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                  <text>Dominio científico: Coronavirus</text>
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                <text>What Does Plant-Based Vaccine Technology Offer to the Fight against COVID-19?</text>
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                <text>Sergio Rosales-Mendoza, Verónica  A. Márquez-Escobar, Omar González-Ortega, Ricardo Nieto-Gómez, Jaime  I. Arévalo-Villalobos</text>
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                <text>The emergence of new pathogenic viral strains is a constant threat to global health, with the new coronavirus strain COVID-19 as the latest example. COVID-19, caused by the SARS-CoV-2 virus has quickly spread around the globe. This pandemic demands rapid development of drugs and vaccines. Plant-based vaccines are a technology with proven viability, which have led to promising results for candidates evaluated at the clinical level, meaning this technology could contribute towards the fight against COVID-19. Herein, a perspective in how plant-based vaccines can be developed against COVID-19 is presented. Injectable vaccines could be generated by using transient expression systems, which offer the highest protein yields and are already adopted at the industrial level to produce VLPs-vaccines and other biopharmaceuticals under GMPC-processes. Stably-transformed plants are another option, but this approach requires more time for the development of antigen-producing lines. Nonetheless, this approach offers the possibility of developing oral vaccines in which the plant cell could act as the antigen delivery agent. Therefore, this is the most attractive approach in terms of cost, easy delivery, and mucosal immunity induction. The development of multiepitope, rationally-designed vaccines is also discussed regarding the experience gained in expression of chimeric immunogenic proteins in plant systems.</text>
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                <text>2020</text>
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                <text>Multi-epitope Vaccine, Zoonosis, epitope-based vaccine, Molecular Farming, mucosal immunization, Oral vaccines</text>
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                <text>10.3390/vaccines8020183</text>
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                <text>Epidemiology and Health</text>
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            <description>An entity responsible for making the resource available</description>
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                <text>Korean Society of Epidemiology</text>
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                <text>Medicine</text>
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              <description>An account of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>What does the COVID-19 pandemic mean for HIV, tuberculosis, and malaria control?</text>
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                <text>Ben Lambert, Floriano Amimo, Anthony Magit</text>
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                <text>Abstract Despite its current relatively low global share of cases and deaths in Africa compared to other regions, coronavirus disease 2019 (COVID-19) has the potential to trigger other larger crises in the region. This is due to the vulnerability of health and economic systems, coupled with the high burden of human immunodeficiency virus (HIV), tuberculosis (TB), and malaria. Here we examine the potential implications of COVID-19 on the control of these major epidemic diseases in Africa. We use current evidence on disease burden of HIV, TB, and malaria, and epidemic dynamics of COVID-19 in Africa, retrieved from the literature. Our analysis shows that the current measures to control COVID-19 neglect important and complex context-specific epidemiological, social, and economic realities in Africa. There is a similarity of clinical features of TB and malaria, with those used to track COVID-19 cases. This coupled with institutional mistrust and misinformation might result in many patients with clinical features similar to those of COVID-19 being hesitant to voluntarily seek care in a formal health facility. Furthermore, most people in productive age in Africa work in the informal sector, and most of those in the formal sector are underemployed. With the current measures to control COVID-19, these populations might face unprecedented difficulties to access essential services, mainly due to reduced ability of patients to support direct and indirect medical costs, and unavailability of transportation means to reach health facilities. Therefore, if not accompanied with appropriate economic and epidemiological considerations, we anticipate that these measures might result in unprecedented difficulties among vulnerable segments of society to access essential services, including antiretroviral and prophylactic drugs among people living with HIV and Acquired Immune Deficiency Syndrome, anti-tuberculosis drugs, and curative and preventive treatments for malaria among pregnant women and children. This might increase the propensity of patients taking substandard doses and/or medicines, which has the potential to compromise drug efficacy, and worsen health inequalities in the region. COVID-19 responses at country level should include measures to protect vulnerable and under-served segments of society.</text>
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                <text>2020</text>
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                <text>HIV, Tuberculosis, Malária, Africa, health systems, COVID-19</text>
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                <text>DOI: 10.1186/s41182-020-00219-6</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Tropical Medicine and Health</text>
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                <text>BMC</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Arctic medicine. Tropical medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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            <description>A name given to the resource</description>
