279 10 20655 https://www.socictopen.socict.org/files/original/13addcb761465d7609b6527dba03939b.pdf 769cb602d41e56c82bfeddafdb9faa9e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource COVID-19 Epidemic as E-Learning Boost? Chronological Development and Effects at an Austrian University against the Background of the Concept of “E-Learning Readiness” Creator An entity primarily responsible for making the resource Martin Ebner, Behnam Taraghi, Sandra Schön, Markus Ebner, Ypatios Grigoriadis, Maria Haas, Philipp Leitner, Clarissa Braun Description An account of the resource The COVID-19 crisis influenced universities worldwide in early 2020. In Austria, all universities were closed in March 2020 as a preventive measure, and meetings with over 100 people were banned and a curfew was imposed. This development also had a massive impact on teaching, which in Austria takes place largely face-to-face. In this paper we would like to describe the situation of an Austrian university regarding e-learning before and during the first three weeks of the changeover of the teaching system, using the example of Graz University of Technology (TU Graz). The authors provide insights into the internal procedures, processes and decisions of their university and present figures on the changed usage behaviour of their students and teachers. As a theoretical reference, the article uses the e-learning readiness assessment according to Alshaher (2013), which provides a framework for describing the status of the situation regarding e-learning before the crisis. The paper concludes with a description of enablers, barriers and bottlenecks from the perspective of the members of the Educational Technology department. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource e-learning, Strategy, Online Learning, E-lectures, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/fi12060094 Source A related resource from which the described resource is derived Future Internet Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Information technology https://www.socictopen.socict.org/files/original/8ce09e28c9b5ed9b505e697935cf2ca5.pdf a80e73617620b0b944b41d9d52825b0f Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource SARS-CoV-2 (COVID-19): New Discoveries and Current Challenges Creator An entity primarily responsible for making the resource Ali Hekmatnia, Rajender S. Varma, Parisa Iravani, Mahmoud Nasrollahzadeh, Salman Fallah, Mohaddeseh Sajjadi, Siavash Iravani, Ghazaleh Jamalipour Soufi, Nasrin Shafiei Description An account of the resource SARS-CoV-2 (COVID-19) has today multiplied globally and various governments are attempting to stop the outbreak of the disease escalation into a worldwide health crisis. At this juncture, readiness, candor, clarity, and partaking of data are of paramount importance to speed up factual evaluation and starting pattern control activities, including serendipitous findings. Owing to the involvement of COVID-19, many facts regarding virulence, pathogenesis, and the real viral infection source and/or transmission mode still need to be addressed. The infected patients often present clinical symptoms with fever, dyspnea, fatigue, diarrhea, vomiting, and dry cough, as well as pulmonary, infiltrates on imaging. Extensive measures to decrease person-to-person transmission of COVID-19 are being implemented to prevent, recognize, and control the current outbreak as it is very similar to SARS-CoV in its clinical spectrum, epidemiology, and pathogenicity. In response to this fatal disease and disruptive outbreak, it is extremely vital to expedite the drug development process to treat the disease and vaccines for the prevention of COVID-19 that would help us defeat this pandemic expeditiously. This paper sums up and unifies the study of virological aspects, disease transmission, clinically administered techniques, therapeutics options, managements, future directions, designing of vaccines, and news dissemination pertaining to COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource diagnosis, cardiovascular systems, SARS-CoV-2, COVID-19, therapeutics options, respiratory systems Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/app10103641 Source A related resource from which the described resource is derived Applied Sciences Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Biology (General), Technology, Physics, Chemistry, Engineering (General). Civil engineering (General) https://www.socictopen.socict.org/files/original/27d8a45a12a43bb504e91382ffdc1bad.pdf 703ccf71773490b3aef50ee681b2d124 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Risk and Financial Management of COVID-19 in Business, Economics and Finance Creator An entity primarily responsible for making the resource Michael McAleer, Chia-Lin Chang, Wing-Keung Wong Description An account of the resource The SARS-CoV-2 coronavirus that causes the COVID-19 disease led to the most significant change in the world order over the past century, destabilizing the global economy and financial stock markets, the world’s economy, social development, business, risk, financial management and financial markets, among others. COVID-19 has generated great uncertainty, and dramatically affected tourism, travel, hospitality, supply chains, consumption, production, operations, valuations, security, financial stress and the prices of all products, including fossil fuel and renewable energy sources. This Editorial introduces a Special Issue of the Journal of Risk and Financial Management (JRFM) on the “Risk and Financial Management of COVID-19 in Business, Economics and Finance”. This Special Issue will attract practical, state-of-the-art applications of mathematics, probability and statistical techniques on the topic, including empirical applications. This paper investigates important issues that have been discussed in tourism, global health security and risk management in business as well as the social and medical sciences. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource tourism, business, Global Health Security, economics and finance, virus and disease, risk and financial management, social and medical sciences Identifier An unambiguous reference to the resource within a given context DOI: 10.3390/jrfm13050102 Source A related resource from which the described resource is derived Journal of Risk and Financial Management Publisher An entity responsible for making the resource available MDPI AG Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Finance, Risk in industry. Risk management https://www.socictopen.socict.org/files/original/7c6fd4b95fd536b7e489b12c39c909dc.pdf bedd3517d8b7b6632e16304f5d804fcb Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The dramatic impact of Coronavirus outbreak on air quality: Has it saved as much as it has killed so far? Creator An entity primarily responsible for making the resource R.J. Isaifan Description An account of the resource The outbreak of coronavirus disease (COVID-19) was first reported from Wuhan, China, on December 31st, 2019. As the number of coronavirus infections has exceeded 100,000 with toll deaths of about 5000 worldwide as of early March, 2020, scientists and researchers are racing to investigate the nature of this virus and evaluate the short and long term effects of this disease. Despite its negative impacts that obliged the World Health Organization to declare COVID-19 epidemic as a Public Health Emergency of International Concern, the rate of mortality of this infection has not exceeded 3.4% globally. On the other hand, the mortality rate caused by ambient air pollution has contributed to 7.6% of all deaths in 2016 worldwide. The outbreak of COVID-19 has forced China to lockdown its industrial activities and hence dropped its NO2 and carbon emissions by 30 and 25%, respectively. This work reports on the first case study that compares the air quality status before and after the crisis. It sheds light on the facts related to the demographics of deaths by gender, age and health status before infection. The historical data on air quality, estimates of annual deaths and its economic burden have been presented and analyzed. The actual daily deaths due to COVID-19 have been obtained from the official records of the daily Situation Reports published by World Health Organization as of March 11th. The rate of mortality due to COVID-19 was impacted by two factors: age and health status. Results show that 75% of deaths were related to cases that had underlying present diseases with the majority aged of 80+ years. The reported figures were compared with the average daily mortality due to poor air quality which reached up to 3287 deaths due to high levels of NO2, O3 and PM. The air quality status before the crisis was compared with the current situation showing that COVID-19 forced-industrial and anthropogenic activities lockdown may have saved more lives by preventing ambient air pollution than by preventing infection. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource China, air quality, Mortality Rate, coronavirus, burden of disease, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.22034/gjesm.2020.03.01 Source A related resource from which the described resource is derived Global Journal of Environmental Science and Management Publisher An entity responsible for making the resource available Global Journal of Environmental Science and Management Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Environmental sciences https://www.socictopen.socict.org/files/original/fa2bb6b3a22dbe6672be21265f6f6632.pdf 2c70328a17846bd58d28bd195c39c9fc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Approaches to Daily Monitoring of the SARS-CoV-2 Outbreak in Northern Italy Creator An entity primarily responsible for making the resource Milena Maule, Lorenzo Richiardi, Carlo Novara, Giovenale Moirano Description An account of the resource Italy was the first European country affected by the Sars-Cov-2 pandemic, with the first autochthonous case identified on Feb 21st. Specific control measures restricting social contacts were introduced by the Italian government starting from the beginning of March. In the current study we analyzed public data from the four most affected Italian regions. We (i) estimated the time-varying reproduction number (Rt), the average number of secondary cases that each infected individual would infect at time t, to monitor the positive impact of restriction measures; (ii) applied the generalized logistic and the modified Richards models to describe the epidemic pattern and obtain short-term forecasts. We observed a monotonic decrease of Rt over time in all regions, and the peak of incident cases ~2 weeks after the implementation of the first strict containment measures. Our results show that phenomenological approaches may be useful to monitor the epidemic growth in its initial phases and suggest that costly and disruptive public health controls might have had a positive impact in limiting the Sars-Cov-2 spread in Northern Italy. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Epidemiology, Public Health, infectious disease, outbreak analyses, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fpubh.2020.00222 Source A related resource from which the described resource is derived Frontiers in Public Health Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine https://www.socictopen.socict.org/files/original/784c5f114955e666b76177b72cf1c2f8.pdf 1e28bba8ded9e4e61b614bfa6cda9777 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials Creator An entity primarily responsible for making the resource Kirsty G. Pringle, Eugenie R. Lumbers, Sarah J Delforce, Gary R. Smith Description An account of the resource Angiotensin-converting enzyme 2 (ACE2) is the receptor for COVID-19 (SARs-CoV-2). ACE2 protects the lung and heart from acute respiratory distress syndrome (ARDS) and acute myocarditis and arrhythmias, because it breaks down Angiotensin II, which has inflammatory effects in the lung and heart as well as in the kidney. When SARS-CoV-2 binds to ACE2, it suppresses it, so this protective action of ACE2 is lost. Death from COVID-19 is due to ARDS and also heart failure and acute cardiac injury. Drugs that prevent the inflammatory actions of Angiotensin II (i.e., Angiotensin receptor blockers, ARBs) prevent acute lung injury caused by SARS-CoV. Clinical trials are underway to test the risks and benefits of ARBs and angiotensin-converting enzyme inhibitors (ACEIs) in COVID-19 patients requiring hospitalization. Other potential treatments are also discussed. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Cardiovascular disease, lung injury, ACE2, renin-angiotensin system (RAS), SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmed.2020.00248 Source A related resource from which the described resource is derived Frontiers in Medicine Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine (General) https://www.socictopen.socict.org/files/original/68e153ed91b97c420c4354d1e0e03f9f.pdf a3fce77ba9d311e9de2de4721f5b040e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis Creator An entity primarily responsible for making the resource Raymond Pranata, Ian Huang Description An account of the resource Abstract Objective Clinical and laboratory biomarkers to predict the severity of coronavirus disease 2019 (COVID-19) are essential in this pandemic situation of which resource allocation must be urgently prepared especially in the context of respiratory support readiness. Lymphocyte count has been a marker of interest since the first COVID-19 publication. We conducted a systematic review and meta-analysis in order to investigate the association of lymphocyte count on admission and the severity of COVID-19. We would also like to analyze whether patient characteristics such as age and comorbidities affect the relationship between lymphocyte count and COVID-19. Methods Comprehensive and systematic literature search was performed from PubMed, SCOPUS, EuropePMC, ProQuest, Cochrane Central Databases, and Google Scholar. Research articles in adult patients diagnosed with COVID-19 with information on lymphocyte count and several outcomes of interest, including mortality, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) care, and severe COVID-19, were included in the analysis. Inverse variance method was used to obtain mean differences and its standard deviations. Maentel-Haenszel formula was used to calculate dichotomous variables to obtain odds ratios (ORs) along with its 95% confidence intervals. Random-effect models were used for meta-analysis regardless of heterogeneity. Restricted-maximum likelihood random-effects meta-regression was performed for age, gender, cardiac comorbidity, hypertension, diabetes mellitus, COPD, and smoking. Results There were a total of 3099 patients from 24 studies. Meta-analysis showed that patients with poor outcome have a lower lymphocyte count (mean difference − 361.06 μL [− 439.18, − 282.95], p < 0.001; I 2 84%) compared to those with good outcome. Subgroup analysis showed lower lymphocyte count in patients who died (mean difference − 395.35 μL [− 165.64, − 625.07], p < 0.001; I 2 87%), experienced ARDS (mean difference − 377.56 μL [− 271.89, − 483.22], p < 0.001; I 2 0%), received ICU care (mean difference − 376.53 μL [− 682.84, − 70.22], p = 0.02; I 2 89%), and have severe COVID-19 (mean difference − 353.34 μL [− 250.94, − 455.73], p < 0.001; I 2 85%). Lymphopenia was associated with severe COVID-19 (OR 3.70 [2.44, 5.63], p < 0.001; I 2 40%). Meta-regression showed that the association between lymphocyte count and composite poor outcome was affected by age (p = 0.034). Conclusion This meta-analysis showed that lymphopenia on admission was associated with poor outcome in patients with COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource coronavirus, lymphopenia, Lymphocyte count, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s40560-020-00453-4 Source A related resource from which the described resource is derived Journal of Intensive Care Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical emergencies. Critical care. Intensive care. First aid https://www.socictopen.socict.org/files/original/bb23fe73f3e9e3eaf0aefa455182f3e3.pdf a77867ad52ba25c06908193599d637d0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource With the current COVID pandemic: should we use single-use flexible bronchoscopes instead of conventional bronchoscopes? Creator An entity primarily responsible for making the resource Patrick M Honoré, David De Bels, Rachid Attou, Sebastien Redant, Andrea Gallerani, Luc Kugener, Aude Mugisha Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13054-020-02965-9 Source A related resource from which the described resource is derived Critical Care Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical emergencies. Critical care. Intensive