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                <text>Bo Zhao, Fanlei Kong, Myo  Nyein Aung, Motoyuki Yuasa, Eun  Woo Nam</text>
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                <text>This study assessed university students’ knowledge and precaution practices of Novel Coronavirus (COVID-19) in South Korea, China, and Japan, and investigated their depressive states during the pandemic. This cross-sectional survey collected data from 821 respondents, using an anonymous online questionnaire designed by the Yonsei Global Health Center, from 23 March to 20 April 2020, which included socio-demographic questions, knowledge and perceptions of COVID-19, preventative practices, and the Patient Health Questionnaire-9 (PHQ-9) scale to assess mental health. High proportions of respondents showed good knowledge of the transmission pathways and information related to COVID-19. Contact history as well as concerns about family members and the disease showed statistically significant distinctions by nationality and gender. On the whole, all participants reported good levels of preventative practices. The Chinese group reported the highest preventative practice scores; and females scored higher than males. Moreover, the Japanese group showed the most severe depressive states; overall, females experienced more severe depression than males. Thus, authorities should especially emphasize the importance of COVID-19 precautions to males. Educational departments and health authorities should observe the mental health of university adults during the pandemic and plan interventions to improve it.</text>
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                <text>A Case of Coronavirus Disease 2019 With Concomitant Acute Cerebral Infarction and Deep Vein Thrombosis</text>
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                <text>Bo Zhou, Jianqing She, Yadan Wang, Xiancang Ma</text>
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                <text>We report a case of a 75-year-old woman diagnosed with severe coronavirus disease 2019 (COVID-19) complicated by acute cerebral infarction. The patient was admitted to our hospital on 5 February 2020 with severe COVID-19. On 20 February 2020, she was diagnosed with concomitant acute cerebral infarction via head computed tomography (CT) and deep vein thrombosis in both lower limbs. After symptomatic and supportive treatments, the patient was discharged on 13 March 2020. She will comply with quarantine for another 2 weeks and receive rehabilitation training from a specialist doctor. Cerebral infarction should be considered and promptly managed in patients with COVID-19.</text>
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                <text>DOI: 10.3389/fneur.2020.00296</text>
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                <text>Frontiers in Neurology</text>
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                <text>Neurology. Diseases of the nervous system</text>
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                <text>Bo-Jian Zheng, Yi Guan, Ka Hing Wong, Jie Zhou, Kin Ling Wong, Betty Wan Y. Young, Liwei Lu, Shui Shan Lee</text>
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                <text>Using immunofluorescence and neutralization assays, we detected antibodies to human severe acute respiratory syndrome–associated coronavirus (SARS-CoV) and/or animal SARS-CoV–like virus in 17 (1.8%) of 938 adults recruited in 2001. This finding suggests that a small proportion of healthy persons in Hong Kong had been exposed to SARS-related viruses at least 2 years before the recent SARS outbreak.</text>
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                <text>DOI: 10.3201/eid1002.030533</text>
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                <text>Bo-Lin Ho, Shu-Chun Cheng, Lin SHI, Tingyun Wang, Kuan I Ho, Chi-Yuan Chou</text>
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                <text>A highly pathogenic human coronavirus (CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), has emerged in Jeddah and other places in Saudi Arabia, and has quickly spread to European and Asian countries since September 2012. Up to the 1st October 2015 it has infected at least 1593 people with a global fatality rate of about 35%. Studies to understand the virus are necessary and urgent. In the present study, MERS-CoV main protease (Mpro) is expressed; the dimerization of the protein and its relationship to catalysis are investigated.The crystal structure of MERS-CoV Mpro indicates that it shares a similar scaffold to that of other coronaviral Mpro and consists of chymotrypsin-like domains I and II and a helical domain III of five helices. Analytical ultracentrifugation analysis demonstrated that MERS-CoV Mpro undergoes a monomer to dimer conversion in the presence of a peptide substrate. Glu169 is a key residue and plays a dual role in both dimerization and catalysis. The mutagenesis of other residues found on the dimerization interface indicate that dimerization of MERS-CoV Mpro is required for its catalytic activity. One mutation, M298R, resulted in a stable dimer with a higher level of proteolytic activity than the wild-type enzyme.MERS-CoV Mpro shows substrate-induced dimerization and potent proteolytic activity. A critical assessment of the residues important to these processes provides insights into the correlation between dimerization and catalysis within the coronaviral Mpro family.</text>
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                <text>DOI: 10.1371/journal.pone.0144865</text>
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                <text>PLoS ONE</text>
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                <text>Trends in cardiovascular medicine</text>
