1656 10 20655 https://www.socictopen.socict.org/files/original/6bb6bb93653ec9bc5028121f885d4dfe.pdf 17a8dccb1340de1b9775cecac368dc8c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reproducción, distribución y abundancia del pez Pseudupeneus grandisquamis (Perciformes: Mullidae), en el Golfo de Tehuantepec, México Creator An entity primarily responsible for making the resource Eduardo Ramos-Santiago, José Martín Ramírez-Gutiérrez, Ricardo Mendoza-Rodríguez, Margarito Tapia-García Description An account of the resource Como resultado de sus estrategias biológicas y ecológicas, el pez Pseudupeneus grandisquamis es una especie dominante en la comunidad demersal del Golfo de Tehuantepec. Nuestro principal objetivo fue conocer estas estrategias con base en su distribución, abundancia y reproducción. Se analizaron un total de 5 175 individuos que forman parte de las recolectas de peces obtenidas en cinco cruceros oceanográficos realizados en el Golfo de Tehuantepec, México, entre 1989-1990. Es una especie demersal típicamente marina, con amplia distribución en la plataforma continental. La mayor abundancia de P. grandisquamis se presenta en marzo y noviembre, alrededor de la isobata de los 40 m y frente a los sistemas lagunares Superior-Inferior y Laguna del Mar Muerto. La reproducción de la especie se presenta durante todos los meses analizados, principalmente durante los meses de agosto a octubre, correspondiente a la época de lluvias. La presencia de jóvenes, principalmente en noviembre y marzo, sugiere un amplio periodo de reclutamiento durante estos meses cuya distribución se refleja principalmente en el área influenciada por las lagunas Superior-Inferior, que representa un área de crianza. La proporción sexual total hembras:machos fue prácticamente 1:1. La talla máxima en la región es de 213 mm y la talla de primera madurez es de 138 mm LT. La alta abundancia y reproducción se presentan cuando el golfo tiene alta producción, acorde con la dinámica del sistema, donde tiene gran relevancia la influencia de las lagunas costeras. Se sugiere aplicar estrategias de protección a las zonas sobre la plataforma continental del Golfo de Tehuantepec influenciadas por procesos estuarinos y que representan áreas de reproducción y crianza para un gran número de especies, entre las que se encuentra P. grandisquamis.Reproduction, distribution and abundance of the fish Pseudupeneus grandisquamis (Perciformes: Mullidae), in the Gulf of Tehuantepec, Mexico. As result of its biological and ecological strategies, Pseudupeneus grandisquamis is a dominant species in the demersal community of the Gulf of Tehuantepec, Mexico. Our main objective was to understand these strategies with respect to distribution, abundance and reproduction. We analyzed 5 175 individuals representing partial collections from five oceanographic expeditions between 1989 and 1990. It is a typical demersal marine species, with a wide distribution on the continental shelf. The highest abundance of P. grandisquamis occurs in March and November, around the 40 m isobath, facing the Superior-Inferior lake systems and Mar Muerto Lagoon. Reproduction occurred during all of the months studied, particularly from August to October, corresponding to the rainy season, when the salinity and temperature is lower. The presence of juveniles, principally in November and March, suggests a long period of recruitment; they are distributed mainly in the Superior-Inferior Lagoons, which serves as a nursery area where they remain until they are adults. The total female to male sex ratio was nearly 1:1 throughout the year. The maximum total length was 213 mm and the size at first maturity was 138 mm TL. The high abundance and reproduction occur when the gulf has a high level of ecological production, in accordance with the dynamics of the system, where the influence of coastal lagoons is important. Protection strategies for the area above the continental shelf of the Gulf of Tehuantepec are recommended for the estuary processes and for the reproduction and rearing of a large number of species, including P. grandisquamis. Rev. Biol. Trop. 54 (4): 1103-1112. Epub 2006 Dec. 15. Date A point or period of time associated with an event in the lifecycle of the resource 2006 Subject The topic of the resource Lagunas, Pseudupeneus grandisquamis, Reproducción, Reproduction, Tehuantepec, demersal, dominance, dominancia, ecology, ecología, lagoons Source A related resource from which the described resource is derived Revista de Biología Tropical Publisher An entity responsible for making the