261 10 20655 https://www.socictopen.socict.org/files/original/2208443f0d8c1a8504241541b4a0ea3f.pdf 1e309fa370f59455c60a13b2b6fbb395 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Awareness and perception of COVID-19 among the general population: A Middle Eastern survey. Creator An entity primarily responsible for making the resource Baraa Mafrachi, Ruba M Jaber, Abdallah Al-Ani, Mustafa Shkara Description An account of the resource Due to the sudden emergence of the novel coronavirus as a worldwide pandemic, this study aimed to evaluate the awareness and practices of both the Jordanian and Iraqi populations during the early stages of the pandemic. A cross-sectional survey was conducted between the 19th and 22nd of March to assess the public's awareness toward COVID-19. Multiple scored domains were used to assess the differences between the two populations. Statistical analysis was conducted to reveal the influence of sociodemographic variables on these scores. A total of 3167 participants were recruited in the study, of which, 1599 (50.5%) were from Jordan and 1568 (49.5%) were from Iraq. More than half of the Jordanian (56.8%) and Iraqi participants (53.2%) showed average or adequate awareness about COVID-19. More than 60% of both populations relied on medical staff for COVID-19 related information. Social media was the second most common COVID-19 information source, as it was reported by 53.7% of Jordanian participants and 62.8% of Iraqi participants. More than 90% of both populations participated in precautionary measurements. Finally, about 20% of both populations failed to recognize droplet inhalation as a source of transmission. Despite the portrayed awareness levels, governmental involvement is warranted to increase the public's awareness and fill the gaps within their knowledge. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Identifier An unambiguous reference to the resource within a given context 10.1371/journal.pone.0250461 Source A related resource from which the described resource is derived PloS one https://www.socictopen.socict.org/files/original/a5c7573bede333ed4730da071984481f.pdf 106dc5c6fed061261f74d03ba0ad893f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Awe/Gratitude as an Experiential Aspect of Spirituality and Its Association to Perceived Positive Changes During the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Arndt Büssing, Arndt Büssing, Daniela Rodrigues Recchia, Thomas Dienberg, Janusz Surzykiewicz, Janusz Surzykiewicz, Klaus Baumann Description An account of the resource Background: While the COVID-19 pandemic has affected the lives of almost all people worldwide, many people observed also positive changes in their attitudes and behaviors. This can be seen in the context of posttraumatic growth. These perceived changes refer to five main categories: Nature/Silence/Contemplation, Spirituality, Relationships, Reflection on life, and Digital media usage. A previous study with persons recruited in June 2020 directly after the lockdown in Germany showed that the best predictors of these perceived changes related to the Corona pandemic were the ability to mindfully stop and pause in distinct situations, to be “spellbound at the moment” and to become “quiet and devout,” indicating moments of wondering awe, with subsequent feelings of gratitude. Now, we intended to analyze (1) by whom and how strongly awe/gratitude was experienced during the COVID-19 pandemic, and (2) how these feelings relate to perceived changes and experienced burden, and (3) whether or not feelings of awe/gratitude contribute to participants' well-being or may buffer perceived burden in terms of a resilience factor.Methods: Online survey with standardized questionnaires [i.e., WHO-Five Well-being Index (WHO5), Life satisfaction (BMLSS), Awe/Gratitude scale (GrAw-7), and Perceived Changes Questionnaire (PCQ)] among 2,573 participants (68% women; mean age 48.7 ± 14.2 years, 74% with a Christian affiliation) from Germany recruited between June and November 2020.Results: Awe/Gratitude scored significantly higher particularly among women (Cohen's d = 0.40), older persons (d = 0.88), persons who rely on their faith as a “stronghold in difficult times” (d = 0.99), those with higher well-being (d = 0.70), and lower perceptions of loneliness (d = 0.49). With respect to perceived changes during the pandemic, more intense feelings of Awe/Gratitude were particularly related to Nature/Silence/Contemplation (r = 0.41), Spirituality (r = 0.41), and Relationships (r = 0.33). Regression analyses revealed that the best predictors of Awe/Gratitude (R2 = 0.40) were the frequency of meditation, female gender, life satisfaction and well-being, faith as a stronghold, and perceived burden and also life reflection, while Nature/Silence/Contemplation and Relationships had a further, but weaker, impact on Awe/Gratitude as a dependent variable. Awe/Gratitude was moderately associated with well-being (r = 0.32) and would predict 9% of participants' well-being variance. The best predictors of participants' well-being were multidimensional life satisfaction and low perceived burden (related to the pandemic), and further Awe/Gratitude and Nature/Silence/Contemplation; these would explain 47% of variance in well-being scores. However, Awe/Gratitude cannot be regarded as a buffer of the negative aspects of the COVID-19 pandemic, as it is only marginally (though negatively) related to perceived burden (r = −0.15). Mediation analysis showed that Awe/Gratitude mediates 42% of the link between well-being as a predictor on Nature/Silence/Contemplation as an outcome and has a direct effect of β = 0.15 (p &lt; 0.001) and an indirect effect of β = 0.11 (p &lt; 0.001). Further, Awe/Gratitude mediates 38% (p &lt; 0.001) of the link between Nature/Silence/Contemplation as a predictor on well-being as the outcome; the direct effect is β = 0.18 (p &lt; 0.001), and the indirect effect is β = 0.11 (p &lt; 0.001).Conclusions: The general ability to experience Awe/Gratitude particularly during the COVID-19 pandemic may sensitize to perceive the world around (including nature and concrete persons) more intensely, probably in terms of, or similar to, posttraumatic growth. As this awareness toward specific moments and situations that deeply “touch” a person was higher in persons with more intense meditation or prayer practice, one may assume that these practices may facilitate these perceptions in terms of a training. However, the experience of Awe/Gratitude does not necessarily buffer against adverse events in life and cannot prevent perceived burden due to the corona pandemic, but it facilitates to, nevertheless, perceive positive aspects of life even within difficult times. As Awe/Gratitude is further mediating the effects of Nature/Silence/Contemplation on well-being, intervention programs could help to train these perceptions, as these self-transcendent feelings are also related to prosocial behaviors with respectful treatment of others and commitment to persons in needs, and well-being. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource resilience, Spirituality, Burden, gratitude, AWE, Perceived changes Identifier An unambiguous reference to the resource within a given context 10.3389/fpsyt.2021.642716 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Psychiatry https://www.socictopen.socict.org/files/original/6ea423c4416fe4e3b41605b05d036a6e.pdf c4bf9e85c7d99e35dcec5d93dc214d42 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Axial presentation of reactive arthritis secondary to Covid-19 infection. Creator An entity primarily responsible for making the resource Fiona Louise Coath, James Mackay, John Karl Gaffney Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource covid-19, spondyloarthritis, Reactive arthritis Identifier An unambiguous reference to the resource within a given context 10.1093/rheumatology/keab009 Source A related resource from which the described resource is derived Rheumatology (Oxford, England) https://www.socictopen.socict.org/files/original/4b651aa04f3b5724a549e1960a5fde0f.pdf 2e9f28508d9b0543c37fc98f021a08f3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Ay mi llanura Creator An entity primarily responsible for making the resource Ana Catalina Londoño Vega Description An account of the resource Flora del Llano. Dirección: Cristina Uribe Hurtado; textos: Julio Betancur Betancur; fotografía: Cristina Uribe Hurtado; versión literaria: Vicente Uribe Uribe; asesoría científica: Julio Betancur Betancur Cristina Uribe Editores, Bogotá, 1997, 111 págs., il. (Naturaleza de la Orinoquia; vol. 6). Date A point or period of time associated with an event in the lifecycle of the resource 2000 Subject The topic of the resource Colombia, Flora llanera, Llanura colombiana, Reseñas de libros, ecología Source A related resource from which the described resource is derived Boletín Cultural y Bibliográfico Publisher An entity responsible for making the resource available Banco de la República Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Bibliography. Library science. Information resources Relation A related resource <a href="http://publicaciones.banrepcultural.org/index.php/boletin_cultural/article/view/1322" target="_blank" rel="noreferrer noopener">http://publicaciones.banrepcultural.org/index.php/boletin_cultural/article/view/1322</a> https://www.socictopen.socict.org/files/original/d4a203cb01f07d2cca4a31ff2d365e7e.pdf 1ba4edf2f3437a5af2b683057af0050e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Aykut, S., Foyer, J. y Morena, E. (eds.) (2017) Globalising the climate: COP21 and the climatization of global debates. Nueva York: Earthscan y Routledge Creator An entity primarily responsible for making the resource Alonso Ramírez Cover Description An account of the resource ¿Cuáles son las posibilidad reales de que las negociaciones sobre el cambio climático ofrezcan una solución real a este problema? ¿Qué proyecciones de éxito podemos hacernos con base en los nuevos instrumentos para abordar el cambio climático sugeridos en las COP de Copenhague 2009 y Paris 2015? ¿Son estos instrumentos innovaciones reales en la gobernanza ambiental global o nuevas e inefectivas 'palabras de moda' en la cooperación para el desarrollo sostenible? En sencillo, ¿cómo sabemos que la discusión global sobre el cambio climático no es discurso político vacío destinado a proponer acciones tangibles respecto a un futuro incierto? Las diferentes contribuciones del libro Globalising the climate: COP21 and the climatization of global debates ofrecen interesantes e innovadoras respuestas a estas enormes preguntas existenciales de hoy. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Cambio climático, Globalización, Gobernanza Ambiental Global, negociación climática, régimen climático Identifier An unambiguous reference to the resource within a given context 10.15517/aciep.v0i10.41957 Source A related resource from which the described resource is derived Anuario (Centro de Investigación y Estudios Políticos) Publisher An entity responsible for making the resource available Universidad de Costa Rica Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Political science Relation A related resource <a href="https://revistas.ucr.ac.cr/index.php/ciep/article/view/41957/42532" target="_blank" rel="noreferrer noopener">https://revistas.ucr.ac.cr/index.php/ciep/article/view/41957/42532</a> https://www.socictopen.socict.org/files/original/95e6cfefcff43c9b03d8eb003875515a.pdf cfc12ce2c0d1e29412773737dddaa9d3 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Azole-Resistant COVID-19-Associated Pulmonary Aspergillosis in an Immunocompetent Host: A Case Report Creator An entity primarily responsible for making the resource Jacques F. Meis, Jochem B. Buil, Eelco F. J. Meijer, Anton S. M. Dofferhoff, Oscar Hoiting Description An account of the resource COVID-19-associated pulmonary aspergillosis (CAPA) is a recently described disease entity affecting patients with severe pulmonary abnormalities treated in intensive care units. Delays in diagnosis contribute to a delayed start of antifungal therapy. In addition, the emergence of resistance to triazole antifungal agents puts emphasis on early surveillance for azole-resistant Aspergillus species. We present a patient with putative CAPA due to Aspergillus fumigatus with identification of a triazole-resistant isolate during therapy. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource co-infection, Pulmonary aspergillosis, ICU, <i>Aspergillus fumigatus</i>, SARS-CoV-2, azole-resistant <i>Aspergillus</i> Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jof6020079 Source A related resource from which the described resource is derived Journal of Fungi Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General) https://www.socictopen.socict.org/files/original/0c2dbbb45a808133914ea91092ef702a.pdf 89249e4701486db204df798a604dded0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Azotobacter chroococcum y Azospirillum lipoferum como bioestimulantes en cultivo de Ipomoea batatas Lam. Creator An entity primarily responsible for making the resource Diana Beatriz Sánchez-López, Jazmín Vanessa Pérez-Pazos, Lily Lorena Luna-Castellanos, Joaquín Alfonso García-Peña, Amaury Aroldo Espitia-Montes Description An account of the resource Introducción. La utilización excesiva de fertilizantes nitrogenados en cultivos de batata contribuye con la contaminación de los ecosistemas, para disminuir este efecto y mejorar la productividad del cultivo, la incorporación, de rizobacterias promotoras de crecimiento vegetal (PGPRs, por sus siglas en inglés) en las estrategias de manejo del cultivo, constituyen una herramienta sostenible. Objetivo. El objetivo de esta investigación fue incorporar las cepas bacterianas Azotobacter chroococcum IBCR19 y Azospirillum lipoferum IBSC7 en la fertilización nitrogenada y evaluar su efecto en el rendimiento y composición bromatológica de las raíces tuberosas de batata (Ipomoea batatasLam). Materiales y métodos. El estudio