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Identification of residues of SARS-CoV nsp1 that differentially affect inhibition of gene expression and antiviral signaling.
An epidemic of Severe Acute Respiratory Syndrome (SARS) led to the identification of an associated coronavirus, SARS-CoV. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which…
Position: 13071 (22 views)
Novel coronavirus and astrovirus in Delaware Bay shorebirds.
Wild birds are an important but to some extent under-studied reservoir for emerging pathogens. We used unbiased sequencing methods for virus discovery in shorebird samples from the Delaware Bay, USA; an important feeding ground for thousands of…
Position: 14096 (21 views)
Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication.
HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune…
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Viral etiology of influenza-like illnesses in Antananarivo, Madagascar, July 2008 to June 2009.
In Madagascar, despite an influenza surveillance established since 1978, little is known about the etiology and prevalence of viruses other than influenza causing influenza-like illnesses (ILIs).From July 2008 to June 2009, we collected respiratory…
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Sampling for global epidemic models and the topology of an international airport network.
Mathematical models that describe the global spread of infectious diseases such as influenza, severe acute respiratory syndrome (SARS), and tuberculosis (TB) often consider a sample of international airports as a network supporting disease spread.…
Position: 15157 (20 views)
Intrapopulation Variability of Cladocerans (Cladocera, Daphniiformes) in Lake Baikal
In lake Baikal (Eastern Siberia, Russia) cladocerans play an important role in the zooplankton of bays and coastal shallows. Populations of D. galeata Sars, 1863 and D. hyalina Leydig, 1860 are characterized by high local variability of size-age…
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Etiology and clinical characterization of respiratory virus infections in adult patients attending an emergency department in Beijing.
BACKGROUND: Acute respiratory tract infections (ARTIs) represent a serious global health burden. To date, few reports have addressed the prevalence of respiratory viruses (RVs) in adults with ARTIs attending an emergency department (ED). Therefore,…
Position: 4327 (37 views)
SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.
BACKGROUND: 9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal…
Position: 15157 (20 views)
Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases.
The outbreaks of emerging infectious diseases caused by pathogens such as SARS coronavirus, H5N1, H1N1, and recently H7N9 influenza viruses, have been associated with significant mortality and morbidity in humans. Neutralizing antibodies from…
Position: 12096 (23 views)
Viral etiologies of hospitalized acute lower respiratory infection patients in China, 2009-2013.
BACKGROUND: Acute lower respiratory infections (ALRIs) are an important cause of acute illnesses and mortality worldwide and in China. However, a large-scale study on the prevalence of viral infections across multiple provinces and seasons has not…
Position: 2957 (44 views)