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                <text>What does the future hold?</text>
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                <text>Fernando Peixoto Ferraz de Campos</text>
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            <description>An account of the resource</description>
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                <text>Since ancient times the knowledge of the human body and physiologic theories were obtained secretly, against the laws of the Catholic Church, through exhumation followed by anatomic dissection of newly buried persons. From those times, the importance of post-mortem study for the advance of medical knowledge was noted. In this context, the nineteenth century saw the heyday of the autopsy. Since then, autopsy has been responsible for the progression of clinical medicine, medical education, epidemiology, and public health. From the 1950s up until 1990, 87 diseases were identified by autopsy. The discovery of severe acute respiratory syndrome (SARS) epidemic in 2003 and the avian flu epidemic in 2006 were through autopsy as well.</text>
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                <text>2012</text>
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                <text>DOI: 10.4322/acr.%y.26080</text>
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            <description>A related resource from which the described resource is derived</description>
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                <text>Autopsy and Case Reports</text>
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                <text>University of São Paulo</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Internal medicine, Medicine</text>
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            <description>A language of the resource</description>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>What ecological factors shape species-area curves in neutral models?</text>
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                <text>Massimo Cencini, Simone Pigolotti, Miguel A. Muñoz</text>
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                <text>Understanding factors that shape biodiversity and species coexistence across scales is of utmost importance in ecology, both theoretically and for conservation policies. Species-area relationships (SARs), measuring how the number of observed species increases upon enlarging the sampled area, constitute a convenient tool for quantifying the spatial structure of biodiversity. While general features of species-area curves are quite universal across ecosystems, some quantitative aspects can change significantly. Several attempts have been made to link these variations to ecological forces. Within the framework of spatially explicit neutral models, here we scrutinize the effect of varying the local population size (i.e. the number of individuals per site) and the level of habitat saturation (allowing for empty sites). We conclude that species-area curves become shallower when the local population size increases, while habitat saturation, unless strongly violated, plays a marginal role. Our findings provide a plausible explanation of why SARs for microorganisms are flatter than those for larger organisms.</text>
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                <text>DOI: 10.1371/journal.pone.0038232</text>
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                <text>PLoS ONE</text>
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                  <text>Dominio científico: Coronavirus</text>
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                <text>What further should be done to control COVID-19 outbreaks in addition to cases isolation and contact tracing measures?</text>
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                <text>Zhenjian He</text>
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                <text>Emily  Ying Yang Chan, Eugene Siu Kai Lo, Zhe Huang, Kevin Kei Ching Hung, Eliza Lai Yi Wong, Samuel Yeung Shan Wong, Jean  Hee Kim, Heidi Hung, Eric  Kam Pui Lee, Martin  Chi Sang Wong</text>
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                <text>People with existing non-communicable diseases (NCDs) are particularly vulnerable to health risks brought upon by emergencies and disasters, yet limited research has been conducted on disease management and the implications of Health-EDRM policies that address health vulnerabilities of people with NCDs during the COVID-19 pandemic. This paper reports the baseline findings of an anonymous, random, population-based, 6-month cohort study that aimed to examine the experiences of people with NCDs and their relevant self-care patterns during the COVID-19 pandemic. A total of 765 telephone interviews were completed from 22nd March to 1st April 2020 in Hong Kong, China. The dataset was representative of the population, with 18.4% of subjects reporting at least one NCD. Results showed that low household income and residence in government-subsidized housing were significant predictors for the subjects who experienced difficulty in managing during first 2 months of the pandemic (11% of the NCD patients). Of those on long-term NCD medication, 10% reported having less than one week’s supply of medication. Targeted services for vulnerable groups during a pandemic should be explored to support NCD self-care.</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>What Happens after the COVID-19 Crisis: Managing “Patient Surge” in Academic Breast Imaging Division</text>
