory distress syndrome, Cytokine release syndrome, 2019ncov, COVID-19, systemic capillary leak</text>
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                <text>DOI: 10.3389/fphar.2020.00796</text>
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                <text>Frontiers in Pharmacology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Therapeutics. Pharmacology</text>
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                <text>Reducing the Impact of the Global COVID-19 Pandemic on Business Entities in the Czech Republic from an Accounting and Tax Perspective</text>
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                <text>Hakalova Jana, Kryskova Sarka, Psenkova Yvetta</text>
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                <text>Research background: The global pandemic declared by WHO on 11 March 2020 has had a widespread impact on the world economy, and the COVID-19 outbreak has severely affected economic life throughout the globalized world. Governments have taken various measures to support their economy and financial stability. The global restrictions on production and services, reduced demand for goods and services and this year’s cash-flow problems will certainly lead to a significant decline in their profits, especially for small and medium-sized companies. The COVID-19 pandemic has undoubtedly affected most business entities in the Czech Republic. Purpose of the article: The purpose of the paper is to describe, analyse and evaluate measures of the government of the Czech Republic, which aimed at reducing the impact of the pandemic on businesses in the Czech Republic. Methods: In the paper, classical types of scientific procedures were applied using theoretical and empirical methods which include description, analysis, synthesis, induction, deduction, comparison and evaluation and so on. Findings &amp; Value added: The paper analyses the impacts of COVID-19 in the context of accounting measures from the perspective of Czech and international accounting regulations. The paper proposes a solution in the area of mandatory reactions of accounting entities to a completely unusual situation caused by the COVID-19 pandemic which should be mandatory and disclosed in the notes to the financial statements. Furthermore, the paper evaluates a set of measures in the field of taxation, wages and insurance premiums intended for business entities and their employees.</text>
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                <text>2021</text>
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                <text>covid-19, Accounting, audit, financial statements, taxes</text>
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            <name>Identifier</name>
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                <text>10.1051/shsconf/20219201012</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Social Sciences</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
                </elementText>
              </elementTextContainer>
            </element>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)</text>
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            <name>Creator</name>
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                <text>Min Li, Ying Liu, Yi Zhang, Li Chen, Gang Wang, Bo Diao, Yuzhang Wu, Ze-Qing Feng, Chenhui Wang, Yongwen Chen, Yueping Liu, Xie-wan Chen, Yingjun Tan, Lifen Ning, Zilin Yuan</text>
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            <description>An account of the resource</description>
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                <text>Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear.Methods: We retrospectively reviewed the counts of T cells and serum cytokine concentration from data of 522 patients with laboratory-confirmed COVID-19 and 40 healthy controls. In addition, the expression of T cell exhaustion markers were measured in 14 COVID-19 cases.Results: The number of total T cells, CD4+ and CD8+ T cells were dramatically reduced in COVID-19 patients, especially in patients requiring Intensive Care Unit (ICU) care. Counts of total T cells, CD8+ T cells or CD4+ T cells lower than 800, 300, or 400/μL, respectively, were negatively correlated with patient survival. T cell numbers were negatively correlated to serum IL-6, IL-10, and TNF-α concentration, with patients in the disease resolution period showing reduced IL-6, IL-10, and TNF-α concentrations and restored T cell counts. T cells from COVID-19 patients had significantly higher levels of the exhausted marker PD-1. Increasing PD-1 and Tim-3 expression on T cells was seen as patients progressed from prodromal to overtly symptomatic stages.Conclusions: T cell counts are reduced significantly in COVID-19 patients, and the surviving T cells appear functionally exhausted. Non-ICU patients with total T cells counts lower than 800/μL may still require urgent intervention, even in the immediate absence of more severe symptoms due to a high risk for further deterioration in condition.</text>
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                <text>2020</text>
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                <text>T-cell exhaustion, SARS-CoV-2, COVID-19, T cell reduction, cytokine strom</text>
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                <text>DOI: 10.3389/fimmu.2020.00827</text>
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                <text>Frontiers in Immunology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Immunologic diseases. Allergy</text>
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                <text>Li Zhang, Yu Wang, Xiaoli Wang, Peng Yang, Man Zhang, C. Raina MacIntyre, Ying Sun, Lei Jia, Huaiyu Tian, Da Huo, Dandan Guo, Quanyi Wang, Xingxing Zhang, Wenting Wu, Baiwei Liu, Ge Lin Kan</text>
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                <text>Reemergencia del Suqqa: paradigma, filosofía de vida, alternativa al simeka, cuajadura del cambio climático</text>
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                <text>Simón Yampara Huarachi</text>
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                <text>Los procesos del cambio climático (cc) y la variabilidad climática (vc), que vivimos hoy, nos advierten y anuncian hacer un alto y cambio al camino del crecimiento de la materialidad, el consumismo y la desmesurada acumulación privada de las castas sociales aristocráticas coloniales[1], que al globalizar el simeka[2] arrastraron a pueblos y civilizaciones a seguir la misma ruta, sin dimensionar adecuada, equitativa y cualitativamente la salud ambiental, ecológica y los alcances del cosmos biótico de la Tierra.[1] Son palabras y conceptos usadas por el autor desde la visión y horizonte de los pueblos ancestrales milenarios[2] Sistema Mercantil Kapitalista, la palabra Kapitalista con k, es nuestra distinción.</text>
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                <text>Ayni: reciprocidad, Cambio climático, Simeka, Suqqa, relacionalidad, variación climática</text>
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                <text>Universidad Nacional de Córdoba</text>
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                <text>&lt;a href="https://revistas.unc.edu.ar/index.php/intersticios/article/view/15592" target="_blank" rel="noreferrer noopener"&gt;https://revistas.unc.edu.ar/index.php/intersticios/article/view/15592&lt;/a&gt;</text>
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                  <text>Dominio científico: Agricultura sostenible</text>
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                <text>Héctor B. Fletes Ocón, Guadalupe Ocampo Guzmán, Guillermo Valdiviezo Ocampo</text>
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                <text>Organismos internacionales y especialistas coinciden en que  los problemas de crisis e inseguridad alimentaria se asocian con las po - líticas  que  diferentes  países  aplicaron  en  las  últimas  dos  décadas,  las   cuales  desmantelaron  los  programas  de  fomento  a  la  agricultura,  en   particular de los pequeños productores. Aunque esta reestructuración  neoliberal  se  realizó  de  manera  heterogénea,  los  retos  para  reactivar   la  producción  agroalimentaria  sustentable  y  de  calidad,  así  como  de   elevar  los  ingresos  rurales,  son  de  gran  magnitud,  y  en  ocasiones  no   aparecen en los objetivos de la política nacional. En este documento analizamos la forma en que la reestructuración ha impactado en ciertos  patrones de creciente inseguridad alimentaria en México y Chiapas, así  como la manera en que pequeños productores han adaptado y retado  este proceso, constituyendo iniciativas con las que revalorizan la lógica  de la agricultura campesina y de pequeña escala.</text>
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                <text>EntreDiversidades: Revista de Ciencias Sociales y Humanidades</text>
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                <text>Universidad Autónoma de Chiapas</text>
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                <text>History of scholarship and learning. The humanities, Social sciences (General)</text>
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                <text>&lt;a href="http://www.redalyc.org/articulo.oa?id=455949153005" target="_blank" rel="noreferrer noopener"&gt;http://www.redalyc.org/articulo.oa?id=455949153005&lt;/a&gt;</text>
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