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                <text>Fear and Stigma: The Epidemic within the SARS Outbreak</text>
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                <text>Bobbie Person, Julia Smith, Marian McDonald, Arthur Liang, Meredith Hickson, Deborah Gould, Francisco Sy, Kelly Holton, Barbara Govert, Brenda Garza, Cecilia Meijer, Liza Veto, Walter Williams, Laura Zauderer</text>
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                <text>Because of their evolving nature and inherent scientific uncertainties, outbreaks of emerging infectious diseases can be associated with considerable fear in the general public or in specific communities, especially when illness and deaths are substantial. Mitigating fear and discrimination directed toward persons infected with, and affected by, infectious disease can be important in controlling transmission. Persons who are feared and stigmatized may delay seeking care and remain in the community undetected. This article outlines efforts to rapidly assess, monitor, and address fears associated with the 2003 severe acute respiratory syndrome (SARS) epidemic in the United States. Although fear, stigmatization, and discrimination were not widespread in the general public, Asian-American communities were particularly affected.</text>
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                <text>discrimination, Fear, health education, community outreach), hotlines, Asian Americans</text>
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                <text>DOI: 10.3201/eid1002.030750</text>
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                <text>Emerging Infectious Diseases</text>
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                <text>Infectious and parasitic diseases, Medicine</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
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                <text>Navigation atlantique de trois galères castillanes au début du XVe siècle d’après &lt;em&gt;Le Victorial&lt;/em&gt; : de la chronique chevaleresque à l’histoire maritime</text>
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              <elementText elementTextId="11744">
                <text>Bochaca, Michel, Aznar Vallejo, Eduardo</text>
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                <text>Beyond the chivalrous figure of Pero Niño and its military exploits during the naval operations conducted in the Bay of Biscay and English Channel in 1405 and 1406, the Victorial provides interesting information on the navigation of three Castilian galleys sent by Henry III to honour the military agreements with France. The cross-checking of these dispersed and fragmentary data allows to reconstruct a part of the universe in which ships and crews are evolving in the late Middle Ages and which usually escapes the historian for lack of writings left by the sailors crossing the seas of Ponant.[fr] Au-delà de la figure chevaleresque de Pero Niño et de ses faits d’armes lors des opérations navales conduites dans le golfe de Gascogne et en Manche en 1405 et 1406, Le Victorial livre des informations sur la navigation des trois galères castillanes envoyées par Henri III pour honorer les accords militaires avec la France. Le recoupement de ces données éparses et fragmentaires permet de reconstituer une partie de l’univers maritime dans lequel navires et équipages évoluent à la fin du Moyen Âge et qui échappe habituellement à l’historien faute d’écrits laissés par les gens de mer sillonnant les mers du Ponant.</text>
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            <name>Date</name>
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                <text>2014</text>
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            <description>The topic of the resource</description>
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                <text>galley, Shipping, Atlantic, Late Middle Ages, galère, Navigation, atlantique, bas Moyen Âge</text>
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            <name>Identifier</name>
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                <text>DOI: </text>
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              <elementText elementTextId="11749">
                <text>Anuario de Estudios Medievales</text>
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            <name>Publisher</name>
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              <elementText elementTextId="11750">
                <text>Consejo Superior de Investigaciones Científicas</text>
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            </elementTextContainer>
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            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Medieval history</text>
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            <description>A language of the resource</description>
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              <elementText elementTextId="11752">
                <text>CA, EN, ES, FR, IT, PT</text>
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              <name>Title</name>
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                  <text>Coronavirus</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                <elementText elementTextId="2">
                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>Cerebral Regional Homogeneity Alternation of Pregnant Women With Antenatal Depression During the Pandemic</text>
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              <elementText elementTextId="59872">
                <text>Bochao Cheng, Yajing Meng, Yushan Zhou, Jinrong Li, Jianguang Zeng, Xi Tan, Kaiyou Zhang, Ya Luo, Yan Zhang</text>