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                <text>The first case of coronavirus disease 2019 (COVID-19) in the Kingdom of Saudi Arabia was reported in the Eastern Province (Qatif City) on March 2, 2020 (Saudi Arabia Ministry of Health, https://www.moh.gov.sa/Pages/Default.aspx). Since then, a cluster of cases continued to expand and spread throughout the kingdom. Several procedures were implemented to contain the pandemic. By May 8, 2020, the Saudi Center for Disease Prevention and Control had reported a total of 35,432 cases (https://covid19.cdc.gov.sa/daily-updates/). As of this writing, the projected peak of cases in Saudi Arabia occurred from April 24 to May 10, 2020. “Bending of the curve” will extend this curve to June and July, with a theoretically ending date of September 10, 2020 (Predictive Monitoring of COVID-19 developed by SUTD Data-Driven Innovation Lab, https://ddi.sutd.edu.sg). However, social distancing practices will remain in force until mid-2021 (Ferguson et al., Imperial College London, https://spiral.imperial.ac.uk:8443/handle/10044/1/77482). This pandemic affected every aspect of people’s lives with a significant impact on medical education and healthcare services, including breast imaging. In this article, the author lists some of the possible solutions for problems relating to patient surge once stay-at-home orders are relaxed.</text>
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                <text>covid-19, patient surge, screening mammography, abbreviated breast MRI, breast imaging preparedness</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>What Has Been the Impact of Covid-19 on Safety Culture? A Case Study from a Large Metropolitan Healthcare Trust</text>
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                <text>Max Denning, Ee  Teng Goh, Alasdair Scott, Guy Martin, Sheraz Markar, Kelsey Flott, Sam Mason, Jan Przybylowicz, Melanie Almonte, Jonathan Clarke, Jasmine Winter Beatty, Swathikan Chidambaram, Seema Yalamanchili, Benjamin  Yong-Qiang Tan, Abhiram Kanneganti, Viknesh Sounderajah, Mary Wells, Sanjay Purkayastha, James Kinross</text>
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                <text>Covid-19 has placed an unprecedented demand on healthcare systems worldwide. A positive safety culture is associated with improved patient safety and, in turn, with patient outcomes. To date, no study has evaluated the impact of Covid-19 on safety culture. The Safety Attitudes Questionnaire (SAQ) was used to investigate safety culture at a large UK healthcare trust during Covid-19. Findings were compared with baseline data from 2017. Incident reporting from the year preceding the pandemic was also examined. SAQ scores of doctors and “other clinical staff”, were relatively higher than the nursing group. During Covid-19, on univariate regression analysis, female gender, age 40–49 years, non-White ethnicity, and nursing job role were all associated with lower SAQ scores. Training and support for redeployment were associated with higher SAQ scores. On multivariate analysis, non-disclosed gender (−0.13), non-disclosed ethnicity (−0.11), nursing role (−0.15), and support (0.29) persisted to a level of significance. A significant decrease (p &lt; 0.003) was seen in error reporting after the onset of the Covid-19 pandemic. This is the first study to investigate SAQ during Covid-19. Differences in SAQ scores were observed during Covid-19 between professional groups when compared to baseline. Reductions in incident reporting were also seen. These changes may reflect perception of risk, changes in volume or nature of work. High-quality support for redeployed staff may be associated with improved safety perception during future pandemics.</text>
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                <text>Nature reviews. Immunology</text>
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                <text>Daniela Cruz Delgado, Zeltzin Rocillo-Aquino, Fernando Cervantes-Escoto, Juan Antonio Leos-Rodríguez, Angélica Espinoza-Ortega</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="209482">
                <text>Abstract The purpose was to specify the concept of traditional food and the dimensions that make it up, identifying: definitions, authors and research projects; as well as to determine what is known and possible topics for future research. A literature review of traditional foods was conducted that examined the conceptual development of the term. Social network analysis (SNA) was also used to identify the most relevant definitions and working groups on the topic. Twenty-three definitions were identified in the period 1995–2019. It reveals the difficulty of establishing one that encompasses such a dynamic concept. Although there is variability in the specific characteristics of these foods, four dimensions have been established: time, place, know-how, and cultural meaning. It was found that their main characteristic is the transmission of knowledge and raw materials between generations. The conceptualization of the term has been developed mainly in Europe, based on the perspective of consumers. New trends in research include the contrast and complementarity of innovation in traditional foods and the difference between these products and those named with similar attributes such as typical, regional, ethnic, local, among others. Social network analysis (SNA) was used to study the definitions of a concept, something that had not been done with this approach. Suggestions are made for possible research on the subject, such as the conceptual delimitation of related terms and the compatibility between innovation and tradition.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="209483">
                <text>2021</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="209484">
                <text>Tradition, Typical foods, food heritage, local foods, social network analysis (SNA)</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="209485">
                <text>10.1186/s42779-021-00113-4</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="209486">
                <text>Journal of Ethnic Foods</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="209487">
                <text>BMC</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="209488">
                <text>Nutrition. Foods and food supply</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="209489">
                <text>&lt;a href="https://doi.org/10.1186/s42779-021-00113-4" target="_blank" rel="noreferrer noopener"&gt;https://doi.org/10.1186/s42779-021-00113-4&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
  </item>
</itemContainer>
