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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Modeling the Spread of COVID-19 Infection Using a Multilayer Perceptron</text>
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                <text>Vedran Mrzljak, Nikola Anđelić, Zlatan Car, Ivan Lorencin, Sandi Baressi Šegota</text>
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                <text>Coronavirus (COVID-19) is a highly infectious disease that has captured the attention of the worldwide public. Modeling of such diseases can be extremely important in the prediction of their impact. While classic, statistical, modeling can provide satisfactory models, it can also fail to comprehend the intricacies contained within the data. In this paper, authors use a publicly available dataset, containing information on infected, recovered, and deceased patients in 406 locations over 51 days (22nd January 2020 to 12th March 2020). This dataset, intended to be a time-series dataset, is transformed into a regression dataset and used in training a multilayer perceptron (MLP) artificial neural network (ANN). The aim of training is to achieve a worldwide model of the maximal number of patients across all locations in each time unit. Hyperparameters of the MLP are varied using a grid search algorithm, with a total of 5376 hyperparameter combinations. Using those combinations, a total of 48384 ANNs are trained (16128 for each patient group—deceased, recovered, and infected), and each model is evaluated using the coefficient of determination (R2). Cross-validation is performed using K-fold algorithm with 5-folds. Best models achieved consists of 4 hidden layers with 4 neurons in each of those layers, and use a ReLU activation function, with R2 scores of 0.98599 for confirmed, 0.99429 for deceased, and 0.97941 for recovered patient models. When cross-validation is performed, these scores drop to 0.94 for confirmed, 0.781 for recovered, and 0.986 for deceased patient models, showing high robustness of the deceased patient model, good robustness for confirmed, and low robustness for recovered patient model.</text>
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                <text>DOI: 10.1155/2020/5714714</text>
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                <text>Computational and Mathematical Methods in Medicine</text>
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                <text>Hindawi Limited</text>
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                <text>Computer applications to medicine. Medical informatics</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>A Case Report of Suicide Attempt Caused by Acute and Transient Psychotic Disorder during the COVID-19 Outbreak</text>
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                <text>Kai Zhang, Kenji Hashimoto, Huanzhong Liu, Yu-Dong Shi</text>
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                <text>We reported a case of suicide attempt caused by acute and transient psychotic disorder during the COVID-19 outbreak, which broke out in December 2019 in Wuhan. An epidemic of infectious diseases brought great psychological pressure to the public. During this period, a 20-year-old man went to the hospital repeatedly because he suspected that he was infected, with suspicious auditory hallucinations, self-laughter, primary delusions, victimization delusions, relationship delusions, and suicide attempts. He was diagnosed with Acute Transient Psychotic Disorder. 0.1 g bid Quetiapine was given orally, then gradually increased to 0.4 g per day, supplemented by cognitive therapy. The patient was discharged from hospital in relief of symptoms on February 9th. Conclusion. During the epidemic period, in addition to strengthening the protection work, we should also monitor the mental and psychological state of the population to prevent mental illness caused by coronavirus.</text>
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                <text>DOI: 10.1155/2020/4320647</text>
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                <text>Case Reports in Psychiatry</text>
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                <text>Hindawi Limited</text>
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                <text>Psychiatry</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Current Concepts Imaging in COVID-19 and the Challenges for Low and Middle Income Countries</text>
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                <text>Jeffrey B. Mendel, Justine T. Lee, David Rosman</text>
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            <description>An account of the resource</description>
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                <text>With nearly 3,800,000 cases and 270,000 deaths reported worldwide, COVID-19 is a global pandemic unlike any we have seen in our lifetimes (1). As early as 1995, the WHO was warning of a global infectious disease crisis, citing 30 new infectious diseases emerging in the past 20 years, loss of antibiotic effectiveness, low rates of immunization, poverty, and inadequate investment in public health contributing to the more than 17 million people dying each year from infectious diseases, principally in Low and Middle Income countries (LMIC) (2). Unlike previous infectious diseases, at the time of this writing over 63% of the total reported cases of COVID-19 are in 6 High Income Countries (HIC): USA, Italy, Spain, France, Germany and the UK.Information concerning the imaging findings in COVID-19 has been rapidly disseminated from the centers first affected by the pandemic. This article attempts to summarize the current state of knowledge regarding the imaging findings in COVID-19, focusing on pulmonary findings, and offer recommendation for the use of imaging for diagnosis and surveillance of COVID-19, particularly in LMIC.</text>