resource available Vicerractoría Investigación Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Relation A related resource <a href="http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0034-77442006000400006" target="_blank" rel="noreferrer noopener">http://www.scielo.sa.cr/scielo.php?script=sci_arttext&amp;pid=S0034-77442006000400006</a> https://www.socictopen.socict.org/files/original/b172b29ff1874a6d964d4ebe8a8b48b4.pdf f4cbf0f56a84ef3527f3e6cde83b2ae0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reproduction of East-African bats may guide risk mitigation for coronavirus spillover Creator An entity primarily responsible for making the resource Diego Montecino-Latorre, Tracey Goldstein, Kirsten Gilardi, David Wolking, Elizabeth VanWormer, Rudovick Kazwala, Benard Ssebide, Julius Nziza, Zikankuba Sijali, Michael Cranfield, PREDICT Consortium, Jonna A.K. Mazet Description An account of the resource Abstract Background Bats provide important ecosystem services; however, current evidence supports that they host several zoonotic viruses, including species of the Coronaviridae family. If bats in close interaction with humans host and shed coronaviruses with zoonotic potential, such as the Severe Acute Respiratory Syndrome virus, spillover may occur. Therefore, strategies aiming to mitigate potential spillover and disease emergence, while supporting the conservation of bats and their important ecological roles are needed. Past research suggests that coronavirus shedding in bats varies seasonally following their reproductive cycle; however, shedding dynamics have been assessed in only a few species, which does not allow for generalization of findings across bat taxa and geographic regions. Methods To assess the generalizability of coronavirus shedding seasonality, we sampled hundreds of bats belonging to several species with different life history traits across East Africa at different times of the year. We assessed, via Bayesian modeling, the hypothesis that chiropterans, across species and spatial domains, experience seasonal trends in coronavirus shedding as a function of the reproductive cycle. Results We found that, beyond spatial, taxonomic, and life history differences, coronavirus shedding is more expected when pups are becoming independent from the dam and that juvenile bats are prone to shed these viruses. Conclusions These findings could guide policy aimed at the prevention of spillover in limited-resource settings, where longitudinal surveillance is not feasible, by identifying high-risk periods for coronavirus shedding. In these periods, contact with bats should be avoided (for example, by impeding or forbidding people access to caves). Our proposed strategy provides an alternative to culling – an ethically questionable practice that may result in higher pathogen levels – and supports the conservation of bats and the delivery of their key ecosystem services. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource bats, coronavirus, shedding, seasonal, reproductive cycle, weaning Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s42522-019-0008-8 Source A related resource from which the described resource is derived One Health Outlook Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences, Public aspects of medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/b35f4f54252bad7f3eeaa484a89d2567.pdf f13095d2d735a2f68e844631efb182fa Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reproductive biology aspects of two species of the genus Gavilea (Orchidaceae, Chloraeinae) in populations from Central Chile Aspectos de la biología reproductiva de dos especies del género Gavilea (Orchidaceae, Chloraeinae) en poblaciones de Chile central Creator An entity primarily responsible for making the resource Carlos E Valdivia, Mauricio A Cisternas, Gabriela S Verdugo Description An account of the resource The extent to which plants depend on pollinators for outcross pollen transportation is a key issue in plant reproductive ecology. We evaluated the putative breeding system, foral display, and natural pollination in two Southern Cone of South American orchids, Gavilea araucana and G. venosa, by performing four hand pollination trials (agamospermy, autogamy, geitonogamy, and xenogamy tests) and by counting each fower and fruit produced by plants in natural conditions. Fruit set differed signifcantly depending on the origin of pollen as well as on the presence of a pollen vector. None of these species produced fruits by the agamospermy tests, therefore indicating that they require the presence of pollen on the stigmas for fruit setting. By contrast, only G. araucana was capable of fruit setting following the autogamy test, therefore demostrating that this orchid needs not depend on pollinators for fruit set. Furthermore, G. araucana and G. venosa produced 100% fruits by geitonogamy and by xenogamy, thereby indicating that both plants are totally self-compatible. The mean number of fowers per plant was 2.1 times higher in G. venosa with respect to G. araucana; however, natural fruiting success was 28.8% and 98.9%, respectively. Furthermore, while the increase in fruiting success signifcantly and positively correlated with an increase in foral display in G. araucana, in G. venosa these variables were unrelated. Certainly, further studies concerning the reproductive strategies in orchids of southern South America are of great importance.El alcance al cual las plantas dependen de polinizadores para el transporte de polen para los exocruzamientos es uno de los temas claves en ecología reproductiva de las plantas. Evaluamos el sistema reproductivo potencial, despliegue foral y polinización natural en dos orquídeas del Cono Sur de Sudamérica, Gavilea araucana y G. venosa, efectuando cuatro ensayos de polinización manual (agamospermia, autogamia, geitonogamia y xenogamia) y contando cada for y fruto producidos por las plantas en condiciones naturales. La producción de frutos difrió signifcativamente dependiendo del origen del polen así como de la presencia de un vector polínico. Ninguna de las especies produjo frutos en las pruebas de agamospermia indicando, por lo tanto, que ellas requieren de la presencia de polen en los estigmas para producir frutos. Por el contrario, solamente G. araucana fue capaz de producir frutos siguiendo la prueba de autogamia demostrando, por ende, que esta orquídea no necesita depender de polinizadores para producir frutos. Además, G. araucana y G. venosa produjeron un 100% de frutos por geitonogamia y xenogamia, indicando esto, que ambas plantas son autocompatibles. El número promedio de fores por planta fue 2,1 veces mayor en G. venosa con respecto a G. araucana; sin embargo, el éxito en la fructifcación natural fue de 28,8% y 98,9%, respectivamente. Además, mientras el incremento en el éxito de la fructifcación se correlacionó positiva y signifcativamente en G. araucana, en G. venosa estas variables no estuvieron relacionadas. Ciertamente, estudios adicionales referidos a las estrategias reproductivas de las orquídeas del sur de Sudamérica son de gran importancia. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Allogamy, Autocompatibilidad, Autogamy, Self-compatibility, alogamia, autogamia, despliegue foral, foral display, fruiting patterns, patrones de fructifcación Source A related resource from which the described resource is derived Gayana: Botanica Publisher An entity responsible for making the resource available Universidad de Concepción Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Botany Relation A related resource <a href="http://www.scielo.cl/scielo.php?script=sci_arttext&amp;pid=S0717-66432010000100005" target="_blank" rel="noreferrer noopener">http://www.scielo.cl/scielo.php?script=sci_arttext&amp;pid=S0717-66432010000100005</a> https://www.socictopen.socict.org/files/original/e6e4887363c9ec51d813100f8e644fa1.pdf 2d07b04a34e6df9045054085ba4227ec Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reproductive biology of Thamnodynastes hypoconia (Serpentes: Dipsadidae) in Brazilian subtemperate wetlands Creator An entity primarily responsible for making the resource MARLUCI M. REBELATO, GLÁUCIA M.F. PONTES, ALEXANDRO M. TOZETTI Description An account of the resource ABSTRACT This study aimed to describe the reproductive biology of populations of Thamnodynastes hypoconia in subtemperate wetlands based on macroscopic analyses of their gonads. We analyzed 101 specimens from the southernmost regions of Brazil. The males had a greater snout-vent length, but the females reached sexual maturity with a greater body size. The reproductive cycle of the females was seasonal, with secondary vitellogenesis occurring between the winter and spring (May-October). Based on macroscopic analysis of gonads, data suggests that males have a continuous reproductive cycle. Parturition occurs between the late summer and early fall (January-April). The clutch size ranged between 4 and 16 embryos and showed no relationship with the female's body size. The recorded reproductive frequency of T. hypoconia is low (38 %) compared to other phylogenetically related species. Conversely, the studied populations appear to have a high reproductive success because it is an abundant species in the study site. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Maturidade Sexual, PAMPA, Serpentes, ciclo reprodutivo, ecología Identifier An unambiguous reference to the resource within a given context 10.1590/0001-3765201620140569 Source A related resource from which the described resource is derived Anais da Academia Brasileira de Ciências Publisher An entity responsible for making the resource available Academia Brasileira de Ciências Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science Relation A related resource <a href="http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0001-37652016005009101&amp;lng=en&amp;tlng=en" target="_blank" rel="noreferrer noopener">http://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0001-37652016005009101&amp;lng=en&amp;tlng=en</a> https://www.socictopen.socict.org/files/original/7b70b2415661c081ac07a39fc6f6c098.pdf 608ee32f745cb4e124e70443ac34a9bf Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity Creator An entity primarily responsible for making the resource Gyula Batta, Lieve Naesens, Anikó Borbás, Zsolt Szűcs, Annelies Stevaert, Eszter Ostorházi, Pál Herczegh Description An account of the resource Influenza A and B viruses are a global threat to human health and increasing resistance to the existing antiviral drugs necessitates new concepts to expand the therapeutic options. Glycopeptide derivatives have emerged as a promising new class of antiviral agents. To avoid potential antibiotic resistance, these antiviral glycopeptides are preferably devoid of antibiotic activity. We prepared six vancomycin aglycone hexapeptide derivatives with the aim of obtaining compounds having anti-influenza virus but no antibacterial activity. Two of them exerted strong and selective inhibition of influenza A and B virus replication, while antibacterial activity was successfully eliminated by removing the critical N-terminal moiety. In addition, these two molecules offered protection against several other viruses, such as herpes simplex virus, yellow fever virus, Zika virus, and human coronavirus, classifying these glycopeptides as broad antiviral molecules with a favorable therapeutic index. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource antiviral, human coronavirus, Influenza Virus, glycopeptide antibiotic, vancomycin aglycone hexapeptide Identifier An unambiguous reference to the resource within a given context 10.3390/ph13070139 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Pharmacy and materia medica https://www.socictopen.socict.org/files/original/45b7a3f851c40eb1ccdf6a8818fc926b.pdf 82cf3cf623ddc1a3d87fba8f557495c1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reptilia, Squamata, Viperidae, Bothrops venezuelensis Leybold, 1873: Distribution extension and first country record Creator An entity primarily responsible for making the resource Juan Mendoza, Viviana Berrio, Diego Gómez Description An account of the resource We report on the presence of Bothrops venezuelensis Leybold, 1873 in Norte de Santander and Boyacá departments, Colombia. These findings represent the first records for the country. Extending the species’ distribution 474 km in a straight-line distance SW from its nearest previously known Venezuelan locality. The present record adds a new clinically important species for Colombia, which needs to be considered in the production of anti-ophidic serum. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context 10.15560/8.2.310 Source A related resource from which the described resource is derived Check List Publisher An entity responsible for making the resource available Pensoft Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Relation A related resource <a href="https://checklist.pensoft.net/article/18407/" target="_blank" rel="noreferrer noopener">https://checklist.pensoft.net/article/18407/</a> https://www.socictopen.socict.org/files/original/5242cc3b9d13574fbaacc72643f71716.pdf 39bf71cc84804764e563e1e3fb240e0a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Republicanismo y Ecología Politica Creator An entity primarily responsible for making the resource Francisco Garrido Peña Description An account of the resource In this work, is formulated a possible ideological hybridization between contemporary republicanism and political ecology. The proposal is an ecological republicanism or a republican ecologism, on condition that the republicanism is based in a weak anthropocentrism and the political ecology is also based in a weak biocentrism. According to this proposal, the political ecology expands the original orientation of republicanism (the equality), and the republicanism sutures one of the potential pathologies (authoritarian fisiocratism) of political ecology.Resumen: En este trabajo formulo una posible hibridación ideológica entre el republicanismo contemporáeo y la ecología política. La propuesta es un republicanismo ecológico o un ecologismo, republicano a condición de que el republicanismo se fundamente en un antropocentrismo débil y la ecología política se base también en un biocentrismo débil. Según esta propuesta, la ecología política amplia la orientación original del republicanismo (la via igualitaria) y el republicanismo sutura alguno de las patologías potenciales (fisiocratismo autoritario) de la ecología política.Abstract: In this work, is formulated a possible ideological hybridization between contemporary republicanism and political ecology. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Subject The topic of the resource Ecologia Política, Ecological republicanism, Political Ecology, Republicanismo ecológico, republicanism, republicanismo Source A related resource from which the described resource is derived Sequência: Estudos Juridicos e Politicos Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Law in general. Comparative and uniform law. Jurisprudence, Law Relation A related resource <a href="http://www.periodicos.ufsc.br/index.php/sequencia/article/view/2177-7055.2012v33n64p15/22463" target="_blank" rel="noreferrer noopener">http://www.periodicos.ufsc.br/index.php/sequencia/article/view/2177-7055.2012v33n64p15/22463</a> https://www.socictopen.socict.org/files/original/f7d6944a8c7f6a82e32903c7a0f84a5b.pdf 1c3074538cc9e2bb7f28bfa98f5864bc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19 Creator An entity primarily responsible for making the resource Santosh Kumar, Kelli Gerth, Kaining Zhi, Ahona Mukherji Description An account of the resource In January 2020, Chinese health agencies reported an outbreak of a novel coronavirus-2 (CoV-2) which can lead to severe acute respiratory syndrome (SARS). The virus, which belongs to the coronavirus family (SARS-CoV-2), was named coronavirus disease 2019 (COVID-19) and declared a pandemic by the World Health Organization (WHO). Full-length genome sequences of SARS-CoV-2 showed 79.6% sequence identity to SARS-CoV, with 96% identity to a bat coronavirus at the whole-genome level. COVID-19 has caused over 133,000 deaths and there are over 2 million total confirmed cases as of April 15th, 2020. Current treatment plans are still under investigation due to a lack of understanding of COVID-19. One potential mechanism to slow disease progression is the use of antiviral drugs to either block the entry of the virus or interfere with viral replication and maturation. Currently, antiviral drugs, including chloroquine/hydroxychloroquine, remdesivir, and lopinavir/ritonavir, have shown effective inhibition of SARS-CoV-2 in vitro. Due to the high dose needed and narrow therapeutic window, many patients are experiencing severe side effects with the above drugs. Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. Extracellular vesicles (EVs) are a family of natural carriers in the human body. They play a critical role in cell-to-cell communications. EVs can be used as unique drug carriers to deliver protease inhibitors to treat COVID-19. EVs may provide targeted delivery of protease inhibitors, with fewer systemic side effects. More importantly, EVs are eligible for major aseptic processing and can be upscaled for mass production. Currently, the FDA is facilitating applications to treat COVID-19, which provides a very good chance to use EVs to contribute in this combat. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource HIV, coronaviruses, extracellular vesicles, Protease inhibitors, antiviral drugs, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/v12050486 Source A related resource from which the described resource is derived Viruses Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/165c432ffc73b7f0ac83f9741d88b8c1.pdf 1c3074538cc9e2bb7f28bfa98f5864bc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19 Creator An entity primarily responsible for making the resource Kelli Gerth, Santosh Kumar, Kaining Zhi, Ahona Mukherji Description An account of the resource In January 2020, Chinese health agencies reported an outbreak of a novel coronavirus-2 (CoV-2) which can lead to severe acute respiratory syndrome (SARS). The virus, which belongs to the coronavirus family (SARS-CoV-2), was named coronavirus disease 2019 (COVID-19) and declared a pandemic by the World Health Organization (WHO). Full-length genome sequences of SARS-CoV-2 showed 79.6% sequence identity to SARS-CoV, with 96% identity to a bat coronavirus at the whole-genome level. COVID-19 has caused over 133,000 deaths and there are over 2 million total confirmed cases as of April 15th, 2020. Current treatment plans are still under investigation due to a lack of understanding of COVID-19. One potential mechanism to slow disease progression is the use of antiviral drugs to either block the entry of the virus or interfere with viral replication and maturation. Currently, antiviral drugs, including chloroquine/hydroxychloroquine, remdesivir, and lopinavir/ritonavir, have shown effective inhibition of SARS-CoV-2 in vitro. Due to the high dose needed and narrow therapeutic window, many patients are experiencing severe side effects with the above drugs. Hence, repurposing these drugs with a proper formulation is needed to improve the safety and efficacy for COVID-19 treatment. Extracellular vesicles (EVs) are a family of natural carriers in the human body. They play a critical role in cell-to-cell communications. EVs can be used as unique drug carriers to deliver protease inhibitors to treat COVID-19. EVs may provide targeted delivery of protease inhibitors, with fewer systemic side effects. More importantly, EVs are eligible for major aseptic processing and can be upscaled for mass production. Currently, the FDA is facilitating applications to treat COVID-19, which provides a very good chance to use EVs to contribute in this combat. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Coronaviruses, HIV, covid-19, Extracellular vesicles, antiviral drugs, Protease Inhibitors Identifier An unambiguous reference to the resource within a given context 10.3390/v12050486 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/c24093ddc6897b7abbd321f04cdc743e.pdf 6ead7242bef029a7cacf0ee0e07c3042 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Repurposing Drugs for COVID-19: Pharmacokinetics and Pharmacogenomics of Chloroquine and Hydroxychloroquine Creator An entity primarily responsible for making the resource Babayeva M, Loewy Z Description An account of the resource Mariana Babayeva,1 Zvi Loewy1,2 1Touro College of Pharmacy, New York, NY, USA; 2New York Medical College, Valhalla, NY, USACorrespondence: Mariana BabayevaTouro College of Pharmacy, 230 West 125th Street, Room 433, New York, NY 10027, USATel + 1 646 981 4740Fax +1 212 678 1780Email mariana.babayeva@touro.eduBackground: A new coronavirus SARS-CoV-2 has been identified as the etiological agent of the severe acute respiratory syndrome, COVID-19, the source and cause of the 2019&ndash; 20 coronavirus pandemic. Hydroxychloroquine and chloroquine have gathered extraordinary attention as therapeutic candidates against SARS-CoV-2 infections. While there is growing scientific data on the therapeutic effect, there is also concern for toxicity of the medications. The therapy of COVID-19 by hydroxychloroquine and chloroquine is off-label. Studies to analyze the personalized effect and safety are lacking.Methods: A review of the literature was performed using Medline/PubMed/Embase database. A variety of keywords were employed in keyword/title/abstract searches. The electronic search was followed by extensive hand searching using reference lists from the identified articles.Results: A total of 126 results were obtained after screening all sources. Mechanisms underlying variability in drug concentrations and therapeutic response with chloroquine and hydroxychloroquine in mediating beneficial and adverse effects of chloroquine and hydroxychloroquine were reviewed and analyzed. Pharmacogenomic studies from various disease states were evaluated to elucidate the role of genetic variation in drug response and toxicity.Conclusion: Knowledge of the pharmacokinetics and pharmacogenomics of chloroquine and hydroxychloroquine is necessary for effective and safe dosing and to avoid treatment failure and severe complications.Keywords: COVID-19, pharmacokinetics, pharmacogenomics, chloroquine, hydroxychloroquine Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Pharmacokinetics, covid-19, Hydroxychloroquine, chloroquine, pharmacogenomics Source A related resource from which the described resource is derived Biotemas Publisher An entity responsible for making the resource available Universidade Federal de Santa Catarina Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology