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                <text>Soheil Ebrahimpour, Jila Masrour-Roudsari, Zeinab Mohseni Afshar, Mostafa Javanian, VeneelaKrishna Rekha Vasigala, Arefeh Babazadeh</text>
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                <text>In December 2019, a new virus called coronavirus disease 2019 (COVID-19) causing severe acute respiratory syndrome emerged in Wuhan, China, and rapidly spread to other areas of China and other regions of the world. Since it was a discovery, COVID-19 has spread to several countries and to this date, affecting about 2,329,651 people and caused about 160,721 deaths. Since most COVID-19 infected cases were diagnosed with pneumonia and characteristic chest computed tomography (CT) scan patterns, radiological examinations have become an important tool in early diagnosis. Nowadays, CT findings combined with normal blood cells (WBCs), lymphopenia and a history of epidemiological exposure have been used as criteria for clinical diagnosis of COVID-19. It is noteworthy that reverse transcription polymerase chain reaction (RT-PCR) test is still gold standard for the diagnosis. This review focuses on role of chest CT in the clinical evaluation of disease progression and more accurate diagnosis.</text>
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                <text>2020</text>
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                <text>covid-19, ground glass opacities, reverse transcription polymerase chain reaction (RT-PCR), chest computed tomography (ct) scan</text>
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                <text>Caspian Journal of Internal Medicine</text>
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            <name>Publisher</name>
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                <text>Babol University of Medical Sciences</text>
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                <text>Internal medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Vitamin D and SARS-CoV-2 infection-evolution of evidence supporting clinical practice and policy development : A position statement from the Covit-D Consortium.</text>
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                <text>Daniel M McCartney, Paula M O'Shea, John L Faul, Martin J Healy, Greg Byrne, Tomás P Griffin, James Bernard Walsh, Declan G Byrne, Rose Anne Kenny</text>
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                <text>10.1007/s11845-020-02427-9</text>
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            <name>Source</name>
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              <elementText elementTextId="70787">
                <text>Irish journal of medical science</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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          <element elementId="50">
            <name>Title</name>
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                <text>Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?</text>
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                <text>Alexandra E. Butler, Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin</text>
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                <text>BackgroundWomen with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the inflammation underlying pulmonary disease in COVID-19. We sought to determine if basal macrophage activation, as a risk factor for COVID-19 infection, was present in PCOS and, if so, was further enhanced by vitamin D deficiency.MethodsA cross-sectional study in 99 PCOS and 68 control women who presented sequentially. Plasma levels of a macrophage-derived cytokine panel were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement. Vitamin D was measured by tandem mass spectroscopy.ResultsVitamin D was lower in PCOS women (p&amp;lt;0.0001) and correlated negatively with body mass index (BMI) in PCOS (r=0.28, p=0.0046). Basal macrophage activation markers CXCL5, CD163 and MMP9 were elevated, whilst protective CD200 was decreased (p&amp;lt;0.05); changes in these variables were related to, and fully accounted for, by BMI. PCOS and control women were then stratified according to vitamin D concentration. Vitamin D deficiency was associated with decreased CD80 and IFN-γ in PCOS and IL-12 in both groups (p&amp;lt;0.05). These factors, important in initiating and maintaining the immune response, were again accounted for by BMI.ConclusionBasal macrophage activation was higher in PCOS with macrophage changes related with increased infection risk associating with vitamin D; all changes were BMI dependent, suggesting that obese PCOS with vitamin D deficiency may be at greater risk of more severe COVID-19 infection, but that it is obesity-related rather than an independent PCOS factor.</text>
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                <text>2021</text>
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                <text>Cytokines, macrophage, vitamin D, polycystic ovary disease, COVID-19 risk factors</text>
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                <text>10.3389/fendo.2021.638621</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Diseases of the endocrine glands. Clinical endocrinology</text>
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                <text>Asuman Celikbilek</text>
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                <text>10.1002/jmv.26920</text>
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                <text>Journal of medical virology</text>
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                <text>Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37</text>
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                <text>Mardi A. Crane-Godreau, Steven Fiering, Peter Payne, Kathleen J. Clem</text>
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                <text>Vitamin D deficiency and insufficiency (VDD) are widely recognized as risk factors for respiratory tract infections. Vitamin D influences expression of many genes with well-established relevance to airway infections and relevant to immune system function. Recently, VDD has been shown to be a risk factor for acquisition and severity of COVID-19. Thus, treating VDD presents a safe and inexpensive opportunity for modulating the severity of the disease. VDD is common in those over 60 years of age, many with co-morbid conditions and in people with skin pigmentation sufficient to reduce synthesis of vitamin D. Exposure to fine particulate air pollution is also associated with worse outcomes from COVID19. Vitamin D stimulates transcription of cathelicidin which is cleaved to generate LL37. LL37 is an innate antimicrobial with demonstrated activity against a wide range of microbes including envelope viruses. LL37 also modulates cytokine signaling at the site of infections. Fine particles in air pollution can interfere with LL37 destruction of viruses and may reduce effective immune signaling modulation by LL37. While vitamin D influences transcription of many immune related genes, the weakened antimicrobial response of those with VDD against SARS-CoV-2 may be in part due to reduced LL37.Conclusion: Vitamin D plays an important role reducing the impact of viral lung disease processes. VDD is an acknowledged public health threat that warrants population-wide action to reduce COVID-19 morbidity and mortality. While vitamin D influences transcription of many immune related genes, the weakened antimicrobial response of those with VDD against SARS-CoV-2 may be in part due to reduced LL37. Action is needed to address COVID-19 associated risks of air pollution from industry, transportation, domestic sources and from primary and second hand tobacco smoke.</text>
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                <text>2020</text>
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                <text>air pollution, Vitamin D deficiency, carbon nanoparticles, cathelicidin (LL-37), COVID-19, citrullination of peptide</text>
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                <text>DOI: 10.3389/fpubh.2020.00232</text>
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                <text>Frontiers in Public Health</text>
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                <text>Frontiers Media S.A.</text>
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                <text>Public aspects of medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Vitamin D deficiency correlates with a reduced number of natural killer cells in intensive care unit (ICU) and non-ICU patients with COVID-19 pneumonia.</text>
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              <elementText elementTextId="71868">
                <text>Alice G Vassiliou, Edison Jahaj, Maria Pratikaki, Chrysi Keskinidou, Maria Detsika, Eirini Grigoriou, Katherina Psarra, Stylianos E Orfanos, Alexandra Tsirogianni, Ioanna Dimopoulou, Anastasia Kotanidou</text>
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                <text>covid-19, vitamin D, natural killer cells</text>
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                <text>10.1016/j.hjc.2020.11.011</text>
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            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="71872">
                <text>Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Vitamin D Deficiency Rickets and COVID-19 Pandemic</text>
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            <name>Creator</name>
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            <elementTextContainer>
              <elementText elementTextId="79105">
                <text>Guwani Liyanage, Yashica de Silva</text>
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            <description>An account of the resource</description>
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                <text>In a breastfed infant, the main source of vitamin D comes from the mother. Thus, maternal vitamin D deficiency is the key reason for vitamin D deficiency (VDD) and rickets during infancy. As they grow older, inadequate sun exposure, diet and lack of supplements also contribute. Individuals with darker skin require at least three to five times longer exposure to the sun than a person with lighter skin to produce adequate endogenous vitamin D. Not many food items naturally contain vitamin D; most of those are less affordable to the poor. We report an 18-month-old child with vitamin D deficiency rickets during strict self-isolation measures during the coronavirus disease 2019 (COVID-19) pandemic. Prolonged periods of confining indoors, low dietary intake of vitamin D, economic distress, maternal deficiency, and nonsupplementation could have contributed to vitamin D deficiency rickets in this child. During an unprecedented pandemic of this nature, simple sun exposure and diet advice may suffice for most. This case report highlights the importance of strengthening individuals and communities with information and formulating strong public health policies to prevent vitamin D deficiency.</text>
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                <text>2021</text>
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              <elementText elementTextId="79108">
                <text>10.1155/2021/5512668</text>
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                <text>Case Reports in Pediatrics</text>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="79110">
                <text>Hindawi Limited</text>
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                <text>Pediatrics</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?</text>
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              <elementText elementTextId="49198">
                <text>Hermann Brenner, Bernd Holleczek, Ben Schöttker</text>
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            <description>An account of the resource</description>
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                <text>The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D3 supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30–50 and</text>
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                <text>respiratory disease, mortality, covid-19, vitamin D</text>
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                <text>10.3390/nu12082488</text>
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                <text>Biotemas</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>Nutrition. Foods and food supply</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>Vitamin D status and seroconversion for COVID-19 in UK healthcare workers.</text>
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                <text>David R. Thickett, Adrian M Shields, Aduragbemi A Faniyi, Sebastian T Lugg, Sian E Faustini, Craig Webster, Joanne E Duffy, Martin Hewison, Peter Nightingale, Alex G Richter</text>
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                <text>10.1183/13993003.04234-2020</text>
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                <text>The European respiratory journal</text>
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