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                  <text>Dominio científico: Coronavirus</text>
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                <text>Invention, Innovation, and Imitation in India—Necessity Arising from the COVID-19 Pandemic</text>
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                <text>Joseph L Mathew, T. Lazar Mathew</text>
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                <text>The COVID-19 pandemic has stimulated tremendous innovation in India, driven by unprecedented novel needs, sense of urgency, availability of time during the lockdown, funding by Government agencies, and accelerated processing of projects. Therefore, the country has witnessed widespread innovation and imitation of existing technologies in recent weeks, but very few inventions. One novel invention, the Artificial Breathing Capability Device (ABCD) is being speeded up by the current necessity. Other innovations and imitations include (i) healthcare devices/products intended for diagnosis, management, or monitoring of suspected/confirmed COVID-19 patients (in healthcare institutions); (ii) improvisations in personal protective equipment (PPE) for frontline healthcare workers and other personnel (including the public); (iii) adaptation of information technology platforms for telehealth, telemedicine, telemonitoring, and tele-education; and (iv) repurposing of existing resources/technologies for COVID-19. Some fruits of these efforts include (i) respiratory support devices (by mechanization of manual ventilation, ventilator splitters, etc.), (ii) personal protective equipment (PPE) (novel face masks, face shields/splash guards, intubation boxes, aerosol guards, etc.), (iii) novel sanitization products, processes or deployment methods, (iv) diagnostic tests (including rapid antibody tests, polymerase chain reaction [PCR] methods, and loop-mediated isothermal amplification [LAMP]), and (v) various adaptations such as repurposing and retrofitting of existing technologies aligned to the needs of COVID-19. These innovations and imitations have laudable features such as extremely rapid development of products (not merely concepts or prototypes); collaboration among individuals, institutions, and industry; willingness of players to work outside traditional comfort zones; and teamwork among stakeholders. Social media and lay press publicity create a sense of achievement and hope in a nation bogged down by the realities of COVID-19. However, these positive developments are associated with unique problems, especially duplication of effort, disregard of intellectual property (IP) issues, unhealthy competition amongst institutions, and failure to consider the needs for which solutions are proposed. The haste for developing products has bypassed the important steps of peer review, laboratory testing, and clinical validation to ensure the safety and efficacy of end users. These unintended side effects of the innovation race can be overcome by coordinated efforts through an innovation pathway proposed in this article under a broader innovation ecosystem.</text>
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                <text>Respiratory Support, innovation eco-system, COVID-19, biomedical innovation, artificial breathing capability device, innovation pathway</text>
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                <text>DOI: 10.1055/s-0040-1713719</text>
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                <text>Annals of the National Academy of Medical Sciences (India)</text>
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                <text>Şenol Adanur, Özkan Polat, Salih Al</text>
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                <text>DOI: 10.5152/eurasianjmed.2020.010620</text>
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                <text>Eurasian Journal of Medicine</text>
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                <text>Medicine (General)</text>
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                <text>Hedong Zhang, Xu-biao Xie, He-long Dai</text>
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                <text>Since December 2019, the ongoing coronavirus disease 2019 (COVID-19) pandemic has significantly affected solid organ transplantation (SOT) worldwide and has become a threat to the lives of SOT recipients. Here, we have reviewed, condensed, and organized the available information on COVID-19 to provide recommendations to transplant healthcare workers. Our review of reported cases shows that the symptoms of SOT patients with COVID-19 are similar to those of the normal population, but their severity and outcomes are worse. Thus far, there is no evidence that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly causes permanent damage to kidney, liver, or heart allografts.</text>
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                <text>2020</text>
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                <text>immunosuppressant, clinical characteristics, solid organ transplantation, COVID-19, transplant safety</text>
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                <text>DOI: 10.3389/fimmu.2020.01392</text>
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                <text>Frontiers in Immunology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Immunologic diseases. Allergy</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Strategy for Disease Diagnosis, Progression Prediction, Risk Group Stratification and Treatment—Case of COVID-19</text>
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                <text>Mauno Vihinen</text>
