2013 10 20655 https://www.socictopen.socict.org/files/original/b3071133b5ac9e506a0d30f9770e313e.pdf ebeea9e5e5a181588f86f36ac7a3ec55 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource INVASIONES BIOLÓGICAS EN AGROECOSISTEMAS DE ECUADOR CONTINENTAL: NICHO ECOLÓGICO DE ESPECIES EXÓTICAS Y CULTIVOS AGRÍCOLAS BAJO RIESGO Creator An entity primarily responsible for making the resource Yarelys Ferrer-Sánchez, Wilmer Raúl Jacho-Saa, Juan Pablo Urdánigo Zambrano, Fernando Abasolo-Pacheco, Alexis Herminio Plasencia-Vázquez, Génesis Jahaira Zambrano-Mero, Mayely Julissa Castillo Macias, Karen Tatiana Muñoz Zambrano, Alex Adrian Coveña-Rosado, Gabriela Veronica Estrella Bravo Description An account of the resource En Ecuador las especies exóticas invasoras (EEI) provocan consecuencias negativas en los aspectos ecológicos, económicos y de seguridad alimentaria. Los agroecosistemas hacen parte de los sectores productivos a nivel mundial, pero son vulnerables a sufrir invasiones biológicas por la constante actividad humana y por el traslado de vegetación, tierra y semillas, por lo que deben ser constantemente monitoreados, pues desempeñan un papel importante en la economía al ser fuente de empleo. El objetivo de esta investigación fue evaluar la influencia potencial de las EEI sobre los agroecosistemas de Ecuador continental a través del modelado del nicho ecológico. Se usó como método de modelación el algoritmo de máxima entropía y se emplearon los registros de presencia de seis especies de plantas y cuatro de insectos en sus regiones nativas y en zonas invadidas a nivel mundial. Los registros provienen de Global Biodiversity Information Facility y de Tropicos. Como variables explicativas se emplearon 19 variables bioclimáticas y seis variables de vegetación. Se obtuvieron los mapas de distribución geográfica potencial, las áreas de superposición de la distribución de las especies y la delimitación de las zonas de mayor riesgo. Se determinó que las condiciones ambientales de las regiones Sierra y Amazónica son idóneas para una posible invasión de seis y siete especies. Además, más del 50 % de la cobertura agropecuaria del país podría ser afectada por las especies Wasmannia rochai, Spondias purpurea L., Lissachatina fulica y Conium maculatum L., siendo los cultivos de ciclo corto los más vulnerables a la invasión por estas especies. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource Agricultura, Especie introducida, diversidad biológica, ecosistemas, modelos, nicho ecológico Source A related resource from which the described resource is derived Acta Biológica Colombiana Publisher An entity responsible for making the resource available Universidad Nacional de Colombia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Relation A related resource <a href="https://revistas.unal.edu.co/index.php/actabiol/article/view/81765" target="_blank" rel="noreferrer noopener">https://revistas.unal.edu.co/index.php/actabiol/article/view/81765</a> https://www.socictopen.socict.org/files/original/92fc0955d1d7a71691c832191ff873ac.pdf fd29330426f56df1f95e3e505130a78f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Confianza del consumidor en la compra de productos orgánicos ante la ausencia de certificaciones Creator An entity primarily responsible for making the resource Yaromir Muñoz, Kelly Johanna Sierra-Gomez, Francisco López Gallego, Antonio Boada Description An account of the resource Este estudio se centra en identificar los elementos que contribuyen a la construcción de confianza entre productor y consumidor de productos orgánicos, cuando éstos últimos carecen de certificaciones formales. Se empleó, por un lado, una metodología cualitativa con entrevistas a productores y a consumidores y, por otro, una cuantitativa que se apoyó en la aplicación de un cuestionario a una muestra efectiva de 226 consumidores de productos orgánicos; se realizó un análisis descriptivo y uno correlacional entre las variables jerárquicas establecidas. Se resalta que conocer y tener cercanía con el productor-agricultor permite establecer con él una relación duradera basada en la confianza y por ello es posible prescindir de las certificaciones externas. Se concluye, que la confianza es esencial para el desarrollo y fortalecimiento de las relaciones de intercambio cuando el productor carece de sellos formales que certifiquen su producto. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource CONFIANZA DEL CONSUMIDOR, Productos orgánicos, apoyo a la economía local, conocimiento de productores Source A related resource from which the described resource is derived Revista Venezolana de Gerencia Publisher An entity responsible for making the resource available Universidad del Zulia Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Business, Commerce Relation A related resource <a href="https://produccioncientificaluz.org/index.php/rvg/article/view/35209/37265" target="_blank" rel="noreferrer noopener">https://produccioncientificaluz.org/index.php/rvg/article/view/35209/37265</a> https://www.socictopen.socict.org/files/original/29f313cbb16cbd22802d330053fbef9c.pdf dbe6520db06b96970935041a8129bf85 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Assessment of algorithms for inferring positional weight matrix motifs of transcription factor binding sites using protein binding microarray data. Creator An entity primarily responsible for making the resource Yaron Orenstein, Chaim Linhart, Ron Shamir Description An account of the resource The new technology of protein binding microarrays (PBMs) allows simultaneous measurement of the binding intensities of a transcription factor to tens of thousands of synthetic double-stranded DNA probes, covering all possible 10-mers. A key computational challenge is inferring the binding motif from these data. We present a systematic comparison of four methods developed specifically for reconstructing a binding site motif represented as a positional weight matrix from PBM data. The reconstructed motifs were evaluated in terms of three criteria: concordance with reference motifs from the literature and ability to predict in vivo and in vitro bindings. The evaluation encompassed over 200 transcription factors and some 300 assays. The results show a tradeoff between how the methods perform according to the different criteria, and a dichotomy of method types. Algorithms that construct motifs with low information content predict PBM probe ranking more faithfully, while methods that produce highly informative motifs match reference motifs better. Interestingly, in predicting high-affinity binding, all methods give far poorer results for in vivo assays compared to in vitro assays. Date A point or period of time associated with an event in the lifecycle of the resource 2012 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pone.0046145 Source A related resource from which the described resource is derived PLoS ONE Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Science, Medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/d99010200a0cebf88f039d20781a92e7.pdf 673cab036b7699dbf198a4e8755e045e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Designing small universal k-mer hitting sets for improved analysis of high-throughput sequencing. Creator An entity primarily responsible for making the resource Yaron Orenstein, David Pellow, Guillaume Marçais, Ron Shamir, Carl Kingsford Description An account of the resource With the rapidly increasing volume of deep sequencing data, more efficient algorithms and data structures are needed. Minimizers are a central recent paradigm that has improved various sequence analysis tasks, including hashing for faster read overlap detection, sparse suffix arrays for creating smaller indexes, and Bloom filters for speeding up sequence search. Here, we propose an alternative paradigm that can lead to substantial further improvement in these and other tasks. For integers k and L > k, we say that a set of k-mers is a universal hitting set (UHS) if every possible L-long sequence must contain a k-mer from the set. We develop a heuristic called DOCKS to find a compact UHS, which works in two phases: The first phase is solved optimally, and for the second we propose several efficient heuristics, trading set size for speed and memory. The use of heuristics is motivated by showing the NP-hardness of a closely related problem. We show that DOCKS works well in practice and produces UHSs that are very close to a theoretical lower bound. We present results for various values of k and L and by applying them to real genomes show that UHSs indeed improve over minimizers. In particular, DOCKS uses less than 30% of the 10-mers needed to span the human genome compared to minimizers. The software and computed UHSs are freely available at github.com/Shamir-Lab/DOCKS/ and acgt.cs.tau.ac.il/docks/, respectively. Date A point or period of time associated with an event in the lifecycle of the resource 2017 Identifier An unambiguous reference to the resource within a given context DOI: 10.1371/journal.pcbi.1005777 Source A related resource from which the described resource is derived PLoS Computational Biology Publisher An entity responsible for making the resource available Public Library of Science (PLoS) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/b44d26a11c276aae105aa9f78522b224.pdf 453c2396eb3ffdfb97aaf16518efb77c Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Venous Thrombo-Embolism in Hospitalized SARS-CoV-2 Patients Treated with Three Different Anticoagulation Protocols: Prospective Observational Study Creator An entity primarily responsible for making the resource Yaroslava Longhitano, Fabrizio Racca, Christian Zanza, Marina Muncinelli, Alberto Guagliano, Elisa Peretti, Anna Chiara Minerba, Marta Mari, Riccardo Boverio, Mario Salio, Guido Chichino, Francesco Franceschi, Andrea Piccioni, Ludovico Abenavoli, Mauro Salvini, Marco Artico Description An account of the resource The purpose of this study is to assess thrombotic risk in CoViD-19/pneumonia patients with acute respiratory failure and to compare populations treated with three different antithrombotic prophylaxis protocols. The primary outcome is to analyze the prevalence of thrombotic events in hospitalized patients, while the secondary outcome is to analyze the correlation between different anticoagulation targets with thrombotic events. All patients referred to our hospital for acute respiratory failure due to COVID-19 pneumonia between 18 and 31 May 2020 were included. Seventy-four patients were enrolled (44 men and 30 women, average age 68.6). Diagnosis of venous thromboembolism was made in 21 cases (28.4%) and thrombotic events were associated with positive pressure ventilation support (p = 0.024) and hospitalization in ICU (p < 0.0001). These patients presented higher levels of D-dimer (p < 0.0001) and their hospital length of stay was >16 days longer. Forty-seven out of 74 patients (63.5%) received intermediate or therapeutic dose of anticoagulation, while twenty-seven patients (34.5%) received standard antithrombotic prophylaxis. The analysis showed that an intermediate or therapeutic dose of anticoagulation did not decrease the prevalence of thrombotic events. On the other hand, six patients reported severe hemorrhagic complications. Despite intermediate or therapeutic-dose of anticoagulation, a high number of patients with acute respiratory failure secondary to COVID-19 developed thrombotic complications. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, acute respiratory failure, coagulopathy, venous thromboembolism, thromboprophylaxis, deep vein thrombosis Identifier An unambiguous reference to the resource within a given context 10.3390/biology9100310 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/0bcbf3e94feea7daafb3fc3dabd81626.pdf c2d6679cdc77bc028ee30e516ca7c212 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Simultaneous detection and differentiation of canine parvovirus and feline parvovirus by high resolution melting analysis Creator An entity primarily responsible for making the resource Yaru Sun, Yuening Cheng, Peng Lin, Hewei Zhang, Li Yi, Mingwei Tong, Zhigang Cao, Shuang Li, Shipeng Cheng, Jianke Wang Description An account of the resource Abstract Background Canine parvovirus (CPV) and feline parvovirus (FPV) are causative agents of diarrhea in dogs and cats, which manifests as depression, vomiting, fever, loss of appetite, leucopenia, and diarrhea in young animals. CPV and FPV can single or mixed infect cats and cause disease. To diagnose sick animals effectively, an effective virus diagnostic and genome typing method with high sensitivity and specificity is required. Results In this study, a conserved segment containing one SNP A4408C of parvovirus was used for real-time PCR amplification. Subsequently, data were auto-analyzed and plotted using Applied Biosystems® High Resolution Melt Software v3.1. Results showed that CPV and FPV can be detected simultaneously in a single PCR reaction. No cross-reactions were observed with canine adenovirus, canine coronavirus, and canine distemper virus. The assay had a detection limit of 4.2 genome copies of CPV and FPV. A total of 80 clinical samples were subjected to this assay, as well as to conventional PCR-sequence assay and virus isolation. Results showed that the percentage of agreement of the assay and other methods are high. Conclusions In short, we have developed a diagnostic test for the accurate detection and differentiation of CPV and FPV in fecal samples, which is also cost effective. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource simultaneous detection, Differentiation, canine parvovirus, Feline parvovirus, HRM Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s12917-019-1898-5 Source A related resource from which the described resource is derived BMC Veterinary Research Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Veterinary medicine Language A language of the resource EN https://www.socictopen.socict.org/files/original/2be2c25176af873af6b8416ade17c0f9.pdf ca5123586ab6414a8ff5e85f7e6fd67e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19. Creator An entity primarily responsible for making the resource Yaseen M Arabi, George P Chrousos, G Umberto Meduri Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context 10.1007/s00134-020-06223-y Source A related resource from which the described resource is derived Intensive care medicine https://www.socictopen.socict.org/files/original/8d1c2ebb0179a9024b45de7fe6fad5ba.pdf db84bd629e8184538ffaa459c5da2f19 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial Creator An entity primarily responsible for making the resource Yaseen M. Arabi, Adel Alothman, Hanan H Balkhy, Abdulaziz Al Dawood, Sameera Al Johani, Shmeylan Al-Harbi, Suleiman Kojan, Majed Al Jeraisy, Ahmad M. Deeb, Abdullah M. Assiri, Fahad Al Hameed, Asim AlSaedi, Yasser Mandourah, Ghaleb A. Almekhlafi, Nisreen Murad Sherbeeni, Fatehi Elnour Elzein, Javed Memon, Yusri Taha, Abdullah Almotairi, Khalid A. Maghrabi, Ismael Qushmaq, Ali Al Bshabshe, Ayman Kharaba, Sarah Shalhoub, Jesna Jose, Robert A Fowler, Frederick G. Hayden, Mohamed A. Hussein, And the MIRACLE trial group Description An account of the resource Abstract Background It had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical trials. Results from in vitro and animal studies suggest that a combination of lopinavir/ritonavir and interferon-β1b (IFN-β1b) may be effective against MERS-CoV. The aim of this study is to investigate the efficacy of treatment with a combination of lopinavir/ritonavir and recombinant IFN-β1b provided with standard supportive care, compared to treatment with placebo provided with standard supportive care in patients with laboratory-confirmed MERS requiring hospital admission. Methods The protocol is prepared in accordance with the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) guidelines. Hospitalized adult patients with laboratory-confirmed MERS will be enrolled in this recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. The trial is initially designed to include 2 two-stage components. The first two-stage component is designed to adjust sample size and determine futility stopping, but not efficacy stopping. The second two-stage component is designed to determine efficacy stopping and possibly readjustment of sample size. The primary outcome is 90-day mortality. Discussion This will be the first randomized controlled trial of a potential treatment for MERS. The study is sponsored by King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. Enrollment for this study began in November 2016, and has enrolled thirteen patients as of Jan 24-2018. Trial registration ClinicalTrials.gov, ID: NCT02845843. Registered on 27 July 2016. Date A point or period of time associated with an event in the lifecycle of the resource 2018 Subject The topic of the resource coronavirus, MERS, antiviral, Saudi Arabia, clinical trial, Lopinavir/ritonavir Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13063-017-2427-0 Source A related resource from which the described resource is derived Trials Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) Language A language of the resource EN https://www.socictopen.socict.org/files/original/a1e9e8345a1f503aa8db38dc7562dc5d.pdf 64b425d28cbb72ad6e64dbf31c488d83 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Treatment of Middle East respiratory syndrome with a combination of lopinavir/ritonavir and interferon-β1b (MIRACLE trial): statistical analysis plan for a recursive