1664 10 20655 https://www.socictopen.socict.org/files/original/132a6f5f44106e6beba1557a713da5e9.pdf bdcfc568f0ad5647956dad635e4d2066 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia Creator An entity primarily responsible for making the resource Lin CY, Yao CA Description An account of the resource Chih-Yin Lin,1 Chun-An Yao2 1Department of Neurology, Chang Gung Memorial Hospital, Linkou 333, Taiwan; 2Department of Dermatology, Cathay General Hospital, Taipei, TaiwanCorrespondence: Chun-An YaoDepartment of Dermatology, Cathay General Hospital, 280 Renai Road Sec. 4, Taipei, TaiwanTel +886-2-27082121Fax +886-2-2709-6521Email chunany115@gmail.comAbstract: The outbreak of coronavirus disease 2019 (COVID-19) pandemic has already caused a huge burden to the global healthcare system, with the death toll reached tens of thousands. Although some antiviral agents were identified and used to inhibit viral replication, the management of cytokine storm is also a critical issue. In this article, we reviewed the literature on drug candidates for severe acute respiratory syndrome (SARS-CoV-1) and provided a brief overview of a class of drugs that exert antiviral and anti-inflammatory effects. These molecules mitigated inflammatory cytokine cascades induced by viral infections via Nrf2 activating capacity and might have additional anti-fibrotic and anti-remodeling properties. Besides, their effects on the regulation of scavenger receptors expression by macrophages may offer some benefits to the pulmonary antibacterial defense system after viral infection. The potential roles of these agents assessed on the basis of the pathophysiology of viral pneumonia and acute respiratory distress syndrome were also discussed. Further research is needed to ascertain whether Nrf2 activators are useful in the management of viral pneumonia.Keywords: COVID-19, viral pneumonia, Nrf2 activators, curcumin, sulforaphane, macrolide Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Curcumin, macrolide, Sulforaphane, viral pneumonia, COVID-19, Nrf2 activators Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Infection and Drug Resistance Publisher An entity responsible for making the resource available Dove Medical Press Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases https://www.socictopen.socict.org/files/original/5a0a462bd2c9bed2f26177a3622f5b64.pdf d11ad3ef39cd0c53fd8d0d84c156e63d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Pandemic a Factor in Delayed Mourning in Survivors: A Letter to The Editor Creator An entity primarily responsible for making the resource Maryam Sajadian, Seyed Mohammad Hossein Javadi Description An account of the resource This article has no abstract. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, delayed mourning, virtual mourning Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Publisher An entity responsible for making the resource available Arak Medical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General), Medicine https://www.socictopen.socict.org/files/original/6c921de76cc7a2348e74db4a00df5387.pdf b5c3d8860e448d61317a9b15f57e465b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Review of the 2019 Novel Coronavirus (Covid-19): Immunopathogenesis, Molecular Biology and Clinical Aspects Creator An entity primarily responsible for making the resource Mohsen Khaki, Ghasem Mosayebi, Ali Ganji, ali Ghazavi Description An account of the resource Background and Aim: COVID-19, a viral respiratory illness. In this review, we discuss issues such as the genetic structure, pathogenic mechanism, clinical characteristics, diagnosis, treatment, and prevention of COVID-19 based on the latest findings. Materials and Methods: The Medline was searched for terms such as “Coronavirus” ،“ COVID-19” and “Respiratory infection”. Findings: In December 2019, the unprecedented outbreak of pneumonia with unknown etiology began in Wuhan, Hubei Province, China. The cause was a new coronavirus, named COVID-19 by the WHO. This virus has high transmissibility and affects the lower respiratory tract. Research into the mechanism and treatment of COVID-19 is under way, and new information is being provided every day, some of which are contradictory. COVID-19 is a serious and dangerous infectious disease and a significant threat to the health of the world's population, and should be prevented from spreading rapidly. Conclusion: Because the exact mechanisms of the disease have not been fully elucidated and specific drug or vaccine have not yet been developed for it, control is mainly based on the interruption of the transmission cycle. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, respiratory infection, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Publisher An entity responsible for making the resource available Arak Medical University Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General), Medicine https://www.socictopen.socict.org/files/original/1b69feb4f5710c09d49d66de714f463c.pdf 73d8271facf00989bb55205e6f8eae4a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Spectrum of Chest Computed Tomography findings of Novel Coronavirus disease 2019 in Medical City in Baghdad, a case series Creator An entity primarily responsible for making the resource Ali Ibrahim, Salam Joori, Atheer Adnan, Zaid Hammoodi, Haider Ghayad Description An account of the resource Background: Native chest Computed Tomography (CT) is a quick, non-invasive and practical investigation & plays an important role in evaluation of Coronavirus Disease 2019. Objective: to describe the chest CT findings in patients with confirmed coronavirus disease 2019 (COVID-19) in sample from Baghdad population. Patients & methods: Study sample consisted of 55 patients with laboratory confirmed COVID-19 from 1st March through 15th April 2020. Native chest CT was performed in radiology departments in Medical City Teaching Complex (MCTH). The chest CT images were reviewed & analyzed. Results: The most frequent CT findings were ground-glass opacities (47.3%) & mixed ground glass & consolidation (43.6%). Most lesions were multiple (67.2%), peripheral (56.3%) & bilateral (81.8%). Least common findings were pleural effusion (7.2%) & mediastinal lymphadenopathy (1.8%). Conclusion: The commonest chest CT findings of COVID-19 in Baghdad population were multiple, bilateral, peripheral ground glass opacity & consolidation.   Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Baghdad, Chest CT, MCTH, Keywords: COVID 19 Identifier An unambiguous reference to the resource within a given context DOI: 10.32007/jfacmedbagdad.621,21744 Source A related resource from which the described resource is derived مجلة كلية الطب Publisher An entity responsible for making the resource available Faculty of Medicine University of Baghdad Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General), Medicine https://www.socictopen.socict.org/files/original/07b84670450adb937d99b50b15c6597b.pdf b6caecb742933ce8734f250c0b6815ef Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Risks of morbidity and mortality during the COVID-19 pandemic in Russian regions Creator An entity primarily responsible for making the resource Vyacheslav L. Baburin, Stepan P. Zemtsov Description An account of the resource The COVID-19 pandemic has covered all Russian regions. As of May 8, 2020, about 190 thousand cases have been identified, more than 1600 people with the corresponding diagnosis have died. The values of the indicators are expected to rise. However, the statistics of confirmed cases and deaths may underestimate their actual extent due to testing peculiarities, lagging reporting and other factors. The article identifies and describes the characteristics of the regions in which the incidence and mortality of COVID-19 is higher. Migration of potential carriers of the virus: summer workers and migrant workers from Moscow and large agglomerations, as well as return of labour migrants to the North increase the risks of the disease spread. The risk of mortality is higher in regions with high proportions of the poor and aged residents, for whom it is difficult to adapt to the pandemic, and lower in regions with greater health infrastructure. Based on the revealed patterns, a typology of regions on possible risks is proposed. Above all the risks in and near the largest agglomerations (the cities of Moscow and Saint Petersburg, Moscow and Leningrad Oblasts), in the northern regions where the share of labour migrants is high (Khanty-Mansi and Yamalo-Nenets Autonomous Okrugs), in southern underdeveloped regions (Ingushetia, Karachay-Cherkess, Kabardino-Balkarian Republics, Dagestan, North Ossetia). For the latter, the consequences may be most significant due to the limited capacity to adapt to the pandemic and self-isolation regime, and additional support measures may be required in these regions. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.3897/popecon.4.e54055 Source A related resource from which the described resource is derived Население и экономика Publisher An entity responsible for making the resource available Moscow State University, Faculty of Economics Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Economic theory. Demography https://www.socictopen.socict.org/files/original/ee149757429fc1f3222d406bf58788e7.pdf b87365cc5ce6c83165d106e7d9278a4e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource EFFECTS OF THE SARS-COV-2 PANDEMIC ON MEDICAL EDUCATION IN ITALY: CONSIDERATIONS AND TIPS Creator An entity primarily responsible for making the resource Serena Bianchi Description An account of the resource The pandemic due to the spread of the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been an unexpected challenge for national health systems worldwide. The severity of the disease has forced Governments to introduce measures of containment and mitigation, including social distancing, smart working, and the closure of commercial activities. Universities have also had to stop lectures and practical training, even for medical, dental, and healthcare students. Online lectures have replaced traditional classroom lectures, and they would appear to be adequate for the teaching of bioscience. In some instances, telemedicine activities have replaced the practicals. The latter maybe efficacious for general medical activity training, but may result in a gap in terms of training for surgical specialties. Therefore, the scientific community should consider carefully the influence that this period has had on medical education and whether the healthcare workers who have experienced these educational changes could be negatively impacted. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Medical Education, Online Teaching, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3269/1970-5492.2020.15.24 Source A related resource from which the described resource is derived Euromediterranean Biomedical Journal Publisher An entity responsible for making the resource available Associazione Italiana Giovani Medici Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/980782e7bef529279ce8eb9a72a2de75.pdf f271ea46264e69af96c9befdbd049ab3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Eight Weeks Later—The Unprecedented Rise of 3D Printing during the COVID-19 Pandemic—A Case Study, Lessons Learned, and Implications on the Future of Global Decentralized Manufacturing Creator An entity primarily responsible for making the resource Tobias Mueller, Ahmed Elkaseer, Amal Charles, Clarissa Marquardt, Katja Nau, Steffen G. Scholz, Janin Fauth, Dominik Rabsch, Amon Scholz Description An account of the resource The eruption of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (corona virus disease, COVID-19) in Wuhan, China, and its global spread has led to an exponentially growing number of infected patients, currently exceeding over 6.6 million and over 390,000 deaths as of the 5th of June 2020. In this pandemic situation, health systems have been put under stress, and the demand for personal protective equipment (PPE) exceeded the delivery capabilities of suppliers. To address this issue, 3D printing was identified as a possible solution to quickly produce PPE items such as face shields, mask straps, masks, valves, and ear savers. Around the world, companies, universities, research institutions, and private individuals/hobbyists stepped into the void, using their 3D printers to support hospitals, doctors, nursing homes, and even refugee camps by providing them with PPE. In Germany, the makervsvirus movement took up the challenge and connected thousands of end users, makers, companies, and logistic providers for the production and supply of face shields, protective masks, and ear savers. The Karlsruhe Institute of Technology (KIT) also joined the makervsvirus movement and used its facilities to print headbands for face shield assemblies and ear savers. Within this paper, the challenges and lessons learned from the quick ramp up of a research laboratory to a production site for medium-sized batches of PPE, the limitations in material supply, selection criteria for suitable models, quality measures, and future prospects are reported and conclusions drawn. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Pandemic, Personal Protective Equipment (PPE), Zero lead time, COVID-19, 3D FFF printing, customized mass production Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/app10124135 Source A related resource from which the described resource is derived Applied Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Technology, Physics, Chemistry, Engineering (General). Civil engineering (General) https://www.socictopen.socict.org/files/original/9cc9d42944395ad22da3eb0a4358df76.pdf 14c927d8d0c4bc46238d2184bfaca244 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource In silico analysis of SARS-CoV-2 spike glycoprotein and insights into antibody binding Creator An entity primarily responsible for making the resource Victor Padilla-Sanchez Description An account of the resource Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China in December 2019. Since then, COVID-19, the disease caused by SARS-CoV-2, has become a rapidly spreading pandemic that has reached most countries in the world. So far, there are no vaccines or therapeutics to fight this virus. Here, I present an in silico analysis of the virus spike glycoprotein (recently determined at atomic resolution) and provide insights into how antibodies against the 2002 virus SARS-CoV might be modified to neutralize SARS-CoV-2. I ran docking experiments with Rosetta Dock to determine which substitutions in the 80R and m396 antibodies might improve the binding of these to SARS-CoV-2 and used molecular visualization and analysis software, including UCSF Chimera and Rosetta Dock, as well as other bioinformatics tools, including SWISS-MODEL. Supercomputers, including Bridges Large, Stampede and Frontera, were used for macromolecular assemblies and large scale analysis and visualization. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource immunology, SARS-CoV-2, COVID-19, computational bi Identifier An unambiguous reference to the resource within a given context DOI: 10.3897/rio.6.e55281 Source A related resource from which the described resource is derived Research Ideas and Outcomes Publisher An entity responsible for making the resource available Pensoft Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science https://www.socictopen.socict.org/files/original/661678e2c0922b910775414b67f7bbfd.pdf ec35a029daa7f822bde4831bf8670174 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia Creator An entity primarily responsible for making the resource Shujin Guo, Xiaohui Li, Meng Xiao, Ye He, Yutian Zhou, Jinxiu Fan, Qiunan Zuo, Danju Liu Description An account of the resource Background: Corona virus disease (COVID-19) is an infectious respiratory disease that has spread rapidly across the world. Many studies have already evaluated the clinical features of COVID-19, but how it compares with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative community-acquired pneumonia (SN-CAP) is still unclear. Moreover, COVID-19 mortality is correlated with disease severity, but indicators for severity grading have not been specified. We aimed to analyze the clinical characteristics of COVID-19 in comparison with SN-CAP and find indicators for disease severity in COVID-19.Methods: Patients diagnosed with COVID-19 and SN-CAP were enrolled. Clinical, radiological, and laboratory data were analyzed.Results: The numbers of COVID-19 and SN-CAP patients enrolled were 304 and 138, respectively. The age of the patients was not significantly different between the groups. Compared with SN-CAP, COVID-19 patients had more symptoms of fever and dyspnea; and showed significant difference in blood count results. Computed tomography (CT) imaging of COVID-19 patients showed patchy ground-glass opacities that correlated with disease severity, whereas the CT imaging of SN-CAP patients showed patchy high-density shadows. COVID-19 patients were classified into moderate, severe, and critically severe groups. The severe and critically severe groups had elevated levels of white blood cells (WBC), neutrophils, platelets, C-reaction protein (CRP), lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), troponin-I, creatinine, and blood urea nitrogen (BUN). However, they had decreased levels of lymphocytes, lymphocyte ratio, and albumin. Compared with the younger patients, the older COVID-19 individuals had more chronic diseases and significantly elevated levels of WBC, neutrophil, and CRP levels.Conclusion: SN-CAP showed more inflammatory reaction than COVID-19. Old people with chronic diseases are more susceptible to COVID-19 and have a high likelihood of developing severe and critically severe infection. Levels of WBC, lymphocytes, neutrophils, CRP, NLR, PLR, troponin-I, creatinine, and BUN are important indicators for severity grading in COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource clinical features, Severity, CAP, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fcimb.2020.00322 Source A related resource from which the described resource is derived Frontiers in Cellular and Infection Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology https://www.socictopen.socict.org/files/original/651bc7262e31ff20dcccadc4d670343f.pdf 474374ac6d61b0f75d5a641942d4c131 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mathematical Modeling of RNA Virus Sensing Pathways Reveals Paracrine Signaling as the Primary Factor Regulating Excessive Cytokine Production Creator An entity primarily responsible for making the resource Jason E. Shoemaker, Jordan J. A. Weaver Description An account of the resource RNA viruses, such as influenza and Severe Acute Respiratory Syndrome (SARS), invoke excessive immune responses; however, the kinetics that regulate inflammatory responses within infected cells remain unresolved. Here, we develop a mathematical model of the RNA virus sensing pathways, to determine the intracellular events that primarily regulate interferon, an important protein for the activation and management of inflammation. Within the ordinary differential equation (ODE) model, we incorporate viral replication, cell death, interferon stimulated genes’ antagonistic effects on viral replication, and virus sensor protein (TLR and RIG-I) kinetics. The model is parameterized to influenza infection data using Markov chain Monte Carlo and then validated against infection data from an NS1 knockout strain of influenza, demonstrating that RIG-I antagonism significantly alters cytokine signaling trajectory. Global sensitivity analysis suggests that paracrine signaling is responsible for the majority of cytokine production, suggesting that rapid cytokine production may be best managed by influencing extracellular cytokine levels. As most of the model kinetics are host cell specific and not virus specific, the model presented provides an important step to modeling the intracellular immune dynamics of many RNA viruses, including the viruses responsible for SARS, Middle East Respiratory Syndrome (MERS), and Coronavirus Disease (COVID-19). Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Systems Biology, interferon signaling, Cytokine storm, ODE modeling Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/pr8060719 Source A related resource from which the described resource is derived Processes Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chemistry, Chemical technology