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                  <text>Dominio científico: Coronavirus</text>
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                <text>Scaling up preparedness activities for responding to the stage of community transmission of coronavirus disease 2019 globally</text>
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                <text>Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava</text>
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                <text>DOI: 10.4103/mjdrdypu.mjdrdypu_181_20</text>
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                <text>Medical Journal of Dr. D.Y. Patil Vidyapeeth</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Scanning Electron Microscopic Findings on Respiratory Organs of Some Naturally Infected Dromedary Camels with the Lineage-B of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Saudi Arabia- 2018</text>
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                <text>Ali Aldoweriej, Abdelmohsen Alnaeem, Samy Kasem, Ibrahim Qasim, Mohamed Refaat, Ali  Al-Houfufi Naser, Abdulkareem Al-Shabebi, Abd-El  Rahman Taha Hereba, Maged  Gomaa Hemida</text>
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                <text>The currently known animal reservoir for MERS-CoV is the dromedary camel. The clinical pattern of the MERS-CoV field infection in dromedary camels is not yet fully studied well. Some pathological changes and the detection of the MERS-CoV antigens by immunohistochemistry have been recently reported. However, the nature of these changes by the scanning electron microscope (SEM) was not revealed. The objective of this study was to document some changes in the respiratory organs induced by the natural MERS-CoV infection using the SEM. We previously identified three positive animals naturally infected with MERS-CoV and two other negative animals. Previous pathological studies on the positive animals showed varying degrees of alterations. MERS-CoV-S and MERS-CoV-Nc proteins were detected in the organs of positive animals. In the current study, we used the same tissues and sections for the SEM examination. We established a histopathology lesion scoring system by the SEM for the nasal turbinate and trachea. Our results showed various degrees of involvement per animal. The main observed characteristic findings are massive ciliary loss, ciliary disorientation, and goblet cell hyperplasia, especially in the respiratory organs, particularly the nasal turbinate and trachea in some animals. The lungs of some affected animals showed signs of marked interstitial pneumonia with damage to the alveolar walls. The partial MERS-CoV-S gene sequencing from the nasal swabs of some dromedary camels admitted to this slaughterhouse confirms the circulating strains belong to clade-B of MERS-CoV. These results confirm the respiratory tropism of the virus and the detection of the virus in the nasal cavity. Further studies are needed to explore the pathological alterations induced by MERS-CoV infection in various body organs of the MERS-CoV naturally infected dromedary camels.</text>
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                <text>MERS-CoV, Dromedary camel, SEM, Lesion scoring, ciliary loss</text>
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                <text>10.3390/pathogens10040420</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Scattering Mechanism Extraction by a Modified Cloude-Pottier Decomposition for Dual Polarization SAR</text>
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                <text>Kefeng Ji, Yong-Hui Wu</text>
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                <text>Dual polarization is a typical operational mode of polarimetric synthetic aperture radar (SAR). However, few studies have considered the scattering mechanism extraction of dual-polarization SARs. A modified Cloude-Pottier decomposition is proposed to investigate the performance of the scattering mechanism extraction of dual-polarization SARs. It is theoretically demonstrated that only HH-VV SAR can discriminate the three canonical scattering mechanisms from an isotropic surface, horizontal dipole, and isotropic dihedral. Various experiments are conducted using 21 scenes from real datasets acquired by AIRSAR, Convair-580 SAR, EMISAR, E-SAR, Pi-SAR, and RADARSAT-2. Division of the  dual-polarization H-α plane is experimentally obtained. The lack of cross-polarization induces the diffusion of scattering mechanisms and their overlap in the HH-VV H-α plane. However, the performance of HH-VV SAR for extracting scattering mechanisms is acceptable. Thus,  HH-VV SAR is a suitable alternative to full-polarization SAR in certain cases. Meanwhile, the extraction performance of the other two dual-polarization SARs is badly degraded due to the lack of co-polarization. Therefore, HH-HV and HV-VV SARs cannot effectively extract the scattering mechanisms in the H-α plane.</text>
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                <text>2015</text>
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                <text>polarimetry, Dual-polarization, Synthetic Aperture Radar (SAR), scattering mechanism, target decomposition</text>
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                <text>DOI: 10.3390/rs70607447</text>
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                <text>Remote Sensing</text>
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                <text>MDPI AG</text>
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                <text>Science</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Scenario analysis of COVID-19 transmission dynamics in Malaysia with the possibility of reinfection and limited medical resources scenarios.</text>
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                <text>Amer M Salman, Issam Ahmed, Mohd Hafiz Mohd, Mohammad Subhi Jamiluddin, Mohammed Ali Dheyab</text>
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                <text>COVID-19 is a major health threat across the globe, which causes severe acute respiratory syndrome (SARS), and it is highly contagious with significant mortality. In this study, we conduct a scenario analysis for COVID-19 in Malaysia using a simple universality class of the SIR system and extensions thereof (i.e., the inclusion of temporary immunity through the reinfection problems and limited medical resources scenarios leads to the SIRS-type model). This system has been employed in order to provide further insights on the long-term outcomes of COVID-19 pandemic. As a case study, the COVID-19 transmission dynamics are investigated using daily confirmed cases in Malaysia, where some of the epidemiological parameters of this system are estimated based on the fitting of the model to real COVID-19 data released by the Ministry of Health Malaysia (MOH). We observe that this model is able to mimic the trend of infection trajectories of COVID-19 pandemic in Malaysia and it is possible for transmission dynamics to be influenced by the reinfection force and limited medical resources problems. A rebound effect in transmission could occur after several years and this situation depends on the intensity of reinfection force. Our analysis also depicts the existence of a critical value in reinfection threshold beyond which the infection dynamics persist and the COVID-19 outbreaks are rather hard to eradicate. Therefore, understanding the interplay between distinct epidemiological factors using mathematical modelling approaches could help to support authorities in making informed decisions so as to control the spread of this pandemic effectively.</text>
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                <text>2021</text>
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                <text>covid-19, numerical simulation, Reinfection force and limited medical resources, SIRS model</text>
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                <text>10.1016/j.compbiomed.2021.104372</text>
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                <text>Computers in biology and medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>School closure in response to epidemic outbreaks: Systems-based logic model of downstream impacts [version 1; peer review: 2 approved]</text>
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                <text>Dylan Kneale, Alison O'Mara-Eves, Rebecca Rees, James Thomas</text>
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                <text>Background: School closures have been a recommended non-pharmaceutical intervention in pandemic response owing to the potential to reduce transmission of infection between children, school staff and those that they contact. However, given the many roles that schools play in society, closure for any extended period is likely to have additional impacts. Literature reviews of research exploring school closure to date have focused upon epidemiological effects; there is an unmet need for research that considers the multiplicity of potential impacts of school closures. Methods: We used systematic searching, coding and synthesis techniques to develop a systems-based logic model. We included literature related to school closure planned in response to epidemics large and small, spanning the 1918-19 ‘flu pandemic through to the emerging literature on the 2019 novel coronavirus. We used over 170 research studies and a number of policy documents to inform our model. Results: The model organises the concepts used by authors into seven higher level domains: children’s health and wellbeing, children’s education, impacts on teachers and other school staff, the school organisation, considerations for parents and families, public health considerations, and broader economic impacts. The model also collates ideas about potential moderating factors and ethical considerations. While dependent upon the nature of epidemics experienced to date, we aim for the model to provide a starting point for theorising about school closures in general, and as part of a wider system that is influenced by contextual and population factors. Conclusions: The model highlights that the impacts of school closures are much broader than those related solely to health, and demonstrates that there is a need for further concerted work in this area. The publication of this logic model should help to frame future research in this area and aid decision-makers when considering future school closure policy and possible mitigation strategies.</text>
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                <text>The COVID-19 pandemic crisis has had a major impact on how schooling is done. With schools closed, teaching, and learning continue dependent on information and communication technologies (ICT). To the degree that this has been a success, there is the possibility that post-pandemic societies might choose to de-school, switching to online teaching and learning only. In this perspective piece, I describe two major risks if that future were to be embraced; that is, lack of equitable access and dehumanization. My argument is that these futures already exist in pockets around the globe and we can use those experiences to evaluate those options. I suggest instead that the post-pandemic period gives us an opportunity to re-imagine what schools and schooling are for and advocate for a re-schooled society in which our investment in schools builds and develops society.</text>
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                <text>Education (General)</text>
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                <text>The COVID-19 pandemic crisis has had a major impact on how schooling is done. With schools closed, teaching, and learning continue dependent on information and communication technologies (ICT). To the degree that this has been a success, there is the possibility that post-pandemic societies might choose to de-school, switching to online teaching and learning only. In this perspective piece, I describe two major risks if that future were to be embraced; that is, lack of equitable access and dehumanization. My argument is that these futures already exist in pockets around the globe and we can use those experiences to evaluate those options. I suggest instead that the post-pandemic period gives us an opportunity to re-imagine what schools and schooling are for and advocate for a re-schooled society in which our investment in schools builds and develops society.</text>
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                <text>Background: Due to the expected increase in child abuse during the period of COVID-19 confinement, it is essential that social researchers and other professionals work together very quickly to provide alternatives that protect children. To respond to this extremely urgent demand, evidence-based actions are presented that are being carried out in nine schools in the autonomous communities of Valencia and Murcia, Spain, during the confinement with the goal of “opening doors” to foster supportive relationships and a safe environment to prevent child abuse. Methods: The research was conducted through the inclusion of teachers who are implementing these actions in dialogue with the researchers to define the study design, analysis, and discussion of the results. Results: Knowledge regarding six evidence-based actions is provided: (1) dialogic workspaces, (2) dialogic gatherings, (3) class assemblies, (4) dialogic pedagogical gatherings with teachers, (5) mixed committees, and (6) dynamisation of social networks with preventive messages and the creation of a sense of community, which are being implemented virtually.</text>
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                <text>DOI: 10.3390/su12114685</text>
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            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Science and Evidence-Based Review and Approval of COVID-19 Vaccines: A Statement of Support for the US FDA.</text>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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                <text>Sudhakar M Pai, Ahmed A Othman, Lorraine Rusch, Joanna C Masters, Douglas Greene, Mark Rogge, Jean-Michel Gries, William Clementi, Parag Kumar, Islam Younis, Ahmed Hamed Salem, Bruce I Gaynes, Gina Pastino, Hartmut Derendorf</text>
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            <name>Date</name>
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                <text>2021</text>
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            <name>Identifier</name>
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              <elementText elementTextId="71528">
                <text>10.1002/jcph.1794</text>
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="71529">
                <text>Journal of clinical pharmacology</text>
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