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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Potential of Flavonoid-Inspired Phytomedicines against COVID-19</text>
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                <text>Rajiv Kumar, Wilfred Ngwa, Ngeh Toyang, Henry Lowe, Daryl Thompson, William Lyerly, Roscoe Moore, Terry-Elinor Reid</text>
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                <text>Flavonoids are widely used as phytomedicines. Here, we report on flavonoid phytomedicines with potential for development into prophylactics or therapeutics against coronavirus disease 2019 (COVID-19). These flavonoid-based phytomedicines include: caflanone, Equivir, hesperetin, myricetin, and Linebacker. Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19. Meanwhile, in vitro studies show potential of caflanone to inhibit virus entry factors including, ABL-2, cathepsin L, cytokines (IL-1β, IL-6, IL-8, Mip-1α, TNF-α), and PI4Kiiiβ as well as AXL-2, which facilitates mother-to-fetus transmission of coronavirus. The potential for the use of smart drug delivery technologies like nanoparticle drones loaded with these phytomedicines to overcome bioavailability limitations and improve therapeutic efficacy are discussed.</text>
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                <text>phytomedicine, SARS-CoV-2, COVID-19, smart nanoparticles, flavonoids and their derivatives</text>
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                <text>DOI: 10.3390/molecules25112707</text>
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                <text>Molecules</text>
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                <text>Organic chemistry</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>RUSSIAN GEOPOLITICAL OBJECTIVES IN THE CURRENT OIL PRICE CRISIS AND THE IMPLICATIONS FOR CANADA</text>
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                <text>Sergey Sukhankin</text>
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                <text>The Russia-Saudi oil price war that devastated energy markets in March alsoilluminated the Kremlin’s thinking. It revealed Russia’s fears and just how farit’s prepared to go to prevent them from becoming reality, even at the cost ofwrecking promising alliances. In 2016, Russia and Saudi Arabia agreed to cooperate in managing oil prices through the OPEC+ agreement. Their partnershipdeepened to the extent that the Kremlin excused some of Saudi Arabia’s recentdirty deeds, while the Saudis began making overtures to draw the Russians awayfrom Iran in the Middle East.</text>
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                <text>China, OPEC, Russia, Saudi Arabia, COVID-19, oil price war</text>
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                <text>The School of Public Policy Publications</text>
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                <text>University of Calgary</text>
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                <text>Political institutions and public administration (General)</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Ferritin levels and COVID-19</text>
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                <text>Christian Cortés-Rojo, Manuel Vargas Vargas</text>
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                <text>DOI: 10.26633/RPSP.2020.72</text>
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                <text>Revista Panamericana de Salud Pública</text>
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                <text>Pan American Health Organization</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Arctic medicine. Tropical medicine, Public aspects of medicine, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Changes in Dietary Behaviours during the COVID-19 Outbreak Confinement in the Spanish COVIDiet Study</text>
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                <text>Belén García-Villanova, Maria Dolores Ruiz-López, Reyes Artacho, Vito Verardo, Esther Molina-Montes, Celia Rodríguez-Pérez, Eduardo Jesús Guerra-Hernández</text>
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                <text>The aim of this study was to evaluate whether dietary behaviours of the Spanish adult population were changed during the COVID-19 outbreak confinement. For that purpose, an online questionnaire, based on 44 items including socio-demographic data, Mediterranean diet (MedDiet) Adherence Screener (MEDAS) as a reference of a healthy diet, processed foods intake, changes in their usual food choices and weight gain was distributed using social media and snowball sampling. A total of 7514 participants (37% aged below 35 years, 70.6% female, 77.9% university-level education or higher) from all the Spanish territory completed the questionnaire. Results outlined healthier dietary behaviours during the confinement when compared to previous habits. Overall, the MEDAS score (ranging from 0 to 14, whereby higher a scoring reflects greater adherence to the MedDiet) increased significantly from 6.53 ± 2 to 7.34 ± 1.93 during the confinement. Multivariate logistic regression models, adjusted for age, gender, region and other variables, showed a statistically significant higher likelihood of changing the adherence to the MedDiet (towards an increase in adherence) in those persons who decreased the intake of fried foods, snacks, fast foods, red meat, pastries or sweet beverages, but increased MedDiet-related foods such as olive oil, vegetables, fruits or legumes during the confinement. COVID-19 confinement in Spain has led to the adoption of healthier dietary habits/behaviours in the studied population, as reflected by a higher adherence to the MedDiet. This improvement, if sustained in the long-term, could have a positive impact on the prevention of chronic diseases and COVID-19-related complications.</text>
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                <text>2020</text>
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                <text>Vegetables, olive oil, mediterranean diet, confinement, Dietary behaviours, COVID-19</text>
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                <text>DOI: 10.3390/nu12061730</text>
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                <text>Nutrients</text>
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                <text>MDPI AG</text>
