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                <text>Mei-Shang Ho, Wei-Ju Chen, Hour-Young Chen, Szu-Fong Lin, Min-Chin Wang, Jiali Di, Yen-Ta Lu, Ching-Lung Liu, Shan-Chwen Chang, Chung-Liang Chao, Chwan-Chuen King, Jeng-Min Chiou, Ih-Jen Su, Jyh-Yuan Yang</text>
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                <text>Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. With a linear mixed model, neutralizing antibody titer was shown to peak between week 5 and week 8 after onset and to decline thereafter, with a half-life of 6.4 weeks. Patients with a longer illness showed a lower neutralizing antibody response than patients with a shorter illness duration (p = 0.008). When early responders were compared with most patients, who seroconverted on and after week 3 of illness, the small proportion (17.4%) of early responders (antibody detectable within 2 weeks) had a higher death rate (29.6% vs. 7.8%) (Fisher exact test, p = 0.004), had a shorter survival time of  60 years of age (Fisher exact test, p = 0.01). Our findings have implications for understanding the pathogenesis of SARS and for SARS vaccine research and development.</text>
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                <text>DOI: 10.3201/eid1111.040659</text>
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                <text>In 2005, a new human coronavirus, HCoV-HKU1, was identified in Hong Kong. We screened respiratory specimens collected from December 16, 2001, to December 15, 2002, from children</text>
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                <text>DOI: 10.3201/eid1205.051316</text>
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                <text>Justin J. O’Hagan, Cristina Carias, Jessica M. Rudd, Huong T. Pham, Yonat Haber, Nicki Pesik, Martin S. Cetron, Manoj Gambhir, Susan I. Gerber, David L. Swerdlow</text>
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                <text>Using data from travelers to 4 countries in the Middle East, we estimated 3,250 (95% CI 1,300–6,600) severe cases of Middle East respiratory syndrome occurred in this region during September 2012–January 2016. This number is 2.3-fold higher than the number of laboratory-confirmed cases recorded in these countries.</text>
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                <text>DOI: 10.3201/eid2210.151121</text>
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                <text>Patrick C. Y. Woo, Susanna K. P. Lau, Ulrich Wernery, Emily Y.M. Wong, Alan K.L. Tsang, Bobby Johnson, Cyril C.Y. Yip, Candy C.Y. Lau, Saritha Sivakumar, Jian-Piao Cai, Rachel Y.Y. Fan, Kwok-Hung Chan, Ringu Mareena, Kwok-yung Yuen</text>
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                <text>In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested. In an analysis of 3 complete DcCoV UAE-HKU23 genomes, we identified the virus as a betacoronavirus in lineage A1. The DcCoV UAE-HKU23 genome has G+C contents; a general preference for G/C in the third position of codons; a cleavage site for spike protein; and a membrane protein of similar length to that of other betacoronavirus A1 members, to which DcCoV UAE-HKU23 is phylogenetically closely related. Along with this coronavirus, viruses of at least 8 other families have been found to infect camels. Because camels have a close association with humans, continuous surveillance should be conducted to understand the potential for virus emergence in camels and for virus transmission to humans.</text>
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                <text>DOI: 10.3201/eid2004.131769</text>
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                <text>PASCAL BARRIER, JEAN GAUDANT, FRANÇOIS RAISSON, DIDIER MERLE, MONIQUE TOUMARKINE</text>
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                <text>Le bassin plio-quaternaire du Monte Torre a livré une faune de milieu lagunaire, qui a permis de reconstituer une partie de son évolution paléogéographique. Pendant tout le Pliocène et vraisemblablement jusqu'à la base du Pléistocène, ce bassin a fonctionné en régime sédimentaire et hydrodynamique de détroit. A cette époque cet étroit couloir reliait les mers tyrrhénienne et ionienne. Les structures sédimentaires et l'exubérance de la faune bathyale rencontrée en témoignent. Le fonctionnement tectono-sédimentaire de ce basin est en de nombreux points comparable à celui du Détroit de Messine pliocène. Vers la base du Pléistocène le détroit du Monte Torre s'interrompt brutalement. Les communicarions entre bassin tyrrhénien et ionien sont interrompues. Une lagune, ouverte sur le bassin ionien, s'installe à la place de I'ancien détroit. Cet événement brutal dans I'histoire du bassin est à relier à une surrection d'ensemble de la Calabre méridionale.</text>
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                <text>DOI: 10.13130/2039-4942/8949</text>
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                <text>Rivista Italiana di Paleontologia e Stratigrafia</text>
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                <text>Università degli Studi di Milano</text>
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                <text>Geology, Paleontology</text>
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                <text>Mart M. Lamers, V. Stalin Raj, Mah’d Shafei, Sami Sheikh Ali, Sultan M. Abdallh, Mahmoud Gazo, Samer Nofal, Xiaoyan Lu, Dean D. Erdman, Marion Koopmans, Mohammad Abdallat, Bart L. Haagmans</text>
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                <text>We characterized Middle East respiratory syndrome coronaviruses from a hospital outbreak in Jordan in 2015. The viruses from Jordan were highly similar to isolates from Riyadh, Saudi Arabia, except for deletions in open reading frames 4a and 3. Transmissibility and pathogenicity of this strain remains to be determined.</text>
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                <text>DOI: 10.3201/eid2204.152065</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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            <description>A language of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Wen Da Guan, Chris Ka Pun Mok, Zi-Lin Chen, Li Qiang Feng, Zhengtu Li, Jicheng Huang, Changwen Ke, Xilong Deng, Yun Ling, Shi Guan Wu, Xuefeng Niu, Ranawaka A Perera, Yuan Da Xu, Jincun Zhao, Lin Qi Zhang, Yimin Li, Rong Chang Chen, Ghazi Kayali, Ling Chen, Nanshan Zhong</text>
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                <text>Middle East respiratory syndrome, MERS, Middle East respiratory syndrome coronavirus, MERS-CoV, Viruses, cytokines</text>
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                <text>DOI: 10.3201/eid2112.151232</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>Wan Beom Park, Ranawaka A.P.M. Perera, Pyoeng Gyun Choe, Eric H. Y. Lau, Seongjin Choi, June Young Chun, Hong Sang Oh, Kyoung-Ho Song, Ji-Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sangwon Park, Nam Joong Kim, Leo Lit-Man Poon, Ghazi Kayali, Myoung-don Oh</text>
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                <text>We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.</text>
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                <text>DOI: 10.3201/eid2112.151421</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                <text>In May 2015 in United Arab Emirates, asymptomatic Middle East respiratory syndrome coronavirus infection was identified through active case finding in 2 men with exposure to infected dromedaries. Epidemiologic and virologic findings suggested zoonotic transmission. Genetic sequences for viruses from the men and camels were similar to those for viruses recently detected in other countries.</text>
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