1983 10 20655 https://www.socictopen.socict.org/files/original/db8b5e01ecc922f867c695cb5500d498.pdf 2a96153d582b097f9068bcee8b14de44 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Supernumerary registrar experience at the University of Cape Town, South Africa Creator An entity primarily responsible for making the resource S Peer, S.A. Burrows, N Mankahla, J J Fagan Description An account of the resource Background. Despite supernumerary registrars (SNRs) being hosted in South African (SA) training programmes, there are no reports of their experience.Objectives. To evaluate the experience of SNRs at the University of Cape Town, SA, and the experience of SNRs from the perspective of SA registrars (SARs).Methods. SNRs and SARs completed an online survey in 2012.Results. Seventy-three registrars responded; 42 were SARs and 31 were SNRs. Of the SNRs 47.8% were self-funded, 17.4% were funded through private organisations, and 34.8% were funded by governments. Average annual income was ZAR102 349 (range ZAR680 - 460 000). Funding was considered insufficient by 61.0%. Eighty-seven percent intended to return to their home countries. Personal sacrifices were deemed worthwhile from academic (81.8%) and social (54.5%) perspectives, but not financially (33.3%). Only a small majority were satisfied with the orientation provided and with assimilation into their departments. Almost half experienced challenges relating to cultural and social integration. Almost all SARs supported having SNRs. SNRs reported xenophobia from patients (23.8%) and colleagues (47.8%), and felt disadvantaged in terms of learning opportunities, academic support and on-call allocations.Conclusions. SNRs are fee-paying students and should enjoy academic and teaching support equal to that received by SARs. Both the university and the teaching hospitals must take steps to improve the integration of SNRs and ensure that they receive equal access to academic support and clinical teaching, and also need to take an interest in their financial wellbeing. Of particular concern are perceptions of xenophobia from SA medical colleagues. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Subject The topic of the resource Supernumerary registrars, residents, University of Cape Town, xenophobia, specialisation, trainees, Funding Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived South African Medical Journal Publisher An entity responsible for making the resource available Health and Medical Publishing Group Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General), Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/da86dca87ca2d79744b634509745c5d1.pdf b67f11dd1bbe9c4f4d8e1dde77efd703 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Emergencia zoonótica por coronavirus: riesgo potencial para la salud pública en America Latina. Creator An entity primarily responsible for making the resource Marco González Tous, Salim Mattar V Description An account of the resource Los coronavirus (CoV) son un grupo de virus de ARN envueltos, monocatenarios (de sentido positivo) que pertenecen al orden Nidovirales, familia Coronaviridae. Se dividen en cuatro grupos principales: alfa, beta, gamma y delta; al parcer solo los alfa y beta  infetan a los humanos. Los primeros coronavirus humanos (HCoV) conocidos, HCoV-229E y HCoV-OC43 son causantes de infecciones respiratorias leves (1). Date A point or period of time associated with an event in the lifecycle of the resource 2018 Identifier An unambiguous reference to the resource within a given context DOI: 10.21897/rmvz.1408 Source A related resource from which the described resource is derived Revista MVZ Cordoba Publisher An entity responsible for making the resource available Universidad de Cordoba Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN, ES https://www.socictopen.socict.org/files/original/00017d8dea85c83c40485360a9705ff7.pdf 172ad2e583abe668e2977811994433fa Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives Creator An entity primarily responsible for making the resource Yingying Xu, Pak-Wai Yuen, Jenny Ka-Wing Lam Description An account of the resource Intranasal delivery of DNA vaccines has become a popular research area recently. It offers some distinguished advantages over parenteral and other routes of vaccine administration. Nasal mucosa as site of vaccine administration can stimulate respiratory mucosal immunity by interacting with the nasopharyngeal-associated lymphoid tissues (NALT). Different kinds of DNA vaccines are investigated to provide protection against respiratory infectious diseases including tuberculosis, coronavirus, influenza and respiratory syncytial virus (RSV) etc. DNA vaccines have several attractive development potential, such as producing cross-protection towards different virus subtypes, enabling the possibility of mass manufacture in a relatively short time and a better safety profile. The biggest obstacle to DNA vaccines is low immunogenicity. One of the approaches to enhance the efficacy of DNA vaccine is to improve DNA delivery efficiency. This review provides insight on the development of intranasal DNA vaccine for respiratory infections, with special attention paid to the strategies to improve the delivery of DNA vaccines using non-viral delivery agents. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource DNA vaccine, Intranasal delivery, infectious diseases, respiratory pathogens, adjuvants, mucosal Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/pharmaceutics6030378 Source A related resource from which the described resource is derived Pharmaceutics Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Pharmacy and materia medica Language A language of the resource EN https://www.socictopen.socict.org/files/original/4789b952f325ca653597f18872ce584d.pdf 0751b1e18727a829124240c12ce74fae Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus infection, ER stress and Apoptosis Creator An entity primarily responsible for making the resource TO SING eFUNG, Ding Xiang eLiu Description An account of the resource The replication of coronavirus, a family of important animal and human pathogens, is closely associated with the cellular membrane compartments, especially the endoplasmic reticulum (ER). Coronavirus infection of cultured cells was previously shown to cause ER stress and induce the unfolded protein response (UPR), a process that aims to restore the ER homeostasis by global translation shutdown and increasing the ER folding capacity. However under prolonged ER stress, UPR can also induce apoptotic cell death. Accumulating evidence from recent studies has shown that induction of ER stress and UPR may constitute a major aspect of coronavirus-host interaction. Activation of the three branches of UPR modulates a wide variety of signaling pathways, such as mitogen-activated protein (MAP) kinases activation, autophagy, apoptosis and innate immune response. ER stress and UPR activation may therefore contribute significantly to the viral replication and pathogenesis during coronavirus infection. In this review, we summarize current knowledge on coronavirus-induced ER stress and UPR activation, with emphasis on their cross-talking to apoptotic signaling. Date A point or period of time associated with an event in the lifecycle of the resource 2014 Subject The topic of the resource apoptosis, coronavirus, Unfolded Protein Response, ER stress, signal transduction pathways, Proinflammatory cytokines Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2014.00296 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology Language A language of the resource EN https://www.socictopen.socict.org/files/original/c2b242c0bea5bc78a782888fc73df24a.pdf 6bf33eb751c1b47910d0499db02f845a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Etiology and immunology of infectious bronchitis virus Creator An entity primarily responsible for making the resource LF Caron Description An account of the resource Infectious bronchitis virus (IBV) of chickens is currently one of the main diseases associated with respiratory syndrome in domestic poultry, as well as with losses related to egg production. The etiological agent is a coronavirus, which presents structural differences in the field, mainly in the S1 spike protein. The immune response against this virus is complicated by the few similarities among serotypes. Environmental and management factors, as well as the high mutation rate of the virus, render it difficult to control the disease and compromise the efficacy of the available vaccines. Bird immune system capacity to respond to challenges depend on the integrity of the mucosae, as an innate compartment, and on the generation of humoral and cell-mediated adaptive responses, and may affect the health status of breeding stocks in the medium run. Vaccination of day-old chicks in the hatchery on aims at eliciting immune responses, particularly cell-mediated responses that are essential when birds are first challenged. Humoral response (IgY and IgA) are also important for virus clearance in subsequent challenges. The presence of antibodies against the S1 spike protein in 3- to 4-week-old birds is important both in broilers and for immunological memory in layers and breeders. Date A point or period of time associated with an event in the lifecycle of the resource 2010 Subject The topic of the resource Chicken Bronchitis, immune response, vaccine Identifier An unambiguous reference to the resource within a given context DOI: 10.1590/S1516-635X2010000200007 Source A related resource from which the described resource is derived Brazilian Journal of Poultry Science Publisher An entity responsible for making the resource available Fundação APINCO de Ciência e Tecnologia Avícolas Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine, Zoology, Animal culture Language A language of the resource EN https://www.socictopen.socict.org/files/original/1f3e25b395b7ea56cb4538b8f40dc77e.pdf 999fc9e6e937ba99742ff44002c32a31 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS (SEVERE ACUTE RESPIRATORY SYNDROME) – A NEW CHALLENGE FOR THE MANKIND Creator An entity primarily responsible for making the resource Andrej Trampuz, Leopold Rezar, Viktorija Tomič, Igor Muzlovič Description An account of the resource Background. SARS (severe acute respiratory syndrome) is a recently recognized new infectious respiratory illness, which first