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                <text>Several epidemiological models are being used around the world to project the number of infected individuals and the mortality rates of the COVID-19 outbreak. Advancing accurate prediction models is of utmost importance to take proper actions. Due to the lack of essential data and uncertainty, the epidemiological models have been challenged regarding the delivery of higher accuracy for long-term prediction. As an alternative to the susceptible-infected-resistant (SIR)-based models, this study proposes a hybrid machine learning approach to predict the COVID-19, and we exemplify its potential using data from Hungary. The hybrid machine learning methods of adaptive network-based fuzzy inference system (ANFIS) and multi-layered perceptron-imperialist competitive algorithm (MLP-ICA) are proposed to predict time series of infected individuals and mortality rate. The models predict that by late May, the outbreak and the total morality will drop substantially. The validation is performed for 9 days with promising results, which confirms the model accuracy. It is expected that the model maintains its accuracy as long as no significant interruption occurs. This paper provides an initial benchmarking to demonstrate the potential of machine learning for future research.</text>
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                <text>&lt;a href="https://revistas.intec.edu.do/index.php/ciso/article/view/374" target="_blank" rel="noreferrer noopener"&gt;https://revistas.intec.edu.do/index.php/ciso/article/view/374&lt;/a&gt;</text>
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                <text>Impact of the COVID-19 pandemic: The perceptions of health professions educators</text>
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                <text>What are health professions educators doing during the COVID-19 pandemic? A search of articles in MedEdPublish on the topics of COVID-19 revealed 39 articles published in the first 3 months of the pandemic.  Topics included curriculum adaptation, guidelines for using technology, assessment adaptation, impact on students, faculty and career development, and conference adaptation.  There was significant overlap among articles, particularly those discussing teaching, learning, and assessment practices. Common themes were adaptation, innovation, remote delivery, flexibility in the face of a pandemic, and how to continue to educate and graduate competent health professionals.  All articles were descriptive, and none included data describing efficacy, likely due to the short timeline since the pandemic's inception.  Additional study is necessary to produce evidence for the teaching and assessment adaptations described. Some changes are likely to persist longer-term and may outlast the pandemic itself.</text>
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                <text>covid-19, Pandemic, innovation, Medical education, Learning Technology</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>COVID-19 in ocrelizumab-treated people with multiple sclerosis.</text>
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                <text>Richard Hughes, Louise Whitley, Kocho Fitovski, Hans-Martin Schneble, Erwan Muros, Annette Sauter, Licinio Craveiro, Paul Dillon, Ulrike Bonati, Nikki Jessop, Rosetta Pedotti, Harold Koendgen</text>
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                <text>There are limited data on the impact of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on people with multiple sclerosis (MS). To better understand SARS-CoV-2 infection in ocrelizumab-treated people with MS. Internal Roche/Genentech data sources: Cases of COVID-19 from ongoing Roche/Genentech clinical trials and from post-marketing use of ocrelizumab until July 31, 2020 were identified and assessed using descriptive statistics. External real-world data (RWD) source: An MS COVID-19 cohort and an ocrelizumab-treated MS COVID-19 cohort were identified and assessed from the OPTUMⓇ de-identified COVID-19 electronic health record (EHR) database. Roche/Genentech clinical trial data: There were 51 (1.3%) suspected or confirmed cases of COVID-19 identified from 4,000 patients ongoing in 10 Roche/Genentech clinical trials. Of these, 26 (51%) were confirmed COVID-19 and 25 (49%) were suspected COVID-19. Sixteen (31.4%) patients were hospitalized. COVID-19 severity was mild to moderate in most patients (35, 68.6%). Ten (19.6%) patients had severe disease and there were three (5.9%) fatal cases. Most patients (43, 84.3%) recovered or were recovering. There was no association apparent between duration of exposure to ocrelizumab and COVID-19. Among COVID-19 patients with previous serum immunoglobulin status (27/51, 52.9%), all (27/27, 100%) had IgG levels within the normal range. Roche/Genentech post-marketing safety database data: There were 307 post-marketing cases of COVID-19 in the Roche/Genentech global safety database. Of these, 263 (85.7%) were confirmed and 44 (14.3%) were suspected COVID-19. 100 (32.6%) patients were hospitalized. COVID-19 was asymptomatic, mild or moderate in 143 (46.6%) patients, severe in 52 (16.9%) patients, and critical in 15 (4.9%) patients. There were 17 (5.5%) fatal cases. Information on severity was not reported in 80 (26.1%) cases. Most patients (211, 68.7%) recovered or were recovering at the time of the report. External RWD data source: As of July 13, 2020, the OPTUMⓇ database included EHRs for almost 1.2 million patients with suspected COVID-19, 130,500 of whom met the criteria for confirmed/clinically diagnosed COVID-19. A total of 357 patients with MS with confirmed COVID-19 were identified. Forty-eight (13.4%) were treated with ocrelizumab, of whom 12 (25.0%) were hospitalized and one died (2.1%). Similar rates of hospitalization, invasive ventilation, and death were observed in the ocrelizumab-treated and non-ocrelizumab-treated MS cohorts. Across the Roche/Genentech and RWD sources assessed, age, male sex, and the presence of comorbidities such as hypertension were associated with a more severe disease course of COVID-19. There was a higher number of comorbidities present in hospitalized versus non-hospitalized patients. This assessment provides evidence that COVID-19 in ocrelizumab-treated people with MS is predominantly mild to moderate in severity with most patients not requiring hospitalization; in line with data reported from the general population and MS datasets. Risk factors known to be associated with severe COVID-19 outcomes in the general population also appear to influence COVID-19 severity in ocrelizumab-treated people with MS. Case fatality rates for ocrelizumab-treated people with MS were within published ranges for the general population and other MS cohorts.</text>
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                <text>2021</text>
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                <text>covid-19, multiple sclerosis, disease-modifying therapy, anti-CD20, ocrelizumab</text>
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                <text>10.1016/j.msard.2020.102725</text>
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                <text>Multiple sclerosis and related disorders</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>COVID-19: where is the national ethical guidance?</text>
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                <text>Richard Huxtable</text>
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                <text>coronavirus, COVID-19, Professional guidance, ethical guidance</text>
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                <text>DOI: 10.1186/s12910-020-00478-2</text>
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                <text>BMC Medical Ethics</text>
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                <text>Medical philosophy. Medical ethics</text>
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                <text>New Alphacoronavirus in Mystacina tuberculata Bats, New Zealand</text>
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                <text>Richard J. Hall, Jing Wang, Matthew Peacey, Nicole E. Moore, Kate McInnes, Daniel M. Tompkins</text>
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                <text>Because of recent interest in bats as reservoirs of emerging diseases, we investigated the presence of viruses in Mystacina tuberculata bats in New Zealand. A novel alphacoronavirus sequence was detected in guano from roosts of M. tuberculata bats in pristine indigenous forest on a remote offshore island (Codfish Island).</text>
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                <text>2014</text>
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                <text>alphacoronavirus, coronavirus, Viruses, guano, metagenomics, bats</text>
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                <text>DOI: 10.3201/eid2004.131441</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Centers for Disease Control and Prevention</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>EN</text>
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                <text>Richard Jiang, Bruno Jacob, Matthew Geiger, Sean Matthew, Bryan Rumsey, Prashant Singh, Fredrik Wrede, Tau-Mu Yi, Brian Drawert, Andreas Hellander, Linda Petzold</text>
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                <text>We present StochSS Live!, a web-based service for modeling, simulation, and analysis of a wide range of mathematical, biological and biochemical systems. Using an epidemiological model of COVID-19, we demonstrate the power of StochSS Live! to enable researchers to quickly develop a deterministic or a discrete stochastic model, infer its parameters, and analyze the results. StochSS Live! is freely available at https://live.stochss.org/. Available at https://github.com/StochSS/Covid19_Modeling.</text>
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                <text>10.1093/bioinformatics/btab061</text>
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                <text>Bioinformatics (Oxford, England)</text>
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