se realizó en el municipio de Corozal (Sucre, Colombia), durante los meses de junio a octubre del 2017. Se utilizó un área experimental de 840 m2, donde se establecieron veinticuatro parcelas con esquejes apicales de la accesión 15020078, distribuidas bajo un diseño completamente aleatorizado con arreglo factorial aumentado (3x2+2). Se evaluó materia seca radicular, rendimiento y composición bromatológica de las raíces de batata.Resultados. El rendimiento fresco y de materia seca radicular presentó diferencias significativas (p≤0,05) entre lostratamientos, en donde la aplicación de A. chroococcum IBCR19 y un 75 % de fertilización nitrogenada alcanzó los mayores valores medios de rendimiento y materia seca radicular 12,18 t.ha-1 y 2,92 t.ha-1, respectivamente. De igualforma, las concentraciones de proteína y extracto etéreo difirieron significativamente (p≤0,05) entre los tratamientosinoculados con relación al testigo absoluto. Conclusión. Con base en los resultados obtenidos se puede inferir que la inoculación con A. chroococcum IBCR19 logró reducir en un 25 % los niveles de fertilización nitrogenada y constituye una cepa promisoria como bioestimulante. Date A point or period of time associated with an event in the lifecycle of the resource 2019 Subject The topic of the resource Fertilidad, Productividad, boniato, microorganismos, nitrógeno Identifier An unambiguous reference to the resource within a given context 10.15517/am.v30i2.33896 Source A related resource from which the described resource is derived Agronomía Mesoamericana Publisher An entity responsible for making the resource available Universidad de Costa Rica Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Agriculture Relation A related resource <a href="https://revistas.ucr.ac.cr/index.php/agromeso/article/view/33896" target="_blank" rel="noreferrer noopener">https://revistas.ucr.ac.cr/index.php/agromeso/article/view/33896</a> https://www.socictopen.socict.org/files/original/ec76c631eb06bba0b9af1fc5dbcc4ced.pdf e7a1360c1e0455004a7e4c16644e8e0b Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Agricultura sostenible Description An account of the resource Dominio científico: Agricultura sostenible Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Azul profundo como escritura y re-escritura metamórfica de poliritmicidades Creator An entity primarily responsible for making the resource Sebastian Wiedemann Description An account of the resource Muchos son los posibles contagios entre el pensamiento de Deleuze y el campo de la educación. Y más aún si asimilamos la dimensión del aprendizaje en tanto implicación y complicación inherente al ejercicio de pensar, como la invención de relaciones no dadas entre heterogéneos. Es decir, si hay pensamiento no solo hay movimiento, pero sobre todo, apre(he)nder inmanente que doblemente es expresión. Es así como podríamos hablar con Deleuze de 'pensar por el medio' como pedagogía radical y en acto. El texto a seguir fue compuesto a  modo de performance filosófica, no solo como gesto de pedagogía radical al querer instaurarse como un plano de experiencia en devenir para el pensamiento, sino que esencialmente como contra-pedagogía en acto ante la forma-academia. A medio camino entre delirio como metodología y fabulación especulativa como fuerza creadora, que he nombrado 'Azul profundo', el texto a modo de critica inmanente se propone a experimentar otros modos de habitar la economía y ecología académica como gesto expresivo y de re-existencia.  Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Deleuze, Performance filosófica, pedagogia radical, reescritura, ritmo Source A related resource from which the described resource is derived Saberes y Prácticas: Revista de Filosofía y Educación Publisher An entity responsible for making the resource available Centro de Investigaciones Interdisciplinarias de Filosofía en la Escuela, Facultad de Filosofía y Letras, Universidad Nacional de Cuyo Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Anthropology, Education (General) Relation A related resource <a href="https://revistas.uncu.edu.ar/ojs/index.php/saberesypracticas/article/view/3547" target="_blank" rel="noreferrer noopener">https://revistas.uncu.edu.ar/ojs/index.php/saberesypracticas/article/view/3547</a> https://www.socictopen.socict.org/files/original/e5e783d881ff3872a6e3bfa0d27ce4c0.pdf 8541053a0f90d9a14f067da8b5f7d759 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource B-Type Natriuretic Peptide as Biomarker of COVID-19 Disease Severity—A Meta-Analysis Creator An entity primarily responsible for making the resource Sabato Sorrentino, Michele Cacia, Isabella Leo, Alberto Polimeni, Jolanda Sabatino, Carmen