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                <text>2020</text>
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            <description>The topic of the resource</description>
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                <text>developing countries, income, Radiography, diagnostic tests, COVID-19, severe acute respiratory syndrome coronovirus 2, routine lung tomography, x-ray computed ultrasonography</text>
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            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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                <text>DOI: 10.7191/jgr.2020.1106</text>
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                <text>Journal of Global Radiology</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>University of Massachusetts Medical School</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medical physics. Medical radiology. Nuclear medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Ensuring health equity during the COVID-19 pandemic: the role of public health infrastructure</text>
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                <text>Georges C. Benjamin</text>
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                <text>The COVID-19 pandemic has significantly stressed public health systems around the world and exposed the gaps in health care for underserved and vulnerable populations. In the context of the social determinants of health, focusing on health system preparedness is paramount for protecting the health of all of society. Faced with old threats (e.g., re-emergence of measles), disruptive new technologies (e.g., electronic cigarettes), increased challenges (e.g. drug-resistant organisms), and new threats (e.g., the current pandemic, climate change, politicized misinformation), our health systems must be robust and resilient. The response must include those who now suffer disproportionately—the poor and the vulnerable. Current World Health Organization priorities call for infrastructures capable of detecting, monitoring, and responding to health emergencies, such as COVID-19, and the health impacts of climate change in the context of health for all. Health care infrastructure can be better prepared and more equitable if systems are strengthened by building on core competencies and following the recommendations made for leadership, stakeholder involvement, accreditation, data collection, and funding resources. Ensuring health equity in a pandemic requires robust and resilient public health infrastructure during normal times.</text>
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                <text>health policy, Communicable disease control, vulnerable populations, health equity, planning and management</text>
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                <text>DOI: 10.26633/RPSP.2020.70</text>
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                <text>Revista Panamericana de Salud Pública</text>
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                <text>Pan American Health Organization</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Arctic medicine. Tropical medicine, Public aspects of medicine, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Recomendaciones para la comunicación de malas noticias por teléfono durante la pandemia por SARS-CoV-2</text>
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                <text>Laura F. Belli</text>
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                <text>La pandemia actual por SARS-CoV-2 presenta desafíos específicos para los profesionales de salud en el campo de la atención sanitaria. En este contexto de emergencia, la comunicación de malas noticias toma especial relevancia por el modo particular en que debe llevarse a cabo: la necesidad de mantener distanciamiento sanitario y las restricciones de movilidad impuestas a la población general hacen que esta tarea deba ser realizada, muchas veces, de manera remota, en su mayoría mediante llamados telefónicos. Esto enfrenta a los profesionales a una serie de obstáculos particulares: a) la mayoría de ellos poseen escasa o nula formación sobre esta clase de habilidades comunicativas, b) la comunicación efectiva de malas noticias depende, en gran parte, del lenguaje corporal utilizado, ausente en este tipo de intercambios, y c) dado que este tipo de diálogo remoto no es recomendable -con excepción de circunstancias particulares como la actual- existe escasa literatura disponible para guiar a quienes deben cumplir esta tarea. Este manuscrito ofrece recomendaciones sobre pautas básicas para la comunicación remota de malas noticias por teléfono, en situaciones en las cuales no se pueda llevar a cabo esta tarea de forma presencial. Se presenta una propuesta estructurada en torno de cuatro “momentos” para orientar la transmisión de malas noticias a distancia, con el fin de mejorar los cuidados a pacientes, familiares y cuidadores durante este intercambio y también reducir el impacto negativo que este intercambio tiene sobre los profesionales de la salud.</text>
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                <text>educación médica, Comunicación en salud, Tele comunicación, betacoronavirus</text>
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                <text>DOI: 10.26633/RPSP.2020.69</text>