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                <text>Nutrition. Foods and food supply</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>A Mathematical Model for the COVID-19 Outbreak and Its Applications</text>
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                <text>Roman Cherniha, Vasyl’ Davydovych</text>
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                <text>A mathematical model based on nonlinear ordinary differential equations is proposed for quantitative description of the outbreak of the novel coronavirus pandemic. The model possesses remarkable properties, such as as full integrability. The comparison with the public data shows that exact solutions of the model (with the correctly specified parameters) lead to the results, which are in good agreement with the measured data in China and Austria. Prediction of the total number of the COVID-19 cases is discussed and examples are presented using the measured data in Austria, France, and Poland. Some generalizations of the model are suggested as well.</text>
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                <text>2020</text>
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                <text>exact solution, integrability, logistic equation, nonlinear mathematical model, modeling infectious diseases</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors</text>
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                <text>Aristidis Tsatsakis, Robin Mesnage, Demetrios Kouretas, Denisa Margina, Evangelia Sarandi, Dimitris Tsoukalas, Anca Ungurianu, Fotios Tekos, Carmen Purdel, Maria Thanasoula</text>
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                <text>The lifestyle adopted by most people in Western societies has an important impact on the propensity to metabolic disorders (e.g., diabetes, cancer, cardiovascular disease, neurodegenerative diseases). This is often accompanied by chronic low-grade inflammation, driven by the activation of various molecular pathways such as STAT3 (signal transducer and activator of transcription 3), IKK (IκB kinase), MMP9 (matrix metallopeptidase 9), MAPK (mitogen-activated protein kinases), COX2 (cyclooxigenase 2), and NF-Kβ (nuclear factor kappa-light-chain-enhancer of activated B cells). Multiple intervention studies have demonstrated that lifestyle changes can lead to reduced inflammation and improved health. This can be linked to the concept of real-life risk simulation, since humans are continuously exposed to dietary factors in small doses and complex combinations (e.g., polyphenols, fibers, polyunsaturated fatty acids, etc.). Inflammation biomarkers improve in patients who consume a certain amount of fiber per day; some even losing weight. Fasting in combination with calorie restriction modulates molecular mechanisms such as m-TOR, FOXO, NRF2, AMPK, and sirtuins, ultimately leads to significantly reduced inflammatory marker levels, as well as improved metabolic markers. Moving toward healthier dietary habits at the individual level and in publicly-funded institutions, such as schools or hospitals, could help improving public health, reducing healthcare costs and improving community resilience to epidemics (such as COVID-19), which predominantly affects individuals with metabolic diseases.</text>
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                <text>2020</text>
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                <text>inflammation, Diet, polyphenols, Fasting, COVID-19, real-life risk simulation</text>
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                <text>DOI: 10.3390/ijerph17114135</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="35523">
                <text>International Journal of Environmental Research and Public Health</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>MDPI AG</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine</text>
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              <name>Title</name>
              <description>A name given to the resource</description>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Prioriteringsutfordringer i helse- og omsorgstjenesten i kommunene under  covid-19-pandemien</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35511">
                <text>Morten Magelssen, Reidar Pedersen, Reidun Førde, Anne Kari Tolo  Heggestad</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.18261/issn.2387-5984-2020-01-11</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="35514">
                <text>Tidsskrift for Omsorgsforskning</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="35515">
                <text>Scandinavian University Press (Universitetsforlaget)</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="35516">
                <text>Nursing</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Epidemiological and Clinical Characteristics of Cases During the Early Phase of COVID-19 Pandemic: A Systematic Review and Meta-Analysis</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35502">
                <text>Junxiong Pang, Pearleen Ee Yong Chua, Jiayun Koh, Shimoni Urvish Shah, Hao Gui</text>
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            <description>An account of the resource</description>
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                <text>Background: On 29th December 2019, a cluster of cases displaying the symptoms of a “pneumonia of unknown cause” was identified in Wuhan, Hubei province of China. This systematic review and meta-analysis aims to review the epidemiological and clinical characteristics of COVID-19 cases in the early phase of the COVID-19 pandemic.Methods: The search strategy involved peer-reviewed studies published between 1st January and 11th February 2020 in Pubmed, Google scholar and China Knowledge Resource Integrated database. Publications identified were screened for their title and abstracts according to the eligibility criteria, and further shortlisted by full-text screening. Three independent reviewers extracted data from these studies, and studies were assessed for potential risk of bias. Studies comprising non-overlapping patient populations, were included for qualitative and quantitative synthesis of results. Pooled prevalence with 95% confidence intervals were calculated for patient characteristics.Results: A total of 29 publications were selected after full-text review. This comprised of 18 case reports, three case series