care. First aid https://www.socictopen.socict.org/files/original/8a216693ccce16f341c48e3538a8e4a5.pdf 6e4a2faceabf208ff2e146eee1170a04 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Perspectives in bioeconomy: strategies, Green Deal and Covid19 Creator An entity primarily responsible for making the resource Marchetti M, Palahí M Description An account of the resource The importance of a sustainable and circular bioeconomy in achieving the Sustainable Development Goals (SDGs) has been recognized at various political levels. The EU Green Deal is one of the most transformative European political initiatives in recent decades. However, such a great vision and ambition can not be delivered without looking at the essence of the economic model we have created, without fundamentally rethinking the way we produce and consume. What is needed is a system change. We have to connect and implement transformative policies holistically to achieve the systemic change that is urgently needed. The bioeconomy, a circular economy based on renewable biological resources and sustainable biobased solutions, could certainly contribute. Three features could help to connect the dots in the Green Deal: bioeconomy is fundamental for inclusive prosperity and fair social transition; moving towards a carbon neutral EU requires moving towards fossil-free energy and fossil-free materials, to replace carbon intense products, such as nanocellulose, wood based textiles, wood engeenering; address the past failure of the economy to value nature and biodiversity. Biological diversity determines the capacity of biological resources to adapt and evolve in a changing environment and is a prerequisite for a long-term, sustainable and resilient bioeconomy. Therefore, bioeconomy is a great opportunity to modernize and make industries more circular: renewable biological resources, like forest resources, are, if managed sustainably at local and responsibly at global level, circular by nature and often easier to manufacture. The potential and crucial role of forests and forestry is not yet addressed enough at European level. Some good examples from member states and economic sectors should be adopted as the main way to promote sustainability at all levels, social, ecological, economic. The stewardship of forest ecosystem services such as biodiversity provision, hydrogeological protection and landscape conservation has increased. In addition to the main dramatic role for the conservation of biodiversity and the mitigation of climate crisis, forests could pave a strategic road to the creation of new green jobs, tackling the new direction that are requested after the current time of pandemic for rethinking our common future. Also in Italy, nowadays the conditions are ripe to plan for a responsible management of the natural capital in the country’s forests. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource strategies, bioeconomy, Forests, COVID-19, Green Deal Identifier An unambiguous reference to the resource within a given context DOI: 10.3832/efor0059-017 Source A related resource from which the described resource is derived Forest@ Publisher An entity responsible for making the resource available Italian Society of Silviculture and Forest Ecology (SISEF) Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Forestry https://www.socictopen.socict.org/files/original/f68cfa3d886d2fd6402fd2cd2e0cf4e3.pdf 904e7cd41ebb063e00208738043f8a0d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis Creator An entity primarily responsible for making the resource Lu Wang, Li Feng, Keliang Wang, Mei Xue, Fang Fu, Wanhai Xu, Changlin Wang, Ziqi Wang, Pinghuang Liu, Ling-Ling Shan, Shuxin Qu Description An account of the resource Porcine epidemic diarrhea virus (PEDV) is an economically important pathogen that has evolved several mechanisms to evade type I IFN responses. Type III interferon (IFN-λ), an innate cytokine that primarily targets the mucosal epithelia, is critical in fighting mucosal infection in the host and has been reported to potently inhibit PEDV infection in vitro. However, how PEDV escapes IFN-λ antiviral response remains unclear. In this study, we found that PEDV infection induced significant IFN-λ expression in type I IFN-defective Vero E6 cells, but virus-induced endogenous IFN-λ did not reduce PEDV titers. Moreover, we demonstrated that PEDV escaped IFN-λ responses by substantially upregulating the suppressor of cytokine signaling protein 1 (SOCS1) expression, which impaired the induction of IFN-stimulated genes (ISGs) and dampened the IFN-λ antiviral response and facilitated PEDV replication in Vero E6 cells. We further showed that PEDV infection increased SOCS1 expression by decreasing host miR-30c-5p expression. MiR-30c-5p suppressed SOCS1 expression through targeting the 3′ untranslated region (UTR) of SOCS1. The inhibition of IFN-λ elicited ISGs expression by SOCS1 was specifically rescued by overexpression of miR-30c-5p. Collectively, our findings identify a new strategy by PEDV to escape IFN-λ-mediated antiviral immune responses by engaging the SOCS1/miR-30c axis, thus improving our understanding of its pathogenesis. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource microRNA, coronavirus, PEDV, SOCS-1, IFN-λ, miR-30c-5p Identifier An unambiguous reference to the resource within a given context DOI: 10.3389/fmicb.2020.01180 Source A related resource from which the described resource is derived Frontiers in Microbiology Publisher An entity responsible for making the resource available Frontiers Media S.A. Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Microbiology