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                <text>Purpose: The COVID-19 epidemic has been a threat to the health of people all over the world. Various precautions during COVID-19 in China have kept a large number of people in isolation, and this has inconvenienced and placed enormous stress on pregnant women. Pregnant women are more likely to suffer from antenatal depression (ANDP) with social isolation or low social support. This research aims to investigate the neurobiological mechanisms underlying ANDP, which impedes early detection and intervention in this disorder.Methods: A total of 43 singleton pregnant women who experienced isolation were recruited, including 21 treatment-naïve ANDP patients and 22 healthy pregnant women (HPW). To explore the intrinsic cerebral activity alternations in ANDP using resting-state functional MRI (rsfMRI), we assessed the local regional homogeneity (ReHo) differences in two groups using the voxel-based whole-brain analysis. The correlation between the regional functional abnormalities and clinical variables in ANDP patients was also examined.Results: Compared with HPW, ANDP patients showed decreased ReHo in the left dorsolateral prefrontal cortex, right insular and the cluster coving the right ventral temporal cortex (VTC), amygdala (AMG), and hippocampus (HIP). The Edinburgh Postnatal Depression Scale (EPDS) scores of ANDP patients negatively correlated with the ReHo in the right VTC, AMG, and HIP.Conclusion: Elucidating the neurobiological features of ANDP patients during COVID-19 is crucial for evolving adequate methods for early diagnosis, precaution, and intervention in a future epidemic.</text>
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                <text>covid-19, Social isolation, Pregnant Women, resting state fMRI, ReHo, Antenatal depression</text>
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                <text>10.3389/fpsyt.2021.627871</text>
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                <text>Epidemiology and Health</text>
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              <elementText elementTextId="59878">
                <text>Korean Society of Epidemiology</text>
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            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
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                <text>Psychiatry</text>
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                  <text>Dominio científico: Coronavirus</text>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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                <text>The role for the metagenome in the pathogenesis of COVID-19.</text>
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                <text>Bodduluri Haribabu, Robert P Friedland</text>
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                <text>10.1016/j.ebiom.2020.103019</text>
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                <text>EBioMedicine</text>
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                <text>Bogdan POPESCU, Șerban Vifor Gabriel BERTEȘTEANU, Răzvan SCĂUNAȘU, Cristian Bălălău, Irina Doinița Oașă, Maria Domuța, Felicia Manole, Alina Lavinia Antoaneta Oancea</text>
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                <text>Since the outbreak of the COVID-19 pandemic in December 2019 there has been an array have studies regarding otolaryngologist and head and neck surgeons considering the exceptionally high risk of exposure. The purpose of this article is to evaluate the current practice in an oncology ENT Department, which ensures health care services for upper aero digestive tract cancer patients. It is of outmost importance that all the health care providers are aware of good clinical practice recommendations and training, according to the current guidelines that needs to be performed as often as possible, so that the implementation of the institution specific guidelines to be optimal. Performing a tracheostomy for an ENT emergency in a patient with suspected or confirmed COVID-19 disease requires preparation from the health care provider so, after reviewing the international literature, we have elaborated a protocol and guidelines in Colțea Clinical Hospital to ensure the possibility of performing emergency surgical interventions for oncology patients. Testing for SARS-CoV-2 is mandatory prior to surgery since opening the trachea and operating on the upper respiratory tract leads to aerosol particles that can infect the surrounding environment and health care providers. Limitations are predictable as long as health care systems are being under tremendous pressure from the general condition and by patients with life threatening disease.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="25757">
                <text>2020</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="25758">
                <text>Surgery, aerosol, upper respiratory tract, COVID-19</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="25759">
                <text>DOI: 10.25083/2559.5555/5.1/34.38</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="25760">
                <text>Journal of Clinical and Investigative Surgery</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="25761">
                <text>Digital ProScholar Media</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="38">
            <name>Coverage</name>
            <description>The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant</description>
            <elementTextContainer>
              <elementText elementTextId="25762">
                <text>Medicine</text>
              </elementText>
            </elementTextContainer>
          </element>
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