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                <text>High Dose Intravenous Methylprednisone in the Treatment of Severe Acute Respiratory Syndrome</text>
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                <text>Brian Bressler, Stephen C Juvet, Sharmistha Mishra, Denis Hadjiliadis, Winnie M Lee</text>
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                <text>The case of a 72-year-old woman with probable severe acute respiratory syndrome is reported. While on treatment with ribavirin and antibiotics (for community-acquired pneumonia), the patient continued to have progressive clinical deterioration and chest radiographic evidence of respiratory deterioration. Pulse dose intravenous corticosteroids were used in an unsuccessful attempt to treat the inflammatory component of this respiratory illness.</text>
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                <text>2004</text>
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                <text>DOI: 10.1155/2004/364284</text>
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                <text>Canadian Respiratory Journal</text>
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                <text>Hindawi Limited</text>
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                <text>Diseases of the respiratory system</text>
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                <text>Corrigendum to 'A linear prognostic score based on the ratio of interleukin-6 to interleukin-10 predicts outcomes in COVID-19'.</text>
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                <text>Brian D Hobbs, Dandi Qiao, Oisín F McElvaney, Matthew Moll, Natalie L McEvoy, Jennifer Clarke, Eoin O'Connor, Sean Walsh, Michael H Cho, Gerard F Curley, Oliver J McElvaney, Noel G McElvaney</text>
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                <text>10.1016/j.ebiom.2020.103116</text>
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                <text>EBioMedicine</text>
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                <text>Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study</text>
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                <text>Brian D. Nicholson, Philip J. Turner, Rafael Perera, Jason Oke, Gail Hayward, F. D. Richard Hobbs, Thomas Fanshawe, Abigail Moore, Filipa Ferreira, Simon de Lusignan, Julian Sherlock, Maria Zambon, Constantinos Koshiaris, Rachel Byford, Joseph J. Lee, Alexandra Deeks, Mary Logan, Anna Seeley, James P. Sheppard, Uy Hoang, Vaishnavi Parimalanathan, George Edwards, Harshana Liyange, Joanna Ellis, Jamie Lopez Bernal, Gayatri Amirthalingam, Ezra Linley, Ray Borrow, Gary Howsam, Sophie Baines</text>
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                <text>Abstract Background The aim of RApid community Point-of-care Testing fOR COVID-19 (RAPTOR-C19) is to assess the diagnostic accuracy of multiple current and emerging point-of-care tests (POCTs) for active and past SARS-CoV2 infection in the community setting. RAPTOR-C19 will provide the community testbed to the COVID-19 National DiagnOstic Research and Evaluation Platform (CONDOR). Methods RAPTOR-C19 incorporates a series of prospective observational parallel diagnostic accuracy studies of SARS-CoV2 POCTs against laboratory and composite reference standards in patients with suspected current or past SARS-CoV2 infection attending community settings. Adults and children with suspected current SARS-CoV2 infection who are having an oropharyngeal/nasopharyngeal (OP/NP) swab for laboratory SARS-CoV2 reverse transcriptase Digital/Real-Time Polymerase Chain Reaction (d/rRT-PCR) as part of clinical care or community-based testing will be invited to participate. Adults (≥ 16 years) with suspected past symptomatic infection will also be recruited. Asymptomatic individuals will not be eligible. At the baseline visit, all participants will be asked to submit samples for at least one candidate point-of-care test (POCT) being evaluated (index test/s) as well as an OP/NP swab for laboratory SARS-CoV2 RT-PCR performed by Public Health England (PHE) (reference standard for current infection). Adults will also be asked for a blood sample for laboratory SARS-CoV-2 antibody testing by PHE (reference standard for past infection), where feasible adults will be invited to attend a second visit at 28 days for repeat antibody testing. Additional study data (e.g. demographics, symptoms, observations, household contacts) will be captured electronically. Sensitivity, specificity, positive, and negative predictive values for each POCT will be calculated with exact 95% confidence intervals when compared to the reference standard. POCTs will also be compared to composite reference standards constructed using paired antibody test results, patient reported outcomes, linked electronic health records for outcomes related to COVID-19 such as hospitalisation or death, and other test results. Discussion High-performing POCTs for community use could be transformational. Real-time results could lead to personal and public health impacts such as reducing onward household transmission of SARS-CoV2 infection, improving surveillance of health and social care staff, contributing to accurate prevalence estimates, and understanding of SARS-CoV2 transmission dynamics in the population. In contrast, poorly performing POCTs could have negative effects, so it is necessary to undertake community-based diagnostic accuracy evaluations before rolling these out. Trial registration ISRCTN, ISRCTN14226970</text>
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                <text>2021</text>
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                <text>covid-19, primary care, Diagnostic Tests, point-of-care tests, community testing</text>
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                <text>10.1186/s41512-021-00093-8</text>
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                <text>Epidemiology and Health</text>
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                <text>Korean Society of Epidemiology</text>
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                <text>Definitive Airway Management of Patients with a King Laryngeal Tube ™ in Place in the COVID-19 Pandemic</text>