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                <text>A novel strategy is presented for reliable diagnosis and progression prediction of diseases with special attention to COVID-19 pandemic. A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity, and variation at all levels, systems, and mechanisms. Poikilosis in diseases can be taken into account in pathogenicity model, which is based on distribution of three independent condition measures—extent, modulation, and severity. Pathogenicity model is a population or cohort-based description of disease components. Evidence-based thresholds can be applied to the pathogenicity model and used for diagnosis as well as for early detection of patients in risk of developing the most severe forms of the disease. Analysis of patients with differential course of disease can help in detecting biomarkers of diagnostic and prognostic significance. A practical and feasible plan is presented how the concepts can be implemented in practice. Collaboration of many actors, including the World Health Organization and national health authorities, will be essential for success.</text>
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                <text>2020</text>
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                <text>diagnosis, SARS-CoV-2, COVID-19, pathogenicity model, progression prediction, poikilosis</text>
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                <text>DOI: 10.3389/fmed.2020.00294</text>
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                <text>Frontiers in Medicine</text>
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                <text>Frontiers Media S.A.</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>I “Protocolli per la ripresa delle celebrazioni delle confessioni diverse dalla cattolica”: una nuova stagione nella politica ecclesiastica italiana</text>
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                <text>Maria Luisa Lo Giacco</text>
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                <text>SOMMARIO: 1. Premessa - 2. La cronaca: come sono nati i protocolli - 3. Un metodo laico.  The Protocols for the resumption of religious ceremonies": the first signal of a new season in the Italian ecclesiastical politics  ABSTRACT: In Italy the religions have signed with the Government some protocols for the resumption of religious ceremonies after the lockdown for the Covid-19 emergency. Those protocols are an important step in the way of an effective protection of religious freedom in a pluralistic society. The protocols inaugurate a new season in the relationships between the religions and the state in Italy."</text>
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                <text>DOI: </text>
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                <text>Stato, Chiese e Pluralismo Confessionale</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Università degli Studi di Milano</text>
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                <text>Law</text>
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                <text>Living With COVID-19: A Systemic and Multi-Criteria Approach to Enact Evidence-Based Health Policy</text>
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                <text>Didier Raboisson, Guillaume Lhermie</text>
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                <text>The lifting of COVID-19 (coronavirus disease 2019) lockdown requires, in the short and medium terms, a holistic and evidence-based approach to population health management based on combining risk factors and bio-economic outcomes, including actors' behaviors. This dynamic and global approach to health control is necessary to deal with the new paradigm of living with an infectious disease, which disrupts our individual freedom and behaviors. The challenge for policymakers consists of defining methods of lockdown-lifting and follow-up (middle-term rules) that best meet the needs for resumption of economic activity, societal wellbeing, and containment of the outbreak. There is no simple and ready-to-use way to do this since it means considering several competing objectives at the same time and continuously adapting the strategy and rules, ideally at local scale. We propose a framework for creating a precision evidence-based health policy that simultaneously considers public health, economic, and societal dimensions while accounting for constraints and uncertainty. It is based on the four following principles: integrating multiple and heterogeneous information, accepting navigation with uncertainty, adjusting the strategy dynamically with feedback mechanisms, and managing clusters through a multi-scalar conception. The evidence-based policy intervention for COVID-19 obtained includes scientific background via epidemiological modeling and bio-economic modeling. A set of quantitative and qualitative indicators are used as feedback to precisely monitor the societal-economic-epidemiological dynamics, allowing tightening or loosening of measures before epidemic damage (re-)occurs. Altogether, this allows an evidence-based policy that steers the strategy with precision and avoids any political shock.</text>
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                <text>2020</text>
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                <text>systemic approach, social-ecological system (SES), Evidence based policy, Population medicine, COVID-19</text>
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                <text>DOI: 10.3389/fpubh.2020.00294</text>
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                <text>Frontiers in Public Health</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="37657">
                <text>Frontiers Media S.A.</text>
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                <text>Public aspects of medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19: An Appeal for an Intersectoral Approach to Tackle With the Emergency</text>
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                <text>Alberto Alberti, Alessandra Scagliarini</text>
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            <description>An account of the resource</description>
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                <text>The knowledge of disease determinants is a pre-requisite for disease prevention. Infectious diseases determinants can be classified in three ways, as: primary or secondary; intrinsic or extrinsic; and associated with host, agent, or environment. In the specific case of COVID-19 several of these determinants are currently unknown leading to difficulties in public health approach to this disease. In this paper, we attempt to address several of the current gaps on COVID-19 using a systematic analysis on recent findings and some preliminary knowledge on animal coronaviruses. A discussion on the impact of COVID-19 determinants in disease prevention and control will be based on the Environmental Change and Infectious Disease (EnVID) systemic framework to address several challenges that may affect the control of the SARS- CoV-2 pandemic spread both in industrialized and in developing Countries.</text>
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                <text>2020</text>
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                <text>Public Health, One Health, Vertebrate Hosts, SARS-CoV-2, COVID-19, disease determinants</text>
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            <name>Identifier</name>
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                <text>DOI: 10.3389/fpubh.2020.00302</text>
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                <text>Frontiers in Public Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="37648">
                <text>Frontiers Media S.A.</text>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Public aspects of medicine</text>
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              <name>Title</name>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Olfaction and COVID: The little we Know and what else we need to know</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Marco Aurélio Fornazieri, Fábio de Rezende Pinna, Richard Louis Voegels, Deusdedit Brandão Neto</text>
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                <text>2020</text>
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              <elementText elementTextId="37637">
                <text>DOI: 10.1055/s-0040-1713143</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>International Archives of Otorhinolaryngology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="37639">
                <text>Thieme Revinter Publicações</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine, Otorhinolaryngology</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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      <elementSet elementSetId="1">
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                <text>Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Lei Fan, Jianyong Li, Yi Miao</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>IL-6, ruxolitinib, Tocilizumab, hemophagocytic lymphohistiocytosis, COVID-19</text>
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                <text>DOI: 10.3389/fimmu.2020.01445</text>
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              <elementText elementTextId="37631">
                <text>Frontiers in Immunology</text>
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              <elementText elementTextId="37632">
                <text>Frontiers Media S.A.</text>
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                <text>Immunologic diseases. Allergy</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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                <text>A Review of Potential Antiviral Drugs and Vaccines to Treat COVID-19</text>
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                <text>Sanjeet Singh, R Jayaram</text>
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                <text>Coronavirus disease 19 (COVID-19) is a challenge to the whole humanity. COVID-19 was first reportedin China and rigorous researches are going on for developing vaccine for the pandemic. This review wasprepared by following PRISMA guidelines and used the resources from the Web of Science and PubMed.This research focuses on the niches of symptoms and vaccines for COVID-19. The research for vaccineinvolves research for new vaccine and drug repurposing. Out of various drug repurposing options,Remdesivir, and Favipiravir, Chloroquine and Lopinavir/Ritonavir were found to be the popular onesfor treating COVID-19 patients across the world. Even though there are concerns regarding asymptoticpatients, the most dominant symptoms of COVID-19 are fever and cough, followed by Dyspnoea andmuscle ache. This review concludes that the COVID-19 related research should focus on developingimmunity vaccines, and repurposing of drugs. Research on the problems of quarantine life, patientmonitoring, and usage of information technology in facing COVID-19 will improve the quality of patienthandling during the pandemic. The research on the effectiveness of various models of lockdown andregulation of social life during lockdown periods, improving the safety of health care workers in theworkplace will definitely help the governments in their fight against COVID-19.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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              <elementText elementTextId="37620">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="37621">
                <text>vaccine, coronavirus, Pandemic, SARS-CoV-2, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="37622">
                <text>DOI: 10.22207/JPAM.14.SPL1.14</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="37623">
                <text>Journal of Pure and Applied Microbiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="37624">
                <text>Journal of Pure and Applied Microbiology</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="37625">
                <text>Microbiology</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
