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Táticas cidadãs para ativação de áreas su- butilizadas: o caso das hortas comunitárias do Rio de Janeiro
Iniciativas comunitárias para transformação de espaços cotidianos “de baixo para cima” têm sido cada dia mais frequentes nas grandes cidades, respondendo, de maneira proativa, à incapacidade dos governos de lidar com os desafios urbanos urgentes, por…
Position: 1288 (57 views)
Tasa de infección de la pudrición del tallo en maíz causada por Fusarium moniliforme
Tasa de infección de la pudrición del tallo en maíz causada por Fusarium moniliforme. El objetivo de éste trabajo fue determinar la resistencia horizontal de 134 líneas S1 de maíz al hongo Fusarium moniliforme. La enfermedad fue inducida mediante…
Position: 7999 (28 views)
Tasa de descuento ambiental Gamma: una aplicación para Colombia
Este artículo tiene como objetivo central describir y aplicar una metodología para estimar la tasa de descuento en proyectos de largo plazo para Colombia, como son los proyectos relacionados con la conservación ambiental y el cambio climático global.…
Position: 3409 (41 views)
Tártago asociado a cultivos anuales: una opción para la agricultura familiar
El tártago por sus características agroecológicas se adapta a la agricultura familiar. Para evaluar la factibilidad de la asociación de tártago con cultivos anuales se instaló un experimento con diseño en bloques completos al azar, con siete…
Position: 2913 (44 views)
Targeting the NLRP3 Inflammasome in Severe COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive-sense RNA virus. Since December of 2019, a global expansion of the…
Position: 7346 (29 views)
Targeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 Patients
In December 2019, following a cluster of pneumonia cases in China caused by a novel coronavirus (CoV), named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the infection disseminated worldwide and, on March 11th, 2020, the World Health…
Position: 16982 (18 views)
Targeting the Immune System for Pulmonary Inflammation and Cardiovascular Complications in COVID-19 Patients
In December 2019, following a cluster of pneumonia cases in China caused by a novel coronavirus (CoV), named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the infection disseminated worldwide and, on March 11th, 2020, the World Health…
Position: 6807 (30 views)
Targeting protein-protein interaction interfaces in COVID-19 drug discovery.
To date, the COVID-19 pandemic has claimed over 1 million human lives, infected another 50 million individuals and wreaked havoc on the global economy. The crisis has spurred the ongoing development of drugs targeting its etiological agent, the…
Position: 13021 (22 views)
Targeting N-Glycan Cryptic Sugar Moieties for Broad-Spectrum Virus Neutralization: Progress in Identifying Conserved Molecular Targets in Viruses of Distinct Phylogenetic Origins
Identifying molecular targets for eliciting broadly virus-neutralizing antibodies is one of the key steps toward development of vaccines against emerging viral pathogens. Owing to genomic and somatic diversities among viral species, identifying…
Position: 10210 (25 views)
Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus.
Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse compounds for anti-human coronavirus 229E activity and identified an inhibitor, designated…
Position: 9424 (26 views)