Anna Maria Spaccarotella, Annalisa Mongiardo, Salvatore De Rosa, Ciro Indolfi Description An account of the resource Up to 15% of coronavirus disease 2019 (COVID-19) patients experience severe clinical presentation, resulting in acute respiratory distress (ARDS) and finally death. N-terminal natriuretic peptide (NT-proBNP) is associated with a worse prognosis in patients with ARDS. However, whether or not this peptide can help discriminate high-risk COVID-19 patients remains unclear. Therefore, in this meta-analysis, we summarized the available evidence on NT-proBNP in patients admitted for COVID-19. Pooled mean, mean differences (MD) and standardized mean difference (SMD) were the summary metrics. Thirteen studies were finally selected for this analysis with a total of 2248 patients, of which 507 had a severe condition (n = 240) or died (n = 267). Pooled mean NT-proBNP levels on admission were 790.57 pg/mL (95% confidence intervals (CIs): 532.50 to 1048.64) in patients that experienced a severe clinical condition or died, and 160.56 pg/mL (95% CI: 118.15 to 202.96) in non-severe patients (SMD: 1.05; 95% (CI): 0.83 to 1.28; p < 0.001; I2 74%; and MD was 645.84 pg/mL (95% CI: 389.50–902.18). Results were consistent in studies categorizing patients as non-survivors versus survivors (SMD: 1.17; 95% CI 0.95 to 1.40; p < 0. 001; I2: 51%), and in those classifying populations in severe versus non-severe clinical condition (SMD: 0.94 95% CI 0.56 to 1.32; p < 0.001; I2: 81%; pinteraction = 0.30). In conclusion, our results suggest that assessing NT-proBNP may support physicians in discriminating high-risk COVID-19 patients. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource covid-19, SARS-CoV-2, Death, NT-proBNP Identifier An unambiguous reference to the resource within a given context 10.3390/jcm9092957 Source A related resource from which the described resource is derived Epidemiology and Health Publisher An entity responsible for making the resource available Korean Society of Epidemiology Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine https://www.socictopen.socict.org/files/original/02fe05bd654b1233a65c0724cf7c3de7.pdf e4c5f704132ff4d8ded8cb632aed415f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Babaodan controls excessive immune responses and may represent a cytokine-targeted agent suitable for COVID-19 treatment. Creator An entity primarily responsible for making the resource Jing Qian, Hangdi Xu, Dongqing Lv, Wei Liu, Enguo Chen, Yong Zhou, Yi Wang, Kejing Ying, Xiaohui Fan Description An account of the resource It has become evident that the actions of pro-inflammatory cytokines and/or the development of a cytokine storm are responsible for the occurrence of severe COVID-19 during SARS-CoV-2 infection. Although immunomodulatory mechanisms vary among viruses, the activation of multiple TLRs that occurs primarily through the recruitment of adapter proteins such as MyD88 and TRIF contributes to the induction of a cytokine storm. Based on this, controlling the robust production of pro-inflammatory cytokines by macrophages may be applicable as a cellular approach to investigate potential cytokine-targeted therapies against COVID-19. In the current study, we utilized TLR2/MyD88 and TLR3/TRIF co-activated macrophages and evaluated the anti-cytokine storm effect of the traditional Chinese medicine (TCM) formula Babaodan (BBD). An RNA-seq-based transcriptomic approach was used to determine the molecular mode of action. Additionally, we evaluated the anti-inflammatory activity of BBD in vivo using a mouse model of post-viral bacterial infection-induced pneumonia and seven severely ill COVID-19 patients. Our study reveals the protective role of BBD against excessive immune responses in macrophages, where the underlying mechanisms involve the inhibition of the NF-κB and MAPK signaling pathways. In vivo, BBD significantly inhibited the release of IL-6, thus resulting in increased survival rates in mice. Based on limited data, we demonstrated that severely ill COVID-19 patients benefited from BBD treatment due to a reduction in the overproduction of IL-6. In conclusion, our study indicated that BBD controls excessive immune responses and may thus represent a cytokine-targeted agent that could be considered to treating COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2021 Subject The topic of the resource inflammation, covid-19, cytokine storm, traditional Chinese medicine, Babaodan Identifier An unambiguous reference to the resource within a given context 10.1016/j.biopha.2021.111586 Source A related resource from which the described resource is derived Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie