280 10 20655 https://www.socictopen.socict.org/files/original/4fa23528b3e16ad30f7c6c2e7d55a393.pdf 3ac8412af0c9503a496ad9bd57feb05e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The journey of remdesivir: from Ebola to COVID-19 Creator An entity primarily responsible for making the resource Ashutosh M Shukla, Joe Pardo, Gajapathiraju Chamarthi, Asmita Gupte Description An account of the resource Countries around the world are currently fighting the coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2). SARS-CoV-2 is a betacoronavirus, belonging to the same genus as severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV. Currently, there are no proven antiviral therapies for COVID-19. Numerous clinical trials have been initiated to identify an effective treatment. One leading candidate is remdesivir (GS-5734), a broad-spectrum antiviral that was initially developed for the treatment of Ebola virus (EBOV). Although remdesivir performed well in preclinical studies, it did not meet efficacy endpoints in a randomized trial conducted during an Ebola outbreak. Remdesivir holds promise for treating COVID-19 based on in vitro activity against SARS-CoV-2, uncontrolled clinical reports, and limited data from randomized trials. Overall, current data are insufficient to judge the efficacy of remdesivir for COVID-19, and the results of additional randomized studies are eagerly anticipated. In this narrative review, we provide an overview of Ebola and coronavirus outbreaks. We then summarize preclinical and clinical studies of remdesivir for Ebola and COVID-19. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Pandemic, remdesivir, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.7573/dic.2020-4-14 Source A related resource from which the described resource is derived Drugs in Context Publisher An entity responsible for making the resource available BioExcel Publishing Ltd Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Therapeutics. Pharmacology https://www.socictopen.socict.org/files/original/cc5578042c91c41a07167ab6880b18b3.pdf d41dd15b93c0d7d6f45337de13dd64d1 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Being an American 2nd Year Medical Student in the COVID-19 Pandemic Creator An entity primarily responsible for making the resource Benjamin D. Liu Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource experience, United States of America, medical student, COVID-19, covid-19 medical student experience, coronavirus medical student experience Identifier An unambiguous reference to the resource within a given context DOI: 10.5195/ijms.2020.528 Source A related resource from which the described resource is derived International Journal of Medical Students Publisher An entity responsible for making the resource available International Journal of Medical Students Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Public aspects of medicine, Medicine (General) https://www.socictopen.socict.org/files/original/3c5708f55cc02e6aae30b773abe381b8.pdf 0cb54e0757a3fbc8a6f5a85e97411431 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Caso clínico: neumonía de comunidad grave COVID-19 Creator An entity primarily responsible for making the resource Juan Higuera Lucas, Clara Serrano Ferrer Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource neumonía, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.25237/revchilanestv49n03.025 Source A related resource from which the described resource is derived Revista Chilena de Anestesia Publisher An entity responsible for making the resource available Editorial Iku Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Anesthesiology https://www.socictopen.socict.org/files/original/7ebdd5738c127564ffad87df4592eedd.pdf c7e4004b0bef5c8fa73c4b2d9fdd219e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Anestesia para pacientes pediátricos con COVID-19 Creator An entity primarily responsible for making the resource Verónica Maureira, María Francisca Bernucci, Alexandra Fajardo Alexandra Fajardo, Rose Marie Heider Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource ANESTESIA, pediatria, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.25237/revchilanestv49n03.022 Source A related resource from which the described resource is derived Revista Chilena de Anestesia Publisher An entity responsible for making the resource available Editorial Iku Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Anesthesiology https://www.socictopen.socict.org/files/original/26ff8aba444f4d37a4c27f8d1f3d2466.pdf 1b689fd4643db50e384db2735e2c2c63 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Paro Cardiorrespiratorio (PCR) y Reanimación Cardiopulmonar (RCP) en un nuevo escenario: COVID19 Creator An entity primarily responsible for making the resource María Mercedes Aguirre C. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Reanimación cardiopulmonar, paro cardiorrespiratorio, COVID-19, reanimación en prono Identifier An unambiguous reference to the resource within a given context DOI: 10.25237/revchilanestv49n03.017 Source A related resource from which the described resource is derived Revista Chilena de Anestesia Publisher An entity responsible for making the resource available Editorial Iku Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Anesthesiology https://www.socictopen.socict.org/files/original/fe4ddefd20dc6a9bf405deb445faa2ff.pdf cd81f4f10d5133b1de4aa30e33800a01 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus y anestesia: Consideraciones en torno a la solidaridad Creator An entity primarily responsible for making the resource José Ricardo Navarro-Vargas, Álvaro Rodríguez-Roa Álvaro Rodríguez-Roa Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource ANESTESIÓLOGO, contagio, Aislamiento, Precauciones Universales, pandemia, Cuarentena, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.25237/revchilanestv49n03.010 Source A related resource from which the described resource is derived Revista Chilena de Anestesia Publisher An entity responsible for making the resource available Editorial Iku Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine, Anesthesiology https://www.socictopen.socict.org/files/original/ebbe641b4e0c903e3e041f3d64851b61.pdf 9d9af9a0507f69d9fa9cb17d06af6943 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The potential insights of Traditional Chinese Medicine on treatment of COVID-19 Creator An entity primarily responsible for making the resource Sheng Liu, Tong Tong, Ai-Zong Shen, Yingqi Wu, Wei-Jian Ni Description An account of the resource Abstract Corona Virus Disease 2019 (COVID-19) broke out in 2019 and spread rapidly around the world. There is still no specific antiviral therapy to the current pandemic. In China, historical records show that Traditional Chinese Medicine (TCM) is effective in prevention and enhancing the resistance to pandemic with unique insights. To fight with COVID-19, National Health and Commission of PRC has recommended some TCM in the guideline, such as HuoxiangZhengqi, LianhuaQingwen ShufengJiedu and XueBijing, and actually displayed a remarkable effect in clinical treatment strategic for COVID-19. We review studies to provide an in-depth understanding into the effect of TCM, and also introduce the possible mechanism involved in COVID-19 treatment. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource treatment, traditional Chinese medicine, mechanism, SARS-CoV-2, COVID-19 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13020-020-00326-w Source A related resource from which the described resource is derived Chinese Medicine Publisher An entity responsible for making the resource available BMC Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Other systems of medicine https://www.socictopen.socict.org/files/original/5063b9bca89c80c636700bd2beaa52da.pdf ad00120807a18fc4a77df0d89fa9aaa0 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Microvascular alterations in patients with SARS-COV-2 severe pneumonia Creator An entity primarily responsible for making the resource Abele Donati, Roberta Domizi, Elisa Damiani, Erica Adrario, Claudia Scorcella, Andrea Carsetti, Erika Casarotta Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1186/s13613-020-00680-w Source A related resource from which the described resource is derived Annals of Intensive Care Publisher An entity responsible for making the resource available SpringerOpen Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medical emergencies. Critical care. Intensive care. First aid https://www.socictopen.socict.org/files/original/315756929b0a90b4786a01cbab8b0d12.pdf ffc7bb6f9bef19c22491b4a2f867acb7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis Creator An entity primarily responsible for making the resource Zhi-Hong Liu, Jiaqi Li, Yue Lang, Guoji Guo, Qilin Chen, Zhi-Dan Xiang Description An account of the resource Background: The new coronavirus (SARS-CoV-2), which has been responsible for the recent coronavirus disease 2019 (COVID-19) pandemic, uses the cell receptor angiotensin converting enzyme-2 (ACE2) for entry and the serine protease TMPRSS2 for spike (S) protein priming. Meanwhile, the presence of B0AT1 (SLC6A19) may prevent TMPRSS2 from accessing the cutting position on ACE2. Identifying the expression of these cell receptor-related genes of SARS-CoV-2 is critical for understanding the pathogenesis of SARS-CoV-2 in various tissues, especially in the kidney. Methods: The single-cell transcription datasets of the human cell landscape (HCL) and other relevant single-cell transcription databases were used to analyze the expression of ACE2, TMPRSS2, and SLC6A19 in various organs and tissues, but mainly in the kidney. Results: ACE2 was significantly expressed in the S1, S2, and S3 segments of proximal tubule (PT) cells. TMPRSS2 was widely expressed in several renal tubule populations extending from the PT cells to the collection system cell type, of which intercalated cells and the distal convoluted tubule cells showed more significant expression than PT cells. Unexpectedly, although expressed on various renal tubule populations, SLC6A19 was mainly enriched in PT cells, in line with ACE2 expression. Although alveolar-type (AT) 2 cells of the lung and intestinal epithelial cells expressed ACE2 as well as PT cells, AT 2 cells significantly expressed TMPRSS2 but not SLC6A19, while all 3 genes were significantly expressed in intestinal epithelial cells. Conclusions: ACE2 was widely expressed in specific cell subgroups of various human tissues, especially in intestinal epithelial cells, kidney PT cells, and also AT 2 cells of the lung. These 3 types of cells demonstrated significant differences in the distribution of the cell receptor-related genes of SARS-CoV-2, which may indicate the diversity of cell surface structures and differences in the affinity between SARS-CoV-2 and cells. Date A point or period of time associated with an event in the lifecycle of the resource 2020 Subject The topic of the resource Angiotensin converting enzyme-2, single-cell transcriptome sequencing, Proximal tubule cells, SARS-CoV-2 Identifier An unambiguous reference to the resource within a given context DOI: 10.1159/000508162 Source A related resource from which the described resource is derived Kidney Diseases Publisher An entity responsible for making the resource available Karger Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Internal medicine https://www.socictopen.socict.org/files/original/1512ce48296f9f2a0091b2040e1113f6.pdf 46db059e7cbda3fde16bdd5c8fabfe1a Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Coronavirus Description An account of the resource Dominio científico: Coronavirus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource 17 Days in Warsan, Dubai, UAE, for COVID-19 Creator An entity primarily responsible for making the resource Jasem Alhashmi Date A point or period of time associated with an event in the lifecycle of the resource 2020 Identifier An unambiguous reference to the resource within a given context DOI: 10.1159/000508553 Source A related resource from which the described resource is derived Dubai Medical Journal Publisher An entity responsible for making the resource available Karger Publishers Coverage The spatial or temporal topic of the resource, the spatial applicability of the resource, or the jurisdiction under which the resource is relevant Medicine