appeared in southern China in November 2002, and has since then within months spread to 29 countries. In total, 8437 cases and 813 deaths occurred (situation as of August 1, 2003). SARS is caused by a novel coronavirus that is primarily spread by large droplet transmission, less commonly by surface contamination or by air (airborne). Around half of the infected were health care workers; the majority of cases acquired the infection in the hospital.Conclusions. Incubation period of SARS is 2 to 10 days. Early manifestations include fever, myalgia, and headache, followed 2 to 4 days later by cough, shortness of breath, and diarrhea. In 10–20% of patients, tracheal intubation and mechanical ventilation is required. Case-fatality is approximately 15%, in patients aged 60 years or older may be higher than 40%. There is no specific therapy or vaccine, and management consists of supportive care. This article summarizes updated information regarding epidemiology, clinical features, etiologic agent, modes of transmission of the disease, and infection control measures to contain SARS. Date A point or period of time associated with an event in the lifecycle of the resource 2003 Subject The topic of the resource SARS, severe acute respiratory syndrome, atypical pneumonia, coronavirus Identifier An unambiguous reference to the resource within a given context DOI: Source A related resource from which the described resource is derived Zdravniški Vestnik Publisher An entity responsible for making the resource available Slovenian Medical Association Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine Language A language of the resource EN, SL https://www.socictopen.socict.org/files/original/7841063338497261a34696fcca0fa681.pdf 8f2dc26a9738a300403ddac1a076d365 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The severe acute respiratory syndrome epidemic in mainland China dissected Creator An entity primarily responsible for making the resource Wu-Chun Cao, Sake J. de Vlas, Jan H Richardus Description An account of the resource This paper provides a review of a recently published series of studies that give a detailed and comprehensive documentation of the severe acute respiratory syndrome (SARS) epidemic in mainland China, which severely struck the country in the spring of 2003. The epidemic spanned a large geographical extent but clustered in two areas: first in Guangdong Province, and about 3 months later in Beijing with its surrounding areas. Reanalysis of all available epidemiological data resulted in a total of 5327 probable cases of SARS, of whom 343 died. The resulting case fatality ratio (CFR) of 6.4% was less than half of that in other SARS-affected countries or areas, and this difference could only partly be explained by younger age of patients and higher number of community acquired infections. Analysis of the impact of interventions demonstrated that strong political commitment and a centrally coordinated response was the most important factor to control SARS in mainland China, whereas the most stringent control measures were all initiated when the epidemic was already dying down. The long-term economic consequence of the epidemic was limited, much consumption was merely postponed, but for Beijing irrecoverable losses to the tourist sector were considerable. An important finding from a cohort study was that many former SARS patients currently suffer from avascular osteo­necrosis, as a consequence of the treatment with corticosteroids during their infection. The SARS epidemic provided valuable information and lessons relevant in controlling outbreaks of newly emerging infectious diseases, and has led to fundamental reforms of the Chinese health system. In particular, a comprehensive nation-wide internet-based disease reporting system was established. Date A point or period of time associated with an event in the lifecycle of the resource 2011 Subject The topic of the resource SARS, China, Case fatality ratio, Avascular Necrosis, epidemic preparedness Identifier An unambiguous reference to the resource within a given context DOI: 10.4081/idr.2011.1794 Source A related resource from which the described resource is derived Infectious Disease Reports Publisher An entity responsible for making the resource available PAGEPress Publications Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Other systems of medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/65fa6e5c24e2abb6d574a9e8a659cab9.pdf a0f80e1d9ccf4590eff85909bf2769a0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A Novel Label-Free Optical Biosensor Using Synthetic Oligonucleotides from E. coli O157:H7: Elementary Sensitivity Tests Creator An entity primarily responsible for making the resource Ahmet Yavuz Oral, Muhammed Hasan Aslan, Aligül Büyükaksoy, Fethi Şimşek, Sinan Mert Ölmezcan, Zehra Banu Bahşi Description An account of the resource SiO2-TiO2 thin films for use as fiber optic guiding layers of optical DNA biosensors were fabricated by the sol-gel dip coating technique. The chemical structure and the surface morphology of the films were characterized before immobilization. Single probe DNA strands were immobilized on the surface and the porosity of the films before the hybridization process was measured. Refractive index values of the films were measured using a Metricon 2010 prism coupler. On the surface of each film, 12 different spots were taken for measurement and calculation of the mean refractive index values with their standard deviations. The increased refractive index values after the immobilization of single DNA strands indicated that immobilization was successfully achieved. A further refractive index increase after the hybridization with target single DNA strands showed the possibility of detection of the E. coli O157:H7 EDL933 species using strands of 20-mers (5’-TAATATCGGTTGCGGAGGTG -3’) sequence. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Subject The topic of the resource sol-gel, optical DNA biosensor, prism coupler Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/s90604890 Source A related resource from which the described resource is derived Sensors Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Chemical technology Language A language of the resource EN https://www.socictopen.socict.org/files/original/da6578982f5ce6b7880fd2d95109f894.pdf b39f37b159f95114e58ebc5fe4647b95 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry Creator An entity primarily responsible for making the resource van Kasteren Puck, Broer Rene, Corver Jeroen, Spaan Willy Description An account of the resource Abstract Background The spike protein (S) of SARS Coronavirus (SARS-CoV) mediates entry of the virus into target cells, including receptor binding and membrane fusion. Close to or in the viral membrane, the S protein contains three distinct motifs: a juxtamembrane aromatic part, a central highly hydrophobic stretch and a cysteine rich motif. Here, we investigate the role of aromatic and hydrophobic parts of S in the entry of SARS CoV and in cell-cell fusion. This was investigated using the previously described SARS pseudotyped particles system (SARSpp) and by fluorescence-based cell-cell fusion assays. Results Mutagenesis showed that the aromatic domain was crucial for SARSpp entry into cells, with a likely role in pore enlargement. Introduction of lysine residues in the hydrophobic stretch of S also resulted in a block of entry, suggesting the borders of the actual transmembrane domain. Surprisingly, replacement of a glycine residue, situated close to the aromatic domain, with a lysine residue was tolerated, whereas the introduction of a lysine adjacent to the glycine, was not. In a model, we propose that during fusion, the lateral flexibility of the transmembrane domain plays a critical role, as do the tryptophans and the cysteines. Conclusions The aromatic domain plays a crucial role in the entry of SARS CoV into target cells. The positioning of the aromatic domain and the hydrophobic domain relative to each other is another essential characteristic of this membrane fusion process. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1743-422X-6-230 Source A related resource from which the described resource is derived Virology Journal Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases Language A language of the resource EN https://www.socictopen.socict.org/files/original/42802a5c0537d15b9fd55291a98cdc9d.pdf 1d6f379d4f2a26bb2919fd6acace6d3f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV Creator An entity primarily responsible for making the resource Ni Bing, Wang Li, Ruan Zhihua, Lv Yanbo, Wu Yuzhang Description An account of the resource Abstract Background The spike (S) protein is a major structural glycoprotein of coronavirus (CoV), the causal agent of severe acute respiratory syndrome (SARS). The S protein is a potent target for SARS-specific cell-mediated immune responses. However, the mechanism CoV pathogenesis in SARS and the role of special CTLs in virus clearance are still largely uncharacterized. Here, we describe a study that leads to the identification of a novel HLA-A*0201-restricted epitope from conserved regions of S protein. Results First, different SARS-CoV sequences were analyzed to predict eight candidate peptides from conserved regions of the S protein based upon HLA-A*0201 binding and proteosomal cleavage. Four of eight candidate peptides were tested by HLA-A*0201 binding assays. Among the four candidate peptides, Sp8 (S958-966, VLNDILSRL) induced specific CTLs both ex vivo in PBLs of healthy HLA-A2+ donors and in HLA-A2.1/Kb transgenic mice immunized with a plasmid encoding full-length S protein. The immunized mice released IFN-γ and lysed target cells upon stimulation with Sp8 peptide-pulsed autologous dendritic cells in comparison to other candidates. Conclusion These results suggest that Sp8 is a naturally processed epitope. We propose that Sp8 epitope should help in the characterization of mechanisms of virus control and immunopathology in SARS-CoV infection. Date A point or period of time associated with an event in the lifecycle of the resource 2009 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/1471-2172-10-61 Source A related resource from which the described resource is derived BMC Immunology Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Immunologic diseases. Allergy Language A language of the resource EN