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                  <text>Dominio científico: Coronavirus</text>
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                <text>Allo-priming as a universal anti-viral vaccine: protecting elderly from current COVID-19 and any future unknown viral outbreak</text>
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                <text>Reuven Or, Michael Har-Noy</text>
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                <text>Abstract Background We present the rationale for a novel allo-priming approach to serve the elderly as a universal anti-virus vaccine, as well serving to remodel the aging immune system in order to reverse immunosenescence and inflammaging. This approach has the potential to protect the most vulnerable from disease and provide society an incalculable economic benefit. Allo-priming healthy elderly adults is proposed to provide universal protection from progression of any type of viral infection, including protection against progression of the current outbreak of COVID-19 infection, and any future variants of the causative SARS-CoV-2 virus or the next ‘Disease X’. Allo-priming is an alternative approach for the COVID-19 pandemic that provides a back-up in case vaccination strategies to elicit neutralizing antibody protection fails or fails to protect the vulnerable elderly population. The allo-priming is performed using activated, intentionally mismatched, ex vivo differentiated and expanded living Th1-like cells (AlloStim®) derived from healthy donors currently in clinical use as an experimental cancer vaccine. Multiple intradermal injections of AlloStim® creates a dominate titer of allo-specific Th1/CTL memory cells in circulation, replacing the dominance of exhausted memory cells of the aged immune system. Upon viral encounter, by-stander activation of the allo-specific memory cells causes an immediate release of IFN-ϒ, leading to development of an “anti-viral state”, by-stander activation of innate cellular effector cells and activation of cross-reactive allo-specific CTL. In this manner, the non-specific activation of allo-specific Th1/CTL initiates a cascade of spatial and temporal immune events which act to limit the early viral titer. The release of endogenous heat shock proteins (HSP) and DAMP from lysed viral-infected cells, in the context of IFN-ϒ, creates of conditions for in situ vaccination leading to viral-specific Th1/CTL immunity. These viral-specific Th1/CTL provide sterilizing immunity and memory for protection from disease recurrence, while increasing the pool of Th1/CTL in circulation capable of responding to the next viral encounter. Conclusion Allo-priming has potential to provide universal protection from viral disease and is a strategy to reverse immunosenescence and counter-regulate chronic inflammation (inflammaging). Allo-priming can be used as an adjuvant for anti-viral vaccines and as a counter-measure for unknown biological threats and bio-economic terrorism.</text>
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                <text>2020</text>
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                <text>immunotherapy, cell therapy, vaccine, immunosenescence, Inflammaging, COVID-19</text>
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                <text>DOI: 10.1186/s12967-020-02363-3</text>
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                <text>Journal of Translational Medicine</text>
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                <text>BMC</text>
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                <text>Revekka Ziogou, Katerina Zografou</text>
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                <text>DOI: 10.18332/ejm/120972</text>
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                <text>European Journal of Midwifery</text>
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                  <text>Repositorio Digital de los números de las revistas de la Asociación de Técnicos Azucareros de Cuba. </text>
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                <text>Técnico, Azucarera, Malezas, Caña, Azúcar, Cepas, Incidencia Económica, Vida, Bacterias Lácticas, Materiales Fibrosos, Mieles, Archivo, Biblioteca, Panamá, 48 Congreso,  </text>
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                <text>Sumario&#13;
&#13;
EDITORIAL p-4&#13;
&#13;
CADA TÉCNICO UN PROTAGONISTA EN EL DESARROLLO&#13;
DE LA INDUSTRIA AZUCARERA p-5&#13;
&#13;
NUEVO SISTEMA AUTOMATIZADO PARA EL CONTROL&#13;
INTEGRAL DE MALEZAS EN CAÑA DE AZÚCAR&#13;
Juan C. Díaz, Yanet Rodriguez, Sixto Hernández.,&#13;
Juan B. Fuentes, Rafael Zuaznábar y Lorenzo Rodríguez p-10&#13;
&#13;
PREMIOS ÁLVARO REYNOSO&#13;
Jaime Porcell Prado p-16&#13;
&#13;
AZÚCAR FORTIFICADA. PRIMERA EXPERIENCIA CUBANA&#13;
Marta Delgado, Juana R. Pérez,&#13;
Reina Rodríguez y Juana M. Chanfón p-21&#13;
&#13;
EVALUACIÓN DE LA COMPOSICIÓN DE CEPAS&#13;
Y VARIEDADES Y SU INCIDENCIA ECONÓMICA&#13;
EN LA UBPC BLAS ROCA CLADERÍO&#13;
Misladys Garcés Camejo, Moizán Hung Miranda,&#13;
Zoila Loddo Vega e Inés Barriento p-25&#13;
&#13;
VIDA DE LA ATAC p-29&#13;
&#13;
PRODUCCIÓN DE UN PREPARADO DE BACTERIAS LÁCTICAS&#13;
PARA LA PRESERVACIÓN DE MATERIALES FIBROSOS A&#13;
PARTIR DE LAS MIELES DE CAÑA. CRITERIOS ECONÓMICOS&#13;
Gladys Blanco Carracedo, Maribel Herryman Munilla,&#13;
Osear Almazán del Olmo y Julio Martínez Valdivieso p-36&#13;
&#13;
DESDE EL ARCHIVO &#13;
Maité Echarri Chávez p-42&#13;
&#13;
EXTENSIÓN AGRÍCOLA EN EL COMPLEJO&#13;
AGROINDUSTRIAL AZUCARERO PANAMÁ&#13;
Eugenio García del Risco, Eduardo Patiño Gardeazábal&#13;
Wilfredo Díaz Martínez y Ramón Fco. Crespo Labrador p-48&#13;
&#13;
48 CONGRESO DE LA ATAC. PROGRAMA TÉCNICO&#13;
PRELIMINAR p-52&#13;
&#13;
ABSTRACTS p-54&#13;
&#13;
PÁGINAS DE NUESTRA BIBLIOTECA&#13;
Carmen García Miranda y María de la Concepción&#13;
Rodríguez Pérez p-56</text>
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Vida de la atac p-11&#13;
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Premio Álvaro Reynoso a la CPA&#13;
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Premio por la Obra de la Vida a 19&#13;
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Premiados por la Obra de la Vida 20&#13;
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Cultivo de la Caña de Azúcar y trabajos&#13;
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Jornada Científico-Productiva&#13;
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Caracterización de las principales etapas&#13;
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Selectividad del Pulgón Melanaphis&#13;
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