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                <text>Brian E. Driver, Calvin A. Brown III, Benjamin J. Sandefur, Robert F. Reardon</text>
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                <text>DOI: 10.5811/westjem.2020.4.47462</text>
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                <text>Western Journal of Emergency Medicine</text>
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                <text>eScholarship Publishing, University of California</text>
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                <text>Medicine, Medical emergencies. Critical care. Intensive care. First aid</text>
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                <text>Virtual Farmers Markets</text>
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                <text>Brian Raison, John Jones</text>
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                <text>This reflective essay discusses the development, structure, operation, and transitioning of an online virtual farmers market in rural Ohio. In this model, customers order online and then pick up their fresh, local produce at a specified time and loca­tion. Through a combination of practitioner expe­rience in the market’s development and informal discussions with people associated with the mar­ket’s development and management, the authors analyze the positive and negative aspects of the online market structure and implementation, as well as suggest critical steps that may be necessary to export this model to other communities. They also consider potential structural and process improvements that could increase viability and success. A last-minute addendum briefly discusses the potential for this model to become a meaning­ful response to the COVID-19 issue as well.</text>
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                <text>covid-19, local food, farmers market, Virtual Farmers Market, Food Council, Online Farmers Market</text>
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                <text>Brian V. Lien, Nolan J. Brown, Bayard Wilson, Stephen Szabadi, Cameron Quon, Vera Ong, Alexander Himstead, Nathan A. Shlobin, Chen Yi Yang, Shane Shahrestani, Katelynn Tran, Ali R. Tafreshi, Jack Birkenbeuel, Seth C. Ransom, Elliot H. Choi, Ronald Sahyouni, Alvin Y. Chan, Aaron Kheriaty, Isaac Yang</text>
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                <text>Abstract At the time of writing of this article, there have been over 110 million cases and 2.4 million deaths worldwide since the start of the Coronavirus Disease 2019 (COVID-19) pandemic, postponing millions of non-urgent surgeries. Existing literature explores the complexities of rationing medical care. However, implications of non-urgent surgery postponement during the COVID-19 pandemic have not yet been analyzed within the context of the four pillars of medical ethics. The objective of this review is to discuss the ethics of elective surgery cancellation during the COVID-19 pandemic in relation to beneficence, non-maleficence, justice, and autonomy. This review hypothesizes that a more equitable decision-making algorithm can be formulated by analyzing the ethical dilemmas of elective surgical care during the pandemic through the lens of these four pillars. This paper’s analysis shows that non-urgent surgeries treat conditions that can become urgent if left untreated. Postponement of these surgeries can cause cumulative harm downstream. An improved algorithm can address these issues of beneficence by weighing local pandemic stressors within predictive algorithms to appropriately increase surgeries. Additionally, the potential harms of performing non-urgent surgeries extend beyond the patient. Non-maleficence is maintained through using enhanced screening protocols and modifying surgical techniques to reduce risks to patients and clinicians. This model proposes a system to transfer patients from areas of high to low burden, addressing the challenge of justice by considering facility burden rather than value judgments concerning the nature of a particular surgery, such as cosmetic surgeries. Autonomy can be respected by giving patients the option to cancel or postpone non-urgent surgeries. However, in the context of limited resources in a global pandemic, autonomy is not absolute. Non-urgent surgeries can ethically be postponed in opposition to the patient’s preference. The proposed algorithm attempts to uphold the four principles of medical ethics in rationing non-urgent surgical care by building upon existing decision models, using additional measures of resource burden and surgical safety to increase health care access and decrease long-term harm as much as possible. The next global health crisis will undoubtedly present its own unique challenges. This model may serve as a comprehensive starting point in determining future guidelines for non-urgent surgical care.</text>
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                <text>Universidade Federal de Santa Catarina</text>
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                <text>In early December 2019, the coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged in Wuhan, China. As of May 10th, 2020, a total of over 4 million COVID-19 cases and 280,000 deaths have been reported globally, reflecting the raised infectivity and severity of this virus. Amongst hospitalised COVID-19 patients, there is a high prevalence of established cardiovascular disease (CVD). There is evidence showing that COVID-19 may exacerbate cardiovascular risk factors and preexisting CVD or may lead to cardiovascular complications. With intensive care units operating at maximum capacity and such staggering mortality rates reported, it is imperative during this time-sensitive COVID-19 outbreak to identify patients with an increased risk of adverse outcomes and/or myocardial injury. Preliminary findings from COVID-19 studies have shown the association of biomarkers of acute cardiac injury and coagulation with worse prognosis. While these biomarkers are recognised for CVD, there is emerging prospect that they may aid prognosis in COVID-19, especially in patients with cardiovascular comorbidities or risk factors that predispose to worse outcomes. Consequently, the aim of this review is to identify cardiovascular prognostic factors associated with morbidity and mortality in COVID-19 and to highlight considerations for incorporating laboratory testing of biomarkers of cardiovascular performance in COVID-19 to optimise outcomes.</text>
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                <text>DOI: 10.3390/v12050527</text>
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                <text>Diálogos de saberes em uma horta urbana: a temática do controle biológico de pragas em uma proposta de educação não formal para o trabalho</text>
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                <text>A agricultura desenvolvida em ambientes urbanos configura contextos especiais, como a proximidade de residências e o cultivo de hortaliças, favorecendo a utilização de técnicas agroecológicas que reduzam a exposição a produtos sintéticos e tóxicos tanto de agricultores quanto consumidores e moradores próximos as áreas de cultivo. A apropriação ou não destas formas de lidar com a produção passa por diferentes processos de observação, diálogos e reconhecimento de questões socioambientais, econômicas, políticas e culturais que norteiam e podem contribuir para sustentar o cultivo de hortaliças propriamente dito. Este artigo se propõe a refletir sobre alguns percursos de aprendizagem vivenciados por meio de pesquisa realizada com os agricultores da Horta Comunitária da Cohab, município de Lavras, Minas Gerais. Para alcance dos objetivos propostos, identificou-se o perfil socioeconômico dos agricultores da horta e suas principais demandas técnicas. Foi utilizado roteiro de entrevista semiestruturado e oficina estratégica de levantamento de demandas. Assim, foram concebidas e desenvolvidas oficinas pedagógicas, palestras, cursos, demonstrações práticas e visitas a outro município para troca de experiências. Um momento específico de devolução e avaliação dos resultados da pesquisa com os agricultores e toda a equipe de trabalho permitiu a identificação de dois eixos analíticos principais: a receptividade e a potencialidade para aprofundamento do conhecimento e ampliação da horta conduzida em bases agroecológicas.</text>
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                <text>Agricultura urbana, agroecologia, entomología</text>
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                <text>Revista IDEAS</text>
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                <text>Universidade Federal Rural do Rio de Janeiro</text>
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                <text>&lt;a href="https://revistaideas.ufrrj.br/ojs/index.php/ideas/article/view/159" target="_blank" rel="noreferrer noopener"&gt;https://revistaideas.ufrrj.br/ojs/index.php/ideas/article/view/159&lt;/a&gt;</text>
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                <text>Advanced 3D Cell Culture Techniques in Micro-Bioreactors, Part II: Systems and Applications</text>
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                <text>In this second part of our systematic review on the research area of 3D cell culture in micro-bioreactors we give a detailed description of the published work with regard to the existing micro-bioreactor types and their applications, and highlight important results gathered with the respective systems. As an interesting detail, we found that micro-bioreactors have already been used in SARS-CoV research prior to the SARS-CoV2 pandemic. As our literature research revealed a variety of 3D cell culture configurations in the examined bioreactor systems, we defined in review part one “complexity levels” by means of the corresponding 3D cell culture techniques applied in the systems. The definition of the complexity is thereby based on the knowledge that the spatial distribution of cell-extracellular matrix interactions and the spatial distribution of homologous and heterologous cell–cell contacts play an important role in modulating cell functions. Because at least one of these parameters can be assigned to the 3D cell culture techniques discussed in the present review, we structured the studies according to the complexity levels applied in the MBR systems.</text>
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                <text>scaffold, co-culture, hydrogels, 3D cell culture, micro-bioreactor, multicellular aggregates</text>
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                  <text>Agricultura sostenible</text>
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                <text>Recolección y preservación de macroalgas marinas: una guía para estudios ficológicos</text>
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                <text>Brigitte Gavio, Lennin Florez-Leiva, Marta Díaz-Ruiz, Olga Camacho, Guillermo Díaz-Pulido</text>
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                <text>Conocer la forma adecuada de recolectar, preservar y conservar las macroalgas marinas es indispensable para generar colecciones biológicas que puedan ser utilizadas en diversas investigaciones (taxonomía, sistemática, ecología, evolución, etc.) y de igual forma brinden importantes herramientas para la educación. De esta forma, las colecciones se constituyen en patrimonio de la nación.</text>
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                <text>Colecciones, Herbario, algas marinas, biodiversidad</text>
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                <text>Intropica</text>
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                <text>Universidad del Magdalena</text>
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            <name>Coverage</name>
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                <text>Agriculture, Environmental sciences, Biology (General)</text>
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            <description>A related resource</description>
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                <text>&lt;a href="http://revistas.unimagdalena.edu.co/index.php/intropica/article/view/157" target="_blank" rel="noreferrer noopener"&gt;http://revistas.unimagdalena.edu.co/index.php/intropica/article/view/157&lt;/a&gt;</text>
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