two-stage group sequential randomized controlled trial Creator An entity primarily responsible for making the resource Yaseen M. Arabi, Adel Alothman, Hanan H. Balkhy, Abdulaziz Al-Dawood, Sameera AlJohani, Shmeylan Al Harbi, Suleiman Kojan, Majed Al Jeraisy, Fahad Al-Hameed, Asim AlSaedi, Ghaleb A. Almekhlafi, Nisreen Murad Sherbeeni, Fatehi Elnour Elzein, Abdullah Almotairi, Ali Al Bshabshe, Ayman Kharaba, Robert A. Fowler, Ayed Y. Asiri, Abdullah M. Assiri, Hani A. Aziz Jokhdar, Ahmad M. Deeb, Ziad A. Memish, Sameeh Ghazal, Sarah Al Faraj, Yasser Mandourah, Jesna Jose, Abdulrahman Al Harthy, Mohammed Al Sulaiman, Ahmed Mady, Frederick G. Hayden, Mohamed Abdelzaher, Wail Bajhmom, Mohamed A. Hussein, and the Saudi Critical Care Trials group Description An account of the resource Abstract The MIRACLE trial (MERS-CoV Infection tReated with A Combination of Lopinavir/ritonavir and intErferon-β1b) investigates the efficacy of a combination therapy of lopinavir/ritonavir and recombinant interferon-β1b provided with standard supportive care, compared to placebo provided with standard supportive care, in hospitalized patients with laboratory-confirmed MERS. The MIRACLE trial is designed as a recursive, two-stage, group sequential, multicenter, placebo-controlled, double-blind randomized controlled trial. The aim of this article is to describe the statistical analysis plan for the MIRACLE trial. The primary outcome is 90-day mortality. The primary analysis will follow the intention-to-treat principle. The MIRACLE trial is the first randomized controlled trial for MERS treatment. Trial registration ClinicalTrials.gov, NCT02845843. Registered on 27 July 2016. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, MERS, antiviral, Clinical trial, lopinavir/ritonavir, interferonβ-1b Identifier An unambiguous reference to the resource within a given context 10.1186/s13063-019-3846-x Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/417837fb981298cb5d92eb118bc3e20f.pdf 3510551d1caee8e6b0049b5f064d3fa2 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Feasibility of Using Convalescent Plasma Immunotherapy for MERS-CoV Infection, Saudi Arabia Creator An entity primarily responsible for making the resource Yaseen M. Arabi, Ali H Hajeer, Thomas Luke, Kanakatte Raviprakash, Hanan Balkhy, Sameera Johani, Abdulaziz Al Dawood, Saad Alqahtani, Awad Al-Omari, Fahad Al Hameed, Frederick G. Hayden, Robert Fowler, Abderrezak Bouchama, Nahoko Shindo, Khalid Al-Khairy, Gail Carson, Yusri Taha, Musharaf Sadat, Mashail Alahmadi Description An account of the resource We explored the feasibility of collecting convalescent plasma for passive immunotherapy of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using ELISA to screen serum samples from 443 potential plasma donors: 196 patients with suspected or laboratory-confirmed MERS-CoV infection, 230 healthcare workers, and 17 household contacts exposed to MERS-CoV. ELISA-reactive samples were further tested by indirect fluorescent antibody and microneutralization assays. Of the 443 tested samples, 12 (2.7%) had a reactive ELISA result, and 9 of the 12 had reactive indirect fluorescent antibody and microneutralization assay titers. Undertaking clinical trials of convalescent plasma for passive immunotherapy of MERS-CoV infection may be feasible, but such trials would be challenging because of the small pool of potential donors with sufficiently high antibody titers. Alternative strategies to identify convalescent plasma donors with adequate antibody titers should be explored, including the sampling of serum from patients with more severe disease and sampling at earlier points during illness. Date A point or period of time associated with an event in the lifecycle of the resource 2016 Subject The topic of the resource Middle East respiratory syndrome coronavirus, MERS-CoV, Middle East respiratory syndrome, intensive care, convalescent plasma, high-titer convalescent plasma Identifier An unambiguous reference to the resource within a given context DOI: 10.3201/eid2209.151164 Source A related resource from which the described resource is derived Emerging Infectious Diseases Publisher An entity responsible for making the resource available Centers for Disease Control and Prevention Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Infectious and parasitic diseases, Medicine Language A language of the resource EN