and eight cross-sectional studies on patients admitted from mid-December of 2019 to early February of 2020. A total of 533 adult patients with pooled median age of 56 (95% CI: 49–57) and a pooled prevalence of male of 60% (95% CI: 52–68%) were admitted to hospital at a pooled median of 7 days (95% CI: 7–7) post-onset of symptoms. The most common symptoms at admission were fever, cough and fatigue, with a pooled prevalence of 90% (95% CI: 81–97%), 58% (95% CI: 47–68%), and 50% (95% CI: 29–71%), respectively. Myalgia, shortness of breath, headache, diarrhea and sore throat were less common with pooled prevalence of 27% (95% CI: 20–36%), 25% (95% CI: 15–35%), 10% (95% CI: 7–13%), 8% (95% CI: 5–13%), and 7% (95% CI: 1–15%), respectively. ICU patients had a higher proportion of shortness of breath at presentation, as well as pre-existing hypertension, cardiovascular disease and COPD, compared to non-ICU patients in 2 studies (n = 179).Conclusion: This study highlights the key epidemiological and clinical features of COVID-19 cases during the early phase of the COVID-19 pandemic.</text>
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                <text>2020</text>
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                <text>Epidemiology, clinical features, systematic review, coronavirus, COVID-19, early pandemic phase</text>
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            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="35506">
                <text>DOI: 10.3389/fmed.2020.00295</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="35507">
                <text>Frontiers in Medicine</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="35508">
                <text>Frontiers Media S.A.</text>
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            </elementTextContainer>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medicine (General)</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Interferon-Induced Transmembrane Protein (IFITM3) Is Upregulated Explicitly in SARS-CoV-2 Infected Lung Epithelial Cells</text>
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                <text>Qutayba Hamid, Azzam A. Maghazachi, Abiola C. Senok, Rabih Halwani, Saba Al Heialy, Mahmood Yaseen Hachim, Ibrahim Yaseen Hachim</text>
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            <description>An account of the resource</description>
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                <text>Current guidelines for COVID-19 management recommend the utilization of various repurposed drugs. Despite ongoing research toward the development of a vaccine against SARS-CoV-2, such a vaccine will not be available in time to contribute to the containment of the ongoing pandemic. Therefore, there is an urgent need to develop a framework for the rapid identification of novel targets for diagnostic and therapeutic interventions. We analyzed publicly available transcriptomic datasets of SARS-CoV infected humans and mammals to identify consistent differentially expressed genes then validated in SARS-CoV-2 infected epithelial cells transcriptomic datasets. Comprehensive toxicogenomic analysis of the identified genes to identify possible interactions with clinically proven drugs was carried out. We identified IFITM3 as an early upregulated gene, and valproic acid was found to enhance its mRNA expression as well as induce its antiviral action. These findings indicate that analysis of publicly available transcriptomic and toxicogenomic data represents a rapid approach for the identification of novel targets and molecules that can modify the action of such targets during the early phases of emerging infections like COVID-19.</text>
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            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Valproic acid, antiviral immunity, interferon-induced transmembrane proteins, SARS-CoV-2, COVID-19</text>
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                <text>DOI: 10.3389/fimmu.2020.01372</text>
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            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="35498">
                <text>Frontiers in Immunology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="35499">
                <text>Frontiers Media S.A.</text>
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            </elementTextContainer>
          </element>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="35500">
                <text>Immunologic diseases. Allergy</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Resuming elective surgical services in times of COVID-19 infection</text>
              </elementText>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="35485">
                <text>Raul Coimbra, Sara Edwards, Arnold Tabuenca, Bruno Cammarota Coimbra</text>
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            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="35486">
                <text>The consequences of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus have been devastating to the healthcare system.As the positive effects of social distancing, mandatory masking, and societal lockdown on the spread of the disease and its incidence in the community were documented, societal and financial pressures mounted worldwide, prompting efforts to “re-open” countries, states, communities, businesses, and schools. The same happened with hospital, which had to start developing strategies to resume elective surgery activities. This manuscript describes the pre-requisites as well as the strategies for resuming surgical activity, be it in the outpatient or inpatient setting.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="35487">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="35488">
                <text>DOI: 10.1136/tsaco-2020-000511</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="35489">
                <text>Trauma Surgery &amp; Acute Care Open</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="35490">
                <text>BMJ Publishing Group</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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              <elementText elementTextId="35491">
                <text>Surgery, Medical emergencies. Critical care. Intensive care. First aid</text>
              </elementText>
            </elementTextContainer>
          </element>
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</itemContainer>