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                <text>Pattanathu K S M Rahman, Stefano Gandolfi, Matthew L. Smith, Philippa M. Coshall</text>
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                <text>The recent outbreak in severe acute respiratory syndrome – coronavirus-2 (SARS-CoV-2) has demonstrated the complete inability of nations across the world to cope with the pressures of a global pandemic, especially one in which the only current feasible treatments are those which deal with the symptoms alone and not the viral cause. As the death toll rises, scientists begin to fall toward new avenues of research, with novelty showing itself to be an incredible and so far, underrated resource. In this case, the use of biosurfactants in dealing with this pandemic justifies extensive study with their potential applications being in the prevention of viral spread; dealing with the symptoms that develop after the incubation period; directly targeting viral infected cells and preventing the spread of the virus throughout the host, all in addition to also acting as potential drug delivery systems and cleaning agents. This extensive avenue of biosurfactants owes to the simplicity in their amphiphilic structure which permits them to interact directly with the lipid membrane of the coronavirus, in a way which wouldn't be of significant threat to the host. Although it could possibly interact and affect the virus, it could also affect human internal organs/cells by interacting with lipid membrane, if (biosurfactant is) ingested, and it still needs further studies in human models. The structure of the coronavirus, in this case SARS-CoV-2, is detrimentally dependent on the integrity of its lipid membrane which encloses its vital proteins and RNA. Biosurfactants possess the innate ability to threaten this membrane, a result of their own hydrophobic domains across their amphiphilic structure. With biosurfactants additionally being both natural and sustainable, while also possessing a remarkably low cytotoxicity, it is of no doubt that they are going to be of increasing significance in dealing with the current pandemic.</text>
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                <text>2020</text>
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                <text>drug delivery, biosurfactants, SOAP, hand wash, cleaning products, COVID-19</text>
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                <text>DOI: 10.3389/fmicb.2020.01341</text>
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                <text>Frontiers in Microbiology</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Microbiology</text>
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                <text>Caring for Health Professionals in the COVID-19 Pandemic Emergency: Toward an “Epidemic of Empathy” in Healthcare</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Guendalina Graffigna, Serena Barello</text>
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                <text>Psychological research into healthcare opened the door to understanding people's emotional reactions when experiencing events perceived as life-threatening. This is the case of the current outbreak of the novel Coronavirus disease (COVID-19) that has recently been declared “a public health emergency of international concern (PHEIC)” by the World Health Organization (WHO). The response to an influenza pandemic might generate remarkable stress and emotional turmoil to healthcare providers who work during the outbreak. Prior experience with disasters, pandemics, and major traumatic events indicates that enhanced support to healthcare professionals enabling them to become aware of their own emotions and effectively share their perspective and lived experience with patients can help them in remaining efficient and focused during these stressful events. This outbreak marks a vital moment where healthcare systems can endorse an “epidemic of empathy” aimed at bringing science and humanism together to benefit patients and consolidate citizens' trust in healthcare providers during this and future healthcare crisis. Perhaps, the greatest opportunity for managing people fears during health emergencies—like the COVID-19 one—lies, in the short term, in restoring our connections with each other. Today, we are all called to rebuild a sense of community and the ties that bind us together as human beings.</text>
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                <text>2020</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>empathy, healthcare professionals, medical humanities, medical psychology, Patient-doctor communication, COVID-19</text>
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                <text>DOI: 10.3389/fpsyg.2020.01431</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Frontiers in Psychology</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="34991">
                <text>Frontiers Media S.A.</text>
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                <text>Psychology</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                <text>A Protracted Course of COVID19 Infection in a Metastatic Breast Cancer Patient During CDK4/6 Inhibitor Therapy</text>
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            <description>An entity primarily responsible for making the resource</description>
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                <text>Albert Grinshpun, Hila Fruchtman, Irit Merlet, Dean Nachman</text>
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                <text>We describe the first case report of a patient with COVID19 infection and metastatic breast cancer, while on systemic therapy with a CDK4/6 inhibitor. The patient had unique disease course, characterized with delayed symptomatology. The case highlights novel findings and stress careful and extended follow-up during COVID19 infection in patients taking biologic therapies affecting the immune system.</text>
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                <text>2020</text>
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                <text>Pneumonia, Metastatic breast cancer, palbociclib, CDK4/6 inhibitors, COVID-19</text>
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                <text>DOI: 10.3389/fonc.2020.01085</text>
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              <elementText elementTextId="34981">
                <text>Frontiers in Oncology</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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                <text>Frontiers Media S.A.</text>
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                <text>Neoplasms. Tumors. Oncology. Including cancer and carcinogens</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Severe bradyarrhythmia requiring temporary pacemaker in a COVID-19 patient receiving lopinavir/ritonavir treatment: case report</text>
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                <text>Zhenisgul Sh. Tlegenova, Bekbolat Zholdin, Meirambek S. Kurmangazin, Bulat K. Khamidulla, Zhambul E. Zhailybaev</text>
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                <text>A 77-year-old Asian female with a history of hypertension and chronic obstructive pulmonary disease was admitted to hospital for coughing, shortness of breath and fatigue; her nasopharyngeal swab was positive for COVID-19.  Lopinavir/ritonavir 800mg/200 mg, daily was started. On the third day of antiviral therapy, the patient complained of dizziness, nausea, she was disorientated, and electrocardiogram showed sinus arrest, junctional escape rhythm 36 beats per min. Patient was successfully treated by temporary pacemaker, normal sinus rhythm was reverted on a 3rd  day after stopping the lopinavir/ritonavir treatment. She was discharged home in stable condition.  Bradyarrhythmia in form of sinus arrest can develop during treatment with lopinavir/ritonavir. The temporal nature of the observed changes and the ECG finding suggests the use of L/R contributed to the changes.  This case highlights off-label prescribing lopinavir/ritonavir outside of a clinical trial setting should be avoided until the data have proven that treatment benefit over placebo.</text>
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                <text>2020</text>
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            <name>Subject</name>
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                <text>Pacemaker, Complication, bradyarrhythmia, Lopinavir, ritonavir, Junctional rhythm, Sinus arrest, COVID-19</text>
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                <text>DOI: 10.24969/hvt.2020.198</text>
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              <elementText elementTextId="34972">
                <text>Heart Vessels and Transplantation</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="34973">
                <text>Center for Scientific Research and Development of Education.</text>
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                <text>Diseases of the circulatory (Cardiovascular) system</text>
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              <name>Title</name>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Contributions of Latin American researchers in the understanding of the novel coronavirus outbreak: a literature review</text>
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                <text>This article aimed to give the visibility of Latin American researchers’ contributions to the comprehension of COVID-19; our method was a literature review. Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus, SARS-CoV-2, and its disease COVID-19. Therefore, in less than 4 months, researchers have published a significant number of articles related to this novel virus. For instance, a search focused on the Scopus database on 10 April 2020, showed 1,224 documents published by authors with 1,797 affiliations from 80 countries. A total of 25.4%, 24.0% and 12.6% of these national affiliations were from China, Europe and the USA, respectively, making these regions leaders in COVID-19 research. In the case of Latin America, on 10 April 2020, we searched different databases, such as Scopus, PubMed and Web of Science, finding that the contribution of this region was 2.7 ± 0.6% of the total publications found. In other words, we found 153 publications related to COVID-19 with at least one Latin American researcher. We summarized and processed the information from these 153 publications, finding active participation in topics like medical, social and environmental considerations, bioinformatics and epidemiology.</text>
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                <text>Pandemic, severe acute respiratory syndrome, SARS-CoV-2, COVID-19, Coronavirus disease</text>
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                <text>DOI: 10.7717/peerj.9332</text>
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                <text>PeerJ Inc.</text>
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                <text>Medicine</text>
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