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Targeting Highly Structured RNA by Cooperative Action of siRNAs and Helper Antisense Oligomers in Living Cells.
RNA target accessibility is one of the most important factors limiting the efficiency of RNA interference-mediated RNA degradation. However, targeting RNA viruses in their poorly accessible, highly structured regions can be advantageous because these…
Position: 3842 (39 views)
Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab
Recently, the stabilization of the endothelium has been explicitly identified as a therapeutic goal in coronavirus disease 2019 (COVID-19). Adrecizumab is a first-in-class humanized monoclonal anti-Adrenomedullin (anti-ADM) antibody, targeting the…
Position: 13049 (22 views)
Targeting Coronaviral Replication and Cellular JAK2 Mediated Dominant NF-κB Activation for Comprehensive and Ultimate Inhibition of Coronaviral Activity
Abstract Tylophorine-based compounds exert broad spectral, potent inhibition of coronaviruses. NF-κB activation is a common pro-inflammatory response of host cells to viral infection. The aims of this study were to (i) find an effective combination…
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Targeting coagulation activation in severe COVID-19 pneumonia: lessons from bacterial pneumonia and sepsis
Novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has rapidly spread throughout the world, resulting in a pandemic with high mortality. There are no effective treatments for the…
Position: 16093 (19 views)
Tarea Vida. Su integración al Trabajo Científico Estudiantil desde la asignatura Metodología de la Investigación Educativa
Fundamento: La Tarea Vida es una propuesta integral del Estado Cubano para el enfrentamiento al cambio climático, en esta juegan un papel fundamental estrategias específicas del Trabajo Científico Estudiantil, sin embargo, es necesario establecer…
Position: 3646 (40 views)
Tantangan Penatalaksanaan STEMI di Pandemi Covid-19
The necessity of timely management of ST-elevation myocardial infarction (STEMI) is now disrupted by the Covid-19 pandemic. This paper discussed the challenge to manage STEMI in Indonesia due to Covid-19. It also discussed the alternative strategies…
Position: 20121 (13 views)
Tamoxifen from chemotherapy to antiviral drug: Possible activity against COVID-19
Tamoxifen (TAM) is the oldest and the most-prescribed selective estrogen receptor modulator (SERM). It is a member of the triphenylethylene group. TAM has been used to treat breast cancer that spreads to other parts of the human body; it is also…
Position: 683 (68 views)
TAMAÑO Y ESTRUCTURA POBLACIONAL DE LA TORTUGA SABALETERA (RHINOCLEMMYS NASUTA, TESTUDINES: GEOEMYDIDAE) EN UN AMBIENTE INSULAR DEL PACIFICO COLOMBIANO
Rhinoclemmys nasuta (Boulenger 1902) es una especie endémica que se encuentra registrada en el libro rojo de los reptiles de Colombia y está catalogada como casi amenazada a nivel mundial. Esta especie, de tamaño mediano, habita…
Position: 3101 (43 views)
Tamaño relativo encefálico e índices cerebrales en Vanellus c. chilensis (Aves: Charadriidae) Relative encephalic size and cerebral indices of Vanellus c. chilensis (Aves: Charadriidae
Se analizó la composición cuantitativa encefálica y se estimaron índices cerebrales en Vanellus c. chilensis (tero o queltehue). Se estimó el volumen porcentual e índices cerebrales del encéfalo total y de siete de sus componentes, como así también…
Position: 10241 (25 views)
Tamaño corporal, tolerancia ecológica y potencial de bioindicación de la calidad del agua de Anacroneuria spp. (Plecoptera: Perlidae) en América del Sur
El conocimiento sobre la biología y la ecología de los organismos acuáticos neotropicales es de gran importancia para evaluar reglas ecológicas generales y para establecer un sistema de protección de los recursos acuáticos. Basado principalmente…
Position: 18617 (16 views)